{"id":"https://openalex.org/W7212444514","doi":"https://doi.org/10.64898/2026.09.11.750931","title":"Evaluation of new adjuvants in enhancing the immune response to a candidate of Severe Fever with Thrombocytopenia Syndrome Virus vaccine","display_name":"Evaluation of new adjuvants in enhancing the immune response to a candidate of Severe Fever with Thrombocytopenia Syndrome Virus vaccine","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212444514","doi":"https://doi.org/10.64898/2026.09.11.750931","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622657"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.11.750931","doi":"https://doi.org/10.64898/2026.09.11.750931","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750931","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.750931.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.750931.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112212331","display_name":"Jorge L\u00e9vican","orcid":"https://orcid.org/0000-0001-9538-6839","observed_orcids":["https://orcid.org/0000-0001-9538-6839"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Levican","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037176178","display_name":"N.M. Ferressini Gerpe","orcid":"https://orcid.org/0000-0003-1210-3085","observed_orcids":["https://orcid.org/0000-0003-1210-3085"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Ferressini Gerpe","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045423635","display_name":"Seok\u2010Chan Park","orcid":"https://orcid.org/0000-0003-2489-2202","observed_orcids":["https://orcid.org/0000-0003-2489-2202"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seok-Chan Park","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019456074","display_name":"Moataz Noureddine","orcid":"https://orcid.org/0000-0003-2516-9577","observed_orcids":["https://orcid.org/0000-0003-2516-9577"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moataz Noureddine","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116055136","display_name":"Farah El-Ayache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farah El-Ayache","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099847913","display_name":"Vivian Yan","orcid":"https://orcid.org/0009-0009-0397-623X","observed_orcids":["https://orcid.org/0009-0009-0397-623X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivian Yan","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140043565","display_name":"Leonie Gruneberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonie Gruneberg","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041755549","display_name":"M Prellberg","orcid":"https://orcid.org/0000-0001-9608-789X","observed_orcids":["https://orcid.org/0000-0001-9608-789X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew Prellberg","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063537600","display_name":"Lauren A. Chang","orcid":"https://orcid.org/0000-0002-3287-3987","observed_orcids":["https://orcid.org/0000-0002-3287-3987"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Chang","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065017531","display_name":"Gabriel Laghlali","orcid":"https://orcid.org/0009-0009-7928-984X","observed_orcids":["https://orcid.org/0009-0009-7928-984X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Laghlali","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066539656","display_name":"Gagandeep Singh","orcid":"https://orcid.org/0000-0001-5848-2741","observed_orcids":["https://orcid.org/0000-0001-5848-2741"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gagandeep Singh","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039707685","display_name":"Pamela T. Wong","orcid":"https://orcid.org/0000-0002-4387-4723","observed_orcids":["https://orcid.org/0000-0002-4387-4723"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela T. Wong","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA","Michigan Center for Infectious Disease Threats and Pandemic Preparedness, University of Michigan, Ann Arbor, MI, USA","Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Michigan Center for Infectious Disease Threats and Pandemic Preparedness, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027593067","display_name":"Arturo Levic\u00e1n","orcid":"https://orcid.org/0000-0002-7250-3382","observed_orcids":["https://orcid.org/0000-0002-7250-3382"]},"institutions":[{"id":"https://openalex.org/I130474213","display_name":"Pontificia Universidad Cat\u00f3lica de Valpara\u00edso","ror":"https://ror.org/02cafbr77","country_code":"CL","type":"education","lineage":["https://openalex.org/I130474213"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Arturo Levican","raw_affiliation_strings":["Centro de Investigaci\u00f3n Interdisciplinaria en Biomedicina, Biotecnolog\u00eda y Bienestar (CID3B). Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso, Chile","Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Ciencias. Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Interdisciplinaria en Biomedicina, Biotecnolog\u00eda y Bienestar (CID3B). Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I130474213"]},{"raw_affiliation_string":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Ciencias. Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I130474213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147535185","display_name":"Gustavo Palacios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Palac\u00edos","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004889712","display_name":"Adolfo Garc\u00eda\u2010Sastre","orcid":"https://orcid.org/0000-0002-6551-1827","observed_orcids":["https://orcid.org/0000-0002-6551-1827"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adolfo Garc\u00eda-Sastre","raw_affiliation_strings":["Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005063202","display_name":"Michael Schotsaert","orcid":"https://orcid.org/0000-0003-3156-3132","observed_orcids":["https://orcid.org/0000-0003-3156-3132"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Schotsaert","raw_affiliation_strings":["Department for Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","Marc and Jennifer Lipschultz Institute of Precision Immunology, Icahn School of Medicine at Mount Sinai, NY, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-3156-3132","affiliations":[{"raw_affiliation_string":"Department for Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department for Microbiology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Marc and Jennifer Lipschultz Institute of Precision Immunology, Icahn School of Medicine at Mount Sinai, NY, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005063202"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-fever-with-thrombocytopenia-syndrome","display_name":"severe fever with thrombocytopenia syndrome","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sftsv","display_name":"SFTSV","score":0.878000020980835},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.777999997138977},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.9509999752044678},{"id":"https://openalex.org/keywords/addavax","display_name":"AddaVax","score":0.765999972820282},{"id":"https://openalex.org/keywords/alhydrogel","display_name":"Alhydrogel","score":0.9739999771118164},{"id":"https://openalex.org/keywords/rig-i-agonist","display_name":"RIG-I agonist","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tlr7-8-agonist","display_name":"TLR7/8 agonist","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.7289999723434448},{"id":"https://openalex.org/keywords/gn-glycoprotein","display_name":"Gn glycoprotein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.699999988079071},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6944000124931335},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6636000275611877},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6025999784469604},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5748999714851379},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5738999843597412},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5654000043869019},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.4742000102996826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44190001487731934},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.3723999857902527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3709999918937683},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.353300005197525},{"id":"https://openalex.org/C2779359726","wikidata":"https://www.wikidata.org/wiki/Q1195394","display_name":"Memory B cell","level":4,"score":0.31859999895095825},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C2778732662","wikidata":"https://www.wikidata.org/wiki/Q3508725","display_name":"Severe fever with thrombocytopenia syndrome","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.30790001153945923},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.2581999897956848}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.11.750931","doi":"https://doi.org/10.64898/2026.09.11.750931","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750931","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.750931.