{"id":"https://openalex.org/W7212297968","doi":"https://doi.org/10.64898/2026.09.09.750392","title":"Glycometabolic, inflammatory and exocrine plasma proteins predict cancer in individuals with cardiovascular disease","display_name":"Glycometabolic, inflammatory and exocrine plasma proteins predict cancer in individuals with cardiovascular disease","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212297968","doi":"https://doi.org/10.64898/2026.09.09.750392"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.09.750392","doi":"https://doi.org/10.64898/2026.09.09.750392","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750392","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.09.750392.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.09.750392.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000957735","display_name":"Marine Fidelle","orcid":"https://orcid.org/0000-0002-5589-9688","observed_orcids":["https://orcid.org/0000-0002-5589-9688"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marine Fidelle","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France"],"raw_orcid":"https://orcid.org/0000-0002-5589-9688","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037983532","display_name":"David Boulate","orcid":"https://orcid.org/0000-0003-4757-4565","observed_orcids":["https://orcid.org/0000-0003-4757-4565"]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210115034","display_name":"H\u00f4pital Nord","ror":"https://ror.org/029a4pp87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210115034"]},{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Boulate","raw_affiliation_strings":["Department of Thoracic Surgery, H\u00f4pital-Nord-APHM, Aix-Marseille University, Marseille, France","Marie Lannelongue Hospital, GHPSJ, Le Plessis-Robinson, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, H\u00f4pital-Nord-APHM, Aix-Marseille University, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210115034"]},{"raw_affiliation_string":"Marie Lannelongue Hospital, GHPSJ, Le Plessis-Robinson, France","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102694104","display_name":"Thao-Nguyen Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thao-Nguyen Pham","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151384301","display_name":"Antoine Giboudot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Giboudot","raw_affiliation_strings":["UMR5308, INSERM U1111, Centre International de Recherche en Infectiologie, Centre National de la Recherche Scientifique, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR5308, INSERM U1111, Centre International de Recherche en Infectiologie, Centre National de la Recherche Scientifique, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106778059","display_name":"Louis Picq","orcid":"https://orcid.org/0009-0003-9898-9178","observed_orcids":["https://orcid.org/0009-0003-9898-9178"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Louis Picq","raw_affiliation_strings":["UMR5308, INSERM U1111, Centre International de Recherche en Infectiologie, Centre National de la Recherche Scientifique, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR5308, INSERM U1111, Centre International de Recherche en Infectiologie, Centre National de la Recherche Scientifique, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059383902","display_name":"Pamela Abdayem","orcid":"https://orcid.org/0000-0002-4477-3633","observed_orcids":["https://orcid.org/0000-0002-4477-3633"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pamela Abdayem","raw_affiliation_strings":["Gustave Roussy, D\u00e9partement de m\u00e9decine oncologique, F-94805, Villejuif France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gustave Roussy, D\u00e9partement de m\u00e9decine oncologique, F-94805, Villejuif France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059057760","display_name":"Aline Renneville","orcid":"https://orcid.org/0000-0003-0805-9640","observed_orcids":["https://orcid.org/0000-0003-0805-9640"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aline Renneville","raw_affiliation_strings":["Department of Medical Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France","Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm UMR1287, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology and Pathology, Gustave Roussy Cancer Campus, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm UMR1287, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067624116","display_name":"Pauline Prad\u00e8re","orcid":"https://orcid.org/0000-0003-4043-4666","observed_orcids":["https://orcid.org/0000-0003-4043-4666"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pauline Prad\u00e8re","raw_affiliation_strings":["Pneumology Department, Marie Lannelongue Hospital, INSERM UMR-S 999, Paris Saint Joseph Hospital and Paris Saclay University, Le Plessis-Robinson, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Department, Marie Lannelongue Hospital, INSERM UMR-S 999, Paris Saint Joseph Hospital and Paris Saclay University, Le Plessis-Robinson, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011984137","display_name":"Caroline Caramella","orcid":"https://orcid.org/0000-0003-1517-2510","observed_orcids":["https://orcid.org/0000-0003-1517-2510"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]},{"id":"https://openalex.org/I4405259047","display_name":"Laboratoire d'Imagerie Biom\u00e9dicale Multimodale