{"id":"https://openalex.org/W7212309060","doi":"https://doi.org/10.1200/cci-26-00027","title":"Reusable Pipeline for Converting Real-World Lymphoma Registry Data to CDISC Standards: Implementation and Validation Using Lymphoma Epidemiology of Outcomes Consortium for Real World Evidence","display_name":"Reusable Pipeline for Converting Real-World Lymphoma Registry Data to CDISC Standards: Implementation and Validation Using Lymphoma Epidemiology of Outcomes Consortium for Real World Evidence","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7212309060","doi":"https://doi.org/10.1200/cci-26-00027","pmid":"https://pubmed.ncbi.nlm.nih.gov/42726020"},"language":"en","primary_location":{"id":"doi:10.1200/cci-26-00027","doi":"https://doi.org/10.1200/cci-26-00027","is_oa":false,"landing_page_url":"https://doi.org/10.1200/cci-26-00027","pdf_url":null,"source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084276871","display_name":"Michael J. Kane","orcid":"https://orcid.org/0000-0003-1899-6662","observed_orcids":["https://orcid.org/0000-0003-1899-6662"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Kane","raw_affiliation_strings":["Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-1899-6662","affiliations":[{"raw_affiliation_string":"Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055368165","display_name":"Dai Chihara","orcid":"https://orcid.org/0000-0002-1153-2294","observed_orcids":["https://orcid.org/0000-0002-1153-2294"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dai Chihara","raw_affiliation_strings":["Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-1153-2294","affiliations":[{"raw_affiliation_string":"Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064395419","display_name":"Amy A. Ayers","orcid":"https://orcid.org/0000-0003-4807-2356","observed_orcids":["https://orcid.org/0000-0003-4807-2356"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Ayers","raw_affiliation_strings":["Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082892912","display_name":"Christopher R. Flowers","orcid":"https://orcid.org/0000-0002-9524-3990","observed_orcids":["https://orcid.org/0000-0002-9524-3990"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Flowers","raw_affiliation_strings":["Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-9524-3990","affiliations":[{"raw_affiliation_string":"Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69345586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"3","first_page":"e2600027","last_page":"e2600027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11937","display_name":"Research Data Management Practices","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/1710","display_name":"Information Systems"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cancer-registry","display_name":"cancer registry","score":0.8769999742507935},{"id":"https://openalex.org/keywords/large-b-cell-lymphoma","display_name":"large B-cell lymphoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.7979999780654907},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sdtm","display_name":"SDTM","score":0.906000018119812},{"id":"https://openalex.org/keywords/axicabtagene-ciloleucel","display_name":"axicabtagene ciloleucel","score":0.8809999823570251},{"id":"https://openalex.org/keywords/federated-analytics","display_name":"federated analysis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/regulatory-decision-support","display_name":"regulatory decision support","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7717000246047974},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6258999705314636},{"id":"https://openalex.org/C3020493868","wikidata":"https://www.wikidata.org/wiki/Q55631277","display_name":"Real world data","level":2,"score":0.5342000126838684},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.48750001192092896},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4706000089645386},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3628999888896942},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3314000070095062},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C2987006973","wikidata":"https://www.wikidata.org/wiki/Q17319650","display_name":"Data entry","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.3172999918460846},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C2778959093","wikidata":"https://www.wikidata.org/wiki/Q5282128","display_name":"Disease registry","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.28870001435279846},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.27070000767707825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C206497026","wikidata":"https://www.wikidata.org/wiki/Q1753883","display_name":"SNOMED