{"id":"https://openalex.org/W7212447168","doi":"https://doi.org/10.12938/bmfh.2026-008","title":"Probiotic strain released-carbamoyl phosphates modify corticosterone metabolism in colonic epithelial cells by elevating 11-beta-hydroxysteroid dehydrogenase isozyme 2","display_name":"Probiotic strain released-carbamoyl phosphates modify corticosterone metabolism in colonic epithelial cells by elevating 11-beta-hydroxysteroid dehydrogenase isozyme 2","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7212447168","doi":"https://doi.org/10.12938/bmfh.2026-008"},"language":"en","primary_location":{"id":"doi:10.12938/bmfh.2026-008","doi":"https://doi.org/10.12938/bmfh.2026-008","is_oa":true,"landing_page_url":"https://doi.org/10.12938/bmfh.2026-008","pdf_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-008/_pdf","source":{"id":"https://openalex.org/S4210171784","display_name":"Bioscience of Microbiota Food and Health","issn_l":"2186-3342","issn":["2186-3342","2186-6953"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of Microbiota, Food and Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-008/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046045233","display_name":"Sohei Arase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sohei ARASE","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Minoru ANDO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru ANDO","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065802959","display_name":"Kosuke Oana","orcid":"https://orcid.org/0009-0009-5506-2106","observed_orcids":["https://orcid.org/0009-0009-5506-2106"]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke OANA","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109390293","display_name":"Yuji Fukuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji FUKUHARA","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035553066","display_name":"Takashi Kurakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi KURAKAWA","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013760859","display_name":"Tetsuji Hori","orcid":"https://orcid.org/0000-0002-1118-1949","observed_orcids":["https://orcid.org/0000-0002-1118-1949"]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuji HORI","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005177820","display_name":"Satoshi Matsumoto","orcid":"https://orcid.org/0000-0003-4836-7170","observed_orcids":["https://orcid.org/0000-0003-4836-7170"]},"institutions":[{"id":"https://openalex.org/I4210153337","display_name":"Yakult Central Institute","ror":"https://ror.org/04gcc2383","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210153337"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi MATSUMOTO","raw_affiliation_strings":["Yakult Central Institute, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yakult Central Institute, Japan","institution_ids":["https://openalex.org/I4210153337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153337"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.569596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/carbamoyl-phosphate","display_name":"carbamoyl phosphate","score":0.8149999976158142},{"id":"https://openalex.org/keywords/corticosterone-metabolism","display_name":"corticosterone metabolism","score":0.8669999837875366},{"id":"https://openalex.org/keywords/11beta-hydroxysteroid-dehydrogenase-type-2","display_name":"11\u03b2-hydroxysteroid dehydrogenase type 2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chronic-psychological-stress","display_name":"chronic psychological stress","score":0.8100000023841858},{"id":"https://openalex.org/keywords/colonic-epithelial-cells","display_name":"colonic epithelial cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"acetylcholine receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/probiotic-metabolites","display_name":"probiotic metabolites","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.6525999903678894},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.6485999822616577},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6122000217437744},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5849000215530396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5769000053405762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5497999787330627},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.541100025177002},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4731000065803528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4535999894142151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537999987602234},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33629998564720154},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2930999994277954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2791999876499176},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C2781330172","wikidata":"https://www.wikidata.org/wiki/Q412837","display_name":"Succinate dehydrogenase","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.12938/bmfh.2026-008","doi":"https://doi.org/10.12938/bmfh.2026-008","is_oa":true,"landing_page_url":"https://doi.org/10.12938/bmfh.2026-008","pdf_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-008/_pdf","source":{"id":"https://openalex.org/S4210171784","display_name":"Bioscience of Microbiota Food and Health","issn_l":"2186-3342","issn":["2186-3342","2186-6953"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of