Paris-Saclay","ror":"https://ror.org/01mxn9q79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210113668","https://openalex.org/I4405259047"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Caramella","raw_affiliation_strings":["BIOMAPS, UMR 1281, Universit\u00e9 Paris-Saclay, Inserm, CNRS, CEA, France","Department of Radiology, H\u00f4pital Marie-Lannelongue, GHPSJ, Le Plessis Robinson, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOMAPS, UMR 1281, Universit\u00e9 Paris-Saclay, Inserm, CNRS, CEA, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4405259047"]},{"raw_affiliation_string":"Department of Radiology, H\u00f4pital Marie-Lannelongue, GHPSJ, Le Plessis Robinson, France","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090572918","display_name":"Sylv\u00e8re Durand","orcid":"https://orcid.org/0000-0001-6356-1006","observed_orcids":["https://orcid.org/0000-0001-6356-1006"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylv\u00e8re Durand","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), Metabolomics Platform, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), Metabolomics Platform, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003267360","display_name":"Fanny Aprahamian","orcid":"https://orcid.org/0000-0002-2457-8435","observed_orcids":["https://orcid.org/0000-0002-2457-8435"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fanny Aprahamian","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), Metabolomics Platform, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), Metabolomics Platform, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073204917","display_name":"Thibault Dayris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thibault Dayris","raw_affiliation_strings":["Gustave Roussy, D\u00e9partement de la recherche, P\u00f4le Data, F-94805, Villejuif France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gustave Roussy, D\u00e9partement de la recherche, P\u00f4le Data, F-94805, Villejuif France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089810939","display_name":"Marc Deloger","orcid":"https://orcid.org/0000-0002-6352-101X","observed_orcids":["https://orcid.org/0000-0002-6352-101X"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Deloger","raw_affiliation_strings":["Gustave Roussy, D\u00e9partement de la recherche, P\u00f4le Data, F-94805, Villejuif France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gustave Roussy, D\u00e9partement de la recherche, P\u00f4le Data, F-94805, Villejuif France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091358858","display_name":"Nathalie M Droin","orcid":"https://orcid.org/0000-0002-6099-5324","observed_orcids":["https://orcid.org/0000-0002-6099-5324"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Droin","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm UMR1287, Villejuif, France","Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm UMR1287, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025798271","display_name":"Oc\u00e9ane Hache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Oc\u00e9ane Hache","raw_affiliation_strings":["Marie Lannelongue Hospital, GHPSJ, Le Plessis-Robinson, France","Research and Innovation Unit, H\u00f4pital Marie Lannelongue, GHPSJ, Le Plessis-Robinson, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marie Lannelongue Hospital, GHPSJ, Le Plessis-Robinson, France","institution_ids":["https://openalex.org/I4210120939"]},{"raw_affiliation_string":"Research and Innovation Unit, H\u00f4pital Marie Lannelongue, GHPSJ, Le Plessis-Robinson, France","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Magalie Martineau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magalie Martineau","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060157202","display_name":"Thierry Walzer","orcid":"https://orcid.org/0000-0002-0857-8179","observed_orcids":["https://orcid.org/0000-0002-0857-8179"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Walzer","raw_affiliation_strings":["UMR5308, INSERM U1111, Centre International de Recherche en Infectiologie, Centre National de la Recherche Scientifique, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR5308, INSERM U1111, Centre International de Recherche en Infectiologie, Centre National de la Recherche Scientifique, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085705865","display_name":"Olaf M Mercier","orcid":"https://orcid.org/0000-0002-4760-6267","observed_orcids":["https://orcid.org/0000-0002-4760-6267"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olaf Mercier","raw_affiliation_strings":["Marie Lannelongue Hospital, GHPSJ, Le Plessis-Robinson, France","Service de chirurgie thoracique et de transplantation cardiopulmonaire, H\u00f4pital Marie Lannelongue, GHPSJ, Le Plessis-Robinson, Universit\u00e9 Paris Saclay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marie Lannelongue Hospital, GHPSJ, Le Plessis-Robinson, France","institution_ids":["https://openalex.org/I4210120939"]},{"raw_affiliation_string":"Service de chirurgie thoracique et de transplantation cardiopulmonaire, H\u00f4pital Marie Lannelongue, GHPSJ, Le Plessis-Robinson, Universit\u00e9 Paris Saclay, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048024665","display_name":"Tatiana Kuznetsova","orcid":"https://orcid.org/0000-0003-4293-4576","observed_orcids":["https://orcid.org/0000-0003-4293-4576","https://orcid.org/0000-0002-6278-1979","https://orcid.org/0000-0002-8032-1132","https://orcid.org/0000-0001-5403-3885"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tatiana