{"id":"https://openalex.org/W7212529917","doi":"https://doi.org/10.64898/2026.09.07.749813","title":"Cross-omics profiling reveals cortical neuronal dysfunction following neonatal intraventricular haemorrhage that is attenuated by decorin treatment","display_name":"Cross-omics profiling reveals cortical neuronal dysfunction following neonatal intraventricular haemorrhage that is attenuated by decorin treatment","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7212529917","doi":"https://doi.org/10.64898/2026.09.07.749813"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.07.749813","doi":"https://doi.org/10.64898/2026.09.07.749813","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749813.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085966107","display_name":"Benjamin J. Hewitt","orcid":"https://orcid.org/0000-0003-1609-6054","observed_orcids":["https://orcid.org/0000-0003-1609-6054"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Benjamin J. Hewitt","raw_affiliation_strings":["Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK"],"raw_orcid":"https://orcid.org/0000-0003-1609-6054","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034213748","display_name":"Mar\u00eda Garc\u00eda\u2010Bonilla","orcid":"https://orcid.org/0000-0002-2951-107X","observed_orcids":["https://orcid.org/0000-0002-2951-107X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Garcia Bonilla","raw_affiliation_strings":["Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA","Department of Neurosurgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Neurosurgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113929239","display_name":"James Pat McAllister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. McAllister","raw_affiliation_strings":["Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA","Department of Neurosurgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Neurosurgery, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151619213","display_name":"Simran Pahuja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simran Pahuja","raw_affiliation_strings":["Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036493039","display_name":"Grant A. Pellowe","orcid":"https://orcid.org/0000-0003-4314-5261","observed_orcids":["https://orcid.org/0000-0003-4314-5261"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant A. Pellowe","raw_affiliation_strings":["Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","School of Medicine, Pharmacy and Biosciences, Aston University, Birmingham B4 7ET, UK"],"raw_orcid":"https://orcid.org/0000-0003-4314-5261","affiliations":[{"raw_affiliation_string":"Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]},{"raw_affiliation_string":"School of Medicine, Pharmacy and Biosciences, Aston University, Birmingham B4 7ET, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410989","display_name":"Mackenzie S. Newman","orcid":"https://orcid.org/0009-0009-1370-4318","observed_orcids":["https://orcid.org/0009-0009-1370-4318"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mackenzie Newman","raw_affiliation_strings":["Office of the Vice President for Research and Innovation. Bioimaging and Applied Research Core, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of the Vice President for Research and Innovation. Bioimaging and Applied Research Core, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123938654","display_name":"Lauren Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lauren Roberts","raw_affiliation_strings":["Aston Institute for Membrane Excellence, Aston University, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138895024","display_name":"James A. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James A. Roberts","raw_affiliation_strings":["Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009542352","display_name":"Philip Kitchen","orcid":"https://orcid.org/0000-0002-1558-4673","observed_orcids":["https://orcid.org/0000-0002-1558-4673"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip Kitchen","raw_affiliation_strings":["Aston Institute for Membrane Excellence, Aston University, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085722901","display_name":"Roslyn M. Bill","orcid":"https://orcid.org/0000-0003-1331-0852","observed_orcids":["https://orcid.org/0000-0003-1331-0852"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roslyn M. Bill","raw_affiliation_strings":["Aston Institute for Membrane Excellence, Aston University, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082005077","display_name":"Lisa J. Hill","orcid":"https://orcid.org/0000-0001-8431-7029","observed_orcids":["https://orcid.org/0000-0001-8431-7029"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210162943","display_name":"NIHR Birmingham Biomedical Research Centre","ror":"https://ror.org/05ccjmp23","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210162943"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lisa J. Hill","raw_affiliation_strings":["Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK","National Institute for Health and Care Research (NIHR) Biomedical Research Centre: Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"National Institute for Health and Care Research (NIHR) Biomedical Research Centre: Birmingham, UK","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210162943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009037177","display_name":"Hannah