{"id":"https://openalex.org/W7212424673","doi":"https://doi.org/10.64898/2026.09.06.749692","title":"Advancing Neurological Liquid Biopsy via Six-Base Sequencing of Cerebrospinal Fluid Cell-Free DNA","display_name":"Advancing Neurological Liquid Biopsy via Six-Base Sequencing of Cerebrospinal Fluid Cell-Free DNA","publication_year":2026,"publication_date":"2026-09-13","ids":{"openalex":"https://openalex.org/W7212424673","doi":"https://doi.org/10.64898/2026.09.06.749692"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.06.749692","doi":"https://doi.org/10.64898/2026.09.06.749692","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.06.749692","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.06.749692.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.06.749692.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019429366","display_name":"Chiara Starvaggi Cucuzza","orcid":"https://orcid.org/0000-0002-9088-7658","observed_orcids":["https://orcid.org/0000-0002-9088-7658"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Chiara Starvaggi Cucuzza","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Center for Neurology, Academic Specialist Center, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-9088-7658","affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Center for Neurology, Academic Specialist Center, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066550730","display_name":"Chandana Rao Prakash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Chandana Rao Prakash","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113482422","display_name":"Cillian Nolan","orcid":"https://orcid.org/0009-0006-4092-5499","observed_orcids":["https://orcid.org/0009-0006-4092-5499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cillian Nolan","raw_affiliation_strings":["biomodal Limited, Chesterford Research Park, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"biomodal Limited, Chesterford Research Park, Cambridge, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034979438","display_name":"Mohammad Hossein Sepehri","orcid":"https://orcid.org/0009-0005-2907-7444","observed_orcids":["https://orcid.org/0009-0005-2907-7444"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mohammad Hossein Sepehri","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034823559","display_name":"Angela Simeone","orcid":"https://orcid.org/0000-0002-0663-0121","observed_orcids":["https://orcid.org/0000-0002-0663-0121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela Simeone","raw_affiliation_strings":["biomodal Limited, Chesterford Research Park, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"biomodal Limited, Chesterford Research Park, Cambridge, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089231319","display_name":"Luke A. Sarre","orcid":"https://orcid.org/0000-0002-5046-065X","observed_orcids":["https://orcid.org/0000-0002-5046-065X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Sarre","raw_affiliation_strings":["biomodal Limited, Chesterford Research Park, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"biomodal Limited, Chesterford Research Park, Cambridge, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014017372","display_name":"Tom Charlesworth","orcid":"https://orcid.org/0000-0001-9233-7679","observed_orcids":["https://orcid.org/0000-0001-9233-7679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Charlesworth","raw_affiliation_strings":["biomodal Limited, Chesterford Research Park, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"biomodal Limited, Chesterford Research Park, Cambridge, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087994072","display_name":"Fabio Puddu","orcid":"https://orcid.org/0000-0002-2033-5209","observed_orcids":["https://orcid.org/0000-0002-2033-5209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabio Puddu","raw_affiliation_strings":["biomodal Limited, Chesterford Research Park, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"biomodal Limited, Chesterford Research Park, Cambridge, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127373050","display_name":"Yanan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yanan Han","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038376395","display_name":"Mohsen Khademi","orcid":"https://orcid.org/0000-0003-0801-1444","observed_orcids":["https://orcid.org/0000-0003-0801-1444"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mohsen Khademi","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082228294","display_name":"Virginija Danylait\u00e9 Karrenbauer","orcid":"https://orcid.org/0000-0002-7166-8951","observed_orcids":["https://orcid.org/0000-0002-7166-8951"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Virginija Danylait\u0117 Karrenbauer","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029157211","display_name":"Bj\u00f6rn Evertsson","orcid":"https://orcid.org/0000-0001-8799-9619","observed_orcids":["https://orcid.org/0000-0001-8799-9619"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Evertsson","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013980439","display_name":"Katharina Fink","orcid":"https://orcid.org/0000-0002-0030-0236","observed_orcids":["https://orcid.org/0000-0002-0030-0236"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Katharina Fink","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Center for Neurology, Academic Specialist Center, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Center for Neurology, Academic Specialist Center, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036364090","display_name":"Per Svenningsson","orcid":"https://orcid.org/0000-0001-6727-3802","observed_orcids":["https://orcid.org/0000-0001-6727-3802"]},"institutions":[{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Svenningsson","raw_affiliation_strings":["Center for Neurology, Academic Specialist Center, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurology, Academic Specialist Center, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059455936","display_name":"Caroline Ingre","orcid":"https://orcid.org/0000-0001-5327-7204","observed_orcids":["https://orcid.org/0000-0001-5327-7204"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Caroline Ingre","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031848841","display_name":"Christina Seitz","orcid":"https://orcid.org/0009-0004-9475-3229","observed_orcids":["https://orcid.org/0009-0004-9475-3229"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christina Seitz","raw_affiliation_strings":["Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386859","display_name":"Fang Fang","orcid":"https://orcid.org/0000-0002-3310-6456","observed_orcids":["https://orcid.org/0000-0002-3310-6456","https://orcid.org/0000-0002-2252-2606"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fang Fang","raw_affiliation_strings":["Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3310-6456","affiliations":[{"raw_affiliation_string":"Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004116035","display_name":"Radu Constantinescu","orcid":"https://orcid.org/0000-0001-5408-5167","observed_orcids":["https://orcid.org/0000-0001-5408-5167"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4210095705","display_name":"Region V\u00e4stra