{"id":"https://openalex.org/W7212372014","doi":"https://doi.org/10.1177/19373368261486376","title":"Efficacy of Growth Factor Therapy for Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies","display_name":"Efficacy of Growth Factor Therapy for Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212372014","doi":"https://doi.org/10.1177/19373368261486376","pmid":"https://pubmed.ncbi.nlm.nih.gov/42728738"},"language":"en","primary_location":{"id":"doi:10.1177/19373368261486376","doi":"https://doi.org/10.1177/19373368261486376","is_oa":false,"landing_page_url":"https://doi.org/10.1177/19373368261486376","pdf_url":null,"source":{"id":"https://openalex.org/S13647896","display_name":"Tissue Engineering Part B Reviews","issn_l":"1937-3368","issn":["1937-3368","1937-3376"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part B: Reviews","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7212372014"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052095689","display_name":"Hailv Ye","orcid":"https://orcid.org/0009-0007-5059-3376","observed_orcids":["https://orcid.org/0009-0007-5059-3376"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210153668","display_name":"Wenzhou-Kean University","ror":"https://ror.org/05609xa16","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153668"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailv Ye","raw_affiliation_strings":["Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, P.R. China","School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":"https://orcid.org/0009-0007-5059-3376","affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I4210153668"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151436325","display_name":"Yuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":["School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102427286","display_name":"Yiting Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Zhu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134073209","display_name":"Aloysius Wong","orcid":"https://orcid.org/0000-0002-9105-5845","observed_orcids":["https://orcid.org/0000-0002-9105-5845"]},"institutions":[{"id":"https://openalex.org/I4210153668","display_name":"Wenzhou-Kean University","ror":"https://ror.org/05609xa16","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153668"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aloysius Wong","raw_affiliation_strings":["Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I4210153668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151478377","display_name":"Yixiang Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixiang Pan","raw_affiliation_strings":["School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151477816","display_name":"Xiaokun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaokun Li","raw_affiliation_strings":["School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139478243","display_name":"Jiang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Wu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, P.R. China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5126407983","display_name":"Huacheng He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huacheng He","raw_affiliation_strings":["Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Oujiang Laboratory, Wenzhou, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"19373368261486376","last_page":"19373368261486376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-factor-therapy","display_name":"growth factor therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.9620000123977661},{"id":"https://openalex.org/keywords/wound-healing-rate","display_name":"wound healing rate","score":0.8999999761581421},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pressure-ulcers","display_name":"pressure ulcers","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.6119999885559082},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7936000227928162},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6615999937057495},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4456000030040741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43849998712539673},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.430400013923645},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3953999876976013},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.3833000063896179},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37929999828338623},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32589998841285706},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3172999918460846},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C2779232120","wikidata":"https://www.wikidata.org/wiki/Q1511599","display_name":"Negative-pressure wound