{"id":"https://openalex.org/W7212489715","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","title":"Molecular hydrogen: a potential guardian against environmental radiation damage","display_name":"Molecular hydrogen: a potential guardian against environmental radiation damage","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212489715","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","pmid":"https://pubmed.ncbi.nlm.nih.gov/42734460","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13667370"},"language":"en","primary_location":{"id":"doi:10.4103/mgr.medgasres-d-25-00163","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","is_oa":true,"landing_page_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","pdf_url":null,"source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054125372","display_name":"Yusuke Ichikawa","orcid":"https://orcid.org/0000-0002-2526-4681","observed_orcids":["https://orcid.org/0000-0002-2526-4681","https://orcid.org/0009-0009-8450-8947"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yusuke Ichikawa","raw_affiliation_strings":["Research and Development Department, MiZ Company Limited, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2526-4681","affiliations":[{"raw_affiliation_string":"Research and Development Department, MiZ Company Limited, Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069932959","display_name":"Bunpei Sato","orcid":"https://orcid.org/0000-0003-1972-9646","observed_orcids":["https://orcid.org/0000-0003-1972-9646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bunpei Sato","raw_affiliation_strings":["Research and Development Department, MiZ Company Limited, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, MiZ Company Limited, Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109503479","display_name":"Yoshiyasu Takefuji","orcid":"https://orcid.org/0000-0002-1826-742X","observed_orcids":["https://orcid.org/0000-0002-1826-742X"]},"institutions":[{"id":"https://openalex.org/I200641316","display_name":"Musashino University","ror":"https://ror.org/04bcbax71","country_code":"JP","type":"education","lineage":["https://openalex.org/I200641316"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyasu Takefuji","raw_affiliation_strings":["Faculty of Data Science, Musashino University, Tokyo, Japan","Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Data Science, Musashino University, Tokyo, Japan","institution_ids":["https://openalex.org/I200641316"]},{"raw_affiliation_string":"Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087345430","display_name":"Fumitake Satoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumitake Satoh","raw_affiliation_strings":["Research and Development Department, MiZ Company Limited, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, MiZ Company Limited, Kanagawa, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054125372"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":"211","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":1.0},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.949999988079071},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hydroxyl-radical-scavenging","display_name":"hydroxyl radical scavenging","score":0.9789999723434448},{"id":"https://openalex.org/keywords/radiation-shielding","display_name":"radiation shielding","score":0.6259999871253967},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/radiation-damage","display_name":"radiation damage","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4749000072479248},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47049999237060547},{"id":"https://openalex.org/C2993084020","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen molecule","level":3,"score":0.4616999924182892},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.4542999863624573},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4505000114440918},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3813000023365021},{"id":"https://openalex.org/C2777620619","wikidata":"https://www.wikidata.org/wiki/Q1574099","display_name":"Radiation protection","level":2,"score":0.37049999833106995},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3546999990940094},{"id":"https://openalex.org/C2265751","wikidata":"https://www.wikidata.org/wiki/Q332007","display_name":"Electromagnetic shielding","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C2986039202","wikidata":"https://www.wikidata.org/wiki/Q123414","display_name":"Environmental stress","level":2,"score":0.34700000286102295},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.33000001311302185},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2779925993","wikidata":"https://www.wikidata.org/wiki/Q336938","display_name":"Radiation exposure","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C3019440502","wikidata":"https://www.wikidata.org/wiki/Q500430","display_name":"Dual