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622657","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622657/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622657/pdf/nihpp-2026.09.11.750931v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42818735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.11.750931","doi":"https://doi.org/10.64898/2026.09.11.750931","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750931","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.750931.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1888821344","display_name":"Strengthening the ISMMS research and response capabilities for pathogens of pandemic potential","funder_award_id":"G20AI174733","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4001010542","display_name":null,"funder_award_id":"75N93019C00046","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000856995","display_name":"Training Program in Mechanisms of Virus-Host Interactions","funder_award_id":"T32AI007647","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000901003","display_name":"Translational Immunology Training Program","funder_award_id":"T32AI078892","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309658","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212444514.pdf","grobid_xml":"https://content.openalex.org/works/W7212444514.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W2015648174","https://openalex.org/W2018608294","https://openalex.org/W2030055923","https://openalex.org/W2055020252","https://openalex.org/W2091123450","https://openalex.org/W2112216439","https://openalex.org/W2132629607","https://openalex.org/W2135182337","https://openalex.org/W2140174844","https://openalex.org/W2170206314","https://openalex.org/W2172081451","https://openalex.org/W2256756668","https://openalex.org/W2369495334","https://openalex.org/W2426189081","https://openalex.org/W2480615819","https://openalex.org/W2557027943","https://openalex.org/W2567447363","https://openalex.org/W2745757394","https://openalex.org/W2886417795","https://openalex.org/W2891323347","https://openalex.org/W2917796724","https://openalex.org/W2927565072","https://openalex.org/W2940575167","https://openalex.org/W2965842656","https://openalex.org/W2969318280","https://openalex.org/W2990439810","https://openalex.org/W3012537395","https://openalex.org/W3018351784","https://openalex.org/W3040428665","https://openalex.org/W3043056027","https://openalex.org/W3047593322","https://openalex.org/W3082091008","https://openalex.org/W3087111048","https://openalex.org/W3092721228","https://openalex.org/W3122011206","https://openalex.org/W3131044756","https://openalex.org/W3133643296","https://openalex.org/W3134025055","https://openalex.org/W3162434529","https://openalex.org/W3185889316","https://openalex.org/W3197082153","https://openalex.org/W3198989599","https://openalex.org/W3213642922","https://openalex.org/W3215854342","https://openalex.org/W4210286387","https://openalex.org/W4281250819","https://openalex.org/W4292261119","https://openalex.org/W4308595008","https://openalex.org/W4316466374","https://openalex.org/W4364353374","https://openalex.org/W4387495399","https://openalex.org/W4388048162","https://openalex.org/W4388128035","https://openalex.org/W4388990528","https://openalex.org/W4390932725","https://openalex.org/W4392805456","https://openalex.org/W4392966147","https://openalex.org/W4395006705","https://openalex.org/W4399301097","https://openalex.org/W4400249500","https://openalex.org/W4403315142","https://openalex.org/W4405112218","https://openalex.org/W4410019452","https://openalex.org/W4413408428"],"related_works":["https://openalex.org/W4206235740","https://openalex.org/W3145515008","https://openalex.org/W4377157453","https://openalex.org/W3216037503","https://openalex.org/W3127770131","https://openalex.org/W2990439810","https://openalex.org/W4390075568","https://openalex.org/W7163692943","https://openalex.org/W7018520874","https://openalex.org/W4410130906"],"abstract_inverted_index":{"Abstract":[0],"Severe":[1,351],"fever":[2,352],"with":[3,43,82,152,236,256,353,369,389,483,503],"thrombocytopenia":[4,354],"syndrome":[5,355],"(SFTS)":[6],"is":[7,19,25,358],"an":[8,116,359],"emerging":[9,360],"zoonotic":[10],"disease":[11,293],"caused":[12],"by":[13,22,35,201,209,288],"the":[14,157,168,172,185,202,223,227,306,331,338,395,400,411,426,438,462,466,484,488,526],"tick-borne":[15,361],"bunyavirus":[16,362],"SFTSV.":[17,505],"SFTSV":[18,74,261,300,314,385],"primarily":[20],"transmitted":[21],"Haemaphysalis":[23],"longicorn":[24],"ticks":[26],"and":[27,40,86,103,132,139,154,161,184,206,213,245,251,274,295,308,317,342,373,380,391,399,408,415,437,453,472,478,492,520,530],"can":[28],"cause":[29],"a":[30,72,100,108,259,312,321,365,382,511],"hemorrhagic":[31,366],"fever-like":[32,367],"illness":[33,368],"characterized":[34,208,381],"high":[36,370],"fever,":[37],"thrombocytopenia,":[38],"leukopenia,":[39],"multiorgan":[41],"