G\u00f6taland","ror":"https://ror.org/00a4x6777","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210095705"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Radu Constantinescu","raw_affiliation_strings":["Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Region V\u00e4stra G\u00f6taland, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Region V\u00e4stra G\u00f6taland, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I4210095705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057206152","display_name":"Lenka Novakova","orcid":"https://orcid.org/0000-0001-7899-6395","observed_orcids":["https://orcid.org/0000-0001-7899-6395"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4210095705","display_name":"Region V\u00e4stra G\u00f6taland","ror":"https://ror.org/00a4x6777","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210095705"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lenka Novakova","raw_affiliation_strings":["Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Region V\u00e4stra G\u00f6taland, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Region V\u00e4stra G\u00f6taland, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I4210095705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082953939","display_name":"Eric Peter Thelin","orcid":"https://orcid.org/0000-0002-2338-4364","observed_orcids":["https://orcid.org/0000-0002-2338-4364"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eric P Thelin","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081657251","display_name":"Fredrik Piehl","orcid":"https://orcid.org/0000-0001-8329-5219","observed_orcids":["https://orcid.org/0000-0001-8329-5219"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fredrik Piehl","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Center for Neurology, Academic Specialist Center, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Center for Neurology, Academic Specialist Center, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052348014","display_name":"Lara Kular","orcid":"https://orcid.org/0000-0002-2907-6071","observed_orcids":["https://orcid.org/0000-0002-2907-6071"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lara Kular","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2907-6071","affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025545067","display_name":"Maria Needhamsen","orcid":"https://orcid.org/0000-0002-1197-5597","observed_orcids":["https://orcid.org/0000-0002-1197-5597"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Needhamsen","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038894883","display_name":"Maja Jagodic","orcid":"https://orcid.org/0000-0003-0756-889X","observed_orcids":["https://orcid.org/0000-0003-0756-889X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Maja Jagodic","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","Center for Neurology, Academic Specialist Center, Stockholm, Sweden","Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Center for Neurology, Academic Specialist Center, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5038894883"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I2801939835","https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.21770000457763672,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.21770000457763672,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.10769999772310257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.996999979019165},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.781000018119812},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8100000023841858},{"id":"https://openalex.org/keywords/epigenetic-profiling","display_name":"epigenetic profiling","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.7652000188827515},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6819999814033508},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.6015999913215637},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5817000269889832},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5806000232696533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5081999897956848},{"id":"https://openalex.org/C2776429142","wikidata":"https://www.wikidata.org/wiki/Q1620189","display_name":"Brain biopsy","level":3,"score":0.47209998965263367},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.43130001425743103},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.33250001072883606},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3208000063896179},{"id":"https://openalex.org/C2991793871","wikidata":"https://www.wikidata.org/wiki/Q575920","display_name":"Liquid medium","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28360000252723694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2743000090122223},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.06.749692","doi":"https://doi.org/10.64898/2026.09.06.749692","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.06.749692","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.06.749692.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.06.749692","doi":"https://doi.org/10.64898/2026.09.06.749692","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.06.749692","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.06.749692.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212424673.pdf","grobid_xml":"https://content.openalex.org/works/W7212424673.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1969353942","https://openalex.org/W2079718713","https://openalex.org/W2152642144","https://openalex.org/W2605359372","https://openalex.org/W2952214509","https://openalex.org/W3007237049","https://openalex.org/W3091573456","https://openalex.org/W4213416459","https://openalex.org/W4226118630","https://openalex.org/W4226239358","https://openalex.org/W4309508076","https://openalex.org/W4313544615","https://openalex.org/W4319310816","https://openalex.org/W4394743424","https://openalex.org/W4417503772","https://openalex.org/W4417520196","https://openalex.org/W7166295461"],"related_works":["https://openalex.org/W4309508076","https://openalex.org/W3185003204","https://openalex.org/W4283320371","https://openalex.org/W4385172633","https://openalex.org/W2801503037","https://openalex.org/W3146088968","https://openalex.org/W2912885956","https://openalex.org/W4416141476","https://openalex.org/W4379931458","https://openalex.org/W6887482077"],"abstract_inverted_index":{"ABSTRACT":[0],"Real-time":[1],"molecular":[2],"insights":[3,54],"into":[4,44,55],"the":[5,22,56,62],"human":[6],"brain":[7],"are":[8],"crucial":[9],"for":[10,64],"understanding":[11],"neurological":[12,70],"conditions":[13],"and":[14,52],"development":[15],"of":[16,37],"soluble":[17],"biomarkers":[18],"but":[19],"challenged":[20],"by":[21],"limited":[23],"access":[24],"to":[25,33,68],"target":[26],"tissue.":[27],"Here":[28],"we":[29],"utilize":[30],"6-base":[31],"sequencing":[32],"profile":[34],"DNA":[35,39],"modifications":[36],"cell-free":[38],"released":[40],"from":[41],"neural":[42],"cells":[43],"cerebrospinal":[45],"fluid.":[46],"This":[47],"strategy":[48],"provides":[49],"molecular,":[50],"quantitative":[51],"qualitative":[53],"ongoing":[57],"neurodegenerative":[58],"biology,":[59],"which":[60],"paves":[61],"way":[63],"liquid":[65],"biopsy":[66],"approaches":[67],"study":[69],"conditions.":[71]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-14T00:00:00"}
