{"id":"https://openalex.org/W7212301713","doi":"https://doi.org/10.64898/2026.09.07.749773","title":"The CD112-TIGIT/PVRIG Axis Mediates NK Cell Evasion in Decitabine-Treated Acute Myeloid Leukemia Cells","display_name":"The CD112-TIGIT/PVRIG Axis Mediates NK Cell Evasion in Decitabine-Treated Acute Myeloid Leukemia Cells","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212301713","doi":"https://doi.org/10.64898/2026.09.07.749773"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.07.749773","doi":"https://doi.org/10.64898/2026.09.07.749773","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749773","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.07.749773.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.07.749773.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070547574","display_name":"Keisuke Nakamura","orcid":"https://orcid.org/0000-0002-6368-2569","observed_orcids":["https://orcid.org/0000-0002-6368-2569","https://orcid.org/0000-0001-7801-2069"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Nakamura","raw_affiliation_strings":["Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan","Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088108345","display_name":"Ikuko Omori","orcid":"https://orcid.org/0000-0002-8040-8764","observed_orcids":["https://orcid.org/0000-0002-8040-8764"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuko Omori","raw_affiliation_strings":["Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8040-8764","affiliations":[{"raw_affiliation_string":"Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102884391","display_name":"Naru Sato","orcid":"https://orcid.org/0000-0003-0452-3194","observed_orcids":["https://orcid.org/0000-0003-0452-3194"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naru Sato","raw_affiliation_strings":["Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0452-3194","affiliations":[{"raw_affiliation_string":"Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086241483","display_name":"Susumu Goyama","orcid":"https://orcid.org/0000-0002-9339-1826","observed_orcids":["https://orcid.org/0000-0002-9339-1826"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Goyama","raw_affiliation_strings":["Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9339-1826","affiliations":[{"raw_affiliation_string":"Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054497666","display_name":"Toshio Kitamura","orcid":"https://orcid.org/0000-0001-7855-1767","observed_orcids":["https://orcid.org/0000-0001-7855-1767"]},"institutions":[{"id":"https://openalex.org/I4210167395","display_name":"Foundation for Biomedical Research and Innovation","ror":"https://ror.org/05xe40a72","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210167395"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Kitamura","raw_affiliation_strings":["Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan","Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7855-1767","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan","institution_ids":["https://openalex.org/I4210167395"]},{"raw_affiliation_string":"Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079737516","display_name":"Yutaka Enomoto","orcid":"https://orcid.org/0000-0002-6346-9362","observed_orcids":["https://orcid.org/0000-0002-6346-9362"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yutaka Enomoto","raw_affiliation_strings":["Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6346-9362","affiliations":[{"raw_affiliation_string":"Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079737516"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cd112","display_name":"CD112","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tigit","display_name":"TIGIT","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pvrig","display_name":"PVRIG","score":0.996999979019165},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.843999981880188},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enhancer-demethylation","display_name":"enhancer demethylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7160000205039978},{"id":"https://openalex.org/keywords/nk-92-cells","display_name":"NK-92 cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/inhibitory-receptors","display_name":"inhibitory receptors","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7070000171661377},{"id":"https://openalex.org/C2779118045","wikidata":"https://www.wikidata.org/wiki/Q21114021","display_name":"TIGIT","level":4,"score":0.6499999761581421},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5935999751091003},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5378000140190125},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5325000286102295},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.5113999843597412},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5095000267028809},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4909000098705292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4652999937534332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4514999985694885},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.45100000500679016},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