{"id":"https://openalex.org/W7212756352","doi":"https://doi.org/10.3390/biology15181611","title":"Subcellular Localization of CD24 Is Associated with Integrin \u03b21 Signaling, Immune Suppression, and Clinical Outcomes Across Human Cancers","display_name":"Subcellular Localization of CD24 Is Associated with Integrin \u03b21 Signaling, Immune Suppression, and Clinical Outcomes Across Human Cancers","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212756352","doi":"https://doi.org/10.3390/biology15181611","pmid":"https://pubmed.ncbi.nlm.nih.gov/42792557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13604725"},"language":"en","primary_location":{"id":"doi:10.3390/biology15181611","doi":"https://doi.org/10.3390/biology15181611","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15181611","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7212756352"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology15181611","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101541125","display_name":"Bhaumik B. Patel","orcid":"https://orcid.org/0000-0001-8304-8509","observed_orcids":["https://orcid.org/0000-0001-8304-8509"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bhaumik Patel","raw_affiliation_strings":["Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA"],"raw_orcid":"https://orcid.org/0000-0001-8304-8509","affiliations":[{"raw_affiliation_string":"Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034345203","display_name":"Marina Curcic","orcid":"https://orcid.org/0000-0001-7735-8885","observed_orcids":["https://orcid.org/0000-0001-7735-8885"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Curcic","raw_affiliation_strings":["Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091326397","display_name":"Mohamed Ashraf Eltokhy","orcid":"https://orcid.org/0000-0002-5229-6291","observed_orcids":["https://orcid.org/0000-0002-5229-6291"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed A. Eltokhy","raw_affiliation_strings":["Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA"],"raw_orcid":"https://orcid.org/0000-0002-5229-6291","affiliations":[{"raw_affiliation_string":"Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118188454","display_name":"Faizah A. Alabi","orcid":"https://orcid.org/0009-0000-5323-7210","observed_orcids":["https://orcid.org/0009-0000-5323-7210"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faizah Alabi","raw_affiliation_strings":["Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA"],"raw_orcid":"https://orcid.org/0009-0000-5323-7210","affiliations":[{"raw_affiliation_string":"Department of Immunotherapeutic and Biotechnology, Texas Tech University Health Science Center, Abilene, TX 79601, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117232116","display_name":"Omar Eltoukhy","orcid":"https://orcid.org/0009-0004-6232-1667","observed_orcids":["https://orcid.org/0009-0004-6232-1667"]},"institutions":[{"id":"https://openalex.org/I47853400","display_name":"Misr International University","ror":"https://ror.org/030vg1t69","country_code":"EG","type":"education","lineage":["https://openalex.org/I47853400"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Omar Eltoukhy","raw_affiliation_strings":["Department of Clinical Pharmacy, Misr International University, Cairo 11566, Egypt"],"raw_orcid":"https://orcid.org/0009-0004-6232-1667","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Misr International University, Cairo 11566, Egypt","institution_ids":["https://openalex.org/I47853400"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101541125"],"corresponding_institution_ids":["https://openalex.org/I12315562"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"18","first_page":"1611","last_page":"1611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd24","display_name":"CD24","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.7870000004768372},{"id":"https://openalex.org/keywords/siglec-10","display_name":"Siglec-10","score":0.9369999766349792},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.5569999814033508},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.800000011920929},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.878000020980835},{"id":"https://openalex.org/keywords/cervical-squamous-cell-carcinoma","display_name":"cervical squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/src-signaling","display_name":"Src signaling","score":0.44999998807907104},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.902999997138977},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.6600000262260437},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2779492189","wikidata":"https://www.wikidata.org/wiki/Q1190762","display_name":"CD24","level":4,"score":0.8866000175476074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8259999752044678},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6588000059127808},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.600600004196167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45739999413490295},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4471000134944916},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.43639999628067017},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.42820000648498535},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42660000920295715},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4180000126361847},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.35120001435279846},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.30820000171661377},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biology15181611","doi":"https://doi.org/10.3390/biology15181611","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15181611","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13604725","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13604725/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13604725/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology (Basel)","raw_type":"Text"},{"id":"pmid:42792557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42792557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:293bffb13308444cb6a215dffe820b1c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/293bffb13308444cb6a215dffe820b1c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, Vol 15, Iss 18, p 1611 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biology15181611","doi":"https://doi.org/10.3390/biology15181611","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15181611","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212756352.pdf","grobid_xml":"https://content.openalex.org/works/W7212756352.