{"id":"https://openalex.org/W7212371767","doi":"https://doi.org/10.1016/j.engreg.2026.08.006","title":"Self-assembling peptide amphiphiles inhibit inflammation in a murine model of colitis","display_name":"Self-assembling peptide amphiphiles inhibit inflammation in a murine model of colitis","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7212371767","doi":"https://doi.org/10.1016/j.engreg.2026.08.006"},"language":"en","primary_location":{"id":"doi:10.1016/j.engreg.2026.08.006","doi":"https://doi.org/10.1016/j.engreg.2026.08.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.engreg.2026.08.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666138126000204/pdf","source":{"id":"https://openalex.org/S4210220692","display_name":"Engineered Regeneration","issn_l":"2666-1381","issn":["2666-1381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Engineered Regeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2666138126000204/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075350944","display_name":"S. Amitha Banu","orcid":"https://orcid.org/0000-0002-7182-8169","observed_orcids":["https://orcid.org/0000-0002-7182-8169"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Amitha B. Shajahan","raw_affiliation_strings":["Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Regenerative Medicine Group, Department of Health Science and Technology, Aalborg University, Gistrup, 9260, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7182-8169","affiliations":[{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Regenerative Medicine Group, Department of Health Science and Technology, Aalborg University, Gistrup, 9260, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064025926","display_name":"Matthew I. Bury","orcid":"https://orcid.org/0000-0001-7128-2162","observed_orcids":["https://orcid.org/0000-0001-7128-2162"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew I. Bury","raw_affiliation_strings":["Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024866785","display_name":"Neeti N. Gandhi","orcid":"https://orcid.org/0009-0009-3882-3655","observed_orcids":["https://orcid.org/0009-0009-3882-3655"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neeti N. Gandhi","raw_affiliation_strings":["Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA"],"raw_orcid":"https://orcid.org/0009-0009-3882-3655","affiliations":[{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134695450","display_name":"Simran M. Sharma","orcid":"https://orcid.org/0009-0003-9453-5523","observed_orcids":["https://orcid.org/0009-0003-9453-5523"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simran M. Sharma","raw_affiliation_strings":["Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208, USA","Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA"],"raw_orcid":"https://orcid.org/0009-0003-9453-5523","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135197830","display_name":"Brooke Hilderbrant","orcid":"https://orcid.org/0009-0009-7140-1120","observed_orcids":["https://orcid.org/0009-0009-7140-1120"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Hilderbrant","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA","Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA"],"raw_orcid":"https://orcid.org/0009-0009-7140-1120","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151534346","display_name":"Norah M. Zimmerman","orcid":"https://orcid.org/0009-0002-2968-0516","observed_orcids":["https://orcid.org/0009-0002-2968-0516"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norah M. Zimmerman","raw_affiliation_strings":["Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA"],"raw_orcid":"https://orcid.org/0009-0002-2968-0516","affiliations":[{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134555197","display_name":"Aitran Le","orcid":"https://orcid.org/0009-0006-4752-3214","observed_orcids":["https://orcid.org/0009-0006-4752-3214"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aitran Le","raw_affiliation_strings":["Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","School of Public Health, University of Illinois at Chicago, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0009-0006-4752-3214","affiliations":[{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"School of Public Health, University of Illinois at Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027849001","display_name":"Arun K. Sharma","orcid":"https://orcid.org/0000-0002-4504-3472","observed_orcids":["https://orcid.org/0000-0002-4504-3472"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun K. Sharma","raw_affiliation_strings":["Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208, USA","Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA"],"raw_orcid":"https://orcid.org/0000-0002-4504-3472","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Surgery, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Division