{"id":"https://openalex.org/W7212394685","doi":"https://doi.org/10.64898/2026.09.08.26362496","title":"Dynamic Prediction to Predict Virologic Failure in Antiretroviral Treated People Living with HIV: Cohort Analysis of Routine Electronic Health Records Data in the Western Cape, South Africa","display_name":"Dynamic Prediction to Predict Virologic Failure in Antiretroviral Treated People Living with HIV: Cohort Analysis of Routine Electronic Health Records Data in the Western Cape, South Africa","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212394685","doi":"https://doi.org/10.64898/2026.09.08.26362496"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.26362496","doi":"https://doi.org/10.64898/2026.09.08.26362496","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.26362496","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362496.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362496.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029126424","display_name":"Frissiano Ernest Honwana","orcid":"https://orcid.org/0000-0001-6662-1027","observed_orcids":["https://orcid.org/0000-0001-6662-1027"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Frissiano Honwana","raw_affiliation_strings":["Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0001-6662-1027","affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035543564","display_name":"Elton E. Mukonda","orcid":"https://orcid.org/0000-0002-3930-3389","observed_orcids":["https://orcid.org/0000-0002-3930-3389"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Elton Mukonda","raw_affiliation_strings":["Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0002-3930-3389","affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084905754","display_name":"Freedom N. Gumedze","orcid":"https://orcid.org/0000-0003-4387-8844","observed_orcids":["https://orcid.org/0000-0003-4387-8844"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Freedom Gumedze","raw_affiliation_strings":["Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0003-4387-8844","affiliations":[{"raw_affiliation_string":"Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046584384","display_name":"Marvin Hsiao","orcid":"https://orcid.org/0000-0003-4926-6216","observed_orcids":["https://orcid.org/0000-0003-4926-6216"]},"institutions":[{"id":"https://openalex.org/I107920810","display_name":"National Health Laboratory Service","ror":"https://ror.org/00znvbk37","country_code":"ZA","type":"government","lineage":["https://openalex.org/I107920810"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Nei-yuan Hsiao","raw_affiliation_strings":["Division of Medical Virology, National Health Laboratory Service, University of Cape Town, Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0003-4926-6216","affiliations":[{"raw_affiliation_string":"Division of Medical Virology, National Health Laboratory Service, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I107920810","https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084732324","display_name":"Landon Myer","orcid":"https://orcid.org/0000-0002-8106-7658","observed_orcids":["https://orcid.org/0000-0002-8106-7658"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Landon Myer","raw_affiliation_strings":["Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0002-8106-7658","affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044468514","display_name":"Maia Lesosky","orcid":"https://orcid.org/0000-0002-2026-958X","observed_orcids":["https://orcid.org/0000-0002-2026-958X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maia Lesosky","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029126424"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virologic-failure","display_name":"virological failure","score":0.906000018119812},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dynamic-prediction","display_name":"dynamic prediction","score":0.828000009059906},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.8619999885559082},{"id":"https://openalex.org/keywords/joint-modeling","display_name":"joint modeling","score":0.5170000195503235},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.6439999938011169},{"id":"https://openalex.org/keywords/clinical-decision-support","display_name":"clinical decision support","score":0.6349999904632568},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.6790000200271606},{"id":"https://openalex.org/keywords/western-cape","display_name":"Western Cape","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7052000164985657},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6583999991416931},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5058000087738037},{"id":"https://openalex.org/C35405484","wikidata":"https://www.wikidata.org/wiki/Q4967066","display_name":"Brier score","level":2,"score":0.5045999884605408},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.47870001196861267},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46160000562667847},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.45350000262260437},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.4361000061035156},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.4228000044822693},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.40639999508857727},{"id":"https://openalex.org/C3020144179","wikidata":"https://www.wikidata.org/wiki/Q10871684","display_name":"Electronic health record","level":3,"score":0.387800008058548},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.383899986743927},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.375900000333786},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.34389999508857727},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3422999978065491},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.34209999442100525},{"id":"https://openalex.org/C133462117","wikidata":"https://www.wikidata.org/wiki/Q4929239","display_name":"Data collection","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C2910823671","wikidata":"https://www.wikidata.org/wiki/Q337517","display_name":"HIV diagnosis","level":5,"score":0.2955000102519989},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2913999855518341},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C45827449","wikidata":"https://www.wikidata.org/wiki/Q5270338","display_name":"Diagnosis code","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C197298091","wikidata":"https://www.wikidata.org/wiki/Q5318963","display_name":"Dynamic data","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.26269999146461487},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.26100000739097595},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C2780513070","wikidata":"https://www.wikidata.org/wiki/Q5318946","display_name":"Dynamic assessment","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.08.26362496","doi":"https://doi.org/10.64898/2026.09.08.26362496","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.26362496","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362496.