{"id":"https://openalex.org/W7212433810","doi":"https://doi.org/10.51168/z25wzc51","title":"Daily versus thrice-weekly antituberculosis therapy for drug-susceptible pulmonary tuberculosis in adults: A systematic review and exploratory meta-analysis.","display_name":"Daily versus thrice-weekly antituberculosis therapy for drug-susceptible pulmonary tuberculosis in adults: A systematic review and exploratory meta-analysis.","publication_year":2026,"publication_date":"2026-09-13","ids":{"openalex":"https://openalex.org/W7212433810","doi":"https://doi.org/10.51168/z25wzc51"},"language":"en","primary_location":{"id":"doi:10.51168/z25wzc51","doi":"https://doi.org/10.51168/z25wzc51","is_oa":true,"landing_page_url":"https://doi.org/10.51168/z25wzc51","pdf_url":null,"source":{"id":"https://openalex.org/S4210191156","display_name":"Student s Journal of Health Research Africa","issn_l":"2709-9997","issn":["2709-9997","3006-1059"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Student's Journal of Health Research Africa","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.51168/z25wzc51","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031884308","display_name":"Suvendu Kumar Panda","orcid":"https://orcid.org/0000-0003-3943-8440","observed_orcids":["https://orcid.org/0000-0003-3943-8440"]},"institutions":[{"id":"https://openalex.org/I250200457","display_name":"Maharaja Krishna Chandra Gajapati Medical College and Hospital","ror":"https://ror.org/00j4pe902","country_code":"IN","type":"education","lineage":["https://openalex.org/I250200457"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suvendu Kumar Panda","raw_affiliation_strings":["Assistant Professor, Department of Pharmacology, MKCG, Medical College and Hospital, Berhampur, Odisha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Pharmacology, MKCG, Medical College and Hospital, Berhampur, Odisha","institution_ids":["https://openalex.org/I250200457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062762421","display_name":"Snehasini Dash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Snehasini Dash","raw_affiliation_strings":["Assistant Professor, Driems Institute of Health Sciences and Hospital, Cuttack, Odisha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Driems Institute of Health Sciences and Hospital, Cuttack, Odisha","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101773061","display_name":"Pratyush Mishra","orcid":"https://orcid.org/0009-0000-6600-9719","observed_orcids":["https://orcid.org/0009-0000-6600-9719"]},"institutions":[{"id":"https://openalex.org/I250200457","display_name":"Maharaja Krishna Chandra Gajapati Medical College and Hospital","ror":"https://ror.org/00j4pe902","country_code":"IN","type":"education","lineage":["https://openalex.org/I250200457"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pratyush Mishra","raw_affiliation_strings":["Assistant Professor, Department of Pharmacology, MKCG, Medical College and Hospital, Berhampur, Odisha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Pharmacology, MKCG, Medical College and Hospital, Berhampur, Odisha","institution_ids":["https://openalex.org/I250200457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119009947","display_name":"Srikanta Panigrahy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I250200457","display_name":"Maharaja Krishna Chandra Gajapati Medical College and Hospital","ror":"https://ror.org/00j4pe902","country_code":"IN","type":"education","lineage":["https://openalex.org/I250200457"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Srikanta Panigrahy","raw_affiliation_strings":["Senior Resident, Department of Pharmacology, MKCG Medical College and Hospital, Berhampur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Resident, Department of Pharmacology, MKCG Medical College and Hospital, Berhampur","institution_ids":["https://openalex.org/I250200457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5139847619","display_name":"Rashmi Ranjan Bhadra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I250200457","display_name":"Maharaja Krishna Chandra Gajapati Medical College and Hospital","ror":"https://ror.org/00j4pe902","country_code":"IN","type":"education","lineage":["https://openalex.org/I250200457"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rashmi Ranjan Bhadra","raw_affiliation_strings":["Senior Resident, Department of Pharmacology, MKCG Medical College, Berhampur, Odisha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Resident, Department of Pharmacology, MKCG Medical College, Berhampur, Odisha","institution_ids":["https://openalex.org/I250200457"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":40,"currency":"USD","value_usd":40},"apc_paid":{"value":40,"currency":"USD","value_usd":40},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"24","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12578","display_name":"Diagnosis and treatment of tuberculosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/drug-susceptible-tuberculosis","display_name":"drug-susceptible tuberculosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cultural-conversion","display_name":"culture conversion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6800000071525574},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hiv-associated-tuberculosis","display_name":"HIV-associated