therapy","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.30559998750686646},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C3019592751","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal study","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26910001039505005},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.250900000333786},{"id":"https://openalex.org/C3020304732","wikidata":"https://www.wikidata.org/wiki/Q1671866","display_name":"Surgical wound","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/19373368261486376","doi":"https://doi.org/10.1177/19373368261486376","is_oa":false,"landing_page_url":"https://doi.org/10.1177/19373368261486376","pdf_url":null,"source":{"id":"https://openalex.org/S13647896","display_name":"Tissue Engineering Part B Reviews","issn_l":"1937-3368","issn":["1937-3368","1937-3376"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part B: Reviews","raw_type":"journal-article"},{"id":"pmid:42728738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42728738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part B, Reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[{"id":"https://openalex.org/G8403602187","display_name":null,"funder_award_id":"82472572","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W1544687753","https://openalex.org/W1606274538","https://openalex.org/W1637721216","https://openalex.org/W1949832432","https://openalex.org/W1950258791","https://openalex.org/W1965442455","https://openalex.org/W1967666761","https://openalex.org/W1970481893","https://openalex.org/W1975250411","https://openalex.org/W1976281443","https://openalex.org/W1986698999","https://openalex.org/W1989483643","https://openalex.org/W1997720029","https://openalex.org/W2001229549","https://openalex.org/W2001543822","https://openalex.org/W2005016150","https://openalex.org/W2005102755","https://openalex.org/W2006951732","https://openalex.org/W2012048902","https://openalex.org/W2014529487","https://openalex.org/W2014581641","https://openalex.org/W2017237256","https://openalex.org/W2022199192","https://openalex.org/W2024623214","https://openalex.org/W2026743018","https://openalex.org/W2031663540","https://openalex.org/W2032554052","https://openalex.org/W2033315842","https://openalex.org/W2038112216","https://openalex.org/W2040537095","https://openalex.org/W2056242981","https://openalex.org/W2057282966","https://openalex.org/W2059848729","https://openalex.org/W2062307013","https://openalex.org/W2062706374","https://openalex.org/W2063539948","https://openalex.org/W2065556081","https://openalex.org/W2067121396","https://openalex.org/W2067396886","https://openalex.org/W2068729659","https://openalex.org/W2070304010","https://openalex.org/W2075354328","https://openalex.org/W2080423395","https://openalex.org/W2084995634","https://openalex.org/W2085293124","https://openalex.org/W2085652943","https://openalex.org/W2087377825","https://openalex.org/W2087556197","https://openalex.org/W2088344769","https://openalex.org/W2089459111","https://openalex.org/W2095166000","https://openalex.org/W2102282098","https://openalex.org/W2102638227","https://openalex.org/W2108330780","https://openalex.org/W2108866232","https://openalex.org/W2109680789","https://openalex.org/W2111002265","https://openalex.org/W2112080359","https://openalex.org/W2112911107","https://openalex.org/W2115047729","https://openalex.org/W2130436850","https://openalex.org/W2146749615","https://openalex.org/W2148393475","https://openalex.org/W2160163930","https://openalex.org/W2162416691","https://openalex.org/W2168132872","https://openalex.org/W2170360183","https://openalex.org/W2171766571","https://openalex.org/W2218702703","https://openalex.org/W2239897467","https://openalex.org/W2317345923","https://openalex.org/W2330380927","https://openalex.org/W2341450400","https://openalex.org/W2400597336","https://openalex.org/W2417002403","https://openalex.org/W2511193066","https://openalex.org/W2532241478","https://openalex.org/W2575770495","https://openalex.org/W2579302807","https://openalex.org/W2611060588","https://openalex.org/W2740397159","https://openalex.org/W2749354327","https://openalex.org/W2757954631","https://openalex.org/W2762129585","https://openalex.org/W2767619057","https://openalex.org/W2783968262","https://openalex.org/W2806375716","https://openalex.org/W2888449613","https://openalex.org/W2900142801","https://openalex.org/W2908225639","https://openalex.org/W2913724570","https://openalex.org/W2921447581","https://openalex.org/W2924472942","https://openalex.org/W2969236979","https://openalex.org/W2981100201","https://openalex.org/W2995116144","https://openalex.org/W2995663483","https://openalex.org/W2995679765","https://openalex.org/W3004201487","https://openalex.org/W3006012565","https://openalex.org/W3013379147","https://