{"id":"https://openalex.org/W7212860591","doi":"https://doi.org/10.64898/2026.09.08.749894","title":"Intrasegmental and propriospinal pre-phrenic interneuron circuitry in intact CNS and following cervical spinal cord injury","display_name":"Intrasegmental and propriospinal pre-phrenic interneuron circuitry in intact CNS and following cervical spinal cord injury","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7212860591","doi":"https://doi.org/10.64898/2026.09.08.749894","pmid":"https://pubmed.ncbi.nlm.nih.gov/42779623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596159"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.749894","doi":"https://doi.org/10.64898/2026.09.08.749894","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.749894","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.08.749894.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.08.749894.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067130246","display_name":"Pauline Michel\u2010Flutot","orcid":"https://orcid.org/0000-0002-5003-217X","observed_orcids":["https://orcid.org/0000-0002-5003-217X"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline Michel-Flutot","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117642928","display_name":"Angela Harbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Harbeck","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630935","display_name":"Lan Cheng","orcid":"https://orcid.org/0000-0002-3620-3366","observed_orcids":["https://orcid.org/0000-0002-3620-3366"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Cheng","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016425539","display_name":"Khalil Rust","orcid":"https://orcid.org/0000-0002-0039-7752","observed_orcids":["https://orcid.org/0000-0002-0039-7752"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalil Rust","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106859595","display_name":"Megan A. Lyttle","orcid":"https://orcid.org/0009-0009-0694-9958","observed_orcids":["https://orcid.org/0009-0009-0694-9958"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan A. Lyttle","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068192147","display_name":"Samantha J. Thomas","orcid":"https://orcid.org/0000-0002-0610-421X","observed_orcids":["https://orcid.org/0000-0002-0610-421X"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha J. Thomas","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010694134","display_name":"David A. Jaffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Jaffe","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057224599","display_name":"Kallon Crowther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kallon Crowther","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060669481","display_name":"Gabriela Daszewska-Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Daszewska-Smith","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011097362","display_name":"George M. Smith","orcid":"https://orcid.org/0000-0002-2614-1624","observed_orcids":["https://orcid.org/0000-0002-2614-1624"]},"institutions":[{"id":"https://openalex.org/I4210129524","display_name":"Shriners Hospitals for Children - Philadelphia","ror":"https://ror.org/036z11b33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210129524","https://openalex.org/I4210144267"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Smith","raw_affiliation_strings":["Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 191405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 191405, USA","institution_ids":["https://openalex.org/I4210129524","https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151608811","display_name":"Shuxin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129524","display_name":"Shriners Hospitals for Children - Philadelphia","ror":"https://ror.org/036z11b33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210129524","https://openalex.org/I4210144267"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuxin Li","raw_affiliation_strings":["Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 191405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 191405, USA","institution_ids":["https://openalex.org/I4210129524","https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019107444","display_name":"Angelo C. Lepore","orcid":"https://orcid.org/0000-0002-5956-6135","observed_orcids":["https://orcid.org/0000-0002-5956-6135"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angelo C. Lepore","raw_affiliation_strings":["Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019107444"],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.4291999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phrenic-motoneurons","display_name":"phrenic motoneurons","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cervical-spinal-cord-injury","display_name":"cervical spinal cord injury","score":0.9399999976158142},{"id":"https://openalex.org/keywords/respiratory-drive","display_name":"respiratory drive","score":0.5329999923706055},{"id":"https://openalex.org/keywords/diaphragm","display_name":"diaphragm","score":0.5839999914169312},{"id":"https://openalex.org/keywords/spinal-cord-plasticity","display_name":"spinal cord plasticity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/propriospinal-interneurons","display_name":"propriospinal interneurons","score":0.7540000081062317},{"id":"https://openalex.org/keywords/c2-hemisection","display_name":"C2 hemisection","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pseudorabies-virus-tracing","display_name":"pseudorabies virus tracing","score":0.7329999804496765},{"id":"https://openalex.org/keywords/spinal-cord-repair","display_name":"spinal cord repair","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7317000031471252},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7275000214576721},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6543999910354614},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5842999815940857},{"id":"https://openalex.org/C2778110749","wikidata":"https://www.wikidata.org/wiki/Q189033","display_name":"Medulla oblongata","level":3,"score":0.5609999895095825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5198000073432922},{"id":"https://openalex.org/C2778222838","wikidata":"https://www.wikidata.org/wiki/Q2700458","display_name":"Spinothalamic tract","level":4,"score":0.49059998989105225},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.4729999899864197},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.3946000039577484},{"id":"https://openalex.org/C7146039","wikidata":"https://www.wikidata.org/wiki/Q3624375","display_name":"Lumbosacral