{"id":"https://openalex.org/W7212377344","doi":"https://doi.org/10.2147/dddt.s625517","title":"Effects of Intranasal Dexmedetomidine on the Night Before Surgery on Postoperative Delirium in Elderly Patients Undergoing Total Knee/Hip Arthroplasty. A Parallel-Arm, Randomized Controlled, Non-Inferiority Trial","display_name":"Effects of Intranasal Dexmedetomidine on the Night Before Surgery on Postoperative Delirium in Elderly Patients Undergoing Total Knee/Hip Arthroplasty. A Parallel-Arm, Randomized Controlled, Non-Inferiority Trial","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7212377344","doi":"https://doi.org/10.2147/dddt.s625517","pmid":"https://pubmed.ncbi.nlm.nih.gov/42757376"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s625517","doi":"https://doi.org/10.2147/dddt.s625517","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s625517","pdf_url":"https://www.dovepress.com/article/download/119562","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/119562","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147376192","display_name":"Yangyang Chen","orcid":"https://orcid.org/0009-0002-2194-2593","observed_orcids":["https://orcid.org/0009-0002-2194-2593"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Chen","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0002-2194-2593","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075359066","display_name":"Keqin Wang","orcid":"https://orcid.org/0000-0001-5248-7672","observed_orcids":["https://orcid.org/0000-0001-5248-7672"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keqin Wang","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340310","display_name":"Yuqi Zhang","orcid":"https://orcid.org/0009-0004-1818-6875","observed_orcids":["https://orcid.org/0009-0004-1818-6875","https://orcid.org/0000-0002-5498-2607"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Zhang","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147343791","display_name":"Ziqian Zhang","orcid":"https://orcid.org/0009-0004-7335-5731","observed_orcids":["https://orcid.org/0009-0004-7335-5731"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqian Zhang","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102622497","display_name":"Tianyu Yin","orcid":"https://orcid.org/0000-0001-6918-3501","observed_orcids":["https://orcid.org/0000-0001-6918-3501"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Yin","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147367967","display_name":"Yucheng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yucheng Liu","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144321866","display_name":"Chi Wang","orcid":"https://orcid.org/0009-0000-1912-0764","observed_orcids":["https://orcid.org/0009-0000-1912-0764"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chi Wang","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0000-1912-0764","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147314473","display_name":"Weijia Chen","orcid":"https://orcid.org/0009-0001-7253-6707","observed_orcids":["https://orcid.org/0009-0001-7253-6707"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijia Chen","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0001-7253-6707","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147362005","display_name":"Mengying Zhang","orcid":"https://orcid.org/0009-0003-1140-9805","observed_orcids":["https://orcid.org/0009-0003-1140-9805"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengying Zhang","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0003-1140-9805","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139076942","display_name":"L H Zhao","orcid":"https://orcid.org/0000-0002-3951-5517","observed_orcids":["https://orcid.org/0000-0002-3951-5517"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Zhao","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108966993","display_name":"Yan Wu","orcid":"https://orcid.org/0009-0009-8277-167X","observed_orcids":["https://orcid.org/0009-0009-8277-167X"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wu","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013240279","display_name":"Xinghe Wang","orcid":"https://orcid.org/0000-0002-4197-8545","observed_orcids":["https://orcid.org/0000-0002-4197-8545","https://orcid.org/0009-0008-3594-7479"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinghe Wang","raw_affiliation_strings":["Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5135994551","display_name":"Su Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su Liu","raw_affiliation_strings":["Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China","institution_ids":["https://openalex.org/I4405272752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76907125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 20","issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.9490000009536743},{"id":"https://openalex.org/keywords/postoperative-delirium","display_name":"postoperative delirium","score":0.9380000233650208},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hip-arthroplasty","display_name":"total hip arthroplasty","score":1.0},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9610000252723694},{"id":"https://openalex.org/keywords/preoperative-sedation","display_name":"preoperative sedation","score":0.718999981880188},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8579999804496765},{"id":"https://openalex.org/keywords/preoperative-anxiety","display_name":"preoperative anxiety","score":0.9649999737739563},{"id":"https://openalex.org/keywords/preoperative-pain","display_name":"preoperative pain","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hemodynamic-stability","display_name":"hemodynamic