Kuznetsova","raw_affiliation_strings":["Department of Cardiovascular Sciences, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074612242","display_name":"Laurence Zitvogel","orcid":"https://orcid.org/0000-0003-1596-0998","observed_orcids":["https://orcid.org/0000-0003-1596-0998"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laurence Zitvogel","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077223134","display_name":"Nikos Paragios A","orcid":"https://orcid.org/0000-0002-9668-4763","observed_orcids":["https://orcid.org/0000-0002-9668-4763"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210107720","display_name":"CentraleSup\u00e9lec","ror":"https://ror.org/019tcpt25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I4210107720"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nikos Paragios","raw_affiliation_strings":["18TheraPanacea, Paris, France","MICS Laboratory, CentraleSup\u00e9lec, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18TheraPanacea, Paris, France","institution_ids":[]},{"raw_affiliation_string":"MICS Laboratory, CentraleSup\u00e9lec, Universit\u00e9 Paris-Saclay, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210107720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":["Department of Biology, Institut du Cancer Paris CARPEM, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, INSERM UMRS1138, Centre de Recherche des Cordeliers, Paris, France","Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), Metabolomics Platform, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Institut du Cancer Paris CARPEM, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, INSERM UMRS1138, Centre de Recherche des Cordeliers, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm US23, Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse (AMMICa), Metabolomics Platform, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5074612242"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-prediction","display_name":"cancer prediction","score":0.6539999842643738},{"id":"https://openalex.org/keywords/circulating-proteins","display_name":"circulating proteins","score":0.5479999780654907},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7829999923706055},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/o-glcnacase","display_name":"O-GlcNAcase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chymotrypsin-c","display_name":"CTRC","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-microseminoprotein","display_name":"beta-microseminoprotein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/glycometabolism","display_name":"glycometabolism","score":0.8930000066757202},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cancer-risk-stratification","display_name":"cancer risk stratification","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785000205039978},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5906999707221985},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.508400022983551},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45489999651908875},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44670000672340393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4431999921798706},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.41429999470710754},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4018000066280365},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.3357999920845032},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3084999918937683},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.3001999855041504},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.09.750392","doi":"https://doi.org/10.64898/2026.09.09.750392","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750392","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.09.750392.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.09.750392","doi":"https://doi.org/10.64898/2026.09.09.750392","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750392","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.09.750392.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1056382719","display_name":null,"funder_award_id":"(ANR-18-IDEX-0001)","funder_id":"https://openalex.org/F4320336689","funder_display_name":"Labex Immuno-Oncology"},{"id":"https://openalex.org/G1085172537","display_name":null,"funder_award_id":"19-CE15-0029-01","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G1397743473","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G161558081","display_name":null,"funder_award_id":"ANR-21-5 RHUS-0017","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G1723499231","display_name":null,"funder_award_id":"ANR-21-5 RHUS-0017","funder_id":"https://openalex.org/F4320336689","funder_display_name":"Labex Immuno-Oncology"},{"id":"https://openalex.org/G1846858737","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G1912211089","display_name":null,"funder_award_id":"RHUS-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2203660494","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G2264961340","display_name":"Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception.","funder_award_id":"101095604","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2485135851","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2633149742","display_name":"Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response.","funder_award_id":"825410","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2699422577","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G282393413","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G3116448791","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3231222199","display_name":null,"funder_award_id":"#ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G3235171639","display_name":null,"funder_award_id":"\u00c9quipe