{"id":"https://openalex.org/W7212365568","doi":"https://doi.org/10.64898/2026.09.08.26362314","title":"Oromucosal administration of oxytocin and its receptor antagonist atosiban respectively increase and decrease preferential attention to dynamic social stimuli in men","display_name":"Oromucosal administration of oxytocin and its receptor antagonist atosiban respectively increase and decrease preferential attention to dynamic social stimuli in men","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212365568","doi":"https://doi.org/10.64898/2026.09.08.26362314"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.26362314","doi":"https://doi.org/10.64898/2026.09.08.26362314","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.26362314","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362314.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362314.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100456344","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-9556-0240","observed_orcids":["https://orcid.org/0000-0002-9556-0240","https://orcid.org/0000-0001-9913-6490"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695150","display_name":"Xinling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinling Wang","raw_affiliation_strings":["The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151478067","display_name":"Yige Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yige Wang","raw_affiliation_strings":["The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338944","display_name":"Huan Liu","orcid":"https://orcid.org/0000-0002-3169-897X","observed_orcids":["https://orcid.org/0000-0002-3169-897X"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Liu","raw_affiliation_strings":["The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000445902","display_name":"Keith Maurice Kendrick","orcid":"https://orcid.org/0000-0002-0371-5904","observed_orcids":["https://orcid.org/0000-0002-0371-5904"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Keith M. Kendrick","raw_affiliation_strings":["The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000445902"],"corresponding_institution_ids":["https://openalex.org/I150229711"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atosiban","display_name":"atosiban","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oxytocin-receptor-antagonist","display_name":"oxytocin receptor antagonist","score":0.8510000109672546},{"id":"https://openalex.org/keywords/social-attention","display_name":"social attention","score":0.8500000238418579},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.6600000262260437},{"id":"https://openalex.org/keywords/eye-tracking","display_name":"eye tracking","score":0.578000009059906},{"id":"https://openalex.org/keywords/gq-coupled-receptors","display_name":"Gq-coupled receptors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/social-impairment","display_name":"social dysfunction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/autism-spectrum-quotient","display_name":"Autism Spectrum Quotient","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.95169997215271},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6827999949455261},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.6797999739646912},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6456999778747559},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5860000252723694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5185999870300293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5166000127792358},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.49939998984336853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48980000615119934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4880000054836273},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4074000120162964},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37959998846054077},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.325300008058548},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C2779760398","wikidata":"https://www.wikidata.org/wiki/Q7551043","display_name":"Social defeat","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.26809999346733093}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.08.26362314","doi":"https://doi.org/10.64898/2026.09.08.26362314","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.26362314","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362314.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.26362314","doi":"https://doi.org/10.64898/2026.09.08.26362314","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.26362314","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/11/2026.09.08.26362314.