of Urology, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, 60611, USA","institution_ids":["https://openalex.org/I1294278766"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027849001","https://openalex.org/A5134695450"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"],"apc_list":{"value":700,"currency":"USD","value_usd":700},"apc_paid":{"value":700,"currency":"USD","value_usd":700},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73212066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":"276","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphiphilic-peptides","display_name":"peptide amphiphiles","score":0.890999972820282},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/self-assembly","display_name":"self-assembly","score":0.7440000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7260000109672546},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.593999981880188},{"id":"https://openalex.org/keywords/epithelial-regeneration","display_name":"epithelial regeneration","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9419999718666077},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7752000093460083},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.753000020980835},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7384999990463257},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5676000118255615},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5615000128746033},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.47369998693466187},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4643000066280365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4065000116825104},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3864000141620636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3788999915122986},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.3619000017642975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.357699990272522},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3262999951839447},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.3019999861717224},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.26190000772476196}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.engreg.2026.08.006","doi":"https://doi.org/10.1016/j.engreg.2026.08.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.engreg.2026.08.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666138126000204/pdf","source":{"id":"https://openalex.org/S4210220692","display_name":"Engineered Regeneration","issn_l":"2666-1381","issn":["2666-1381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Engineered Regeneration","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:467805136f9642f09789bfb42889259c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/467805136f9642f09789bfb42889259c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Engineered Regeneration, Vol 7, Iss , Pp 276-285 (2026)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire/763a7d38-0457-4867-9870-960b5881e0c1","doi":null,"is_oa":true,"landing_page_url":"https://vbn.aau.dk/da/publications/763a7d38-0457-4867-9870-960b5881e0c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Shajahan, A B, Bury, M I, Gandhi, N N, Sharma, S M, Hilderbrant, B, Zimmerman, N M, Le, A & Sharma, A K 2026, 'Self-assembling peptide amphiphiles inhibit inflammation in a murine model of colitis', Engineered Regeneration, vol. 7, pp. 276-285. https://doi.org/10.1016/j.engreg.2026.08.006","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.engreg.2026.08.006","doi":"https://doi.org/10.1016/j.engreg.2026.08.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.engreg.2026.08.006","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666138126000204/pdf","source":{"id":"https://openalex.org/S4210220692","display_name":"Engineered Regeneration","issn_l":"2666-1381","issn":["2666-1381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Engineered Regeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.49601349234580994,"id":"https://metadata.un.org/sdg/11","display_name":"Sustainable cities and communities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1276186940","display_name":null,"funder_award_id":"1542205","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G336680401","display_name":null,"funder_award_id":"ECCS-1542205","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G3823477440","display_name":null,"funder_award_id":"TL1DK132769","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5815712311","display_name":"NNCI: Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource","funder_award_id":"1542205","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7540035370","display_name":null,"funder_award_id":"U2C