CT","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.25200000405311584},{"id":"https://openalex.org/C1668388","wikidata":"https://www.wikidata.org/wiki/Q1149776","display_name":"Data management","level":2,"score":0.25}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1200/cci-26-00027","doi":"https://doi.org/10.1200/cci-26-00027","is_oa":false,"landing_page_url":"https://doi.org/10.1200/cci-26-00027","pdf_url":null,"source":{"id":"https://openalex.org/S4210181501","display_name":"JCO Clinical Cancer Informatics","issn_l":"2473-4276","issn":["2473-4276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Clinical Cancer Informatics","raw_type":"journal-article"},{"id":"pmid:42726020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42726020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO clinical cancer informatics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2153587171","https://openalex.org/W3084470313","https://openalex.org/W3207044036","https://openalex.org/W4206238712","https://openalex.org/W4220992493","https://openalex.org/W4283459994","https://openalex.org/W4284899279","https://openalex.org/W4389180535","https://openalex.org/W4399570961","https://openalex.org/W4399608295","https://openalex.org/W4400524256","https://openalex.org/W4402250210","https://openalex.org/W4405430212","https://openalex.org/W4407237403","https://openalex.org/W4408211445","https://openalex.org/W4413362448"],"related_works":["https://openalex.org/W4413774088","https://openalex.org/W4410448615","https://openalex.org/W4413810731","https://openalex.org/W4387900904","https://openalex.org/W4399480796","https://openalex.org/W4311211347","https://openalex.org/W7166095517","https://openalex.org/W4399480668","https://openalex.org/W7202373802","https://openalex.org/W6946012512"],"abstract_inverted_index":{"PURPOSE:":[0],"Heterogeneity":[1],"in":[2,27,35,199,218],"cancer":[3],"registries":[4],"limits":[5],"reuse":[6],"of":[7,55,176,204],"real-world":[8],"data":[9,72,91],"(RWD)":[10],"alongside":[11],"clinical":[12],"trials":[13,32],"to":[14,50],"support":[15],"regulatory":[16],"decisions.":[17],"Rituximab,":[18],"gemcitabine,":[19],"and":[20,33,84,101,147,195],"oxaliplatin":[21],"(R-GemOx)":[22],"is":[23],"commonly":[24],"a":[25,47,76,183,211],"comparator":[26],"large":[28],"B-cell":[29],"lymphoma":[30],"(LBCL)":[31],"used":[34],"practice,":[36],"but":[37],"RWD":[38,217],"are":[39],"not":[40],"structured":[41],"for":[42,58,107,131,215],"trial":[43],"comparison.":[44],"We":[45],"developed":[46],"reusable":[48,213],"pipeline":[49,214],"convert":[51],"the":[52,98,117,158],"Lymphoma":[53],"Epidemiology":[54],"Outcomes":[56],"Consortium":[57,70],"Real":[59],"World":[60],"Evidence":[61],"(LEO":[62],"CReWE)":[63],"registry":[64],"into":[65],"Clinical":[66],"Data":[67,80,88],"Interchange":[68],"Standards":[69],"(CDISC)-compliant":[71],"sets":[73],"by":[74],"constructing":[75],"generalized,":[77],"registry-wide":[78],"Study":[79],"Tabulation":[81],"Model":[82,89],"(SDTM)":[83],"deriving":[85],"analysis-ready":[86],"Analysis":[87],"(ADaM)":[90],"sets.":[92],"METHODS:":[93],"Using":[94],"R":[95],"4.5.2":[96],"with":[97,110,114,128,187],"sdtm.oak,":[99],"admiral,":[100],"admiralonco":[102],"packages,":[103],"we":[104],"generated":[105],"ADaM":[106,177],"183":[108],"patients":[109],"relapsed/refractory":[111],"LBCL":[112],"treated":[113,186],"R-GemOx":[115],"across":[116],"multicenter":[118],"LEO":[119],"cohort.":[120],"RESULTS:":[121],"ADaM-derived":[122],"summary":[123],"statistics":[124],"showed":[125],"exact":[126],"concordance":[127],"published":[129],"results":[130],"this":[132],"cohort:":[133],"median":[134,142,148],"age":[135],"68":[136],"years,":[137],"complete":[138],"response":[139],"rate":[140],"29%,":[141],"overall":[143],"survival":[144,150],"13.5":[145],"months,":[146],"event-free":[149],"2.3":[151],"months.":[152],"CDISC":[153,159],"conformance":[154],"was":[155],"assessed":[156],"using":[157],"Open":[160],"Rules":[161],"Engine":[162],"(CORE);":[163],"no":[164],"finding":[165],"represented":[166],"rejection-level":[167],"structural":[168],"nonconformance.":[169],"The":[170],"generalized":[171],"SDTM":[172],"enabled":[173],"rapid":[174],"regeneration":[175],"as":[178],"cohort":[179,185],"definitions":[180],"changed,":[181],"including":[182],"separate":[184],"axicabtagene":[188],"ciloleucel":[189],"(a":[190],"chimeric":[191],"antigen":[192],"receptor":[193],"T-cell),":[194],"supports":[196],"federated":[197],"analyses":[198],"which":[200],"sites":[201],"retain":[202],"control":[203],"patient-level":[205],"data.":[206],"CONCLUSION:":[207],"This":[208],"work":[209],"demonstrates":[210],"practical,":[212],"CDISC-standardized":[216],"lymphoma.":[219]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-09-12T00:00:00"}