role","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.25380000472068787}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4103/mgr.medgasres-d-25-00163","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","is_oa":true,"landing_page_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","pdf_url":null,"source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13667370","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13667370/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13667370/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Gas Res","raw_type":"Text"},{"id":"pmid:42734460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42734460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical gas research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/mgr.medgasres-d-25-00163","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","is_oa":true,"landing_page_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00163","pdf_url":null,"source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1496946619","display_name":null,"funder_award_id":"82090014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336500","display_name":"Peking University Health Science Center","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212489715.pdf","grobid_xml":"https://content.openalex.org/works/W7212489715.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1515564094","https://openalex.org/W1974894924","https://openalex.org/W1990379124","https://openalex.org/W2010187828","https://openalex.org/W2026362149","https://openalex.org/W2089708720","https://openalex.org/W2098772291","https://openalex.org/W2099576434","https://openalex.org/W2119334342","https://openalex.org/W2141645501","https://openalex.org/W2144927877","https://openalex.org/W2146943828","https://openalex.org/W2149957086","https://openalex.org/W2344056905","https://openalex.org/W2414438694","https://openalex.org/W2787836307","https://openalex.org/W2804341160","https://openalex.org/W2978968361","https://openalex.org/W2985723672","https://openalex.org/W3035406560","https://openalex.org/W3048734093","https://openalex.org/W3089116745","https://openalex.org/W3107907383","https://openalex.org/W3111087290","https://openalex.org/W3115477054","https://openalex.org/W3128522390","https://openalex.org/W3131368121","https://openalex.org/W3155265357","https://openalex.org/W3159251768","https://openalex.org/W3165830143","https://openalex.org/W3182633410","https://openalex.org/W3200630158","https://openalex.org/W3203848047","https://openalex.org/W3205420382","https://openalex.org/W4205846623","https://openalex.org/W4283119993","https://openalex.org/W4285741580","https://openalex.org/W4289130253","https://openalex.org/W4323276047","https://openalex.org/W4376279237","https://openalex.org/W4385579717","https://openalex.org/W4403718807","https://openalex.org/W4404925235","https://openalex.org/W4406598684","https://openalex.org/W4408227422","https://openalex.org/W4412423247"],"related_works":["https://openalex.org/W3047099873","https://openalex.org/W3159251768","https://openalex.org/W2054601210","https://openalex.org/W2139821868","https://openalex.org/W2125799290","https://openalex.org/W4391892176","https://openalex.org/W1995309420","https://openalex.org/W3124895941","https://openalex.org/W3137758835","https://openalex.org/W4413757611"],"abstract_inverted_index":{"Molecular":[0],"hydrogen":[1,19,55,67,128],"is":[2],"known":[3],"to":[4,18,24],"selectively":[5],"convert":[6],"hydroxyl":[7],"radicals":[8],"into":[9],"harmless":[10],"water":[11],"and":[12,26,32,51,60,81,88,104,116,122],"thereby":[13],"mitigating":[14,113],"oxidative":[15,114],"stress.":[16],"Due":[17],"molecules":[20],"have":[21],"masses":[22],"comparable":[23],"protons":[25,33],"neutrons,":[27],"can":[28,68],"also":[29],"decelerate":[30],"neutrons":[31],"present":[34],"in":[35,112],"environmental":[36,79,120],"radiation,":[37,121],"thus":[38],"exerting":[39],"a":[40,124],"physical":[41,52],"shielding":[42],"effect.":[43],"Through":[44],"this":[45],"dual":[46],"action,":[47],"chemical":[48],"radical":[49],"scavenging":[50],"radiation":[53,80],"shielding,":[54],"may":[56],"protect":[57],"cellular":[58,89],"integrity":[59],"potentially":[61],"promote":[62],"biological":[63,140],"longevity.":[64,141],"In":[65],"contrast,":[66],"intervene":[69],"at":[70,85],"the":[71,86,102],"stage":[72],"of":[73,107],"preventing":[74],"biomolecular":[75],"damage":[76],"induced":[77],"by":[78],"provide":[82],"comprehensive":[83],"protection":[84],"tissue":[87],"levels,":[90],"uniquely":[91],"minimizing":[92],"radiation-induced":[93,133],"damage.":[94],"This":[95],"review":[96],"systematically":[97],"summarizes":[98],"existing":[99],"knowledge":[100],"regarding":[101],"antioxidant":[103],"radioprotective":[105],"effects":[106],"hydrogen,":[108],"discusses":[109],"its":[110,136],"role":[111],"stress":[115],"protecting":[117],"cells":[118],"from":[119,132],"proposes":[123],"novel":[125],"hypothesis":[126],"that":[127],"has":[129],"universally":[130],"protected":[131],"damage,":[134],"highlighting":[135],"potential":[137],"for":[138],"promoting":[139]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-15T00:00:00"}