{"id":"https://openalex.org/W7212405490","doi":"https://doi.org/10.64898/2026.09.10.750675","title":"Characterization of Host Cell Cytosol-filled Vesicles in the Human Malaria Parasite Plasmodium falciparum","display_name":"Characterization of Host Cell Cytosol-filled Vesicles in the Human Malaria Parasite Plasmodium falciparum","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212405490","doi":"https://doi.org/10.64898/2026.09.10.750675"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.10.750675","doi":"https://doi.org/10.64898/2026.09.10.750675","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750675","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750675.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750675.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097221907","display_name":"Anna-Lena Ro\u00dfmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna-Lena Ro\u00dfmann","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097740071","display_name":"Jana Dr\u00f6ge","orcid":"https://orcid.org/0000-0002-4018-6175","observed_orcids":["https://orcid.org/0000-0002-4018-6175"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Dr\u00f6ge","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050700219","display_name":"Hanyu Wang","orcid":"https://orcid.org/0000-0001-8703-0293","observed_orcids":["https://orcid.org/0000-0001-8703-0293","https://orcid.org/0009-0000-6269-4667"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanyu Wang","raw_affiliation_strings":["Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138504826","display_name":"Charlotte Duda","orcid":"https://orcid.org/0009-0000-1018-3822","observed_orcids":["https://orcid.org/0009-0000-1018-3822"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Charlotte Duda","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090972612","display_name":"James Zhen","orcid":"https://orcid.org/0000-0002-5163-835X","observed_orcids":["https://orcid.org/0000-0002-5163-835X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Zhen","raw_affiliation_strings":["Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056278275","display_name":"Ricarda Sabitzki","orcid":"https://orcid.org/0000-0001-7422-1381","observed_orcids":["https://orcid.org/0000-0001-7422-1381"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ricarda Sabitzki","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7422-1381","affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049775069","display_name":"Katharina H\u00f6hn","orcid":"https://orcid.org/0009-0000-7008-0884","observed_orcids":["https://orcid.org/0009-0000-7008-0884"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina H\u00f6hn","raw_affiliation_strings":["Electron Microscopy Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0000-7008-0884","affiliations":[{"raw_affiliation_string":"Electron Microscopy Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135863017","display_name":"Guilherme B. Farias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210157805","display_name":"Centre for Structural Systems Biology","ror":"https://ror.org/04fhwda97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I137251492","https://openalex.org/I159176309","https://openalex.org/I2801876189","https://openalex.org/I315704651","https://openalex.org/I34809795","https://openalex.org/I4210108711","https://openalex.org/I4210124929","https://openalex.org/I4210128097","https://openalex.org/I4210138560","https://openalex.org/I4210153543","https://openalex.org/I4210157805","https://openalex.org/I94402716"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guilherme B. Farias","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","Centre for Structural Systems Biology, Hamburg, Germany","University of Hamburg, Department of Biology, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"Centre for Structural Systems Biology, Hamburg, Germany","institution_ids":["https://openalex.org/I4210157805"]},{"raw_affiliation_string":"University of Hamburg, Department of Biology, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045643276","display_name":"Andr\u00e9s Guill\u00e9n-Samander","orcid":"https://orcid.org/0000-0002-6882-3850","observed_orcids":["https://orcid.org/0000-0002-6882-3850"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andres Guillen-Samander","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6882-3850","affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058136107","display_name":"Tim\u2010Wolf Gilberger","orcid":"https://orcid.org/0000-0002-7965-8272","observed_orcids":["https://orcid.org/0000-0002-7965-8272"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210157805","display_name":"Centre for Structural Systems Biology","ror":"https://ror.org/04fhwda97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I137251492","https://openalex.org/I159176309","https://openalex.org/I2801876189","https://openalex.org/I315704651","https://openalex.org/I34809795","https://openalex.org/I4210108711","https://openalex.org/I4210124929","https://openalex.org/I4210128097","https://openalex.org/I4210138560","https://openalex.org/I4210153543","https://openalex.org/I4210157805","https://openalex.org/I94402716"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim-Wolf Gilberger","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","Centre for Structural Systems Biology, Hamburg, Germany","University of Hamburg, Department of Biology, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"Centre for Structural Systems Biology, Hamburg, Germany","institution_ids":["https://openalex.org/I4210157805"]},{"raw_affiliation_string":"University of Hamburg, Department of Biology, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049610765","display_name":"Chi-Min Ho","orcid":"https://orcid.org/0000-0003-2132-7320","observed_orcids":["https://orcid.org/0000-0003-2132-7320"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Minh