Microbiota, Food and Health","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-7258444/v1","doi":"https://doi.org/10.21203/rs.3.rs-7258444/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7258444/v1","pdf_url":"https://www.researchsquare.com/article/rs-7258444/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.12938/bmfh.2026-008","doi":"https://doi.org/10.12938/bmfh.2026-008","is_oa":true,"landing_page_url":"https://doi.org/10.12938/bmfh.2026-008","pdf_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-008/_pdf","source":{"id":"https://openalex.org/S4210171784","display_name":"Bioscience of Microbiota Food and Health","issn_l":"2186-3342","issn":["2186-3342","2186-6953"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of Microbiota, Food and Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327436","display_name":"Yakult Honsha","ror":"https://ror.org/03wmnrc91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212447168.pdf","grobid_xml":"https://content.openalex.org/works/W7212447168.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1979295973","https://openalex.org/W1985382600","https://openalex.org/W1992089537","https://openalex.org/W1999327751","https://openalex.org/W2011336114","https://openalex.org/W2020896282","https://openalex.org/W2023597383","https://openalex.org/W2041454039","https://openalex.org/W2049504958","https://openalex.org/W2051992129","https://openalex.org/W2063500485","https://openalex.org/W2081375824","https://openalex.org/W2083096979","https://openalex.org/W2090488505","https://openalex.org/W2094376648","https://openalex.org/W2114229205","https://openalex.org/W2126897394","https://openalex.org/W2140654128","https://openalex.org/W2143496052","https://openalex.org/W2145189896","https://openalex.org/W2146781730","https://openalex.org/W2148930555","https://openalex.org/W2159567970","https://openalex.org/W2163334221","https://openalex.org/W2323352759","https://openalex.org/W2485088535","https://openalex.org/W2516700628","https://openalex.org/W2589118859","https://openalex.org/W2609196293","https://openalex.org/W2804081205","https://openalex.org/W2889766685","https://openalex.org/W2895269825","https://openalex.org/W2979835635","https://openalex.org/W2988471964","https://openalex.org/W2999173212","https://openalex.org/W3005441056","https://openalex.org/W3034632308","https://openalex.org/W3037523163","https://openalex.org/W3212335159","https://openalex.org/W4252027575","https://openalex.org/W4282932724","https://openalex.org/W4303184202","https://openalex.org/W4328049092","https://openalex.org/W4362471755","https://openalex.org/W4378213262","https://openalex.org/W4387096557","https://openalex.org/W4387398047","https://openalex.org/W4389794957","https://openalex.org/W4392301355","https://openalex.org/W4402284788","https://openalex.org/W4404286398"],"related_works":["https://openalex.org/W4414500955","https://openalex.org/W7165662363","https://openalex.org/W4415357270","https://openalex.org/W1962329976","https://openalex.org/W2273595760","https://openalex.org/W2127775549","https://openalex.org/W2727737474","https://openalex.org/W1965449862","https://openalex.org/W1735386202","https://openalex.org/W2527979336"],"abstract_inverted_index":{"Abstract":[0],"Chronic":[1],"psychological":[2],"stress":[3,63],"contributes":[4],"to":[5,35,119,166],"functional":[6],"disorder":[7],"development,":[8],"including":[9,140],"irritable":[10],"bowel":[11],"syndrome":[12],"(IBS).":[13],"Although":[14],"probiotics":[15,155],"have":[16],"shown":[17],"potential":[18],"in":[19,53,122,160],"ameliorating":[20],"these":[21],"disorders,":[22],"the":[23,37,40,49,62,85,96,145,161],"precise":[24],"mechanisms":[25],"remain":[26],"incompletely":[27],"understood.":[28],"The":[29,59],"aim":[30],"of":[31,42,61,84,92,106,111],"this":[32],"study":[33],"was":[34,74],"elucidate":[36],"mechanism":[38,132,152],"underlying":[39],"effect":[41],"Lacticaseibacillus":[43],"paracasei":[44],"strain":[45],"Shirota":[46],"(LcS)":[47],"on":[48],"host":[50],"anti-stress":[51,138,158],"response":[52],"a":[54,90,129],"colonic":[55,123,162],"epithelial":[56,124],"cell":[57],"line.":[58],"expression":[60],"hormone-degrading":[64],"enzyme,":[65],"11":[66],"\u03b2-hydroxysteroid":[67],"dehydrogenase":[68],"type":[69],"2":[70],"(":[71],"Hsd11b2":[72,102,121,141],"),":[73],"suppressed":[75],"by":[76,80,143,153],"corticosterone":[77],"and":[78,109,147],"restored":[79],"LcS":[81,86,135],"treatment.":[82,168],"Fractionation":[83],"culture":[87],"supernatant":[88],"revealed":[89],"derivative":[91],"carbamoyl":[93],"phosphate":[94],"as":[95],"key":[97],"factor":[98],"responsible":[99],"for":[100],"inducing":[101],".":[103],"Moreover,":[104],"activation":[105],"acetylcholine":[107,146],"receptor":[108],"inhibition":[110],"NF-\u03baB":[112,148],"p50":[113],"homodimer":[114],"nuclear":[115],"translocation":[116],"were":[117],"required":[118],"induce":[120],"cells.":[125],"These":[126],"findings":[127],"reveal":[128],"novel":[130],"probiotic":[131],"whereby":[133],"an":[134],"metabolite":[136],"triggers":[137],"responses,":[139],"induction,":[142],"modulating":[144],"pathways.":[149],"This":[150],"new":[151],"which":[154],"can":[156],"stimulate":[157],"effects":[159],"mucosa":[163],"may":[164],"contribute":[165],"IBS":[167]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-14T00:00:00"}
