{"id":"https://openalex.org/W7212325807","doi":"https://doi.org/10.64898/2026.09.08.750075","title":"Deoxyribonucleotide dephosphorylation by VENOSA4 supports organellar genome replication in plants","display_name":"Deoxyribonucleotide dephosphorylation by VENOSA4 supports organellar genome replication in plants","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212325807","doi":"https://doi.org/10.64898/2026.09.08.750075"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.750075","doi":"https://doi.org/10.64898/2026.09.08.750075","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750075","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.08.750075.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.08.750075.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101622532","display_name":"Lisa Fischer","orcid":"https://orcid.org/0000-0001-5033-2490","observed_orcids":["https://orcid.org/0000-0001-5033-2490"]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Fischer","raw_affiliation_strings":["Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5033-2490","affiliations":[{"raw_affiliation_string":"Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037253656","display_name":"Henryk Straube","orcid":"https://orcid.org/0000-0001-9286-7784","observed_orcids":["https://orcid.org/0000-0001-9286-7784"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henryk Straube","raw_affiliation_strings":["Section for Plant Biochemistry, Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9286-7784","affiliations":[{"raw_affiliation_string":"Section for Plant Biochemistry, Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151324457","display_name":"Nele Passon","orcid":"https://orcid.org/0009-0002-6585-152X","observed_orcids":["https://orcid.org/0009-0002-6585-152X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nele Passon","raw_affiliation_strings":["Institute for Plant Sciences, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0009-0002-6585-152X","affiliations":[{"raw_affiliation_string":"Institute for Plant Sciences, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151386433","display_name":"Hildegard Thoelke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hildegard Th\u00f6lke","raw_affiliation_strings":["Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082035581","display_name":"Claus\u2010Peter Witte","orcid":"https://orcid.org/0000-0002-3617-7807","observed_orcids":["https://orcid.org/0000-0002-3617-7807"]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus-Peter Witte","raw_affiliation_strings":["Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3617-7807","affiliations":[{"raw_affiliation_string":"Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048745808","display_name":"Marco Herde","orcid":"https://orcid.org/0000-0003-2804-0613","observed_orcids":["https://orcid.org/0000-0003-2804-0613"]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marco Herde","raw_affiliation_strings":["Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2804-0613","affiliations":[{"raw_affiliation_string":"Institute of Plant Nutrition, Leibniz University Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I114112103"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048745808"],"corresponding_institution_ids":["https://openalex.org/I114112103"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloroplast-dna-replication","display_name":"chloroplast DNA replication","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mitochondrial-dna-replication","display_name":"mitochondrial DNA replication","score":0.9900000095367432},{"id":"https://openalex.org/keywords/germination","display_name":"germination","score":0.6029999852180481},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6725999712944031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6065999865531921},{"id":"https://openalex.org/C2780349520","wikidata":"https://www.wikidata.org/wiki/Q28751","display_name":"Deoxyribonucleotide","level":4,"score":0.5784000158309937},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49799999594688416},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.48989999294281006},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.4016999900341034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38109999895095825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3695000112056732},{"id":"https://openalex.org/C69305403","wikidata":"https://www.wikidata.org/wiki/Q47263","display_name":"Chloroplast","level":3,"score":0.36169999837875366},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.3424000144004822},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.3416000008583069},{"id":"https://openalex.org/C101097943","wikidata":"https://www.wikidata.org/wiki/Q5176983","display_name":"Counterintuitive","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.3287000060081482},{"id":"https://openalex.org/C48050816","wikidata":"https://www.wikidata.org/wiki/Q3182853","display_name":"Chloroplast DNA","level":4,"score":0.32829999923706055},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3199000060558319},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.313400000333786},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.29739999771118164},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C54266558","wikidata":"https://www.wikidata.org/wiki/Q6543075","display_name":"Licensing factor","level":5,"score":0.28760001063346863},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.26339998841285706},{"id":"https://openalex.org/C149187182","wikidata":"https://www.wikidata.org/wiki/Q22325217","display_name":"Replisome","level":5,"score":0.2603999972343445},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.2549000084400177},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.08.750075","doi":"https://doi.org/10.64898/2026.09.08.750075","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750075","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.08.750075.