labellis\u00e9e LIGUE (EL2016.LNCC)","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G3599999703","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320336689","funder_display_name":"Labex Immuno-Oncology"},{"id":"https://openalex.org/G3772543176","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G3925730256","display_name":null,"funder_award_id":"19-CE15-0029-01","funder_id":"https://openalex.org/F4320336689","funder_display_name":"Labex Immuno-Oncology"},{"id":"https://openalex.org/G4323719209","display_name":null,"funder_award_id":"RHU5 - IMMUNOLIFE ANR-21-5 RHUS-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4555503603","display_name":"Regulation of ileal immune responses in the immunosurveillance of colon cancer: role of DAMPs, PAMPs, and self antigens.","funder_award_id":"ANR-19-CE15-0029","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4562215606","display_name":null,"funder_award_id":"EL2016","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G4656594441","display_name":null,"funder_award_id":"ANR18","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4880911435","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G4900465205","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G528741065","display_name":null,"funder_award_id":"19-CE15-0029-01","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G5474765000","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320336689","funder_display_name":"Labex Immuno-Oncology"},{"id":"https://openalex.org/G5644614043","display_name":null,"funder_award_id":"16698","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G5767140378","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G6300110603","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G6318841463","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G6610179393","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G668953012","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G7041469554","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G7101784390","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G7156242582","display_name":null,"funder_award_id":"19-CE15-0029-01","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G7466508714","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G7662726268","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G7666431813","display_name":null,"funder_award_id":"ANR-21-5 RHUS-0017","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G816800923","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G8312322146","display_name":null,"funder_award_id":"E-Rare-2","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8471630636","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8538166538","display_name":"Universit\u00e9 de Paris","funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8591183789","display_name":null,"funder_award_id":"ANR-21-5 RHUS-0017","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320315890","display_name":"Seerave Foundation","ror":"https://ror.org/01p3x3413"},{"id":"https://openalex.org/F4320317617","display_name":"E-Rare","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322893","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320324826","display_name":"Institut Gustave-Roussy","ror":"https://ror.org/0321g0743"},{"id":"https://openalex.org/F4320325668","display_name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","ror":null},{"id":"https://openalex.org/F4320330882","display_name":"European Research Area Network on Cardiovascular Diseases","ror":null},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320336689","display_name":"Labex Immuno-Oncology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212297968.pdf","grobid_xml":"https://content.openalex.org/works/W7212297968.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W130099911","https://openalex.org/W1979293255","https://openalex.org/W2012944782","https://openalex.org/W2021035028","https://openalex.org/W2032372031","https://openalex.org/W2048833477","https://openalex.org/W2069197202","https://openalex.org/W2096910745","https://openalex.org/W2107092018","https://openalex.org/W2108234281","https://openalex.org/W2110417468","https://openalex.org/W2115044652","https://openalex.org/W2119180969","https://openalex.org/W2128505445","https://openalex.org/W2135675362","https://openalex.org/W2137586531","https://openalex.org/W2148658155","https://openalex.org/W2149199519","https://openalex.org/W2152649563","https://openalex.org/W2154053567","https://openalex.org/W2156682635","https://openalex.org/W2168205205","https://openalex.org/W2170551349","https://openalex.org/W2204204249","https://openalex.org/W2224691248","https://openalex.org/W2241763745","https://openalex.org/W2316348835","https://openalex.org/W2432815617","https://openalex.org/W2562842059","https://openalex.org/W2582666496","https://openalex.org/W2613467753","https://openalex.org/