tuberculosis","score":0.640999972820282},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8866999745368958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8569999933242798},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7477999925613403},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.44690001010894775},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.43160000443458557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42899999022483826},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.40369999408721924},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.399399995803833},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C2908628106","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Pulmonary tuberculosis","level":3,"score":0.37880000472068787},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.29330000281333923},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2556000053882599},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.51168/z25wzc51","doi":"https://doi.org/10.51168/z25wzc51","is_oa":true,"landing_page_url":"https://doi.org/10.51168/z25wzc51","pdf_url":null,"source":{"id":"https://openalex.org/S4210191156","display_name":"Student s Journal of Health Research Africa","issn_l":"2709-9997","issn":["2709-9997","3006-1059"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Student's Journal of Health Research Africa","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.51168/z25wzc51","doi":"https://doi.org/10.51168/z25wzc51","is_oa":true,"landing_page_url":"https://doi.org/10.51168/z25wzc51","pdf_url":null,"source":{"id":"https://openalex.org/S4210191156","display_name":"Student s Journal of Health Research Africa","issn_l":"2709-9997","issn":["2709-9997","3006-1059"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Student's Journal of Health Research Africa","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588098415","https://openalex.org/W2793872709","https://openalex.org/W2154670021","https://openalex.org/W4210386635","https://openalex.org/W1596095440","https://openalex.org/W2706303571","https://openalex.org/W1982573150","https://openalex.org/W2172247972","https://openalex.org/W2078128501","https://openalex.org/W1965777990"],"abstract_inverted_index":{"Background:":[0],"Historical":[1],"thrice-weekly":[2,49,150,222],"antituberculosis":[3,50],"regimens":[4],"reduced":[5],"the":[6,35,127,161,184],"number":[7],"of":[8,97,115,218,238,242,249],"supervised":[9],"treatment":[10,38,151],"encounters,":[11],"but":[12],"concerns":[13],"remain":[14],"regarding":[15],"microbiological":[16,214],"efficacy,":[17,36],"relapse,":[18,40],"and":[19,29,41,61,108,113,203,216,244,252],"acquired":[20,42,178,219],"resistance":[21,44,180],"compared":[22],"with":[23,46,54,66,132,147,177],"daily":[24,47,148,211,230,239],"therapy.":[25],"This":[26],"systematic":[27],"review":[28],"exploratory":[30,188],"meta-analysis":[31],"aimed":[32],"to":[33,255],"compare":[34],"safety,":[37],"outcomes,":[39],"drug":[43,246],"associated":[45],"versus":[48,170],"therapy":[51,212,223],"in":[52,183],"adults":[53,65],"drug-susceptible":[55,67,70],"pulmonary":[56,71],"tuberculosis.":[57],"Methods:":[58],"Comparative":[59],"randomized":[60,106,164],"observational":[62,91,111,135],"studies":[63,92,125,136],"involving":[64],"or":[68],"presumed":[69],"tuberculosis":[72],"were":[73,78,93],"synthesized.":[74],"Risk":[75,96],"ratios":[76],"(RRs)":[77],"calculated":[79],"for":[80,105,110,213],"dichotomous":[81],"outcomes.":[82],"Randomized":[83,206],"evidence":[84,116,130,200,207],"was":[85,99,117,145,168,192],"prioritized,":[86],"while":[87],"pooled":[88,189],"analyses":[89,254],"incorporating":[90],"considered":[94],"exploratory.":[95],"bias":[98],"assessed":[100],"using":[101,119],"Cochrane":[102],"RoB":[103],"2":[104],"trials":[107],"ROBINS-I":[109],"studies,":[112],"certainty":[114],"evaluated":[118],"GRADE":[120],"principles.":[121],"Results:":[122],"Six":[123],"unique":[124],"constituted":[126],"strict/historical":[128],"adult-focused":[129],"set,":[131],"two":[133],"additional":[134],"included":[137],"as":[138],"supportive":[139],"sensitivity":[140],"evidence.":[141],"Two-month":[142],"culture":[143],"conversion":[144,215],"higher":[146],"than":[149],"(85%":[152],"vs":[153],"77%;":[154],"RR":[155,193],"1.10,":[156],"95%":[157,174],"CI":[158,175,196],"1.04\u20131.17).":[159],"In":[160],"HIV-positive":[162],"whole-course":[163],"trial,":[165],"favourable":[166],"outcome":[167],"91%":[169],"77%":[171],"(RR":[172],"1.19,":[173],"1.05\u20131.35),":[176],"rifampicin":[179],"occurring":[181],"only":[182],"intermittent":[185],"arm.":[186],"The":[187],"favourable-outcome":[190],"estimate":[191],"1.08":[194],"(95%":[195],"0.94\u20131.24;":[197],"I\u00b2=22.6%).":[198],"Safety":[199],"remained":[201],"sparse":[202],"heterogeneous.":[204],"Conclusions:":[205],"most":[208],"consistently":[209],"favours":[210],"prevention":[217],"resistance.":[220],"Planned":[221],"should":[224,234],"not":[225],"be":[226],"preferred":[227],"over":[228],"guideline-concordant":[229],"treatment.":[231],"Future":[232],"research":[233],"prioritize":[235],"patient-centred":[236],"delivery":[237],"therapy,":[240],"predictors":[241],"toxicity":[243],"poor":[245],"exposure,":[247],"consequences":[248],"missed":[250],"doses,":[251],"individual-patient-data":[253],"identify":[256],"clinically":[257],"vulnerable":[258],"subgroups.":[259]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-14T00:00:00"}