{"id":"https://openalex.org/W7212434512","doi":"https://doi.org/10.1111/adb.70191","title":"Acquisition\u2010Recruited and MOR\u2010Expressing Striatal dMSNs Differentially Regulate Extinction and Cue\u2010Induced Relapse of Alcohol Seeking","display_name":"Acquisition\u2010Recruited and MOR\u2010Expressing Striatal dMSNs Differentially Regulate Extinction and Cue\u2010Induced Relapse of Alcohol Seeking","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7212434512","doi":"https://doi.org/10.1111/adb.70191","pmid":"https://pubmed.ncbi.nlm.nih.gov/42146474","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13174283"},"language":"en","primary_location":{"id":"doi:10.1111/adb.70191","doi":"https://doi.org/10.1111/adb.70191","is_oa":true,"landing_page_url":"https://doi.org/10.1111/adb.70191","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.70191","source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.70191","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016250687","display_name":"Xueyi Xie","orcid":"https://orcid.org/0000-0002-2349-1223","observed_orcids":["https://orcid.org/0000-0002-2349-1223"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueyi Xie","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics Naresh K. Vashisht College of Medicine, Texas A&M University Health Science Center  Bryan Texas USA"],"raw_orcid":"https://orcid.org/0000-0002-2349-1223","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics Naresh K. Vashisht College of Medicine, Texas A&M University Health Science Center  Bryan Texas USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101962350","display_name":"Xuehua Wang","orcid":"https://orcid.org/0000-0002-5317-6822","observed_orcids":["https://orcid.org/0000-0002-5317-6822"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuehua Wang","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics Naresh K. Vashisht College of Medicine, Texas A&M University Health Science Center  Bryan Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics Naresh K. Vashisht College of Medicine, Texas A&M University Health Science Center  Bryan Texas USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100384673","display_name":"Jun Wang","orcid":"https://orcid.org/0000-0002-0085-4722","observed_orcids":["https://orcid.org/0000-0002-0085-4722"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Wang","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics Naresh K. Vashisht College of Medicine, Texas A&M University Health Science Center  Bryan Texas USA"],"raw_orcid":"https://orcid.org/0000-0002-0085-4722","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics Naresh K. Vashisht College of Medicine, Texas A&M University Health Science Center  Bryan Texas USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100384673"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57508012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"9","first_page":"e70191","last_page":"e70191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcohol-seeking-behavior","display_name":"alcohol seeking","score":0.7580000162124634},{"id":"https://openalex.org/keywords/extinction","display_name":"extinction","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cue-induced-relapse","display_name":"cue-induced relapse","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dorsomedial-striatum","display_name":"dorsomedial striatum","score":0.9589999914169312},{"id":"https://openalex.org/keywords/striosomes","display_name":"striosomes","score":0.7540000081062317},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.875},{"id":"https://openalex.org/keywords/chemogenetic-manipulation","display_name":"chemogenetic manipulation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/neuronal-ensembles","display_name":"neuronal ensembles","score":0.43700000643730164},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.8510000109672546},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6395999789237976},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5371000170707703},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.5001999735832214},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4657999873161316},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.424699991941452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40059998631477356},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.38370001316070557},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.3741999864578247},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C522683910","wikidata":"https://www.wikidata.org/wiki/Q11290178","display_name":"Alcohol and health","level":4,"score":0.2786000072956085},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C3018430727","wikidata":"https://www.wikidata.org/wiki/Q11058472","display_name":"Alcohol intake","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.26930001378059387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2578999996185303},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1111/adb.70191","doi":"https://doi.org/10.1111/adb.70191","is_oa":true,"landing_page_url":"https://doi.org/10.1111/adb.70191","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.70191","source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},{"id":"doi:10.64898/2026.04.30.722024","doi":"https://doi.org/10.64898/2026.04.30.722024","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.30.722024","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/05/2026.04.30.722024.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13571901","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13571901/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13571901/pdf/ADB-31-e70191.