F. Botfield","orcid":"https://orcid.org/0000-0003-4564-0282","observed_orcids":["https://orcid.org/0000-0003-4564-0282"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Hannah F. Botfield","raw_affiliation_strings":["Birmingham Centre for Neurogenetics, University of Birmingham, Birmingham, United Kingdom","Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham Centre for Neurogenetics, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009037177","https://openalex.org/A5085966107"],"corresponding_institution_ids":["https://openalex.org/I79619799"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6370000243186951},{"id":"https://openalex.org/keywords/posthemorrhagic-hydrocephalus","display_name":"posthemorrhagic hydrocephalus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5860000252723694},{"id":"https://openalex.org/keywords/microglial-phagocytosis","display_name":"microglial phagocytosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neurofilaments","display_name":"neurofilaments","score":0.718999981880188},{"id":"https://openalex.org/keywords/synaptic-vesicle-proteins","display_name":"synaptic vesicle proteins","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.722000002861023},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.6539999842643738},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.9110999703407288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6208000183105469},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6134999990463257},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.503000020980835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4991999864578247},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.4020000100135803},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3625999987125397},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.34850001335144043},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.3456999957561493},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34220001101493835},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.3398999869823456},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.32899999618530273},{"id":"https://openalex.org/C2779252433","wikidata":"https://www.wikidata.org/wiki/Q6058597","display_name":"Intraventricular hemorrhage","level":4,"score":0.31150001287460327},{"id":"https://openalex.org/C2993744773","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Neuronal damage","level":3,"score":0.3109000027179718},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.3052999973297119},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3025999963283539},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.30000001192092896},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C2776318716","wikidata":"https://www.wikidata.org/wiki/Q22677801","display_name":"Neuroglobin","level":4,"score":0.2858999967575073},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.28209999203681946},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.09.07.749813","doi":"https://doi.org/10.64898/2026.09.07.749813","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/cec92cd8-0905-4fe8-9c19-e6037e7ef3b5","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/cec92cd8-0905-4fe8-9c19-e6037e7ef3b5","pdf_url":"https://pure-oai.bham.ac.uk/ws/files/319925554/HewittBJ2026Crossomics_preprint.pdf","source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hewitt, B J, Garcia Bonilla, M, McAllister II, J P, Pahuja, S, Pellowe, G A, Newman, M, Roberts, L, Roberts, J A, Kitchen, P, Bill, R M, Hill, L J & Botfield, H F 2026 'Cross-omics profiling reveals cortical neuronal dysfunction following neonatal intraventricular haemorrhage that is attenuated by decorin treatment' bioRxiv. https://doi.org/10.64898/2026.09.07.749813","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.09.07.749813","doi":"https://doi.org/10.64898/2026.09.07.749813","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2777504453","display_name":"Cutting-edge Mass Spectrometry for the Midlands Membrane and Bioscience Communities","funder_award_id":"BB/Z51584X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5828315659","display_name":"de.NBI - Etablierungsphase - Leistungszentrum: RBC - RNA Bioinformatic","funder_award_id":"031A538A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320311096","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320336061","display_name":"Research England","ror":"https://ror.org/02wxr8x18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212529917.pdf","grobid_xml":"https://content.openalex.org/works/W7212529917.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1237543223","https://openalex.org/W1526364313","https://openalex.org/W1582225030","https://openalex.org/W1981431290","https://openalex.org/W1984978318","https://openalex.org/W1994943548","https://openalex.org/W1997183854","https://openalex.org/W2000361391","https://openalex.org/W2003342131","https://openalex.org/W2015752601","https://openalex.org/W2034219417","https://openalex.org/W2045401715","https://openalex.org/W2048637158","https://openalex.org/W2050530435","https://openalex.org/W2060384627","https://openalex.org/W2069350576","https://openalex.org/W2074658534","https://openalex.org/W2087592242","https://openalex.org/W2107281049","https://openalex.org/W2127672210","https://openalex.org/W2130410032","https://openalex.org/W2138207763","https://openalex.org/W2144403655","https://openalex.org/W2154100802","https://openalex.org/W2166555