openalex.org/W3013563410","https://openalex.org/W3043512354","https://openalex.org/W3081323605","https://openalex.org/W3082979654","https://openalex.org/W3087599145","https://openalex.org/W3101734683","https://openalex.org/W3121019394","https://openalex.org/W3134648489","https://openalex.org/W3137169605","https://openalex.org/W3148234391","https://openalex.org/W3152885827","https://openalex.org/W3183041177","https://openalex.org/W3194255318","https://openalex.org/W3195920559","https://openalex.org/W3200256564","https://openalex.org/W3214862583","https://openalex.org/W3217002530","https://openalex.org/W4206323205","https://openalex.org/W4211234775","https://openalex.org/W4296578038","https://openalex.org/W4297546433","https://openalex.org/W4307945158","https://openalex.org/W4310474867","https://openalex.org/W4312314934","https://openalex.org/W4313898310","https://openalex.org/W4316041166","https://openalex.org/W4319063493","https://openalex.org/W4319767881","https://openalex.org/W4362469481","https://openalex.org/W4364369904","https://openalex.org/W4382344354","https://openalex.org/W4382918816","https://openalex.org/W4386386454","https://openalex.org/W4389101316","https://openalex.org/W4391171454","https://openalex.org/W4391540184","https://openalex.org/W4396776758","https://openalex.org/W4396883600","https://openalex.org/W4399041329","https://openalex.org/W4399155935","https://openalex.org/W4399391945","https://openalex.org/W4407910009"],"related_works":["https://openalex.org/W3037931083","https://openalex.org/W2051202228","https://openalex.org/W1586551928","https://openalex.org/W4392385725","https://openalex.org/W4410898480","https://openalex.org/W4212786085","https://openalex.org/W2400597336","https://openalex.org/W2046944434","https://openalex.org/W2066797344","https://openalex.org/W1765289887"],"abstract_inverted_index":{"Wound":[0],"healing":[1,130,218],"remains":[2],"a":[3,19,41,99],"complex":[4],"clinical":[5],"challenge,":[6],"often":[7],"associated":[8],"with":[9,147],"various":[10],"complications.":[11],"Despite":[12],"the":[13,71,105,120,134,165,216,220],"availability":[14],"of":[15,77,84,102,110,122,167,176,179],"multiple":[16],"treatment":[17,142,185],"options,":[18],"universally":[20],"effective":[21,193],"strategy":[22],"for":[23,44],"managing":[24],"severe":[25],"or":[26],"chronic":[27],"wounds":[28,196],"has":[29,38],"not":[30,127],"yet":[31],"been":[32],"established.":[33],"Growth":[34],"factor":[35,226],"(GF)":[36],"therapy":[37,190,227],"emerged":[39],"as":[40,51],"promising":[42],"approach":[43],"promoting":[45],"tissue":[46],"repair":[47],"in":[48,79,88,194],"difficult-to-heal":[49],"wounds,":[50],"evidenced":[52],"by":[53],"numerous":[54],"preclinical":[55,66],"investigations.":[56],"A":[57,82],"systematic":[58],"review":[59],"and":[60,73,93,108,181,197,204],"meta-analysis":[61,222],"were":[62,96],"conducted":[63],"based":[64],"on":[65,184],"animal":[67,182],"studies":[68,86,124,137],"to":[69],"evaluate":[70],"efficacy":[72],"potential":[74],"biological":[75,232],"mechanisms":[76],"GFs":[78],"wound":[80,129,168,172,217],"healing.":[81],"total":[83],"80":[85],"published":[87],"English":[89],"between":[90],"January":[91],"1990":[92],"April":[94],"2025":[95],"identified":[97],"through":[98],"structured":[100],"search":[101],"EMBASE,":[103],"PubMed,":[104],"Cochrane":[106],"Library,":[107],"Web":[109],"Science.":[111],"Data":[112],"analysis":[113],"was":[114,191],"performed":[115],"using":[116],"RevMan":[117],"5.3.":[118],"With":[119],"exception":[121],"two":[123],"that":[125,140,188,224],"did":[126],"report":[128],"rate":[131],"(WHR)":[132],"data,":[133],"remaining":[135],"78":[136],"consistently":[138],"demonstrated":[139],"GF":[141,170,189],"significantly":[143,228],"enhanced":[144],"WHR":[145],"compared":[146],"controls":[148],"(":[149],"n":[150],"=":[151,156],"2031,":[152],"standardized":[153],"mean":[154],"difference":[155],"2.62,":[157],"95%":[158],"confidence":[159],"interval:":[160],"2.22\u20133.01).":[161],"Subgroup":[162],"analyses":[163],"explored":[164],"influence":[166],"type,":[169,171],"size,":[173],"dosage,":[174],"mode":[175],"administration,":[177],"type":[178],"placebo,":[180],"model":[183],"outcomes,":[186],"revealing":[187],"particularly":[192],"infectious":[195],"pressure":[198],"ulcers.":[199],"Although":[200],"angiogenesis,":[201],"collagen":[202],"deposition,":[203],"proliferating":[205],"cell":[206],"nuclear":[207],"antigen":[208],"expression":[209],"are":[210],"secondary":[211],"outcome":[212],"measures":[213],"indirectly":[214],"reflecting":[215],"process,":[219],"present":[221],"demonstrates":[223],"growth":[225],"enhances":[229],"these":[230],"reparative":[231],"processes.":[233]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2026-09-13T00:00:00"}