stability","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.9713000059127808},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9628999829292297},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.8022000193595886},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6539999842643738},{"id":"https://openalex.org/C2779753318","wikidata":"https://www.wikidata.org/wiki/Q160796","display_name":"Delirium","level":2,"score":0.623199999332428},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.578000009059906},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5120999813079834},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5103999972343445},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4560999870300293},{"id":"https://openalex.org/C2780651394","wikidata":"https://www.wikidata.org/wiki/Q394116","display_name":"Emergence delirium","level":3,"score":0.43810001015663147},{"id":"https://openalex.org/C2781312054","wikidata":"https://www.wikidata.org/wiki/Q5354947","display_name":"Elective surgery","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.36239999532699585},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C2992051495","wikidata":"https://www.wikidata.org/wiki/Q32333487","display_name":"Hip surgery","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C2777722626","wikidata":"https://www.wikidata.org/wiki/Q2902695","display_name":"Preoperative care","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C2776983577","wikidata":"https://www.wikidata.org/wiki/Q166543","display_name":"General anaesthesia","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C2780043718","wikidata":"https://www.wikidata.org/wiki/Q956181","display_name":"Postoperative cognitive dysfunction","level":3,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2147/dddt.s625517","doi":"https://doi.org/10.2147/dddt.s625517","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s625517","pdf_url":"https://www.dovepress.com/article/download/119562","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmid:42757376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42757376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Equivalence Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:13585183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13585183/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13585183/pdf/DDDT-20-625517.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmh:oai:dovepress.com/119562","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/effects-of-intranasal-dexmedetomidine-on-the-night-before-surgery-on-p-peer-reviewed-fulltext-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Clinical Trial Report"}],"best_oa_location":{"id":"doi:10.2147/dddt.s625517","doi":"https://doi.org/10.2147/dddt.s625517","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s625517","pdf_url":"https://www.dovepress.com/article/download/119562","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7676116824150085,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320327501","display_name":"Xuzhou Medical University","ror":"https://ror.org/04fe7hy80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212377344.pdf","grobid_xml":"https://content.openalex.org/works/W7212377344.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Importance:":[0],"It":[1],"is":[2,32,234],"crucial":[3],"to":[4,34,68,112,123,135,236],"identify":[5],"preoperative":[6,24,200,252],"treatment":[7],"methods":[8],"that":[9],"can":[10],"safely":[11],"and":[12,103,127,160,198,202,218,256],"effectively":[13],"reduce":[14],"the":[15,39,75,115,124,128,177,194,206,230],"incidence":[16,166,207],"of":[17,167,208],"postoperative":[18,30,168,242],"delirium.":[19,243],"Objective:":[20],"To":[21],"evaluate":[22],"whether":[23],"intranasal":[25,137,148,227,245],"dexmedetomidine":[26,36,138,155,228],"administration":[27],"for":[28,44,74,98,240],"preventing":[29,241],"delirium":[31,169],"non-inferior":[33,235],"intravenous":[35,238],"infusion":[37,239],"on":[38,80,193],"operative":[40],"day":[41],"before":[42,141,153,196,232],"induction":[43],"elderly":[45,221],"patients":[46,96,119,222],"undergoing":[47,223],"elective":[48],"knee/hip":[49],"arthroplasty.":[50],"Design:":[51],"This":[52,85],"randomized":[53,134],"clinical":[54],"trial":[55],"was":[56,78,86,165,211],"performed":[57],"at":[58],"a":[59,87],"tertiary":[60],"hospital":[61],"in":[62,114,185,214],"China":[63],"between":[64],"January":[65],"10,":[66],"2025":[67],"August":[69],"30,":[70],"2025.":[71,83],"The":[72,162,244],"follow-up":[73],"last":[76],"subject":[77],"completed":[79],"September":[81],"6,":[82],"Setting:":[84],"single":[88],"center":[89],"trial.":[90],"Participants:":[91],"After":[92],"qualification":[93],"screening,":[94],"535":[95],"scheduled":[97],"unilateral":[99],"total":[100,104],"knee":[101],"arthroplasty":[102,106],"hip":[105],"under":[107],"general":[108],"anesthesia":[109],"were":[110,120,133],"invited":[111],"participate":[113],"study.":[116],"Ultimately,":[117],"316":[118],"randomly":[121],"assigned":[122],"experimental":[125,186,215],"group":[126,187],"control":[129],"group.":[130,216],"Interventions:":[131],"Patients":[132,184],"receive":[136],"(the":[139,151],"night":[140,152,195,231],"surgery)+intravenous":[142,154],"normal":[143,149],"saline":[144,150],"(before":[145,156],"induction)":[146],"or":[147],"induction).":[157],"Main":[158],"Outcomes":[159],"Measures:":[161],"primary":[163],"outcome":[164],"within":[170],"3":[171],"days":[172],"after":[173],"surgery":[174,197,233],"assessed":[175],"by":[176],"Confusion":[178],"Assessment":[179],"Method.":[180],"Results:":[181],"<":[182],"0.001).":[183],"showed":[188],"significantly":[189,212],"improved":[190,251],"sleep":[191],"quality":[192],"lower":[199,213],"anxiety":[201],"pain":[203],"scores.":[204],"Furthermore,":[205],"adverse":[209],"events":[210],"Conclusions":[217],"Relevance:":[219],"For":[220],"major":[224],"joint":[225],"arthroplasty,":[226],"administered":[229],"pre-induction":[237],"route":[246],"offers":[247],"additional":[248],"benefits,":[249],"including":[250],"sleep,":[253],"reduced":[254],"anxiety,":[255],"superior":[257],"hemodynamic":[258],"stability.":[259]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2026-09-13T00:00:00"}
