{"id":"https://openalex.org/W7212356458","doi":"https://doi.org/10.64898/2026.09.11.751054","title":"Microevolutionary cophylogeny reflects host-symbiont population dynamics and human mitonuclear interactions","display_name":"Microevolutionary cophylogeny reflects host-symbiont population dynamics and human mitonuclear interactions","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7212356458","doi":"https://doi.org/10.64898/2026.09.11.751054","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622707"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.11.751054","doi":"https://doi.org/10.64898/2026.09.11.751054","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.751054","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.751054.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.751054.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067518261","display_name":"Rowan Hart","orcid":"https://orcid.org/0000-0002-7645-2439","observed_orcids":["https://orcid.org/0000-0002-7645-2439"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rowan Hart","raw_affiliation_strings":["Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0002-7645-2439","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014537180","display_name":"Matthias Steinr\u00fccken","orcid":"https://orcid.org/0000-0001-6331-7900","observed_orcids":["https://orcid.org/0000-0001-6331-7900"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias Steinr\u00fccken","raw_affiliation_strings":["Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA","Department of Human Genetics, University of Chicago, Chicago, Illinois, USA","National Institute for Theory and Mathematics in Biology, Northwestern University and University of Chicago, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0001-6331-7900","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Human Genetics, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"National Institute for Theory and Mathematics in Biology, Northwestern University and University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.31859999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.31859999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.1656000018119812,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cophylogeny","display_name":"cophylogeny","score":0.921999990940094},{"id":"https://openalex.org/keywords/host-symbiont-interactions","display_name":"host-symbiont interactions","score":0.890999972820282},{"id":"https://openalex.org/keywords/microevolution","display_name":"microevolution","score":0.753000020980835},{"id":"https://openalex.org/keywords/ancestral-recombination-graph","display_name":"ancestral recombination graph","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mitonuclear-incompatibility","display_name":"mitonuclear incompatibility","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vertical-transmission","display_name":"vertical transmission","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.7089999914169312},{"id":"https://openalex.org/keywords/population-structure","display_name":"population structure","score":0.5839999914169312},{"id":"https://openalex.org/keywords/admixture","display_name":"admixture","score":0.9559999704360962},{"id":"https://openalex.org/keywords/meiotic-recombination","display_name":"meiotic recombination","score":0.7860000133514404},{"id":"https://openalex.org/keywords/human-populations","display_name":"human populations","score":0.6060000061988831},{"id":"https://openalex.org/keywords/1000-genomes-project","display_name":"1000 Genomes Project","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.798799991607666},{"id":"https://openalex.org/C11710620","wikidata":"https://www.wikidata.org/wiki/Q680054","display_name":"Microevolution","level":3,"score":0.7947999835014343},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.7156999707221985},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6370999813079834},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5587000250816345},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5307999849319458},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.5224000215530396},{"id":"https://openalex.org/C33009525","wikidata":"https://www.wikidata.org/wiki/Q208841","display_name":"Coevolution","level":2,"score":0.4733999967575073},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.43950000405311584},{"id":"https://openalex.org/C2554327","wikidata":"https://www.wikidata.org/wiki/Q2698599","display_name":"Coalescent theory","level":4,"score":0.42320001125335693},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.38769999146461487},{"id":"https://openalex.org/C44527532","wikidata":"https://www.wikidata.org/wiki/Q722612","display_name":"Macroevolution","level":4,"score":0.37610000371932983},{"id":"https://openalex.org/C21833749","wikidata":"https://www.wikidata.org/wiki/Q7189431","display_name":"Viral phylodynamics","level":4,"score":0.3747999966144562},{"id":"https://openalex.org/C85721925","wikidata":"https://www.wikidata.org/wiki/Q31151","display_name":"Population genetics","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.3582000136375427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35019999742507935},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C167683757","wikidata":"https://www.wikidata.org/wiki/Q5937774","display_name":"Human evolutionary genetics","level":4,"score":0.33399999141693115},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3248000144958496},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C54809848","wikidata":"https://www.wikidata.org/wiki/Q1918189","display_name":"Meiotic drive","level":4,"score":0.31360000371932983},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C106978037","wikidata":"https://www.wikidata.org/wiki/Q967880","display_name":"Panmixia","level":5,"score":0.3001999855041504},{"id":"https://openalex.org/C2776838516","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C196662502","wikidata":"https://www.wikidata.org/wiki/Q827541","display_name":"Molecular