{"id":"https://openalex.org/W7212959643","doi":"https://doi.org/10.17219/acem/213798","title":"Clinical characteristics and risk factors for carbapenem-resistant Pseudomonas aeruginosa infection","display_name":"Clinical characteristics and risk factors for carbapenem-resistant Pseudomonas aeruginosa infection","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7212959643","doi":"https://doi.org/10.17219/acem/213798","pmid":"https://pubmed.ncbi.nlm.nih.gov/42735429"},"language":"en","primary_location":{"id":"doi:10.17219/acem/213798","doi":"https://doi.org/10.17219/acem/213798","is_oa":true,"landing_page_url":"https://doi.org/10.17219/acem/213798","pdf_url":"https://advances.umw.edu.pl/ahead-of-print/213798.pdf","source":{"id":"https://openalex.org/S948795172","display_name":"Advances in Clinical and Experimental Medicine","issn_l":"1899-5276","issn":["1899-5276","2451-2680"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4353108602","host_organization_name":"Wroclaw Medical University","host_organization_lineage":["https://openalex.org/P4353108602"],"host_organization_lineage_names":["Wroclaw Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Clinical and Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://advances.umw.edu.pl/ahead-of-print/213798.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028913831","display_name":"Huilin Xie","orcid":"https://orcid.org/0009-0006-9072-5014","observed_orcids":["https://orcid.org/0009-0006-9072-5014","https://orcid.org/0000-0001-7719-2547"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huilin Xie","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China"],"raw_orcid":"https://orcid.org/0009-0006-9072-5014","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151672772","display_name":"Sheng Zhang","orcid":"https://orcid.org/0009-0005-7883-4333","observed_orcids":["https://orcid.org/0009-0005-7883-4333"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Zhang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China"],"raw_orcid":"https://orcid.org/0009-0005-7883-4333","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151651644","display_name":"Yuzhuo Zhong","orcid":"https://orcid.org/0009-0005-6674-113X","observed_orcids":["https://orcid.org/0009-0005-6674-113X"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhuo Zhong","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China"],"raw_orcid":"https://orcid.org/0009-0005-6674-113X","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151621154","display_name":"Wenling Zhang","orcid":"https://orcid.org/0009-0003-6029-1874","observed_orcids":["https://orcid.org/0009-0003-6029-1874"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenling Zhang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China"],"raw_orcid":"https://orcid.org/0009-0003-6029-1874","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101493626","display_name":"Zhen Lei","orcid":"https://orcid.org/0000-0002-0618-5208","observed_orcids":["https://orcid.org/0000-0002-0618-5208","https://orcid.org/0009-0005-3432-8244"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Lei","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China"],"raw_orcid":"https://orcid.org/0009-0005-3432-8244","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China","institution_ids":["https://openalex.org/I4210108565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210108565"],"apc_list":{"value":700,"currency":"EUR","value_usd":754},"apc_paid":{"value":700,"currency":"EUR","value_usd":754},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61268817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"9","first_page":"1525","last_page":"1533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbapenem-resistant-pseudomonas-aeruginosa","display_name":"carbapenem-resistant Pseudomonas aeruginosa","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/prior-carbapenem-exposure","display_name":"prior carbapenem exposure","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lower-respiratory-tract-infection","display_name":"lower respiratory tract infection","score":0.8460000157356262},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.921999990940094},{"id":"https://openalex.org/keywords/antimicrobial-stewardship","display_name":"antimicrobial stewardship","score":0.8009999990463257},{"id":"https://openalex.org/keywords/empirical-antibiotic-therapy","display_name":"empirical antibiotic therapy","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8198000192642212},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6723999977111816},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5336999893188477},{"id":"https://openalex.org/C2781433018","wikidata":"https://www.wikidata.org/wiki/Q133966","display_name":"Pseudomonadales","level":4,"score":0.36550000309944153},{"id":"https://openalex.org/C2776738503","wikidata":"https://www.wikidata.org/wiki/Q138058","display_name":"Pseudomonadaceae","level":4,"score":0.35339999198913574},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22849999368190765},{"id":"https://openalex.org/C3019879152","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Infection risk","level":2,"score":0.21580000221729279},{"id":"https://openalex.org/C2993737187","wikidata":"https://www.wikidata.org/wiki/Q16000070","display_name":"Cross infection","level":2,"score":0.21369999647140503}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.17219/acem/213798","doi":"https://doi.org/10.17219/acem/213798","is_oa":true,"landing_page_url":"https://doi.org/10.17219/acem/213798","pdf_url":"https://advances.umw.edu.pl/ahead-of-print/213798.pdf","source":{"id":"https://openalex.org/S948795172","display_name":"Advances in Clinical and Experimental Medicine","issn_l":"1899-5276","issn":["1899-5276","2451-2680"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4353108602","host_organization_name":"Wroclaw Medical