W2624831627","https://openalex.org/W2628145035","https://openalex.org/W2752419857","https://openalex.org/W2765314233","https://openalex.org/W2770095154","https://openalex.org/W2800392236","https://openalex.org/W2862606086","https://openalex.org/W2912912813","https://openalex.org/W2924359886","https://openalex.org/W2951912016","https://openalex.org/W2954157188","https://openalex.org/W2955948108","https://openalex.org/W2990871782","https://openalex.org/W3003415550","https://openalex.org/W3008456393","https://openalex.org/W3011704876","https://openalex.org/W3021579311","https://openalex.org/W3023120239","https://openalex.org/W3048665145","https://openalex.org/W3112924817","https://openalex.org/W3118862865","https://openalex.org/W3129054011","https://openalex.org/W3131055609","https://openalex.org/W4205954025","https://openalex.org/W4210773546","https://openalex.org/W4211061706","https://openalex.org/W4224293098","https://openalex.org/W4285592685","https://openalex.org/W4311287891","https://openalex.org/W4312181672","https://openalex.org/W4364376252","https://openalex.org/W4366478635","https://openalex.org/W4379057683","https://openalex.org/W4380482751","https://openalex.org/W4382363431","https://openalex.org/W4385295387","https://openalex.org/W4385691272","https://openalex.org/W4386694133","https://openalex.org/W4389373763","https://openalex.org/W4389939983","https://openalex.org/W4394692624","https://openalex.org/W4394857110","https://openalex.org/W4395661248","https://openalex.org/W4396574532","https://openalex.org/W4398236132","https://openalex.org/W4399725773","https://openalex.org/W4399854892","https://openalex.org/W4401825058","https://openalex.org/W4402321108","https://openalex.org/W4402865626","https://openalex.org/W4405268751","https://openalex.org/W4405282800","https://openalex.org/W4408922338","https://openalex.org/W4409766365","https://openalex.org/W4413333415","https://openalex.org/W4416672780","https://openalex.org/W6949985536","https://openalex.org/W7133195062","https://openalex.org/W7161543969","https://openalex.org/W7163383449","https://openalex.org/W7163591960","https://openalex.org/W7164506792","https://openalex.org/W7165911756","https://openalex.org/W7167225516"],"related_works":["https://openalex.org/W4409633809","https://openalex.org/W4379057683","https://openalex.org/W4393096381","https://openalex.org/W4402951633","https://openalex.org/W7124158883","https://openalex.org/W4382133459","https://openalex.org/W7162289713","https://openalex.org/W3129054011","https://openalex.org/W2011896331","https://openalex.org/W7214644776"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1],"development":[2],"is":[3,199],"preceded":[4],"by":[5,177],"systemic":[6],"immune,":[7],"metabolic":[8],"and":[9,65],"tissue":[10],"perturbation.":[11],"We":[12],"asked":[13],"whether":[14],"a":[15,34,52,91,114,139],"minimal":[16],"circulating-protein":[17],"signature":[18],"anticipates":[19],"incident":[20,46,76],"cancer":[21,60,186],"in":[22,117],"patients":[23],"with":[24,86,109],"atheromatous":[25],"cardiovascular":[26],"disease":[27],"(ACVD)":[28],"exposed":[29],"to":[30,72,142],"tobacco.":[31],"Discovery":[32],"used":[33],"nested":[35],"case\u2013control":[36],"set":[37],"drawn":[38],"from":[39],"the":[40,143,185],"longitudinal":[41],"FLEMENGHO":[42],"cohort":[43],"(n=156;":[44],"38":[45],"lung":[47],"cancers).":[48],"Multi-omic":[49],"profiling":[50],"returned":[51],"two-step":[53],"classifier:":[54],"four":[55],"proteins,":[56],"smoking":[57],"status,":[58],"personal":[59],"history.":[61],"Preprocessing":[62],"constants,":[63],"classifiers":[64],"both":[66],"thresholds":[67],"were":[68],"fixed":[69],"before":[70,195],"transfer":[71],"PREVALUNG":[73],"(n=397;":[74],"58":[75,97],"cancers,":[77],"26":[78],"of":[79,96,120,188],"them":[80],"lung).":[81],"There,":[82],"low":[83,87,105],"O-GlcNAcase":[84],"(OGA)":[85],"interleukin-6":[88],"(IL-6)":[89],"defined":[90,113],"very-low-risk":[92],"stratum":[93,116],"holding":[94],"1":[95],"cancers":[98,153,162],"(sensitivity":[99],"98.3%,":[100],"negative":[101],"predictive":[102],"value":[103],"98.8%);":[104],"chymotrypsin":[106],"C":[107],"(CTRC)":[108],"high":[110],"\u03b2-microseminoprotein":[111],"(MSMB)":[112],"high-risk":[115],"which":[118],"15":[119],"28":[121],"participants":[122],"developed":[123],"cancer.":[124],"No":[125],"additional":[126],"omic":[127],"feature":[128],"\u2014":[129,135],"metabolomic,":[130],"immunophenotypic,":[131],"clonal-haematopoietic":[132],"or":[133],"metagenomic":[134],"was":[136,150],"retained":[137],"as":[138],"reproducible":[140],"improvement":[141],"classifier":[144],"under":[145],"our":[146],"selection":[147],"framework.":[148],"Discrimination":[149],"greater":[151],"for":[152,160],"diagnosed":[154],"\u226512":[155],"months":[156],"after":[157],"sampling":[158],"than":[159],"near-term":[161],"(AUC":[163],"0.766,":[164],"95%":[165],"CI":[166],"0.671\u20130.857,":[167],"versus":[168],"0.589,":[169],"0.485\u20130.692),":[170],"arguing":[171],"against":[172],"performance":[173],"being":[174],"driven":[175],"principally":[176],"occult":[178],"disease.":[179],"These":[180],"estimates":[181],"are":[182],"conditional":[183],"on":[184],"frequency":[187],"this":[189],"population.":[190],"They":[191],"require":[192],"prospective":[193],"confirmation":[194],"any":[196],"imaging":[197],"schedule":[198],"changed.":[200]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-12T00:00:00"}