Ho","raw_affiliation_strings":["Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074183968","display_name":"Tobias Spielmann","orcid":"https://orcid.org/0000-0002-3968-4601","observed_orcids":["https://orcid.org/0000-0002-3968-4601"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Tobias Spielmann","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3968-4601","affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074183968"],"corresponding_institution_ids":["https://openalex.org/I94402716"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.2296999990940094,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9919999837875366},{"id":"https://openalex.org/keywords/host-cell-cytosol","display_name":"host cell cytosol","score":0.6729999780654907},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/digestive-vacuole","display_name":"digestive vacuole","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endosomal-transport","display_name":"endosomal transport","score":0.9390000104904175},{"id":"https://openalex.org/keywords/rab11a","display_name":"Rab11a","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vps35","display_name":"VPS35","score":0.8330000042915344},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.6439999938011169},{"id":"https://openalex.org/keywords/vesicle-maturation","display_name":"vesicle maturation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/vesicle-fusion","display_name":"vesicle fusion","score":0.6779999732971191},{"id":"https://openalex.org/keywords/blood-stage-malaria","display_name":"blood-stage malaria","score":0.5009999871253967},{"id":"https://openalex.org/keywords/cryo-electron-tomography","display_name":"cryo-electron tomography","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.882099986076355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.694599986076355},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6934999823570251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.666700005531311},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6610999703407288},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6244999766349792},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.567300021648407},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5580999851226807},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5554999709129333},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.5374000072479248},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.5253999829292297},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5026999711990356},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.48579999804496765},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.44999998807907104},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.4408000111579895},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.41200000047683716},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.39079999923706055},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3334999978542328},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.31060001254081726},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.2842999994754791},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.28209999203681946},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.27459999918937683},{"id":"https://openalex.org/C167019083","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular transport protein","level":4,"score":0.26600000262260437},{"id":"https://openalex.org/C2777867350","wikidata":"https://www.wikidata.org/wiki/Q7908031","display_name":"Vacuolar protein sorting","level":4,"score":0.2648000121116638},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C2778566189","wikidata":"https://www.wikidata.org/wiki/Q101274","display_name":"Protozoa","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.10.750675","doi":"https://doi.org/10.64898/2026.09.10.750675","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750675","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750675.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.10.750675","doi":"https://doi.org/10.64898/2026.09.10.750675","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750675","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750675.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8252629973","display_name":null,"funder_award_id":"GRK2771","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212405490.pdf","grobid_xml":"https://content.openalex.org/works/W7212405490.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W959475177","https://openalex.org/W1517631297","https://openalex.org/W1963573377","https://openalex.org/W1971439989","https://openalex.org/W1976757612","https://openalex.org/W1982630721","https://openalex.org/W1986280009","https://openalex.org/W2002289928","https://openalex.org/W2014429457","https://openalex.org/W2015304918","https://openalex.org/W2020875902","https://openalex.org/W2023766870","https://openalex.org/W2028252330","https://openalex.org/W2034320996","https://openalex.org/W2038939970","https://openalex.org/W2046133662","https://openalex.org/W2058740569","https://openalex.org/W2062256554","https://openalex.org/W2069274491","https://openalex.org/W2070709903","https://openalex.org/W2071219905","https://openalex.org/W2075027086","https://openalex.org/W2079916438","https://openalex.org/W2087267967","https://openalex.org/W2087508628","https://openalex.org/W2089113991","https://openalex.org/W2094625991","https://openalex.org/W2097808534","https://openalex.org/W2099540110","https://openalex.org/W2105707485","https://openalex.org/W2105923417","https://openalex.org/W2112855946","https://openalex.org/W2116002414","https://openalex.org/W2116022454","https://openalex.org/W2122598723","https://openalex.org/W2126943884","https://openalex.org/W2127474550","https://openalex.org/W2129797485","https://openalex.org/W2135155264","https://openalex.org/W2143832645","https