University","host_organization_lineage":["https://openalex.org/P4353108602"],"host_organization_lineage_names":["Wroclaw Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Clinical and Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:42735429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42735429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in clinical and experimental medicine : official organ Wroclaw Medical University","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.17219/acem/213798","doi":"https://doi.org/10.17219/acem/213798","is_oa":true,"landing_page_url":"https://doi.org/10.17219/acem/213798","pdf_url":"https://advances.umw.edu.pl/ahead-of-print/213798.pdf","source":{"id":"https://openalex.org/S948795172","display_name":"Advances in Clinical and Experimental Medicine","issn_l":"1899-5276","issn":["1899-5276","2451-2680"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4353108602","host_organization_name":"Wroclaw Medical University","host_organization_lineage":["https://openalex.org/P4353108602"],"host_organization_lineage_names":["Wroclaw Medical University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Clinical and Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212959643.pdf","grobid_xml":"https://content.openalex.org/works/W7212959643.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1982939735","https://openalex.org/W2052712657","https://openalex.org/W2102302463","https://openalex.org/W2142343447","https://openalex.org/W2151958462","https://openalex.org/W2155745631","https://openalex.org/W2550317740","https://openalex.org/W2810044729","https://openalex.org/W2970596142","https://openalex.org/W2990002543","https://openalex.org/W3005762177","https://openalex.org/W3014508302","https://openalex.org/W3198277983","https://openalex.org/W4224266833","https://openalex.org/W4289950985"],"related_works":["https://openalex.org/W2889181928","https://openalex.org/W7171290216","https://openalex.org/W4317210750","https://openalex.org/W3029636846","https://openalex.org/W4224217815","https://openalex.org/W2970596142","https://openalex.org/W2751867965","https://openalex.org/W4366778845","https://openalex.org/W7160820501","https://openalex.org/W3212237910"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pseudomonas":[1],"aeruginosa":[2],"(PA)":[3],"is":[4],"a":[5,27,235],"major":[6],"opportunistic":[7],"pathogen":[8],"responsible":[9],"for":[10,70,126,227],"nosocomial":[11],"infections,":[12,51],"particularly":[13,241],"those":[14],"affecting":[15],"the":[16,42,71,127,137,161,253,262,268,274,277],"lower":[17,150],"respiratory":[18,151],"tract.":[19],"The":[20,59,258],"emergence":[21],"of":[22,49,62,73,255,276],"carbapenem-resistant":[23],"PA":[24,144,232],"(CRPA)":[25],"poses":[26],"significant":[28],"global":[29],"therapeutic":[30],"challenge,":[31],"as":[32,223,267],"increasing":[33],"resistance":[34,47,175,296],"rates":[35,176],"complicate":[36],"clinical":[37,43,299],"management.":[38],"OBJECTIVES:":[39],"To":[40],"investigate":[41],"characteristics":[44,111],"and":[45,67,76,96,107,112,120,155,181,212,249,282,297],"antimicrobial":[46,280,289],"profiles":[48],"CRPA":[50,92,171,228,256],"identify":[52],"associated":[53],"risk":[54,113,225,254,265],"factors":[55,114,226,266],"among":[56,242],"patients":[57,90,98],"at":[58],"Affiliated":[60],"Hospital":[61],"North":[63],"Sichuan":[64],"Medical":[65],"College,":[66],"provide":[68],"evidence":[69],"development":[72],"effective":[74],"prevention":[75],"control":[77],"strategies.":[78],"MATERIAL":[79],"AND":[80],"METHODS:":[81],"A":[82],"retrospective":[83],"case-control":[84],"study":[85],"was":[86,130],"conducted":[87],"involving":[88],"94":[89],"with":[91,99,168],"infection":[93,101,233],"(study":[94],"group)":[95,103],"50":[97],"CSPA":[100,169],"(control":[102],"between":[104],"January":[105],"2021":[106],"December":[108],"2022.":[109],"Clinical":[110],"were":[115,146,156],"analyzed":[116],"using":[117,132,189],"univariate":[118],"analyses":[119],"multivariable":[121],"logistic":[122,187],"regression.":[123],"Variable":[124],"selection":[125,134,191],"primary":[128],"model":[129,260],"performed":[131],"best-subset":[133,190],"based":[135],"on":[136],"Bayesian":[138],"information":[139],"criterion":[140],"(BIC).":[141],"RESULTS:":[142],"Carbapenem-resistant":[143,231],"isolates":[145],"primarily":[147],"recovered":[148],"from":[149],"tract":[152],"secretions":[153],"(77.66%)":[154],"most":[157],"frequently":[158],"identified":[159,192,261],"in":[160,238],"intensive":[162],"care":[163],"unit":[164],"(ICU)":[165],"(41.49%).":[166],"Compared":[167],"strains,":[170],"exhibited":[172],"significantly":[173,251],"higher":[174],"to":[177,195,247,287,294],"aztreonam,":[178],"ciprofloxacin,":[179],"levofloxacin,":[180],"cephalosporins":[182],"(p":[183],"<":[184,210],"0.05).":[185],"Multivariable":[186],"regression":[188],"prior":[193],"exposure":[194,246],"carbapenems":[196,248],"(adjusted":[197],"odds":[198],"ratio":[199],"(aOR)":[200],"=":[201,215,221],"6.914,":[202],"95%":[203,217],"confidence":[204],"interval":[205],"(95%":[206],"CI):":[207],"2.765-17.290,":[208],"p":[209,220],"0.001)":[211],"aminoglycosides":[213,250],"(aOR":[214],"6.209,":[216],"CI:":[218],"1.701-22.668,":[219],"0.006)":[222],"independent":[224],"infection.":[229,257],"CONCLUSIONS:":[230],"imposes":[234],"considerable":[236],"burden":[237],"our":[239],"hospital,":[240],"ICU":[243],"patients.":[244],"Prior":[245],"increases":[252],"BIC-selected":[259],"same":[263],"main":[264],"fully":[269],"adjusted":[270],"sensitivity":[271],"analysis,":[272],"supporting":[273],"consistency":[275],"findings.":[278],"Strengthening":[279],"stewardship":[281],"tailoring":[283],"empirical":[284],"therapy":[285],"according":[286],"local":[288],"susceptibility":[290],"patterns":[291],"are":[292],"essential":[293],"curb":[295],"improve":[298],"outcomes.":[300]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-15T00:00:00"}
