{"id":"https://openalex.org/W7212965799","doi":"https://doi.org/10.3390/healthcare14183005","title":"Clinical Outcomes of Ankaferd Hemostat Mouthwash for High-Grade Oral Mucositis During Systemic Anticancer Therapy: A Single-Center, Retrospective, Single-Arm Cohort Study","display_name":"Clinical Outcomes of Ankaferd Hemostat Mouthwash for High-Grade Oral Mucositis During Systemic Anticancer Therapy: A Single-Center, Retrospective, Single-Arm Cohort Study","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7212965799","doi":"https://doi.org/10.3390/healthcare14183005","pmid":"https://pubmed.ncbi.nlm.nih.gov/42793543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13606083"},"language":"en","primary_location":{"id":"doi:10.3390/healthcare14183005","doi":"https://doi.org/10.3390/healthcare14183005","is_oa":true,"landing_page_url":"https://doi.org/10.3390/healthcare14183005","pdf_url":null,"source":{"id":"https://openalex.org/S4210214101","display_name":"Healthcare","issn_l":"2227-9032","issn":["2227-9032"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Healthcare","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7212965799"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/healthcare14183005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111285786","display_name":"G\u00f6khan \u00c7olak","orcid":"https://orcid.org/0000-0002-3802-461X","observed_orcids":["https://orcid.org/0000-0002-3802-461X"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gokhan Colak","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3802-461X","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009130147","display_name":"Bilgin Demir","orcid":"https://orcid.org/0000-0003-4380-9419","observed_orcids":["https://orcid.org/0000-0003-4380-9419"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Bilgin Demir","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4380-9419","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016380492","display_name":"Merve Turan","orcid":"https://orcid.org/0000-0003-4021-6095","observed_orcids":["https://orcid.org/0000-0003-4021-6095"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Merve Turan","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4021-6095","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071738025","display_name":"Esin Oktay","orcid":"https://orcid.org/0000-0002-5974-6339","observed_orcids":["https://orcid.org/0000-0002-5974-6339"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esin Oktay","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-5974-6339","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Aydin Adnan Menderes University, 09100 Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009130147"],"corresponding_institution_ids":["https://openalex.org/I76806599"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"18","first_page":"3005","last_page":"3005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mouthwash","display_name":"mouthwash","score":0.7580000162124634},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6430000066757202},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6779999732971191},{"id":"https://openalex.org/keywords/systemic-anticancer-therapy","display_name":"systemic cancer therapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.6320000290870667},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9592000246047974},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.9156000018119812},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.786300003528595},{"id":"https://openalex.org/C2777552930","wikidata":"https://www.wikidata.org/wiki/Q707806","display_name":"Hemostat","level":2,"score":0.6363999843597412},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5146999955177307},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.49239999055862427},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.4726000130176544},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44769999384880066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42419999837875366},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.40059998631477356},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3416999876499176},{"id":"https://openalex.org/C2777054765","wikidata":"https://www.wikidata.org/wiki/Q6402731","display_name":"Dysgeusia","level":3,"score":0.33970001339912415},{"id":"https://openalex.org/C2987828669","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical study","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.2736000120639801},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2565999925136566}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/healthcare14183005","doi":"https://doi.org/10.3390/healthcare14183005","is_oa":true,"landing_page_url":"https://doi.org/10.3390/healthcare14183005","pdf_url":null,"source":{"id":"https://openalex.org/S4210214101","display_name":"Healthcare","issn_l":"2227-9032","issn":["2227-9032"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Healthcare","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13606083","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13606083/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13606083/pdf/healthcare-14-03005.