4219000041484833},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4083000123500824},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.39660000801086426},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3946000039577484},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.38609999418258667},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.3774999976158142},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.36629998683929443},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34200000762939453},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.3147999942302704},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3059000074863434},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C2776012956","wikidata":"https://www.wikidata.org/wiki/Q17125294","display_name":"Hypomethylating agent","level":5,"score":0.2987000048160553},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26980000734329224},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.2655999958515167},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.2524999976158142},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2500999867916107},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.07.749773","doi":"https://doi.org/10.64898/2026.09.07.749773","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749773","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.07.749773.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.07.749773","doi":"https://doi.org/10.64898/2026.09.07.749773","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749773","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.07.749773.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1957627928","display_name":null,"funder_award_id":"JPMJSP2108","funder_id":"https://openalex.org/F4320322832","funder_display_name":"University of Tokyo"},{"id":"https://openalex.org/G2096142221","display_name":"Exploration of molecules that induce activation of anti-tumor immunity and enhance the efficacy of AML drug therapy","funder_award_id":"22K08496","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3752857035","display_name":null,"funder_award_id":"JPMJSP2108","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212301713.pdf","grobid_xml":"https://content.openalex.org/works/W7212301713.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966013694","https://openalex.org/W3209912486","https://openalex.org/W4386910609","https://openalex.org/W3206831592","https://openalex.org/W2470200249","https://openalex.org/W3216661796","https://openalex.org/W2080016709","https://openalex.org/W3000002303","https://openalex.org/W2977942575","https://openalex.org/W4400358350"],"abstract_inverted_index":{"Abstract":[0],"Both":[1],"drug":[2],"resistance":[3],"and":[4,18,33,72,145,171,194],"immune":[5,31,190],"evasion":[6,191],"are":[7],"considered":[8],"to":[9,11,56,69,131,208],"contribute":[10],"the":[12,50,116,164,205],"persistence":[13],"of":[14,38,52,76,85,92,111,120,138,143,166,188,204],"residual":[15],"AML":[16,54,62,88,151,193],"cells":[17,24,55,63,89,104],"disease":[19],"relapse.":[20],"Natural":[21],"killer":[22,58],"(NK)":[23,59],"play":[25],"an":[26],"important":[27],"role":[28],"in":[29,41,87,102,192],"antileukemic":[30,47,212],"surveillance":[32],"represent":[34],"a":[35,186,196],"key":[36],"component":[37],"antitumor":[39],"immunity":[40],"AML.":[42],"Here,":[43],"we":[44],"investigated":[45],"whether":[46],"drugs":[48,170],"alter":[49],"susceptibility":[51],"surviving":[53,64],"natural":[57],"cell-mediated":[60,211],"cytotoxicity.":[61,106],"decitabine":[65,108],"treatment":[66],"became":[67],"resistant":[68],"NK-92-mediated":[70,81],"killing":[71],"showed":[73],"marked":[74],"upregulation":[75,154],"CD112.":[77],"CD112":[78,86,117,124,133,139,153,177],"overexpression":[79],"reduced":[80],"cytotoxicity,":[82],"whereas":[83],"deletion":[84,91],"or":[90,95,140,160],"either":[93,121],"TIGIT":[94,144],"PVRIG,":[96],"two":[97,112],"inhibitory":[98],"receptors":[99],"for":[100,198],"CD112,":[101],"NK-92":[103],"restored":[105],"Mechanistically,":[107],"induced":[109],"demethylation":[110,129],"enhancer":[113,122,128,183],"regions":[114],"within":[115],"locus.":[118],"Deletion":[119],"attenuated":[123],"upregulation,":[125,178],"suggesting":[126],"that":[127],"contributes":[130],"decitabine-induced":[132],"expression.":[134],"Furthermore,":[135],"antibody-mediated":[136],"blockade":[137,142,203],"combined":[141],"PVRIG":[146],"enhanced":[147],"cytotoxicity":[148],"against":[149],"decitabine-treated":[150],"cells.":[152],"was":[155],"also":[156],"observed":[157],"following":[158],"azacitidine":[159],"cytarabine":[161],"treatment,":[162],"although":[163],"magnitude":[165],"induction":[167],"varied":[168],"across":[169],"cell":[172],"lines.":[173],"These":[174],"findings":[175],"identify":[176],"which":[179],"is":[180],"associated":[181],"with":[182,202],"demethylation,":[184],"as":[185],"mechanism":[187],"drug-induced":[189],"provide":[195],"rationale":[197],"combining":[199],"hypomethylating":[200],"agents":[201],"CD112-TIGIT/PVRIG":[206],"axis":[207],"enhance":[209],"NK":[210],"activity.":[213]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-12T00:00:00"}