://openalex.org/W2145206503","https://openalex.org/W2146512944","https://openalex.org/W2154558221","https://openalex.org/W2166155213","https://openalex.org/W2167311952","https://openalex.org/W2171537806","https://openalex.org/W2187132725","https://openalex.org/W2282348015","https://openalex.org/W2312836697","https://openalex.org/W2418477898","https://openalex.org/W2487704570","https://openalex.org/W2596280611","https://openalex.org/W2607310450","https://openalex.org/W2726949767","https://openalex.org/W2734356283","https://openalex.org/W2803359629","https://openalex.org/W2830758472","https://openalex.org/W2888208011","https://openalex.org/W2905964137","https://openalex.org/W2912372464","https://openalex.org/W2977933365","https://openalex.org/W3019312809","https://openalex.org/W3025393782","https://openalex.org/W3031031934","https://openalex.org/W3031294224","https://openalex.org/W3034539442","https://openalex.org/W3104572769","https://openalex.org/W3186400583","https://openalex.org/W3208696114","https://openalex.org/W4206661518","https://openalex.org/W4226226858","https://openalex.org/W4229457981","https://openalex.org/W4251751280","https://openalex.org/W4307540205","https://openalex.org/W4313491541","https://openalex.org/W4365814277","https://openalex.org/W4377692971","https://openalex.org/W4384662305","https://openalex.org/W4384665185","https://openalex.org/W4385665108","https://openalex.org/W4389233731","https://openalex.org/W4390782971","https://openalex.org/W4396688707","https://openalex.org/W4396721167","https://openalex.org/W4399202078","https://openalex.org/W4399731500","https://openalex.org/W4405516967","https://openalex.org/W4409196762","https://openalex.org/W4409249862","https://openalex.org/W4413290763","https://openalex.org/W4414645972","https://openalex.org/W4415123442","https://openalex.org/W7141815177","https://openalex.org/W7203629571","https://openalex.org/W7203823329","https://openalex.org/W7214586255"],"related_works":["https://openalex.org/W2905964137","https://openalex.org/W4399202078","https://openalex.org/W4362672305","https://openalex.org/W2002289928","https://openalex.org/W2004355652","https://openalex.org/W2116022454","https://openalex.org/W150184081","https://openalex.org/W2168989177","https://openalex.org/W2046821095","https://openalex.org/W1969488544"],"abstract_inverted_index":{"Abstract":[0],"Endocytosis":[1],"of":[2,19,40,49,62,90,117,134,151,153,171,182,190,205,216,254,264,273,299],"host":[3],"cell":[4],"cytosol":[5,212],"is":[6,23,33,43],"a":[7,81,111,128,160,169,199,234,247,265,271,278,310],"key":[8],"process":[9],"in":[10,66,75,83,209,256,270,280,319],"malaria":[11],"blood":[12],"stages.":[13],"The":[14,165],"endocytosed":[15],"material":[16],"consists":[17],"mostly":[18],"haemoglobin":[20],"(Hb)":[21],"and":[22,70,97,113,177,213,224,237,259,296,308],"transported":[24,304],"to":[25,59,99,192,198,286],"the":[26,36,41,60,67,76,88,100,188,193,210,239,252,257,262,289],"parasite\u2019s":[27],"digestive":[28],"vacuole":[29],"(DV),":[30],"where":[31],"it":[32,158,231],"degraded.":[34],"However,":[35,86],"endosomal":[37,84,101,241,317],"transport":[38,102,189,242],"pathway":[39,103],"parasite":[42,68,211],"not":[44],"well":[45],"defined.":[46],"A":[47],"number":[48,170],"proteins":[50],"are":[51,122],"known":[52],"that":[53,238],"\u2013":[54,57],"when":[55],"inactivated":[56],"lead":[58],"appearance":[61],"Hb-filled":[63,207],"vesicles":[64,126],"(HbVs)":[65],"cytoplasm":[69],"prevent":[71],"Hb":[72,191],"from":[73,246,261],"arriving":[74],"DV,":[77],"indicating":[78],"they":[79],"play":[80],"role":[82],"transport.":[85],"despite":[87],"prominence":[89],"these":[91,154,275],"HbVs,":[92,300],"their":[93],"morphology,":[94],"molecular":[95,297],"composition,":[96],"relationship":[98],"remain":[104],"poorly":[105],"understood.":[106],"Here":[107],"we":[108],"carried":[109],"out":[110],"morphological":[112,295],"surface":[114,139],"proteome":[115],"study":[116],"HbVs.":[118],"CryoET":[119,263],"showed":[120,184],"HbVs":[121,282],"coatless,":[123],"double":[124],"membraned":[125],"with":[127,251,288],"very":[129],"narrow":[130],"inter-membrane":[131],"space":[132],"devoid":[133],"larger":[135],"protein":[136,302],"densities.":[137],"HbV":[138,163,268],"proteomes":[140],"generated":[141],"by":[142,203],"BioIDs":[143],"most":[144],"prominently":[145],"detected":[146,222],"DV":[147,155,217],"proteases.":[148],"Halo-based":[149],"tracking":[150],"one":[152],"protease":[156,218],"confirmed":[157],"as":[159],"bona":[161],"fide":[162],"cargo.":[164],"BioID":[166,258],"also":[167],"identified":[168],"vesicle":[172],"trafficking":[173,318],"proteins,":[174],"including":[175],"PfTBC8":[176,183,220,225],"Rab11":[178],"proteins.":[179],"Functional":[180],"analysis":[181],"its":[185],"importance":[186],"for":[187,316],"DV.":[194,290],"This":[195],"was":[196],"due":[197],"novel":[200],"phenotype":[201,243],"characterized":[202],"accumulation":[204],"diverse":[206],"structures":[208],"gradual":[214],"decline":[215],"trafficking.":[219],"DiQ-BioID":[221],"Rab11a":[223,228,235],"inactivation":[226],"altered":[227],"localization,":[229],"suggesting":[230],"may":[232,244],"be":[233],"effector":[236],"new":[240],"result":[245],"recycling":[248],"defect.":[249],"Together":[250],"detection":[253],"VPS35":[255],"evidence":[260],"disrupted":[266],"inner":[267],"membrane":[269],"proportion":[272],"vesicles,":[274],"findings":[276,293],"support":[277],"model":[279],"which":[281],"undergo":[283],"maturation":[284],"prior":[285],"fusion":[287],"Overall,":[291],"our":[292],"define":[294],"features":[298],"identify":[301],"cargo":[303],"through":[305],"this":[306],"pathway,":[307],"reveal":[309],"previously":[311],"unrecognized":[312],"Rab-regulatory":[313],"component":[314],"required":[315],"blood-stage":[320],"P.":[321],"falciparum":[322],"parasites.":[323]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-13T00:00:00"}