DK129917","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8230932042","display_name":null,"funder_award_id":"ECCS-1542205","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G9000039705","display_name":null,"funder_award_id":"U2CDK129917","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000129401","display_name":null,"funder_award_id":"TL1DK132769","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309331","display_name":"Hartwell Foundation","ror":"https://ror.org/038cgyc59"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320310642","display_name":"Dr. Ralph and Marian Falk Medical Research Trust","ror":"https://ror.org/01ctnwa22"},{"id":"https://openalex.org/F4320312687","display_name":"Children\u2019s Hospital of Wisconsin Research Institute","ror":"https://ror.org/058g1h315"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212371767.pdf","grobid_xml":"https://content.openalex.org/works/W7212371767.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1522526317","https://openalex.org/W1969144895","https://openalex.org/W1975430023","https://openalex.org/W2000208875","https://openalex.org/W2019326608","https://openalex.org/W2029215926","https://openalex.org/W2030491651","https://openalex.org/W2037317463","https://openalex.org/W2043977207","https://openalex.org/W2060862592","https://openalex.org/W2067844788","https://openalex.org/W2073795835","https://openalex.org/W2073970540","https://openalex.org/W2096015012","https://openalex.org/W2112824098","https://openalex.org/W2115004477","https://openalex.org/W2120322119","https://openalex.org/W2123692136","https://openalex.org/W2139724506","https://openalex.org/W2140898147","https://openalex.org/W2141301636","https://openalex.org/W2142438877","https://openalex.org/W2201859789","https://openalex.org/W2899412362","https://openalex.org/W2978084647","https://openalex.org/W3006764495","https://openalex.org/W3007332863","https://openalex.org/W3036674673","https://openalex.org/W3092785712","https://openalex.org/W3107076968","https://openalex.org/W3158265593","https://openalex.org/W3165016349","https://openalex.org/W3201482214","https://openalex.org/W4224269052","https://openalex.org/W4280529994","https://openalex.org/W4386624403","https://openalex.org/W4392347151"],"related_works":[],"abstract_inverted_index":{"Ulcerative":[0],"colitis":[1],"(UC)":[2],"arises":[3],"from":[4,72],"complex":[5],"interactions":[6],"between":[7],"genetic":[8],"susceptibility,":[9],"environmental":[10],"triggers,":[11],"and":[12,18,28,48,81,86,95,122,140,165],"immune":[13],"dysregulation,":[14],"posing":[15],"significant":[16],"clinical":[17],"socioeconomic":[19],"challenges.":[20],"Current":[21],"therapeutics":[22],"cannot":[23],"precisely":[24,179],"target":[25,164],"intestinal":[26,183],"inflammation":[27],"cause":[29],"deleterious":[30],"side":[31],"effects.":[32],"Here,":[33],"we":[34],"investigate":[35],"the":[36,99],"local":[37],"delivery":[38],"of":[39,91,119,169],"supramolecular":[40],"anti-inflammatory":[41,154],"peptide":[42],"amphiphiles":[43],"(AIF-PAs)":[44],"as":[45,173],"a":[46,149,174],"biocompatible":[47],"comprehensive":[49],"therapeutic":[50,177],"for":[51,178],"UC":[52,100,170],"by":[53,114],"administering":[54],"these":[55],"nanomolecules":[56],"to":[57,103,127,143],"an":[58,181],"established":[59],"IL-2":[60],"knockout":[61],"(IL-2\u2212/\u2212)":[62],"murine":[63],"model":[64,101],"that":[65,76,161],"simulates":[66],"human":[67],"UC-like":[68],"disease.":[69],"Data":[70],"derived":[71],"this":[73,158],"study":[74],"demonstrated":[75],"colonic":[77,93],"lavage":[78],"with":[79],"AIF-PA1":[80,108,146],"AIF-PA2":[82],"exhibit":[83],"improved":[84],"anatomical":[85],"physiological":[87],"function":[88],"including":[89,137],"restoration":[90,118],"normal":[92],"architecture":[94],"transit":[96],"times":[97],"in":[98,148,153],"compared":[102,126],"control":[104],"groups.":[105],"In":[106],"particular,":[107],"exhibited":[109],"superior":[110],"tissue":[111],"repair":[112,166],"characterized":[113],"enhanced":[115],"epithelial":[116],"regeneration,":[117],"crypt":[120],"architecture,":[121],"reduced":[123,133],"inflammatory":[124,182],"infiltrates":[125],"other":[128],"treatments.":[129],"Both":[130],"AIF-PA":[131],"treatments":[132],"pro-inflammatory":[134],"cytokine":[135,155],"secretion,":[136],"TNF-\u03b1,":[138],"IFN-\u03b3,":[139],"IL-1\u03b2":[141],"up":[142],"3-fold.":[144],"Notably,":[145],"resulted":[147],"concomitant":[150],"5-fold":[151],"increase":[152],"IL-10.":[156],"Altogether,":[157],"data":[159],"demonstrates":[160],"AIF-PAs":[162],"can":[163],"several":[167],"aspects":[168],"pathology":[171],"serving":[172],"potential":[175],"novel":[176],"mitigating":[180],"milieu.":[184]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-13T00:00:00"}