{"id":"https://openalex.org/W7212910523","doi":"https://doi.org/10.1038/s41467-026-77525-w","title":"BRAINCELL modelling platform for stochastic nanoscale organisation and dynamic extracellular signalling among neurons and glia","display_name":"BRAINCELL modelling platform for stochastic nanoscale organisation and dynamic extracellular signalling among neurons and glia","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7212910523","doi":"https://doi.org/10.1038/s41467-026-77525-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42875412","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13669385"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-77525-w","doi":"https://doi.org/10.1038/s41467-026-77525-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77525-w","pdf_url":"https://www.nature.com/articles/s41467-026-77525-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-77525-w_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071813017","display_name":"Leonid P. Savtchenko","orcid":"https://orcid.org/0000-0003-4383-0445","observed_orcids":["https://orcid.org/0000-0003-4383-0445"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Leonid P. Savtchenko","raw_affiliation_strings":["Queen Square Institute of Neurology, University College London, London, UK. leonid.savtchenko@ucl.ac.uk"],"raw_orcid":"https://orcid.org/0000-0003-4383-0445","affiliations":[{"raw_affiliation_string":"Queen Square Institute of Neurology, University College London, London, UK. leonid.savtchenko@ucl.ac.uk","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028628280","display_name":"Sergey G. Aleksin","orcid":"https://orcid.org/0000-0001-6087-8956","observed_orcids":["https://orcid.org/0000-0001-6087-8956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey G. Aleksin","raw_affiliation_strings":["UnboltSoft, Dnipro, Ukraine"],"raw_orcid":"https://orcid.org/0000-0001-6087-8956","affiliations":[{"raw_affiliation_string":"UnboltSoft, Dnipro, Ukraine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115513450","display_name":"Chrysoula Tsimperi","orcid":"https://orcid.org/0000-0003-4229-082X","observed_orcids":["https://orcid.org/0000-0003-4229-082X"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Chrysoula Tsimperi","raw_affiliation_strings":["Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain","Neuroscience Program, Del Mar Hospital Research Institute, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4229-082X","affiliations":[{"raw_affiliation_string":"Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Neuroscience Program, Del Mar Hospital Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043687800","display_name":"Pablo Villoslada","orcid":"https://orcid.org/0000-0002-8735-6119","observed_orcids":["https://orcid.org/0000-0002-8735-6119"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Villoslada","raw_affiliation_strings":["Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain","Department of Neurology, Hospital del Mar Research Institute, Barcelona, Spain","Neuroscience Program, Del Mar Hospital Research Institute, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8735-6119","affiliations":[{"raw_affiliation_string":"Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Department of Neurology, Hospital del Mar Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]},{"raw_affiliation_string":"Neuroscience Program, Del Mar Hospital Research Institute, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027852598","display_name":"Igor Muttik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184558857","display_name":"Royal Holloway University of London","ror":"https://ror.org/04g2vpn86","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I184558857"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Igor Muttik","raw_affiliation_strings":["CyberCurio LLC, Woodlands, Berkhamsted, UK","Royal Holloway University of London, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CyberCurio LLC, Woodlands, Berkhamsted, UK","institution_ids":[]},{"raw_affiliation_string":"Royal Holloway University of London, Surrey, UK","institution_ids":["https://openalex.org/I184558857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090829486","display_name":"Dmitri A. Rusakov","orcid":"https://orcid.org/0000-0001-9539-9947","observed_orcids":["https://orcid.org/0000-0001-9539-9947"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dmitri A. Rusakov","raw_affiliation_strings":["Queen Square Institute of Neurology, University College London, London, UK. d.rusakov@ucl.ac.uk"],"raw_orcid":"https://orcid.org/0000-0001-9539-9947","affiliations":[{"raw_affiliation_string":"Queen Square Institute of Neurology, University College London, London, UK. d.rusakov@ucl.ac.uk","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071813017","https://openalex.org/A5090829486"],"corresponding_institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.626965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.08290000259876251,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoscale-morphology","display_name":"nanoscale morphology","score":0.7260000109672546},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9829999804496765},{"id":"https://openalex.org/keywords/extracellular-signalling","display_name":"extracellular signalling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.8259999752044678},{"id":"https://openalex.org/keywords/whole-cell-model","display_name":"whole-cell model","score":0.5889999866485596},{"id":"https://openalex.org/keywords/computational-neuroscience-software","display_name":"computational neuroscience software","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7228999733924866},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5758000016212463},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5407000184059143},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.511900007724762},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.41659998893737793},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.41290000081062317},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3971000015735626},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3716999888420105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3628999888896942},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C2775993382","wikidata":"https://www.wikidata.org/wiki/Q4677565","display_name":"Active matter","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2890999913215637},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28610000014305115},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.26109999418258667},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.2578999996185303}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-026-77525-w","doi":"https://doi.org/10.1038/s41467-026-77525-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77525-w","pdf_url":"https://www.nature.com/articles/s41467-026-77525-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.64898/2026.08.22.746419","doi":"https://doi.org/10.64898/2026.08.22.746419","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.22.746419","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/25/2026.08.22.746419.