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1548628091","https://openalex.org/W1983701937","https://openalex.org/W1985397502","https://openalex.org/W1992287629","https://openalex.org/W1994320377","https://openalex.org/W2012871013","https://openalex.org/W2024829903","https://openalex.org/W2030186131","https://openalex.org/W2045100170","https://openalex.org/W2051816002","https://openalex.org/W2068424305","https://openalex.org/W2072424784","https://openalex.org/W2073710439","https://openalex.org/W2075555706","https://openalex.org/W2089103717","https://openalex.org/W2098503878","https://openalex.org/W2102549114","https://openalex.org/W2112195516","https://openalex.org/W2135961909","https://openalex.org/W2158924104","https://openalex.org/W2219775909","https://openalex.org/W2410340000","https://openalex.org/W2560950503","https://openalex.org/W2898036475","https://openalex.org/W2937823726","https://openalex.org/W2966214074","https://openalex.org/W2969253527","https://openalex.org/W2999597532","https://openalex.org/W3042947402","https://openalex.org/W3185265412","https://openalex.org/W3205433204","https://openalex.org/W4288447796","https://openalex.org/W4389058682","https://openalex.org/W4391033379","https://openalex.org/W4391277972","https://openalex.org/W4391846090","https://openalex.org/W4392292081","https://openalex.org/W4399246573","https://openalex.org/W4403985851","https://openalex.org/W4405794482","https://openalex.org/W4406376759","https://openalex.org/W4413961296","https://openalex.org/W4416414448","https://openalex.org/W7125913799","https://openalex.org/W7140887548","https://openalex.org/W7150960625"],"related_works":["https://openalex.org/W4402133520","https://openalex.org/W3049357948","https://openalex.org/W3158481643","https://openalex.org/W7150960625","https://openalex.org/W7140887548","https://openalex.org/W2081944219","https://openalex.org/W3125946240","https://openalex.org/W4376460112","https://openalex.org/W4394820737","https://openalex.org/W3088265793"],"abstract_inverted_index":{"CD24":[0,21,50,94,128,135,153,180,188,194,224,253,272],"is":[1,51],"an":[2,203],"emerging":[3],"innate":[4],"immune":[5,12,27,67,262],"checkpoint":[6],"that":[7,61,248],"regulates":[8],"inflammatory":[9,41],"and":[10,29,40,66,74,85,101,119,132,142,149,154,159,165,174,181,209,219,234,264],"antiviral":[11],"responses":[13],"through":[14,69],"interactions":[15],"with":[16,198,202,214,228,257],"Siglec":[17],"family":[18],"receptors.":[19],"Although":[20],"has":[22,30],"been":[23],"extensively":[24],"studied":[25],"in":[26,38,45,53,130,139,207,232,242,274],"regulation":[28],"recently":[31],"gained":[32],"attention":[33],"as":[34],"a":[35,171,184],"therapeutic":[36],"target":[37],"infectious":[39],"diseases,":[42],"its":[43,82,276],"role":[44],"cancer":[46,107,112],"remains":[47,88],"incompletely":[48],"understood.":[49],"overexpressed":[52],"multiple":[54],"human":[55],"malignancies,":[56],"where":[57],"accumulating":[58],"evidence":[59],"suggests":[60],"it":[62],"promotes":[63],"tumor":[64,205,259],"progression":[65],"evasion":[68],"activation":[70],"of":[71,81,156,252,271],"diverse":[72],"intracellular":[73],"extracellular":[75],"signaling":[76,87,97,161],"pathways.":[77],"However,":[78],"the":[79,237,249,261,268],"importance":[80,270],"subcellular":[83,250],"localization":[84,129,273],"associated":[86,197,227,256],"poorly":[89],"defined.":[90],"Here,":[91],"we":[92,169],"investigated":[93],"expression,":[95],"localization,":[96],"associations,":[98],"immune-cell":[99],"infiltration,":[100],"clinical":[102],"outcomes":[103],"using":[104],"publicly":[105],"available":[106],"datasets,":[108],"focusing":[109],"on":[110],"breast":[111],"(BRCA),":[113],"cervical":[114],"squamous":[115],"cell":[116],"carcinoma":[117],"(CESC),":[118],"glioblastoma":[120],"multiforme":[121],"(GBM).":[122],"Our":[123],"analyses":[124],"revealed":[125],"prominent":[126],"membrane-associated":[127],"BRCA":[131,141,208,233],"CESC,":[133,210,235],"whereas":[134,236],"was":[136,196,226,240],"predominantly":[137],"cytoplasmic":[138],"GBM.":[140,243],"CESC":[143],"exhibited":[144],"increased":[145],"integrin":[146,157],"\u03b21":[147],"expression":[148,195,225],"distinct":[150,258],"associations":[151,213],"between":[152,179],"components":[155],"\u03b21/SRC":[158],"TGF\u03b2-associated":[160],"networks,":[162],"including":[163,211],"MEK1":[164],"SMAD7.":[166],"In":[167],"addition,":[168],"identified":[170],"structurally":[172],"consistent":[173,201],"energetically":[175],"favorable":[176],"predicted":[177],"interface":[178],"Siglec-10,":[182],"suggesting":[183],"mechanism":[185],"by":[186],"which":[187],"may":[189,254],"suppress":[190],"anti-tumor":[191],"immunity.":[192],"Elevated":[193],"immune-infiltration":[199],"patterns":[200],"immunosuppressive":[204],"microenvironment":[206],"negative":[212],"M1":[215],"macrophage,":[216],"CD8+":[217],"T-cell,":[218],"NK-cell":[220],"infiltration.":[221],"Importantly,":[222],"high":[223],"unfavorable":[229],"overall":[230],"survival":[231],"opposite":[238],"relationship":[239],"observed":[241],"Collectively,":[244],"these":[245],"findings":[246],"suggest":[247],"distribution":[251],"be":[255],"signaling,":[260],"microenvironment,":[263],"prognostic":[265],"profiles,":[266],"highlighting":[267],"potential":[269],"determining":[275],"tumor-type-specific":[277],"biological":[278],"functions.":[279]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-09-15T00:00:00"}