967","https://openalex.org/W2167279371","https://openalex.org/W2172216752","https://openalex.org/W2239467861","https://openalex.org/W2289046895","https://openalex.org/W2341358513","https://openalex.org/W2432815617","https://openalex.org/W2462361970","https://openalex.org/W2573216293","https://openalex.org/W2604210857","https://openalex.org/W2762729970","https://openalex.org/W2898371604","https://openalex.org/W2952481429","https://openalex.org/W2981157462","https://openalex.org/W2989140974","https://openalex.org/W3007119857","https://openalex.org/W3038503389","https://openalex.org/W3201476493","https://openalex.org/W4200478282","https://openalex.org/W4221073619","https://openalex.org/W4255830679","https://openalex.org/W4280567188","https://openalex.org/W4291398628","https://openalex.org/W4292386361","https://openalex.org/W4293009239","https://openalex.org/W4308493521","https://openalex.org/W4308834893","https://openalex.org/W4381033594","https://openalex.org/W4385298083","https://openalex.org/W4385583717","https://openalex.org/W4392134869","https://openalex.org/W4396810564","https://openalex.org/W4398182689","https://openalex.org/W4399139716","https://openalex.org/W4399660396","https://openalex.org/W4402749575","https://openalex.org/W4403479110","https://openalex.org/W4404010251","https://openalex.org/W4404046121","https://openalex.org/W4406087958","https://openalex.org/W4406489441","https://openalex.org/W4406894255","https://openalex.org/W4407121976","https://openalex.org/W4407339295","https://openalex.org/W4410189348","https://openalex.org/W4411019219","https://openalex.org/W4411882268","https://openalex.org/W4414281035","https://openalex.org/W4414613774","https://openalex.org/W7125819776","https://openalex.org/W7130845674","https://openalex.org/W7143476043","https://openalex.org/W7143652533","https://openalex.org/W7161313499","https://openalex.org/W7162199824"],"related_works":["https://openalex.org/W3081698539","https://openalex.org/W2112836819","https://openalex.org/W4411980965","https://openalex.org/W2228866506","https://openalex.org/W1970512961","https://openalex.org/W3191854364","https://openalex.org/W4312126077","https://openalex.org/W4293237393","https://openalex.org/W4221119169","https://openalex.org/W4282932809"],"abstract_inverted_index":{"1.":[0],"Abstract":[1],"Neonatal":[2],"intraventricular":[3],"haemorrhage":[4],"(IVH)":[5],"is":[6,13,34],"a":[7,104,117,139,177,185,239,257],"form":[8],"of":[9,28,47,55,66,83,89,121,126,131,142,188,218,225],"haemorrhagic":[10],"stroke":[11],"which":[12,202],"most":[14],"common":[15],"in":[16,116,163,233,261],"premature":[17],"infants":[18],"and":[19,23,50,68,106,129,171,192,200,235,255],"can":[20,158],"cause":[21],"mortality":[22],"lifelong":[24],"disability.":[25],"The":[26,52,135],"reaction":[27],"brain":[29,74,133],"tissue":[30],"to":[31,36,59,93,110,114,123,154,228,251],"extraneous":[32],"blood":[33,60,115],"known":[35],"trigger":[37],"several":[38],"complications":[39],"including":[40],"post-haemorrhagic":[41],"hydrocephalus":[42],"(PHH),":[43],"furthering":[44],"the":[45,56,62,87,95,127,143,164,169,223],"likelihood":[46],"neurological":[48],"disability":[49],"death.":[51],"molecular":[53],"response":[54,214],"neuron-rich":[57],"cortex":[58],"within":[61],"first":[63],"24":[64],"hours":[65],"injury,":[67],"how":[69],"this":[70,262],"may":[71,85,249],"precipitate":[72],"secondary":[73],"injury":[75,96,181,230,254],"or":[76],"neurodegeneration,":[77],"remains":[78],"poorly":[79],"defined.":[80],"This":[81],"lack":[82],"understanding":[84,125],"reduce":[86],"development":[88],"novel":[90],"therapeutics":[91],"aiming":[92],"limit":[94],"caused":[97,184],"by":[98,205],"neonatal":[99,118],"IVH.":[100],"Here,":[101],"we":[102],"utilised":[103],"proteome":[105,172],"transcriptome":[107,170],"cross-omics":[108],"approach":[109],"characterise":[111],"cortical":[112,180,189,226,253],"responses":[113],"mouse":[119],"model":[120],"IVH":[122,183,232],"improve":[124],"effects":[128,162],"drivers":[130],"IVH-induced":[132],"injury.":[134],"pleiotropic":[136],"proteoglycan":[137],"decorin,":[138],"well-characterised":[140],"modulator":[141],"inflammatory":[144],"cytokine":[145],"transforming":[146],"growth":[147],"factor":[148],"beta":[149],"1,":[150],"was":[151],"also":[152,209,244],"studied":[153],"identify":[155],"if":[156],"it":[157],"have":[159],"any":[160],"beneficial":[161],"cortex.":[165],"Cross-omics":[166],"analysis":[167],"between":[168],"highlighted":[173],"ferroptosis-associated":[174,247],"signatures":[175],"as":[176,238],"key":[178],"post-IVH":[179],"mechanism.":[182],"marked":[186],"depletion":[187],"neurons,":[190],"neurofilaments,":[191],"synaptic":[193],"vesicle":[194],"proteins,":[195],"observed":[196],"through":[197,216],"transcriptomics,":[198],"immunostaining,":[199],"proteomics,":[201],"were":[203],"attenuated":[204],"decorin":[206,237],"treatment.":[207],"Decorin":[208],"produced":[210],"an":[211],"enhanced":[212],"phagocytic":[213],"potentially":[215],"activation":[217],"microglia.":[219],"These":[220],"findings":[221],"highlight":[222],"vulnerability":[224],"neurons":[227],"early":[229,252],"following":[231],"neonates":[234],"support":[236],"potential":[240,258],"neuroprotective":[241],"agent.":[242],"They":[243],"suggest":[245],"that":[246],"pathways":[248],"contribute":[250],"represent":[256],"therapeutic":[259],"target":[260],"context.":[263]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-15T00:00:00"}
