{"id":"https://openalex.org/W7212458998","doi":null,"title":"Analytical Performance of an Alternative Wavelength in the O-CPC Calcium Assay.","display_name":"Analytical Performance of an Alternative Wavelength in the O-CPC Calcium Assay.","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7212458998","pmid":"https://pubmed.ncbi.nlm.nih.gov/42730034","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13563543"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13563543","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/pdf/ejifcc-37-04-659.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},"parent_works":[],"lineage":["https://openalex.org/W7212458998"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/pdf/ejifcc-37-04-659.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003607595","display_name":"Serdar H\u0131ra","orcid":"https://orcid.org/0009-0006-3803-7601","observed_orcids":["https://orcid.org/0009-0006-3803-7601"]},"institutions":[{"id":"https://openalex.org/I4210148263","display_name":"GATA Haydarpa\u015fa E\u011fitim Hastanesi","ror":"https://ror.org/04760qd13","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210148263"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serdar Hira","raw_affiliation_strings":["Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210148263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036153623","display_name":"\u00d6mer \u00d6zcan","orcid":"https://orcid.org/0009-0006-7843-4986","observed_orcids":["https://orcid.org/0009-0006-7843-4986"]},"institutions":[{"id":"https://openalex.org/I4210148263","display_name":"GATA Haydarpa\u015fa E\u011fitim Hastanesi","ror":"https://ror.org/04760qd13","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210148263"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6mer \u00d6zcan","raw_affiliation_strings":["Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210148263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087898356","display_name":"Osman Metin \u0130p\u00e7io\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148263","display_name":"GATA Haydarpa\u015fa E\u011fitim Hastanesi","ror":"https://ror.org/04760qd13","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210148263"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Osman Metin \u0130pcio\u011flu","raw_affiliation_strings":["Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210148263"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066874395","display_name":"Mustafa G\u00fcltepe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148263","display_name":"GATA Haydarpa\u015fa E\u011fitim Hastanesi","ror":"https://ror.org/04760qd13","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210148263"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa G\u00fcltepe","raw_affiliation_strings":["Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, GATA Haydarpa\u015fa Training and Research Hospital, \u0130stanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210148263"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210148263"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4","first_page":"659","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11890","display_name":"Scientific Measurement and Uncertainty Evaluation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/analytical-bias","display_name":"analytical bias","score":0.5849999785423279},{"id":"https://openalex.org/keywords/analytical-performance","display_name":"analytical performance","score":0.39399999380111694},{"id":"https://openalex.org/keywords/spectrophotometric-method","display_name":"spectrophotometric assay","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.782800018787384},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.7620000243186951},{"id":"https://openalex.org/C158007255","wikidata":"https://www.wikidata.org/wiki/Q1055222","display_name":"Spectrum analyzer","level":2,"score":0.6466000080108643},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.5947999954223633},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.5069000124931335},{"id":"https://openalex.org/C202799725","wikidata":"https://www.wikidata.org/wiki/Q272035","display_name":"Accuracy and precision","level":2,"score":0.4781000018119812},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4553000032901764},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41119998693466187},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.37310001254081726},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.3230000138282776},{"id":"https://openalex.org/C4839761","wikidata":"https://www.wikidata.org/wiki/Q212111","display_name":"Spectral