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42875412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42875412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13669385","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13669385/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1326cd1eec3e4081aa60cc5742a092c5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1326cd1eec3e4081aa60cc5742a092c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-77525-w","doi":"https://doi.org/10.1038/s41467-026-77525-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77525-w","pdf_url":"https://www.nature.com/articles/s41467-026-77525-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1540786275","display_name":"Targeting Kir4.1 To Control Brain Excitability And Seizures","funder_award_id":"MR/W019752/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2242984383","display_name":null,"funder_award_id":"223131/Z/21/Z","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2287368063","display_name":null,"funder_award_id":"NC/X001067/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3036229722","display_name":null,"funder_award_id":"NC/X001067/1","funder_id":"https://openalex.org/F4320326623","funder_display_name":"National Centre for the Replacement Refinement and Reduction of Animals in Research"},{"id":"https://openalex.org/G3484276656","display_name":"Inhibitory brain dynamics for adaptive behaviour","funder_award_id":"223131/Z/21/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4104770518","display_name":"Neural coding with the tripartite synapse.","funder_award_id":"101896/Z/13/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5695892717","display_name":"Dynamic mapping of micro-viscosity in the intact brain","funder_award_id":"BB/Y009959/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G577876787","display_name":null,"funder_award_id":"NC3Rs","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7597458351","display_name":"Memory trace formation at and beyond individual synapses in the intact brain","funder_award_id":"BB/Y003926/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320326623","display_name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","ror":null},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212910523.pdf","grobid_xml":"https://content.openalex.org/works/W7212910523.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204154344","https://openalex.org/W2884343236","https://openalex.org/W2807952107","https://openalex.org/W7215030207","https://openalex.org/W7164464288","https://openalex.org/W45059477","https://openalex.org/W2736114868","https://openalex.org/W2328374301","https://openalex.org/W2418960958","https://openalex.org/W6943149347"],"abstract_inverted_index":{"ABSRACT":[0],"Biophysical":[1],"cell":[2],"models":[3,73],"have":[4,37,66],"been":[5,67,120],"key":[6,144],"to":[7,69],"our":[8,151],"understanding":[9],"of":[10,51,75,91,104,163,190],"information":[11],"processing":[12],"in":[13,39,58,63,98,150],"neurons":[14,59,174],"and":[15,29,32,78,94,136,140,148,175,180,196],"their":[16,33,76,110],"networks.":[17],"However,":[18],"as":[19,55,122,172],"brain":[20,45,105],"computation":[21],"emerges":[22],"from":[23,210],"the":[24,114,168,187],"complex":[25],"interaction":[26],"among":[27],"neuronal":[28],"non-neuronal":[30],"cells":[31,46,106],"microenvironment,":[34],"critical":[35],"limitations":[36],"persisted":[38],"existing":[40],"modelling":[41,162],"approaches.":[42],"Firstly,":[43],"most":[44],"exhibit":[47],"a":[48,85],"rich":[49],"repertoire":[50],"nanoscopic":[52,61],"structures,":[53],"such":[54,171],"dendritic":[56],"spines":[57],"or":[60,177],"protrusions":[62],"astrocytes,":[64],"which":[65,117],"difficult":[68],"incorporate":[70],"into":[71],"whole-cell":[72],"because":[74],"numbers":[77],"complexity.":[79],"To":[80],"address":[81],"this,":[82],"BRAINCELL":[83,124,145,203,216],"introduces":[84],"stochastic":[86],"framework":[87],"for":[88,134,185],"generating":[89],"populations":[90],"nanoscale":[92],"morphological":[93,195],"physiological":[95,102],"features":[96],"grounded":[97],"empirical":[99,191],"statistics.":[100],"Secondly,":[101],"activity":[103],"critically":[107],"depends":[108],"on":[109],"dynamic":[111],"interactions":[112,165],"with":[113,199],"extracellular":[115,128,169,201],"environment,":[116],"has":[118],"traditionally":[119],"treated":[121],"static.":[123],"creates":[125],"an":[126],"interactive":[127],"environment":[129],"that":[130,157,207],"tracks":[131],"concentration":[132],"dynamics":[133,200],"ions":[135],"signalling":[137],"molecules":[138],"inside":[139],"outside":[141],"cells.":[142],"With":[143],"algorithms":[146],"tested":[147],"validated":[149],"previous":[152],"experimental":[153],"studies,":[154],"we":[155],"show":[156],"these":[158],"advances":[159],"enable":[160],"realistic":[161],"cell-cell":[164],"mediated":[166],"by":[167,213],"space,":[170],"between":[173,178],"astrocyte":[176],"axons":[179],"myelin,":[181],"opening":[182],"new":[183],"avenues":[184],"testing":[186],"biophysical":[188],"basis":[189],"observations.":[192],"By":[193],"integrating":[194],"functional":[197],"stochasticity":[198],"interactions,":[202],"enables":[204],"task-specific":[205],"predictions":[206],"often":[208],"diverge":[209],"those":[211],"produced":[212],"conventional":[214],"models.":[215],"is":[217],"freely":[218],"available":[219],"at":[220],"www.neuroalgebra.net":[221],".":[222]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-15T00:00:00"}