{"id":"https://openalex.org/W7212363301","doi":"https://doi.org/10.1016/j.colsurfb.2026.116180","title":"Study on the formation, release and stability mechanisms of self-assembled nanoparticles based on machine learning, explainable artificial intelligence and multiscale simulations","display_name":"Study on the formation, release and stability mechanisms of self-assembled nanoparticles based on machine learning, explainable artificial intelligence and multiscale simulations","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212363301","doi":"https://doi.org/10.1016/j.colsurfb.2026.116180","pmid":"https://pubmed.ncbi.nlm.nih.gov/42735595"},"language":"en","primary_location":{"id":"doi:10.1016/j.colsurfb.2026.116180","doi":"https://doi.org/10.1016/j.colsurfb.2026.116180","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.colsurfb.2026.116180","pdf_url":null,"source":{"id":"https://openalex.org/S22793308","display_name":"Colloids and Surfaces B Biointerfaces","issn_l":"0927-7765","issn":["0927-7765","1873-4367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloids and Surfaces B: Biointerfaces","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100326666","display_name":"Xiaoyang Zhang","orcid":"https://orcid.org/0000-0002-0031-0290","observed_orcids":["https://orcid.org/0000-0002-0031-0290"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyang Zhang","raw_affiliation_strings":["College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151539136","display_name":"Junjie Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjie Zhou","raw_affiliation_strings":["College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112071667","display_name":"Shuo Sun","orcid":"https://orcid.org/0009-0007-2243-7659","observed_orcids":["https://orcid.org/0009-0007-2243-7659"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo Sun","raw_affiliation_strings":["College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685467","display_name":"Xiaojian Zhang","orcid":"https://orcid.org/0000-0001-6558-0956","observed_orcids":["https://orcid.org/0000-0001-6558-0956"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojian Zhang","raw_affiliation_strings":["College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China","institution_ids":["https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017575132","display_name":"Zijian Zhao","orcid":"https://orcid.org/0000-0003-0697-1329","observed_orcids":["https://orcid.org/0000-0003-0697-1329","https://orcid.org/0009-0006-2550-7264"]},"institutions":[{"id":"https://openalex.org/I12393601","display_name":"Huaihua University","ror":"https://ror.org/04zn6xq74","country_code":"CN","type":"education","lineage":["https://openalex.org/I12393601"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijian Zhao","raw_affiliation_strings":["College of Chemistry and Materials Engineering, Huaihua University, Huaihua, 418000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Materials Engineering, Huaihua University, Huaihua, 418000, China","institution_ids":["https://openalex.org/I12393601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100425939","display_name":"Wenlong Li","orcid":"https://orcid.org/0000-0001-7961-7975","observed_orcids":["https://orcid.org/0000-0001-7961-7975"]},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenlong Li","raw_affiliation_strings":["College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin, 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, China. Electronic address: wshlwl@tjutcm.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-7961-7975","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin, 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, China. Electronic address: wshlwl@tjutcm.edu.cn","institution_ids":["https://openalex.org/I12411659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100425939"],"corresponding_institution_ids":["https://openalex.org/I12411659"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55241361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"269","issue":null,"first_page":"116180","last_page":"116180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.10639999806880951,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticle-self-assembly","display_name":"nanoparticle self-assembly","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nanoparticle-formation-mechanism","display_name":"nanoparticle formation mechanism","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ph-sensitive-release","display_name":"pH-dependent release","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intermolecular-interactions","display_name":"intermolecular interactions","score":0.9179999828338623},{"id":"https://openalex.org/keywords/electrostatic-attraction","display_name":"electrostatic attraction","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.968999981880188},{"id":"https://openalex.org/keywords/pi-pi-stacking","display_name":"\u03c0-\u03c0 stacking","score":0.9959999918937683},{"id":"https://openalex.org/keywords/solvent-exposure","display_name":"solvent exposure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.527999997138977},{"id":"https://openalex.org/keywords/explainable-ai","display_name":"explainable AI","score":0.9850000143051147},{"id":"https://openalex.org/keywords/natural-product-delivery","display_name":"natural product delivery","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.779699981212616},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.758400022983551},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5705000162124634},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5418999791145325},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.49079999327659607},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4422000050544739},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40549999475479126},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3862999975681305},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.384799987077713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3720000088214874},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.3682999908924103},{"id":"https://openalex.org/C117626034","wikidata":"https://www.wikidata.org/wiki/Q26336","display_name":"Electrostatics","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.3375000059604645},{"id":"https://openalex.org/C155673373","wikidata":"https://www.wikidata.org/wiki/Q1648886","display_name":"Structural stability","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C4679612","wikidata":"https://www.wikidata.org/wiki/Q866298","display_name":"Aggregate (composite)","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C141123601","wikidata":"https://www.wikidata.org/wiki/Q6935072","display_name":"Multiscale modeling","level":2,"score":0.2623000144958496}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.colsurfb.2026.116180","doi":"https://doi.org/10.1016/j.colsurfb.2026.116180","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.colsurfb.2026.116180","pdf_url":null,"source":{"id":"https://openalex.org/S22793308","display_name":"Colloids and Surfaces B Biointerfaces","issn_l":"0927-7765","issn":["0927-7765","1873-4367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloids and Surfaces B: Biointerfaces","raw_type":"journal-article"},{"id":"pmid:42735595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42735595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloids and surfaces. B, Biointerfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2146415105","display_name":null,"funder_award_id":"SKLBMDA-2025119","funder_id":"https://openalex.org/F4320322292","funder_display_name":"Jinan University"},{"id":"https://openalex.org/G2602577380","display_name":null,"funder_award_id":"2023YFC3504502","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6074506439","display_name":null,"funder_award_id":"23JCZDJC00720","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"}],"funders":[{"id":"https://openalex.org/F4320322292","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W2000924336","https://openalex.org/W2091357955","https://openalex.org/W2132525235","https://openalex.org/W2346448021","https://openalex.org/W2897122330","https://openalex.org/W3207341750","https://openalex.org/W4291318715","https://openalex.org/W4319037425","https://openalex.org/W4386529459","https://openalex.org/W4391521579","https://openalex.org/W4398201209","https://openalex.org/W4401916766","https://openalex.org/W4403531008","https://openalex.org/W4404202035","https://openalex.org/W4404860707","https://openalex.org/W4407566251","https://openalex.org/W4411399467","https://openalex.org/W4412035147","https://openalex.org/W4413001201","https://openalex.org/W4413295064","https://openalex.org/W4413849560","https://openalex.org/W4413890505","https://openalex.org/W4416410946","https://openalex.org/W4417188053","https://openalex.org/W4417425982","https://openalex.org/W7115716883","https://openalex.org/W7116887395","https://openalex.org/W7127572527","https://openalex.org/W7130590734","https://openalex.org/W7131383662","https://openalex.org/W7137818551","https://openalex.org/W7139000803","https://openalex.org/W7156114747"],"related_works":["https://openalex.org/W4401488485","https://openalex.org/W4389463367","https://openalex.org/W1180742121","https://openalex.org/W2792363583","https://openalex.org/W2913072704","https://openalex.org/W2125063610","https://openalex.org/W7171494166","https://openalex.org/W1966481828","https://openalex.org/W7211918987","https://openalex.org/W3217713093"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-13T00:00:00"}