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212365568.pdf","grobid_xml":"https://content.openalex.org/works/W7212365568.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W236622834","https://openalex.org/W2003021017","https://openalex.org/W2005665656","https://openalex.org/W2023636464","https://openalex.org/W2062508009","https://openalex.org/W2167835104","https://openalex.org/W2322603007","https://openalex.org/W2613367519","https://openalex.org/W2767130940","https://openalex.org/W2792606000","https://openalex.org/W2795935739","https://openalex.org/W2953311247","https://openalex.org/W2964849146","https://openalex.org/W3006553795","https://openalex.org/W3017907080","https://openalex.org/W3025637596","https://openalex.org/W3031412498","https://openalex.org/W3119440286","https://openalex.org/W3128971131","https://openalex.org/W3163329352","https://openalex.org/W3168745519","https://openalex.org/W3215163584","https://openalex.org/W4224248954","https://openalex.org/W4280590233","https://openalex.org/W4281777229","https://openalex.org/W4307370591","https://openalex.org/W4366986394","https://openalex.org/W4376224773","https://openalex.org/W4384207539","https://openalex.org/W4392201158","https://openalex.org/W4402812168","https://openalex.org/W4406558226","https://openalex.org/W4413161005","https://openalex.org/W4416439348","https://openalex.org/W7117551583","https://openalex.org/W7134039162"],"related_works":["https://openalex.org/W2606298500","https://openalex.org/W3025637596","https://openalex.org/W2557098163","https://openalex.org/W2333923087","https://openalex.org/W2735278545","https://openalex.org/W2168647678","https://openalex.org/W1886502274","https://openalex.org/W2809900380","https://openalex.org/W3208133655","https://openalex.org/W2107169322"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Reduced":[2],"concentrations":[3,24,167],"of":[4,20,45,53,151,193,239],"the":[5,18,177,222,230,236],"neuropeptide":[6],"oxytocin":[7,23,48,54,57,136,146,166,205,240],"can":[8,206],"occur":[9],"in":[10,31,36,79,214,229],"disorders":[11],"with":[12,74,171],"social":[13,34,62,122,152,184,215,242],"dysfunction,":[14],"notably":[15],"autism.":[16],"However,":[17],"role":[19],"peripheral":[21,47,209],"endogenous":[22,204],"and":[25,55,99,129,157,162,168,203],"increased":[26,148,165],"ones":[27],"following":[28],"exogenous":[29,202],"administration":[30,52,192],"modulating":[32],"key":[33],"behaviors":[35],"humans":[37],"is":[38],"still":[39],"unclear.":[40],"Here":[41],"we":[42],"investigated":[43],"effects":[44,158],"targeting":[46],"receptors":[49,210,228],"through":[50],"oromucosal":[51,108],"an":[56,119],"receptor":[58],"antagonist":[59],"(atosiban)":[60],"on":[61,226],"attention.":[63],"Methods":[64],"We":[65],"carried":[66],"out":[67],"a":[68],"pre-registered,":[69],"randomized,":[70],"double-blind,":[71],"placebo-controlled":[72],"experiment":[73],"250":[75],"adult":[76],"male":[77],"subjects":[78,117],"five":[80],"treatment":[81],"groups":[82],"(placebo":[83],"+":[84,87,92,97,101],"placebo,":[85,98,156],"placebo":[86,91,188],"24":[88,102],"IU":[89,94,103],"OT,":[90,95],"48":[93],"atosiban":[96,100,180],"OT),":[104],"each":[105],"receiving":[106],"two":[107],"(lingual)":[109],"administrations":[110],"separated":[111],"by":[112],"15":[113],"minutes.":[114],"Following":[115],"treatment,":[116],"performed":[118],"autism-sensitive":[120],"dynamic":[121],"versus":[123],"geometric":[124],"pattern":[125],"eye-tracking":[126],"paradigm.":[127],"Pre-":[128],"post-treatment":[130],"blood":[131],"samples":[132],"were":[133,159],"collected":[134],"for":[135,183,241],"measurement.":[137],"Results":[138,139],"showed":[140],"that":[141,200],"48IU":[142],"but":[143],"not":[144],"24IU":[145,194],"significantly":[147],"preferential":[149],"viewing":[150],"stimuli":[153,185],"relative":[154,186,216],"to":[155,187,211,217],"associated":[160],"with,":[161],"mediated":[163],"by,":[164],"negatively":[169],"correlated":[170],"subjects\u2019":[172],"autism":[173],"quotient":[174],"scores.":[175],"On":[176],"other":[178],"hand,":[179],"reduced":[181],"preference":[182],"even":[189],"after":[190],"subsequent":[191],"oxytocin.":[195],"Conclusions":[196],"Our":[197],"findings":[198],"suggest":[199],"both":[201],"act":[207],"via":[208,224],"enhance":[212],"interest":[213],"non-social":[218],"stimuli,":[219],"possibly":[220],"influencing":[221],"brain":[223],"acting":[225],"G[q]-coupled":[227],"vagal":[231],"system.":[232],"This":[233],"further":[234],"supports":[235],"therapeutic":[237],"potential":[238],"dysfunction.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-13T00:00:00"}