{"id":"https://openalex.org/W7212376712","doi":"https://doi.org/10.1016/j.clinbiochem.2026.111203","title":"Population-specific reference intervals for cystatin C, creatinine and urea, and their impact on diagnostic classification and eGFR stratification in Nigerian adults","display_name":"Population-specific reference intervals for cystatin C, creatinine and urea, and their impact on diagnostic classification and eGFR stratification in Nigerian adults","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212376712","doi":"https://doi.org/10.1016/j.clinbiochem.2026.111203","pmid":"https://pubmed.ncbi.nlm.nih.gov/42731779"},"language":"en","primary_location":{"id":"doi:10.1016/j.clinbiochem.2026.111203","doi":"https://doi.org/10.1016/j.clinbiochem.2026.111203","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clinbiochem.2026.111203","pdf_url":null,"source":{"id":"https://openalex.org/S17140621","display_name":"Clinical Biochemistry","issn_l":"0009-9120","issn":["0009-9120","1873-2933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7212376712"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144053128","display_name":"Imafidor Iyabode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128271","display_name":"University of Abuja Teaching Hospital","ror":"https://ror.org/03jza6h92","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210128271"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Imafidor Iyabode","raw_affiliation_strings":["Department of Chemical Pathology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210128271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039314535","display_name":"Bruno Basil","orcid":"https://orcid.org/0000-0002-2631-285X","observed_orcids":["https://orcid.org/0000-0002-2631-285X"]},"institutions":[{"id":"https://openalex.org/I4405255170","display_name":"David Umahi Federal University of Health Sciences Uburu","ror":"https://ror.org/02ph9d254","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405255170"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Bruno Basil","raw_affiliation_strings":["International Institute of Pathology and Forensic Science Research, David Umahi Federal University of Health Sciences, Uburu, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute of Pathology and Forensic Science Research, David Umahi Federal University of Health Sciences, Uburu, Nigeria","institution_ids":["https://openalex.org/I4405255170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085306322","display_name":"Izuchukwu Nnachi Mba","orcid":"https://orcid.org/0000-0003-3001-1440","observed_orcids":["https://orcid.org/0000-0003-3001-1440"]},"institutions":[{"id":"https://openalex.org/I4210165297","display_name":"Nile University of Nigeria","ror":"https://ror.org/05saqv884","country_code":"NG","type":"education","lineage":["https://openalex.org/I4210165297"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Izuchukwu Nnachi Mba","raw_affiliation_strings":["Department of Chemical Pathology, Nile University of Nigeria, Abuja, Nigeria. Electronic address: mbaizuchukwu@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, Nile University of Nigeria, Abuja, Nigeria. Electronic address: mbaizuchukwu@gmail.com","institution_ids":["https://openalex.org/I4210165297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109778593","display_name":"Jamila Aminu Mohammed","orcid":"https://orcid.org/0009-0009-9248-0796","observed_orcids":["https://orcid.org/0009-0009-9248-0796"]},"institutions":[{"id":"https://openalex.org/I4210165297","display_name":"Nile University of Nigeria","ror":"https://ror.org/05saqv884","country_code":"NG","type":"education","lineage":["https://openalex.org/I4210165297"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Jamila Aminu Mohammed","raw_affiliation_strings":["Department of Chemical Pathology, Nile University of Nigeria, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, Nile University of Nigeria, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210165297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006886954","display_name":"Maxwell Nwegbu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128271","display_name":"University of Abuja Teaching Hospital","ror":"https://ror.org/03jza6h92","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210128271"]},{"id":"https://openalex.org/I8033065","display_name":"University of Abuja","ror":"https://ror.org/007e69832","country_code":"NG","type":"education","lineage":["https://openalex.org/I8033065"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Maxwell Nwegbu","raw_affiliation_strings":["Department of Chemical Pathology, University of Abuja/University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, University of Abuja/University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210128271","https://openalex.org/I8033065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110313509","display_name":"Amos Gadzama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128271","display_name":"University of Abuja Teaching Hospital","ror":"https://ror.org/03jza6h92","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210128271"]},{"id":"https://openalex.org/I8033065","display_name":"University of Abuja","ror":"https://ror.org/007e69832","country_code":"NG","type":"education","lineage":["https://openalex.org/I8033065"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Amos Ali Gadzama","raw_affiliation_strings":["Department of Chemical Pathology, University of Abuja/University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, University of Abuja/University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210128271","https://openalex.org/I8033065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085306322"],"corresponding_institution_ids":["https://openalex.org/I4210165297"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":null,"first_page":"111203","last_page":"111203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9779999852180481},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/serum-urea","display_name":"serum urea","score":0.9459999799728394},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.8510000109672546},{"id":"https://openalex.org/keywords/renal-function-markers","display_name":"renal function markers","score":0.6890000104904175},{"id":"https://openalex.org/keywords/diagnostic-misclassification","display_name":"diagnostic misclassification","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.640999972820282},{"id":"https://openalex.org/keywords/african-populations","display_name":"African populations","score":0.6869999766349792},{"id":"https://openalex.org/keywords/nigerian-adults","display_name":"Nigerian adults","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8720999956130981},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.7501999735832214},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7343000173568726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5756000280380249},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5383999943733215},{"id":"https://openalex.org/C192943249","wikidata":"https://www.wikidata.org/wiki/Q1893382","display_name":"Stratification (seeds)","level":5,"score":0.5054000020027161},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.4625999927520752},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32120001316070557},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31869998574256897},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2655999958515167}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.clinbiochem.2026.111203","doi":"https://doi.org/10.1016/j.clinbiochem.2026.111203","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clinbiochem.2026.111203","pdf_url":null,"source":{"id":"https://openalex.org/S17140621","display_name":"Clinical Biochemistry","issn_l":"0009-9120","issn":["0009-9120","1873-2933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Biochemistry","raw_type":"journal-article"},{"id":"pmid:42731779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42731779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W2005273854","https://openalex.org/W2783349386","https://openalex.org/W2937794088","https://openalex.org/W3128017084","https://openalex.org/W3135224653","https://openalex.org/W3190057319","https://openalex.org/W3201595862","https://openalex.org/W4210422441","https://openalex.org/W4213326229","https://openalex.org/W4281256884","https://openalex.org/W4307931699","https://openalex.org/W4308993661","https://openalex.org/W4386634285","https://openalex.org/W4388347444","https://openalex.org/W4388713764","https://openalex.org/W4392777592","https://openalex.org/W4404565629","https://openalex.org/W4405351251","https://openalex.org/W4408216703","https://openalex.org/W4413971904","https://openalex.org/W4414163895","https://openalex.org/W4415648040","https://openalex.org/W7134241880"],"related_works":["https://openalex.org/W2005273854","https://openalex.org/W7219566077","https://openalex.org/W2937794088","https://openalex.org/W4414163895","https://openalex.org/W2387090486","https://openalex.org/W4413971904","https://openalex.org/W7171796166","https://openalex.org/W2042548492","https://openalex.org/W4387081384"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-09-13T00:00:00"}