line","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C170814935","wikidata":"https://www.wikidata.org/wiki/Q4751159","display_name":"Analytical technique","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C151304367","wikidata":"https://www.wikidata.org/wiki/Q910067","display_name":"Chemometrics","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C178144697","wikidata":"https://www.wikidata.org/wiki/Q2111609","display_name":"Process analytical technology","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C100253034","wikidata":"https://www.wikidata.org/wiki/Q196372","display_name":"Systematic error","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.25270000100135803}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:13563543","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/pdf/ejifcc-37-04-659.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},{"id":"pmid:42730034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42730034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13563543","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13563543/pdf/ejifcc-37-04-659.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212458998.pdf","grobid_xml":"https://content.openalex.org/works/W7212458998.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2064260484","https://openalex.org/W2136678826","https://openalex.org/W2735360365","https://openalex.org/W2921636669","https://openalex.org/W3040970953","https://openalex.org/W4389942748","https://openalex.org/W4409140891"],"related_works":["https://openalex.org/W1938031836","https://openalex.org/W2067119775","https://openalex.org/W2364088560","https://openalex.org/W1879591971","https://openalex.org/W2143438792","https://openalex.org/W102329799","https://openalex.org/W1559097583","https://openalex.org/W2334525636","https://openalex.org/W4403983516","https://openalex.org/W2019869887"],"abstract_inverted_index":{"Objective:":[0],"The":[1],"o-cresolphthalein":[2],"complexone":[3],"(O-CPC)":[4],"method":[5],"is":[6],"widely":[7],"used":[8],"for":[9,81,226],"serum":[10],"calcium":[11,27,233],"measurement":[12],"but":[13],"may":[14,221],"exhibit":[15],"analytical":[16,33,82,110,194,228],"limitations":[17],"related":[18],"to":[19,107,138,148,180,196],"background":[20],"absorbance":[21,58],"and":[22,95,119,140,202],"bias,":[23],"particularly":[24],"at":[25,144,159,177,183,188],"low":[26,164,211],"concentrations.":[28],"This":[29],"study":[30],"evaluated":[31,116],"the":[32,43,52,77,109,163,197,210],"performance":[34,195,229],"of":[35,51],"an":[36,98],"alternative":[37,80,218],"wavelength":[38,65,201,219],"(524":[39],"nm)":[40],"compared":[41],"with":[42,97,205],"conventional":[44,198],"572":[45,149,178,199],"nm":[46,73,146,179,190,200],"measurement.":[47],"Methods:":[48],"Spectral":[49],"analysis":[50,125,133,152],"calcium-O-CPC":[53],"complex":[54],"identified":[55],"a":[56,135,141,223],"secondary":[57],"feature":[59],"near":[60],"536":[61],"nm.":[62,150,185],"Because":[63],"this":[64],"was":[66,74,85,115,172,203],"not":[67],"available":[68],"in":[69,101,209,230],"routine":[70,231],"analysers,":[71],"524":[72,145,184,189],"selected":[75],"as":[76],"nearest":[78],"operational":[79],"evaluation.":[83],"Performance":[84],"assessed":[86],"using":[87,117],"multipoint":[88],"calibration":[89],"models,":[90],"control":[91],"sera,":[92],"precision":[93],"analysis,":[94],"comparison":[96],"automated":[99],"analyzer":[100],"40":[102],"samples,":[103],"including":[104],"prepared":[105],"mixtures":[106],"extend":[108],"range.":[111,213],"Agreement":[112],"between":[113,130,157],"methods":[114,158],"regression":[118],"Bland-Altman":[120,151],"analyses.":[121],"Results:":[122],"\u22480.998).":[123],"Precision":[124],"demonstrated":[126,153,191],"comparable":[127,154,192],"CV%":[128],"values":[129],"wavelengths.":[131,161],"Regression":[132],"showed":[134],"slope":[136],"closer":[137],"unity":[139],"smaller":[142],"intercept":[143],"relative":[147],"overall":[155,193],"agreement":[156],"both":[160],"In":[162],"concentration":[165,212],"subgroup":[166],"(<9":[167],"mg/dL),":[168],"mean":[169],"negative":[170,207],"bias":[171,208],"reduced":[173,206],"from":[174],"-0.55":[175],"mg/dL":[176,182],"-0.30":[181],"Conclusions:":[186],"Measurement":[187],"associated":[204],"These":[214],"findings":[215],"suggest":[216],"that":[217],"selection":[220],"represent":[222],"practical":[224],"approach":[225],"optimizing":[227],"O-CPC":[232],"assays.":[234]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-14T00:00:00"}