{"id":"https://openalex.org/W7212379035","doi":"https://doi.org/10.1016/j.cej.2026.181876","title":"3D-printed ion-engineered TaTiCu porous scaffolds for promoting bone defect repair","display_name":"3D-printed ion-engineered TaTiCu porous scaffolds for promoting bone defect repair","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212379035","doi":"https://doi.org/10.1016/j.cej.2026.181876"},"language":"en","primary_location":{"id":"doi:10.1016/j.cej.2026.181876","doi":"https://doi.org/10.1016/j.cej.2026.181876","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.181876","pdf_url":null,"source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cej.2026.181876","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151502831","display_name":"Jie Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Jiang","raw_affiliation_strings":["Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031265522","display_name":"Mingxia Wang","orcid":"https://orcid.org/0000-0002-5244-432X","observed_orcids":["https://orcid.org/0000-0002-5244-432X"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxia Wang","raw_affiliation_strings":["School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101411798","display_name":"Chaoqun You","orcid":"https://orcid.org/0000-0002-0811-7516","observed_orcids":["https://orcid.org/0000-0002-0811-7516"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoqun You","raw_affiliation_strings":["Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114626840","display_name":"Fanwei Zeng","orcid":"https://orcid.org/0000-0003-2508-0011","observed_orcids":["https://orcid.org/0000-0003-2508-0011"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanwei Zeng","raw_affiliation_strings":["Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076216609","display_name":"Ling Ren","orcid":"https://orcid.org/0000-0001-7519-1380","observed_orcids":["https://orcid.org/0000-0001-7519-1380"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210126304","display_name":"Institute of Metal Research","ror":"https://ror.org/03pa1rf77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210126304"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Ren","raw_affiliation_strings":["Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210126304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113789534","display_name":"Xiaodong Tang","orcid":"https://orcid.org/0009-0000-1760-4167","observed_orcids":["https://orcid.org/0009-0000-1760-4167"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaodong Tang","raw_affiliation_strings":["Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5151514336","display_name":"Yu Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Guo","raw_affiliation_strings":["Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076216609","https://openalex.org/A5113789534","https://openalex.org/A5151514336"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124809","https://openalex.org/I4210126304"],"apc_list":{"value":4830,"currency":"USD","value_usd":4830},"apc_paid":{"value":4830,"currency":"USD","value_usd":4830},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65726041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"548","issue":null,"first_page":"181876","last_page":"181876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11442","display_name":"Titanium Alloys Microstructure and Properties","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-printing","display_name":"3D printing","score":0.8650000095367432},{"id":"https://openalex.org/keywords/porous-scaffolds","display_name":"porous scaffolds","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-defect-reconstruction","display_name":"bone defect repair","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.7269999980926514},{"id":"https://openalex.org/keywords/titanium-alloys","display_name":"titanium alloys","score":0.4129999876022339},{"id":"https://openalex.org/keywords/scaffold-fabrication","display_name":"scaffold fabrication","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5156000256538391},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.49869999289512634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4805000126361847},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3935000002384186},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.303600013256073},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2766999900341034},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cej.2026.181876","doi":"https://doi.org/10.1016/j.cej.2026.181876","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.181876","pdf_url":null,"source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.cej.2026.181876","doi":"https://doi.org/10.1016/j.cej.2026.181876","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cej.2026.181876","pdf_url":null,"source":{"id":"https://openalex.org/S149937609","display_name":"Chemical