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Healthcare (Basel)","raw_type":"Text"},{"id":"pmid:42793543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42793543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Healthcare (Basel, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/healthcare14183005","doi":"https://doi.org/10.3390/healthcare14183005","is_oa":true,"landing_page_url":"https://doi.org/10.3390/healthcare14183005","pdf_url":null,"source":{"id":"https://openalex.org/S4210214101","display_name":"Healthcare","issn_l":"2227-9032","issn":["2227-9032"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Healthcare","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212965799.pdf","grobid_xml":"https://content.openalex.org/works/W7212965799.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1971224117","https://openalex.org/W1977579375","https://openalex.org/W1989353288","https://openalex.org/W2009623762","https://openalex.org/W2131473193","https://openalex.org/W2149050045","https://openalex.org/W2158334747","https://openalex.org/W2769296373","https://openalex.org/W2775638027","https://openalex.org/W2782703631","https://openalex.org/W3004109749","https://openalex.org/W3006126190","https://openalex.org/W3092643048","https://openalex.org/W3106963946","https://openalex.org/W4376955260","https://openalex.org/W4379768660","https://openalex.org/W4399205566","https://openalex.org/W4399477213","https://openalex.org/W4400351185","https://openalex.org/W7152394935"],"related_works":["https://openalex.org/W4379768660","https://openalex.org/W2782703631","https://openalex.org/W7152394935","https://openalex.org/W2947812763","https://openalex.org/W7122784785","https://openalex.org/W2093713352","https://openalex.org/W1479969397","https://openalex.org/W2151109814","https://openalex.org/W2044738098"],"abstract_inverted_index":{"Background/Objectives:":[0],"Oral":[1],"mucositis":[2],"(OM)":[3],"is":[4],"a":[5,23,110],"serious":[6],"toxicity":[7],"that":[8],"develops":[9],"due":[10],"to":[11,170,236,246],"cancer":[12,84],"treatment":[13,185,189,239],"and":[14,28,37,69,71,86,104,125,144,186,221],"impairs":[15],"patients\u2019":[16],"quality":[17],"of":[18,39,157],"life.":[19],"Ankaferd":[20],"Hemostat":[21],"(AH),":[22],"phytotherapeutic":[24],"agent,":[25],"has":[26],"anti-inflammatory":[27],"tissue-healing":[29],"properties.":[30],"This":[31],"study":[32,64],"evaluated":[33],"the":[34,97,132,137,145,162],"clinical":[35,119],"outcomes":[36],"safety":[38],"topical":[40],"AH":[41,213],"in":[42,136,155,228],"adult":[43],"patients":[44,74,134,158,164,229],"with":[45,75,89,217,230],"solid":[46,76],"tumors":[47],"who":[48],"developed":[49,79],"grade":[50,141,148],"3":[51,142],"or":[52],"4":[53,149,173],"OM":[54,80,102,143],"during":[55],"systemic":[56,83],"anticancer":[57],"therapy.":[58],"Methods:":[59],"A":[60],"single-center":[61],"retrospective,":[62],"single-arm":[63],"was":[65,94,107,153,172,181,215],"conducted":[66],"between":[67],"2020":[68],"2024":[70],"included":[72,135],"43":[73,133],"tumors.":[77],"They":[78],"while":[81],"undergoing":[82],"therapy":[85],"were":[87,128,199,226],"treated":[88],"topic":[90],"AH.":[91],"Mucositis":[92],"severity":[93],"graded":[95],"using":[96,109],"World":[98],"Health":[99],"Organization":[100],"(WHO)":[101],"scale,":[103],"pain":[105],"intensity":[106],"assessed":[108],"Numeric":[111],"Rating":[112],"Scale":[113],"(NRS)":[114],"daily,":[115],"from":[116],"baseline":[117],"until":[118],"resolution.":[120],"Treatment":[121],"response,":[122],"recovery":[123,171,220],"time":[124,169],"adverse":[126,197,224],"events":[127,198,225],"analyzed.":[129],"Results:":[130],"Of":[131],"study,":[138],"81.4%":[139],"had":[140,147],"others":[146],"OM.":[150],"Grade":[151,166,194],"0":[152,187],"observed":[154],"86%":[156],"after":[159,188],"treatment.":[160],"Among":[161],"37":[163],"achieving":[165],"0,":[167],"median":[168,178],"days":[174],"(IQR":[175],"4\u20135).":[176],"The":[177],"NRS":[179],"score":[180],"5":[182],"points":[183],"before":[184],"(p":[190],"<":[191],"0.001).":[192],"No":[193],"\u2265":[195],"2":[196],"observed.":[200],"Only":[201],"one":[202],"patient":[203],"reported":[204],"mild":[205],"dry":[206],"mouth.":[207],"Conclusions:":[208],"In":[209],"this":[210],"retrospective":[211],"cohort,":[212],"mouthwash":[214],"associated":[216],"rapid":[218],"mucosal":[219],"no":[222],"severe":[223],"documented":[227],"high-grade":[231],"OM,":[232],"supporting":[233],"its":[234],"potential":[235],"reduce":[237],"oncological":[238],"toxicity;":[240],"prospective":[241],"controlled":[242],"studies":[243],"are":[244],"warranted":[245],"confirm":[247],"these":[248],"findings.":[249]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-09-15T00:00:00"}