joint","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C2776378061","wikidata":"https://www.wikidata.org/wiki/Q7317035","display_name":"Retrograde tracing","level":3,"score":0.3653999865055084},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.36239999532699585},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C2777905999","wikidata":"https://www.wikidata.org/wiki/Q571057","display_name":"Lateral funiculus","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C2778474254","wikidata":"https://www.wikidata.org/wiki/Q3752103","display_name":"Zona incerta","level":3,"score":0.34049999713897705},{"id":"https://openalex.org/C2779946112","wikidata":"https://www.wikidata.org/wiki/Q2073982","display_name":"Cordotomy","level":3,"score":0.3402999937534332},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33250001072883606},{"id":"https://openalex.org/C169453685","wikidata":"https://www.wikidata.org/wiki/Q1054066","display_name":"Central pattern generator","level":3,"score":0.32899999618530273},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.32330000400543213},{"id":"https://openalex.org/C2781092067","wikidata":"https://www.wikidata.org/wiki/Q316180","display_name":"Pseudorabies","level":3,"score":0.3147999942302704},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.31119999289512634},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C2777099253","wikidata":"https://www.wikidata.org/wiki/Q737313","display_name":"Phrenic nerve","level":3,"score":0.3052000105381012},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C70471684","wikidata":"https://www.wikidata.org/wiki/Q11829331","display_name":"Antidromic","level":3,"score":0.25859999656677246}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.08.749894","doi":"https://doi.org/10.64898/2026.09.08.749894","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.749894","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.08.749894.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42779623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596159","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779623/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.749894","doi":"https://doi.org/10.64898/2026.09.08.749894","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.749894","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.08.749894.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212860591.pdf","grobid_xml":"https://content.openalex.org/works/W7212860591.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3174687781","https://openalex.org/W1989560803","https://openalex.org/W3174547098","https://openalex.org/W4389007884","https://openalex.org/W6906652980","https://openalex.org/W3167782296","https://openalex.org/W3133787178","https://openalex.org/W2617659077","https://openalex.org/W2896820257","https://openalex.org/W2782057048"],"abstract_inverted_index":{"Cervical":[0],"spinal":[1,145,165,246,273,284],"cord":[2,166,274],"injury":[3],"(SCI)":[4],"disrupts":[5],"descending":[6],"respiratory":[7,26],"circuitry,":[8],"resulting":[9],"in":[10,107,149,167,238,264],"debilitating":[11],"and":[12,77,86,154,194,206,224,257,321],"often":[13],"persistent":[14],"ventilatory":[15],"deficits.":[16],"Respiratory":[17],"drive":[18],"emerges":[19],"within":[20,244],"medulla":[21],"from":[22],"the":[23,42,72,87,115,168,197,231],"rostral":[24,108,193,229],"ventral":[25,128,155],"group":[27],"(rVRG),":[28],"whose":[29],"neurons":[30,36,49],"project":[31],"to":[32,58,104,196,215,230,262,267,307],"C3-C6":[33,245],"phrenic":[34,116],"motor":[35],"(PhMNs),":[37],"which":[38],"then":[39],"innervate":[40],"diaphragm,":[41],"primary":[43],"muscle":[44],"of":[45,92,98,114,132,137,184,240,295,310],"inspiration.":[46],"Though":[47],"rVRG":[48,56],"make":[50],"extensive":[51],"monosynaptic":[52],"connection":[53],"with":[54,179,208,292,312],"PhMNs,":[55,180,209],"input":[57],"PhMNs":[59,78,105,223],"can":[60],"also":[61,190,258,301],"be":[62],"relayed":[63],"through":[64],"pre-phrenic":[65],"interneurons":[66,278],"(PP-INs)":[67],"via":[68],"polysynaptic":[69],"pathways.":[70],"However,":[71],"neuroanatomical":[73],"connectivity":[74,177,239,290,309],"between":[75,222,318],"PP-INs":[76,99,139,160,172,189,202,227,242,300,311,320],"remains":[79],"incompletely":[80],"understood.":[81],"In":[82],"both":[83,192,204],"uninjured":[84,169,282],"rats":[85],"C2":[88],"hemisection":[89],"(C2HS)":[90],"model":[91],"cervical":[93,144,283],"SCI,":[94,232],"we":[95],"performed":[96],"tracing":[97],"that":[100,159],"were":[101],"synaptically":[102],"connected":[103],"located":[106,228,243],"(C3-C4)":[109],"or":[110,129],"caudal":[111,195],"(C5-C6)":[112],"portions":[113],"nucleus":[117],"by":[118],"unilaterally":[119],"injecting":[120],"retrograde":[121],"trans-synaptic":[122],"tracer,":[123],"pseudorabies":[124],"(PRV),":[125],"selectively":[126],"into":[127],"dorsal":[130,150],"regions":[131],"hemi-diaphragm.":[133],"We":[134,157],"quantified":[135],"numbers":[136,183,294],"PRV-labeled":[138],"individually":[140],"at":[141],"segments":[142],"across":[143],"cord,":[146],"including":[147],"separately":[148],"horn,":[151],"intermediate":[152],"gray,":[153],"horn.":[156],"found":[158],"are":[161,279],"widespread":[162,280],"throughout":[163,281],"C1-C7":[164],"condition.":[170],"These":[171,248],"have":[173,286],"a":[174,212,287,304],"predominant":[175,288],"intrasegmental":[176,241,289],"pattern":[178,291],"though":[181],"significant":[182],"longer":[185,296],"distance":[186,297],"projecting":[187,298],"propriospinal":[188,226,299,319],"exist":[191],"PhMN":[198],"pool.":[199],"Furthermore,":[200],"while":[201],"connect":[203],"ipsilaterally":[205],"contralaterally":[207],"there":[210],"is":[211,303],"strong":[213,305],"bias":[214,306],"ipsilateral":[216,308],"projection.":[217],"C2HS":[218],"induced":[219,235],"major":[220,316],"disconnection":[221,317],"ipsilesional":[225],"but":[233],"conversely":[234],"limited":[236],"plasticity":[237,270],"cord.":[247],"findings":[249],"greatly":[250],"improve":[251],"our":[252],"knowledge":[253],"about":[254],"PP-IN":[255,269],"circuitry":[256],"provide":[259],"important":[260],"information":[261],"aid":[263],"developing":[265],"approaches":[266],"target":[268],"for":[271],"promoting":[272],"repair.":[275],"HIGHLIGHTS:":[276],"Pre-phrenic":[277],"cord.PP-INs":[285],"PhMNs.Significant":[293],"exist.There":[302],"PhMNs.Cervical":[313],"SCI":[314],"induces":[315],"PhMNs.":[322]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-15T00:00:00"}