Engineering Journal","issn_l":"1385-8947","issn":["1385-8947","1873-3212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7010754942893982,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G797394925","display_name":null,"funder_award_id":"2024ZD0525800","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"}],"funders":[{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2913025510","https://openalex.org/W3043932858","https://openalex.org/W3112909112","https://openalex.org/W3130213199","https://openalex.org/W3174294290","https://openalex.org/W4213146112","https://openalex.org/W4383620694","https://openalex.org/W4391645929","https://openalex.org/W4391745407","https://openalex.org/W4392016097","https://openalex.org/W4392245331","https://openalex.org/W4396796416","https://openalex.org/W4400382476","https://openalex.org/W4401500767","https://openalex.org/W4401610706","https://openalex.org/W4402359154","https://openalex.org/W4402891604","https://openalex.org/W4407024133","https://openalex.org/W4407360033","https://openalex.org/W4407554191","https://openalex.org/W4408072194","https://openalex.org/W4408104505","https://openalex.org/W4408266031","https://openalex.org/W4409528151","https://openalex.org/W4409923553","https://openalex.org/W4409983298","https://openalex.org/W4411009957","https://openalex.org/W4412028223","https://openalex.org/W4412441366","https://openalex.org/W4413368320","https://openalex.org/W4413815620","https://openalex.org/W4414097163","https://openalex.org/W4416018651","https://openalex.org/W4416569838","https://openalex.org/W4416898593","https://openalex.org/W4417361731","https://openalex.org/W7116746129","https://openalex.org/W7128796011","https://openalex.org/W7135223249","https://openalex.org/W7140088700","https://openalex.org/W7154703874","https://openalex.org/W7155179163","https://openalex.org/W7159961753","https://openalex.org/W7160698645","https://openalex.org/W7161166927"],"related_works":[],"abstract_inverted_index":{"Large":[0],"bone":[1,164,194],"defect":[2,42,152,195],"repair":[3],"remains":[4],"challenging":[5],"because":[6],"successful":[7],"regeneration":[8],"requires":[9],"not":[10],"only":[11],"structural":[12],"reconstruction":[13],"but":[14],"also":[15],"simultaneous":[16],"control":[17],"of":[18],"infection,":[19],"vascularization,":[20],"and":[21,59,72,81,91,99,110,113,120,141,162,170],"osteogenic":[22,116],"activation.":[23],"Conventional":[24],"metallic":[25],"scaffolds":[26,157],"provide":[27],"mechanical":[28,70],"support,":[29],"yet":[30],"their":[31,36],"limited":[32],"biological":[33],"activity":[34,83],"restricts":[35],"ability":[37],"to":[38,53],"actively":[39],"regulate":[40],"the":[41,102,174],"microenvironment.":[43],"Herein,":[44],"a":[45,130],"3D-printed":[46,154,182],"ion-engineered":[47],"TaTiCu":[48,77,106,126,155,183],"porous":[49,67,156,184],"scaffold":[50,63,190],"was":[51],"developed":[52],"integrate":[54],"architectural":[55],"support":[56],"with":[57,97],"antibacterial":[58,80],"pro-regenerative":[60],"functions.":[61],"The":[62],"possessed":[64],"an":[65,145,187],"interconnected":[66],"architecture,":[68],"suitable":[69],"performance,":[71],"sustained":[73],"Cu":[74],"2+":[75],"release.":[76],"exhibited":[78],"broad-spectrum":[79],"antibiofilm":[82],"against":[84],"Staphylococcus":[85],"aureus":[86,147],",":[87,90],"Escherichia":[88],"coli":[89],"MRSA,":[92],"while":[93],"maintaining":[94],"favorable":[95],"cytocompatibility":[96],"HUVECs":[98],"BMSCs":[100,128],"under":[101],"tested":[103],"conditions.":[104],"Functionally,":[105],"enhanced":[107],"endothelial":[108],"migration":[109],"tube":[111],"formation":[112],"promoted":[114,163],"BMSC":[115],"differentiation,":[117],"matrix":[118,137],"maturation,":[119],"mineralization.":[121],"Transcriptomic":[122],"analysis":[123],"revealed":[124],"that":[125],"reprogrammed":[127],"toward":[129],"regenerative":[131],"phenotype":[132],"involving":[133],"metabolic":[134],"adaptation,":[135],"extracellular":[136],"remodeling,":[138],"cell-matrix":[139],"interaction,":[140],"angiogenic-osteogenic":[142],"coupling.":[143],"In":[144],"S.":[146],"-infected":[148],"rabbit":[149],"femoral":[150],"condyle":[151],"model,":[153],"suppressed":[158],"early":[159],"bacterial":[160],"colonization":[161],"ingrowth,":[165],"trabecular":[166],"reconstruction,":[167],"mineral":[168],"deposition,":[169],"bone-scaffold":[171],"integration":[172],"during":[173],"12-week":[175],"observation":[176],"period.":[177],"Overall,":[178],"this":[179],"study":[180],"presents":[181],"metal":[185],"as":[186],"active":[188],"microenvironment-regulating":[189],"strategy":[191],"for":[192],"large":[193],"repair.":[196]},"counts_by_year":[],"updated_date":"2026-09-30T09:27:27.532063","created_date":"2026-09-13T00:00:00"}