failure,":[42],"reported":[44],"case-fatality":[45],"rates":[46,372],"ranging":[47],"from":[48,249,258,272,476],"10%":[49],"to":[50],"over":[51],"30%.":[52],"Despite":[53],"its":[54,237],"growing":[55],"public":[56],"health":[57],"relevance,":[58],"no":[59],"licensed":[60],"vaccines":[61],"or":[62,88,112],"specific":[63],"antiviral":[64,347,534],"therapies":[65],"are":[66],"currently":[67],"available.":[68],"Here,":[69,377],"we":[70,120,378],"evaluated":[71],"beta-propiolactone-inactivated":[73],"vaccine":[75,315,386,459,518],"candidate":[76,387],"based":[77],"on":[78],"strain":[79,491],"YL1,":[80],"formulated":[81,388],"benchmark":[83,390],"adjuvants":[84],"(Addavax":[85],"Alhydrogel)":[87],"experimental":[89,392],"innate":[90],"immune":[91,177,326,431],"agonists,":[92],"including":[93,394],"Sendai":[94],"virus-derived":[95],"defective":[96],"interfering":[97],"RNA":[98],"(SDI),":[99],"RIG-I":[101,396],"agonist,":[102,110],"imidazoquinoline-poly(ethylene":[104],"glycol)-cholesterol":[105],"conjugate":[106],"(IMDQ-P-C),":[107],"TLR7/8":[109,401],"alone":[111],"in":[113,142,336],"combination.":[114],"Using":[115],"extended":[117],"prime-boost":[118],"regimen,":[119],"examined":[121],"adjuvant-dependent":[122],"modulation":[123],"of":[124,175,226,311,324,333,345,429,465,487,515,533],"humoral":[125,150,240,471],"immunity,":[126],"antigen-specific":[127],"cellular":[128,232,473],"recall,":[129],"antibody":[130,163,182,265,417,435],"cross-reactivity,":[131],"functional":[133,343,531],"protection":[134,279,495],"following":[135,190,280,496],"passive":[136,281,497],"serum":[137],"transfer":[138,282,498],"live-virus":[140],"challenge":[141],"IFNAR-/-":[143,284,500],"mice.":[144],"All":[145],"adjuvanted":[146],"formulations":[147],"induced":[148,200],"detectable":[149],"responses,":[151,234],"Addavax":[153,407],"SDI":[155,250,273,398,409],"eliciting":[156,433],"highest":[158],"virus-specific":[159,413],"binding":[160,414],"neutralizing":[162,416],"titers.":[164],"Antigen-specific":[165,419],"analyses":[166,421],"identified":[167,422],"nucleoprotein":[169,423],"(NP)":[170,424],"as":[171,286,320,425,510],"dominant":[173,427],"target":[174,323,428,514],"vaccine-induced":[176,325,346,430],"memory.":[178,327],"NP":[179,319,509],"elicited":[180,230,410,469],"robust":[181,434],"response":[183,195],"broadest":[186,439],"cytokine":[187,440],"recall":[188,233,420,441,448],"profile":[189,442],"ex":[191,444],"vivo":[192,445],"stimulation.":[193,446],"This":[194],"was":[196,207],"broader":[197,264],"than":[198],"that":[199,216,363,456],"whole":[203],"inactivated":[204,517],"virus":[205,356],"mixed":[210,450],"Th1-associated,":[211,451],"Th2-associated,":[212,452],"proinflammatory-associated":[214,454],"features":[215,455],"varied":[217,457],"across":[218,267,458],"adjuvant":[219,334,523],"formulations.":[220],"In":[221,349,404],"contrast,":[222],"head":[224,463],"domain":[225,464],"Gn":[228,257,467,485],"glycoprotein":[229,468,486],"limited":[231,470],"consistent":[235],"relatively":[238],"weak":[239],"immunogenicity":[241,307],"after":[242,298,443],"both":[243],"priming":[244],"boosting.":[246],"Nevertheless,":[247],"sera":[248,271],"Addavax-adjuvanted":[252],"groups":[253,480],"displayed":[254,481],"cross-reactivity":[255,482],"heterologous":[260,489],"strain,":[262],"suggesting":[263],"recognition":[266],"viral":[268,290],"genotypes.":[269],"Functionally,":[270],"Addavax-immunized":[275],"mice":[276,501],"conferred":[277,493],"partial":[278,494],"into":[283,499],"recipients,":[285],"reflected":[287],"reduced":[289],"loads,":[291],"delayed":[292],"onset,":[294],"prolonged":[296],"survival":[297],"lethal":[299],"challenge.":[301],"Together,":[302],"these":[303],"findings":[304,507],"support":[305],"protective":[309],"potential":[310],"BPL-inactivated":[313],"platform":[316,519],"identify":[318,508],"major":[322,512],"They":[328],"further":[329],"highlight":[330,521],"importance":[332],"selection":[335,524],"shaping":[337],"magnitude,":[339,527],"antigenic":[340,528],"focus,":[341,529],"quality":[344,532],"immunity.":[348,535],"brief":[350],"(SFTSV)":[357],"causes":[364],"fatality":[371],"lacks":[374],"approved":[375],"vaccines.":[376],"developed":[379],"\u03b2-propiolactone-inactivated":[383],"whole-virus":[384],"adjuvants,":[393],"agonist":[397,402],"IMDQ-P-C.":[403],"BALB/c":[405],"mice,":[406],"strongest":[412],"responses.":[418,474],"memory,":[432],"responses":[436],"NP-induced":[447],"showed":[449],"formulations,":[460],"whereas":[461],"Sera":[475],"Addavax-":[477],"SDI-adjuvanted":[479],"HB29":[490],"challenged":[502],"live":[504],"These":[506],"immunological":[513],"this":[516],"how":[522],"shapes":[525]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-14T00:00:00"}