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.26362496","doi":"https://doi.org/10.64898/2026.09.08.26362496","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.26362496","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362496.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212394685.pdf","grobid_xml":"https://content.openalex.org/works/W7212394685.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W636916345","https://openalex.org/W1556637198","https://openalex.org/W1967396577","https://openalex.org/W2004655916","https://openalex.org/W2030118009","https://openalex.org/W2032758468","https://openalex.org/W2057765075","https://openalex.org/W2067210808","https://openalex.org/W2109242212","https://openalex.org/W2120817231","https://openalex.org/W2130416410","https://openalex.org/W2130902307","https://openalex.org/W2136073265","https://openalex.org/W2162619707","https://openalex.org/W2215476268","https://openalex.org/W2239032355","https://openalex.org/W2274668488","https://openalex.org/W2289327638","https://openalex.org/W2336000508","https://openalex.org/W2525514966","https://openalex.org/W2741235538","https://openalex.org/W2744337429","https://openalex.org/W2769267084","https://openalex.org/W2889907011","https://openalex.org/W2906541879","https://openalex.org/W2978216081","https://openalex.org/W3033313535","https://openalex.org/W3035439429","https://openalex.org/W3039141081","https://openalex.org/W3042009984","https://openalex.org/W3057148430","https://openalex.org/W3138338733","https://openalex.org/W3144378421","https://openalex.org/W3154927053","https://openalex.org/W4205509818","https://openalex.org/W4205704500","https://openalex.org/W4223545017","https://openalex.org/W4224807380","https://openalex.org/W4240400659","https://openalex.org/W4282977912","https://openalex.org/W4292229870","https://openalex.org/W4386096349","https://openalex.org/W4387420591","https://openalex.org/W4387966977","https://openalex.org/W4393393691","https://openalex.org/W4399083793","https://openalex.org/W4399639002","https://openalex.org/W4410892387","https://openalex.org/W7132848371"],"related_works":["https://openalex.org/W7113210583","https://openalex.org/W3099036167","https://openalex.org/W2110497525","https://openalex.org/W4210794648","https://openalex.org/W2525514966","https://openalex.org/W4410500373","https://openalex.org/W7168927467","https://openalex.org/W4410312073","https://openalex.org/W7132848371","https://openalex.org/W4311694756"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"Virologic":[2],"failure":[3],"(VF)":[4],"remains":[5,46],"a":[6,54,81,92],"major":[7],"challenge":[8],"in":[9,13,72,121,270],"HIV":[10,67,87],"care,":[11],"particularly":[12],"resource-limited":[14],"settings":[15],"where":[16],"timely":[17,219,232],"identification":[18],"is":[19],"critical.":[20],"Dynamic":[21,202,223],"prediction":[22,56,224,272],"models":[23,225],"can":[24],"provide":[25],"continuously":[26],"updated,":[27],"individual-level":[28],"risk":[29,217],"estimates":[30],"using":[31,60,111,150],"longitudinal":[32,86],"biomarker":[33],"data.":[34],"However,":[35,237],"their":[36],"applicability":[37],"to":[38,91,97,211,229],"routinely":[39],"collected":[40],"electronic":[41],"health":[42],"record":[43],"(EHR)":[44],"data":[45,63,117,239,257],"poorly":[47],"understood.":[48],"We":[49],"developed":[50,110],"and":[51,105,139,160,165,181,187,189,195,199,246,259],"internally":[52],"validated":[53],"dynamic":[55],"model":[57,78,84,94,178],"for":[58,85,95,101,218,235],"VF":[59,216],"routine":[61,112],"EHR":[62,238],"from":[64,118],"people":[65],"with":[66,240],"(PWH)":[68],"receiving":[69],"antiretroviral":[70],"therapy":[71],"South":[73,125],"Africa.":[74],"Methods":[75],"A":[76],"joint":[77],"(JM)":[79],"linking":[80],"linear":[82],"mixed-effects":[83],"viral":[88],"load":[89],"(HIVVL)":[90],"Cox":[93],"time":[96],"first":[98],"VF,":[99],"adjusted":[100],"baseline":[102],"age":[103],"group":[104],"sex":[106],"at":[107,163,197,206,214,263],"birth,":[108],"was":[109,148,179],"National":[113],"Health":[114],"Laboratory":[115],"Service":[116],"122,425":[119],"PWH":[120,171],"the":[122,154],"Western":[123],"Cape,":[124],"Africa":[126],"(SA)":[127],"(January":[128],"2008-September":[129],"2018),":[130],"randomly":[131],"split":[132],"into":[133],"development":[134],"(n":[135,141],"=":[136,142],"91,818;":[137],"75%)":[138],"validation":[140],"30,607;":[143],"25%)":[144],"cohorts.":[145],"Predictive":[146],"performance":[147,251],"evaluated":[149],"time-dependent":[151],"area":[152],"under":[153],"receiver":[155],"operating":[156],"characteristic":[157],"curve":[158],"(AUC)":[159],"Brier":[161],"scores":[162],"12":[164,198],"24":[166,200],"months.":[167,201],"Results":[168],"Overall,":[169],"12,547":[170],"(10.2%)":[172],"experienced":[173],"VF.":[174],"The":[175],"current":[176],"value-parameterized":[177],"used":[180],"showed":[182],"moderate":[183],"discrimination":[184],"(AUC:":[185],"0.69":[186],"0.73)":[188],"good":[190],"calibration":[191],"(Brier":[192],"scores:":[193],"0.033":[194],"0.051)":[196],"predictions":[203],"updated":[204],"meaningfully":[205],"each":[207],"visit,":[208],"demonstrating":[209,255],"potential":[210],"flag":[212],"individuals":[213],"elevated":[215],"clinical":[220,233,244],"intervention.":[221],"Conclusions":[222],"hold":[226],"genuine":[227],"promises":[228],"support":[230],"personalized,":[231],"decision-making":[234],"PWH.":[236],"sparse":[241],"measurements,":[242],"missing":[243],"covariates,":[245],"irregular":[247],"follow-up":[248],"limit":[249],"discriminative":[250],"despite":[252],"adequate":[253],"calibration,":[254],"that":[256],"quality":[258],"covariate":[260],"availability":[261],"are":[262],"least":[264],"as":[265,267],"consequential":[266],"modelling":[268],"strategy":[269],"real-world":[271],"settings.":[273]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-13T00:00:00"}