clock","level":4,"score":0.2973000109195709},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C2777949028","wikidata":"https://www.wikidata.org/wiki/Q25303868","display_name":"Rate of evolution","level":4,"score":0.29109999537467957},{"id":"https://openalex.org/C2779040068","wikidata":"https://www.wikidata.org/wiki/Q7229807","display_name":"Population genomics","level":5,"score":0.2856000065803528},{"id":"https://openalex.org/C68775705","wikidata":"https://www.wikidata.org/wiki/Q903761","display_name":"Parallel evolution","level":4,"score":0.2775999903678894},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.27559998631477356},{"id":"https://openalex.org/C124388736","wikidata":"https://www.wikidata.org/wiki/Q3247497","display_name":"Tree of life (biology)","level":4,"score":0.2732999920845032},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C2780263730","wikidata":"https://www.wikidata.org/wiki/Q4254955","display_name":"Horizontal transmission","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C26619641","wikidata":"https://www.wikidata.org/wiki/Q3142246","display_name":"Phylogenetic network","level":4,"score":0.258899986743927},{"id":"https://openalex.org/C2781011139","wikidata":"https://www.wikidata.org/wiki/Q181537","display_name":"Amniote","level":4,"score":0.25679999589920044},{"id":"https://openalex.org/C71640776","wikidata":"https://www.wikidata.org/wiki/Q16521","display_name":"Taxon","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C67205732","wikidata":"https://www.wikidata.org/wiki/Q966735","display_name":"Cline (biology)","level":3,"score":0.2533999979496002}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.11.751054","doi":"https://doi.org/10.64898/2026.09.11.751054","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.751054","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.751054.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622707","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622707/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.11.751054","doi":"https://doi.org/10.64898/2026.09.11.751054","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.751054","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/12/2026.09.11.751054.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G403155455","display_name":"NSF-Simons National Institute for Theory and Mathematics in Biology","funder_award_id":"2235451","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000873382","display_name":"Genetic Mechanisms and Evolution","funder_award_id":"T32GM139782","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000901551","display_name":"Population genetic methods to detect population structure and adaptation using modern and ancient genomic datasets","funder_award_id":"R01GM146051","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212356458.pdf","grobid_xml":"https://content.openalex.org/works/W7212356458.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393303805","https://openalex.org/W3163779515","https://openalex.org/W2749943006","https://openalex.org/W2092048008","https://openalex.org/W4392736405","https://openalex.org/W7100308901","https://openalex.org/W2952902141","https://openalex.org/W7167675872","https://openalex.org/W7151120961","https://openalex.org/W4377293776"],"abstract_inverted_index":{"Cophylogeny,":[0],"the":[1,12,21,30,33,48,51,80,94,104,108,142,193],"study":[2],"of":[3,18,24,35,96,107,144,219,225],"phylogenetic":[4,70],"similarity":[5],"between":[6,54,75,166],"interacting":[7],"organisms,":[8],"provides":[9],"insights":[10],"into":[11],"specificity":[13],"and":[14,91,150,168,189,221],"shared":[15],"evolutionary":[16,121],"history":[17],"symbiosis.":[19],"While":[20],"ecological":[22],"drivers":[23],"cophylogeny":[25,116,167,178,210,220],"have":[26],"been":[27],"investigated":[28],"at":[29],"macroevolutionary":[31,159],"scale,":[32],"influence":[34],"these":[36],"processes":[37],"on":[38,153],"microevolution":[39],"remains":[40],"unclear.":[41],"This":[42,86,127],"is":[43],"due,":[44],"in":[45,179,207],"part,":[46],"to":[47,83,113,123,158,187],"fact":[49],"that":[50],"ancestral":[52,98],"relations":[53],"individuals":[55,76],"within":[56,192],"a":[57,68,119,124,163,197],"sexually":[58],"reproducing":[59],"eukaryotic":[60],"host":[61,125],"species":[62],"cannot":[63],"be":[64,89],"well":[65,134],"represented":[66],"with":[67,171,200],"single":[69],"tree,":[71],"since":[72],"genetic":[73],"distances":[74],"change":[77],"substantially":[78],"across":[79,211],"genome":[81],"due":[82],"meiotic":[84],"recombination.":[85],"heterogeneity":[87],"can":[88],"captured":[90],"utilized":[92],"through":[93],"inference":[95],"an":[97],"recombination":[99],"graph":[100],"(ARG)":[101],"built":[102],"from":[103],"genomic":[105],"data":[106],"host.":[109],"Here,":[110],"we":[111,140,161,215],"propose":[112],"measure":[114],"microevolutionary":[115,154],"by":[117],"comparing":[118],"symbiont":[120],"tree":[122],"ARG.":[126],"approach":[128,186],"simultaneously":[129],"measures":[130],"genome-wide":[131],"cophylogeny,":[132],"as":[133,135],"locus-specific":[136,217],"signals.":[137],"Through":[138],"simulations,":[139],"investigate":[141,216],"effects":[143],"transmission":[145],"mode,":[146],"population":[147],"structure,":[148],"admixture,":[149],"allelic":[151],"incompatibility":[152],"cophylogeny.":[155],"In":[156],"contrast":[157],"patterns,":[160],"find":[162],"limited":[164,223],"relationship":[165],"vertical":[169],"transmission,":[170],"vertically":[172],"transmitted":[173],"host-symbiont":[174,198],"systems":[175],"displaying":[176],"no":[177],"large":[180],"panmictic":[181],"populations.":[182,213],"We":[183],"apply":[184],"our":[185],"mitochondrial":[188],"nuclear":[190],"genomes":[191],"1000":[194],"Genomes":[195],"Project-":[196],"system":[199],"strict":[201],"maternal":[202],"transmission-and":[203],"observe":[204,222],"substantial":[205],"variation":[206],"mitochondrial-nuclear":[208],"(mitonuclear)":[209],"human":[212],"Finally,":[214],"signals":[218],"evidence":[224],"mitonuclear":[226],"incompatibility.":[227]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-13T00:00:00"}