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.750075","doi":"https://doi.org/10.64898/2026.09.08.750075","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750075","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.08.750075.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212325807.pdf","grobid_xml":"https://content.openalex.org/works/W7212325807.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W758219017","https://openalex.org/W1964767348","https://openalex.org/W1966619967","https://openalex.org/W1966681259","https://openalex.org/W1970374486","https://openalex.org/W1973756031","https://openalex.org/W1981985887","https://openalex.org/W1987230629","https://openalex.org/W1987348130","https://openalex.org/W1989288968","https://openalex.org/W1989682879","https://openalex.org/W1992007798","https://openalex.org/W1999699035","https://openalex.org/W2015762875","https://openalex.org/W2027853473","https://openalex.org/W2030537039","https://openalex.org/W2030912673","https://openalex.org/W2034380296","https://openalex.org/W2038028859","https://openalex.org/W2052666860","https://openalex.org/W2073842077","https://openalex.org/W2074692601","https://openalex.org/W2079171949","https://openalex.org/W2082855334","https://openalex.org/W2091350791","https://openalex.org/W2105199418","https://openalex.org/W2107277218","https://openalex.org/W2109589477","https://openalex.org/W2136362180","https://openalex.org/W2136748758","https://openalex.org/W2159267296","https://openalex.org/W2163215727","https://openalex.org/W2165389589","https://openalex.org/W2167279371","https://openalex.org/W2168777478","https://openalex.org/W2246615985","https://openalex.org/W2532475852","https://openalex.org/W2751108361","https://openalex.org/W2756555302","https://openalex.org/W2768767645","https://openalex.org/W2806513379","https://openalex.org/W2883213833","https://openalex.org/W2889971538","https://openalex.org/W2897309739","https://openalex.org/W2897849962","https://openalex.org/W2946113823","https://openalex.org/W2973685516","https://openalex.org/W2981466220","https://openalex.org/W2992808754","https://openalex.org/W3043986447","https://openalex.org/W3049565896","https://openalex.org/W3121909075","https://openalex.org/W3156267483","https://openalex.org/W3191630617","https://openalex.org/W3217339595","https://openalex.org/W4210926397","https://openalex.org/W4256321774","https://openalex.org/W4281400720","https://openalex.org/W4284966778","https://openalex.org/W4285590450","https://openalex.org/W4286449572","https://openalex.org/W4286489478","https://openalex.org/W4310709907","https://openalex.org/W4385703543","https://openalex.org/W4399568544","https://openalex.org/W4413309075"],"related_works":["https://openalex.org/W4385703543","https://openalex.org/W2992808754","https://openalex.org/W6906047123","https://openalex.org/W3052063446","https://openalex.org/W2096587462","https://openalex.org/W1987230629","https://openalex.org/W4286489478","https://openalex.org/W2028374636","https://openalex.org/W1042552443","https://openalex.org/W272651521"],"abstract_inverted_index":{"The":[0,31],"replication":[1],"of":[2,20,40,64,132,140,149,170],"the":[3,23,26,36,44,53,67,130,136,152,155],"three":[4],"genomes":[5],"in":[6,52,85,147],"plant":[7],"cells":[8],"during":[9],"germination":[10],"is":[11,59,69,80],"a":[12,17,77,180],"complex":[13],"process,":[14],"which":[15],"requires":[16],"high":[18],"degree":[19],"coordination":[21],"between":[22,187],"genome-containing":[24],"compartments:":[25],"nucleus,":[27],"mitochondria,":[28],"and":[29,120,154,176,193],"chloroplasts.":[30],"first":[32],"committed":[33],"step":[34],"for":[35,47,66,82,163],"de":[37,103,171],"novo":[38,104,172],"synthesis":[39],"deoxynucleoside":[41],"triphosphates":[42],"(dNTPs),":[43],"building":[45],"blocks":[46],"DNA":[48,145,164,184],"replication,":[49],"occurs":[50],"exclusively":[51],"cytosol.":[54],"A":[55],"major":[56],"unresolved":[57],"question":[58],"how":[60],"an":[61],"adequate":[62],"supply":[63],"dNTPs":[65,106,162],"organelles":[68],"achieved.":[70],"Here,":[71],"we":[72,97],"show":[73],"that":[74,99,143],"VENOSA4":[75],"(VEN4),":[76],"dNTP":[78,137,174],"triphosphohydrolase,":[79],"critical":[81],"this":[83,111],"process":[84],"Arabidopsis":[86],"thaliana":[87],".":[88],"Using":[89],"isotope":[90],"feeding":[91],"combined":[92],"with":[93],"mass":[94],"spectrometry":[95],"analysis,":[96],"demonstrate":[98],"VEN4":[100,114,141],"converts":[101],"most":[102],"-synthesized":[105],"to":[107,157,161,182],"deoxynucleosides":[108],"(dNs).":[109],"Preventing":[110],"conversion":[112],"by":[113,129],"mutation":[115],"strongly":[116],"diminishes":[117],"both":[118],"cpDNA":[119],"mtDNA":[121],"amounts,":[122],"but":[123],"these":[124],"can":[125],"be":[126,158],"partially":[127],"rescued":[128],"application":[131],"exogenous":[133],"dNs.":[134],"Hence,":[135],"catabolic":[138],"activity":[139],"ensures":[142],"sufficient":[144],"precursors":[146],"form":[148],"dNs":[150],"reach":[151],"chloroplasts":[153],"mitochondria":[156],"salvaged":[159],"there":[160],"synthesis.":[165],"This":[166],"seemingly":[167],"counterintuitive":[168],"coupling":[169],"synthesis,":[173],"hydrolysis,":[175],"salvage":[177],"may":[178],"provide":[179],"mechanism":[181],"control":[183],"precursor":[185],"allocation":[186],"cellular":[188],"compartments":[189],"through":[190],"selective":[191],"transport":[192],"metabolic":[194],"trapping.":[195]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-12T00:00:00"}