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addict Biol","raw_type":"Text"},{"id":"pmid:42146474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42146474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42732882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42732882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13174283","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13174283/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/adb.70191","doi":"https://doi.org/10.1111/adb.70191","is_oa":true,"landing_page_url":"https://doi.org/10.1111/adb.70191","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/adb.70191","source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2858557326","display_name":"Ethanol drinking and the basal ganglia circuitry","funder_award_id":"R01AA027768","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5138970847","display_name":"Ethanol and glutamatergic transmission in the dorsal striatum","funder_award_id":"R01AA021505","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6353216312","display_name":"Synaptic Plasticity and Alcohol Use Disorder","funder_award_id":"U01AA025932","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7371684277","display_name":null,"funder_award_id":"R01AA032498","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000899915","display_name":"Striatal ensemble plasticity in alcohol use disorder","funder_award_id":"R01AA030293","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320310164","display_name":"Texas A and M University","ror":"https://ror.org/01f5ytq51"},{"id":"https://openalex.org/F4320315400","display_name":"Texas Research Society on Alcoholism","ror":"https://ror.org/01063sw77"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212434512.pdf","grobid_xml":"https://content.openalex.org/works/W7212434512.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1554715089","https://openalex.org/W1594941540","https://openalex.org/W1664214798","https://openalex.org/W1982977141","https://openalex.org/W2002928138","https://openalex.org/W2004650335","https://openalex.org/W2009000833","https://openalex.org/W2022633426","https://openalex.org/W2024365408","https://openalex.org/W2026145070","https://openalex.org/W2026547228","https://openalex.org/W2028499790","https://openalex.org/W2043662856","https://openalex.org/W2061996597","https://openalex.org/W2068388264","https://openalex.org/W2072880001","https://openalex.org/W2077884847","https://openalex.org/W2080059055","https://openalex.org/W2093405266","https://openalex.org/W2112337921","https://openalex.org/W2118830830","https://openalex.org/W2119259385","https://openalex.org/W2122637192","https://openalex.org/W2127822020","https://openalex.org/W2128252744","https://openalex.org/W2128443527","https://openalex.org/W2131557002","https://openalex.org/W2161853532","https://openalex.org/W2396428346","https://openalex.org/W2508875940","https://openalex.org/W2521335002","https://openalex.org/W2558551813","https://openalex.org/W2560248355","https://openalex.org/W2613928298","https://openalex.org/W2615775020","https://openalex.org/W2619679515","https://openalex.org/W2768620954","https://openalex.org/W2789862286","https://openalex.org/W2801760391","https://openalex.org/W2806704674","https://openalex.org/W2808647362","https://openalex.org/W2879398029","https://openalex.org/W2903944365","https://openalex.org/W2935468986","https://openalex.org/W2945545496","https://openalex.org/W2953204260","https://openalex.org/W2985251923","https://openalex.org/W2987772439","https://openalex.org/W2998470023","https://openalex.org/W3022235856","https://openalex.org/W3086489375","https://openalex.org/W3089128271","https://openalex.org/W3089184362","https://openalex.org/W3092916192","https://openalex.org/W3118170080","https://openalex.org/W3132748331","https://openalex.org/W3153382048","https://openalex.org/W3189497181","https://openalex.org/W3194089406","https://openalex.org/W4226128274","https://openalex.org/W4320915104","https://openalex.org/W4366138589","https://openalex.org/W4379515710","https://openalex.org/W4381943746","https://openalex.org/W4382011609","https://openalex.org/W4382752558","https://openalex.org/W4391145695","https://openalex.org/W4399556048","https://openalex.org/W4401305009","https://openalex.org/W4403682408","https://openalex.org/W4404914109","https://openalex.org/W4405516899","https://openalex.org/W4409094552","https://openalex.org/W4409838565","https://openalex.org/W4413008751","https://openalex.org/W4413115935","https://openalex.org/W4413403054","https://openalex.org/W7124182188","https://openalex.org/W7154344932","https://openalex.org/W7163744816"],"related_works":["https://openalex.org/W7160291016","https://openalex.org/W4413403054","https://openalex.org/W7154344932","https://openalex.org/W2945545496","https://openalex.org/W2011293417","https://openalex.org/W4401305009","https://openalex.org/W2599400127","https://openalex.org/W7167798809","https://openalex.org/W3165607808","https://openalex.org/W4413284777"],"abstract_inverted_index":{"Relapse":[0],"to":[1,9,167],"alcohol":[2,26,36,133],"use":[3],"is":[4,102],"frequently":[5],"triggered":[6],"by":[7],"re-exposure":[8],"alcohol-associated":[10],"cues,":[11],"and":[12,64,84,119,150,171],"extinction-based":[13,182],"interventions":[14],"reduce":[15],"relapse":[16],"vulnerability.":[17],"However,":[18],"the":[19,55,90],"cellular":[20],"mechanisms":[21],"through":[22,135],"which":[23],"extinction":[24,41,80,82,115,117,131,163],"suppresses":[25,132],"seeking":[27,134],"remain":[28],"unclear.":[29],"Using":[30],"a":[31],"mouse":[32],"model":[33],"of":[34,45,67,75,92,99,111,138,147,152],"operant":[35],"self-administration,":[37],"we":[38],"examined":[39],"how":[40,162],"training":[42],"alters":[43],"activity":[44],"defined":[46,173],"striatal":[47,140,165,174],"direct-pathway":[48],"medium":[49],"spiny":[50],"neuron":[51],"(dMSN)":[52],"populations":[53,176],"in":[54,89],"dorsomedial":[56],"striatum":[57],"(DMS).":[58],"Extinction":[59],"significantly":[60],"reduced":[61,121,145],"cue-induced":[62],"reinstatement":[63,122],"decreased":[65],"reactivation":[66],"acquisition-recruited":[68,76],"dMSN":[69,77,141,175],"ensembles":[70,78,101,149],"during":[71,79,114],"relapse.":[72],"Chemogenetic":[73],"activation":[74,110],"impaired":[81],"learning":[83,118],"enhanced":[85],"subsequent":[86],"reinstatement,":[87],"even":[88],"absence":[91],"manipulation":[93],"at":[94],"test,":[95],"indicating":[96],"that":[97,130],"suppression":[98],"these":[100,156],"required":[103],"for":[104,180],"effective":[105],"extinction.":[106],"In":[107],"contrast,":[108],"selective":[109],"striosomal":[112,153],"dMSNs":[113],"accelerated":[116],"further":[120],"without":[123],"affecting":[124],"locomotor":[125],"activity.":[126],"These":[127],"findings":[128,157],"demonstrate":[129],"coordinated":[136],"modulation":[137],"distinct":[139],"populations,":[142],"involving":[143],"both":[144],"engagement":[146],"acquisition-related":[148],"recruitment":[151],"circuits.":[154],"Together,":[155],"provide":[158],"mechanistic":[159],"insight":[160],"into":[161],"reshapes":[164],"circuitry":[166],"suppress":[168],"relapse-related":[169],"behavior":[170],"highlight":[172],"as":[177],"potential":[178],"substrates":[179],"enhancing":[181],"interventions.":[183]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-14T00:00:00"}