{"id":"https://openalex.org/W7212293063","doi":"https://doi.org/10.64898/2026.09.07.749921","title":"Aryl Hydrocarbon Receptor (Ahr) Pathway Drives TBBPA Induced Cartilage Development Defects","display_name":"Aryl Hydrocarbon Receptor (Ahr) Pathway Drives TBBPA Induced Cartilage Development Defects","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212293063","doi":"https://doi.org/10.64898/2026.09.07.749921","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622643"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.07.749921","doi":"https://doi.org/10.64898/2026.09.07.749921","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749921","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.07.749921.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.07.749921.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107570638","display_name":"Kanchaka Senarath Pathirajage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanchaka Senarath Pathirajage","raw_affiliation_strings":["Department of Biological Sciences, Clemson University, Clemson, SC, USA","Environmental Toxicology Graduate Program, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"Environmental Toxicology Graduate Program, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126693075","display_name":"Sunil Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Sharma","raw_affiliation_strings":["Department of Biological Sciences, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151397441","display_name":"Tyler Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Johnson","raw_affiliation_strings":["Department of Biological Sciences, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111070840","display_name":"Arnob Sarker","orcid":"https://orcid.org/0009-0003-8195-3195","observed_orcids":["https://orcid.org/0009-0003-8195-3195"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnob Sarker","raw_affiliation_strings":["Department of Biological Sciences, Clemson University, Clemson, SC, USA","Environmental Toxicology Graduate Program, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]},{"raw_affiliation_string":"Environmental Toxicology Graduate Program, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077842032","display_name":"Subham Dasgupta","orcid":"https://orcid.org/0000-0001-5996-5948","observed_orcids":["https://orcid.org/0000-0001-5996-5948"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Subham Dasgupta","raw_affiliation_strings":["Department of Biological Sciences, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077842032"],"corresponding_institution_ids":["https://openalex.org/I8078737"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrabromobisphenol-a","display_name":"tetrabromobisphenol A","score":0.9010000228881836},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ahr2","display_name":"AHR2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/brominated-flame-retardants","display_name":"brominated flame retardants","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cyp1a","display_name":"CYP1A","score":0.8370000123977661},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7419999837875366},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8510000109672546},{"id":"https://openalex.org/keywords/zebrafish-embryos","display_name":"zebrafish embryos","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.8910999894142151},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6797999739646912},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.670199990272522},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6498000025749207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6435999870300293},{"id":"https://openalex.org/C136571751","wikidata":"https://www.wikidata.org/wiki/Q424607","display_name":"Morpholino","level":4,"score":0.5407000184059143},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.49219998717308044},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.4587000012397766},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.451200008392334},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.4496999979019165},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4325000047683716},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.41190001368522644},{"id":"https://openalex.org/C2776224515","wikidata":"https://www.wikidata.org/wiki/Q102253084","display_name":"ADAMTS","level":5,"score":0.3873000144958496},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.36399999260902405},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3456000089645386},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.2630000114440918},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.07.749921","doi":"https://doi.org/10.64898/2026.09.07.749921","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749921","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.07.749921.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622643","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622643/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.07.749921","doi":"https://doi.org/10.64898/2026.09.07.749921","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749921","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.07.749921.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309106","display_name":"Clemson University","ror":"https://ror.org/037s24f05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212293063.pdf","grobid_xml":"https://content.openalex.org/works/W7212293063.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1523791335","https://openalex.org/W1552027151","https://openalex.org/W1970889804","https://openalex.org/W2033858947","https://openalex.org/W2047544230","https://openalex.org/W2058140055","https://openalex.org/W2059470587","https://openalex.org/W2097256926","https://openalex.org/W2134967712","https://openalex.org/W2218252866","https://openalex.org/W2330948534","https://openalex.org/W2551153979","https://openalex.org/W2594825330","https://openalex.org/W2755708290","https://openalex.org/W2888485483","https://openalex.org/W2896022704","https://openalex.org/W2898228542","https://openalex.org/W2899070097","https://openalex.org/W2906120852","https://openalex.org/W3016549119","https://openalex.org/W3088942896","https://openalex.org/W3098910719","https://openalex.org/W3152962648","https://openalex.org/W3160216513","https://openalex.org/W4200375212","https://openalex.org/W4214950984","https://openalex.org/W4283017800","https://openalex.org/W4313201375","https://openalex.org/W4323854588","https://openalex.org/W4377605757","https://openalex.org/W4402713050","https://openalex.org/W4406482135","https://openalex.org/W4414038344","https://openalex.org/W4416769018","https://openalex.org/W7131225475","https://openalex.org/W7160538900"],"related_works":["https://openalex.org/W4416769018","https://openalex.org/W4386225768","https://openalex.org/W4404276785","https://openalex.org/W7214591095","https://openalex.org/W7096241779","https://openalex.org/W4414113602","https://openalex.org/W2095396181","https://openalex.org/W3129175287","https://openalex.org/W4206281213","https://openalex.org/W7117306241"],"abstract_inverted_index":{"Abstract":[0],"Tetrabromobisphenol":[1],"A":[2],"(TBBPA),":[3],"is":[4],"one":[5],"the":[6,54,122,129,148,183,217,221,245,271],"most":[7],"widely":[8],"produced":[9],"brominated":[10],"flame":[11],"retardant,":[12],"detected":[13],"in":[14,38,105,136,176,209,248],"human":[15],"matrices":[16],"including":[17,72],"cord":[18],"plasma,":[19],"raising":[20],"concern":[21],"over":[22],"its":[23],"impact":[24],"on":[25],"embryonic":[26],"development.":[27],"Our":[28],"previous":[29],"work":[30],"demonstrated":[31],"that":[32,263],"TBBPA":[33,118,215,273],"disrupts":[34],"craniofacial":[35,138,210,250,275],"cartilage":[36,139,211,230,234,251],"development":[37],"zebrafish;":[39],"however,":[40],"inhibition":[41],"of":[42,56,65,102,117,131,143,157,185,214],"bone":[43],"morphogenetic":[44],"protein":[45],"(BMP)":[46],"signaling":[47,70,133],"did":[48],"not":[49],"rescue":[50],"these":[51,93],"defects,":[52],"suggesting":[53],"involvement":[55],"alternative":[57],"molecular":[58,112],"mechanisms.":[59],"Transcriptomic":[60],"profiling":[61],"revealed":[62],"significant":[63,100],"upregulation":[64],"aryl":[66],"hydrocarbon":[67],"receptor":[68],"(Ahr)":[69],"genes,":[71,85],"cyp1a":[73],"and":[74,89,111,134,147,159,189,191,200,223,226,254,266],"cyp1c":[75],",":[76],"as":[77,79,87,257],"well":[78],"reactive":[80],"oxygen":[81],"species":[82],"(ROS)":[83],"responsive":[84],"such":[86],"nfe":[88],"gstp.":[90],"Consistent":[91],"with":[92,216],"findings,":[94],"KEGG":[95],"pathway":[96],"enrichment":[97,101],"analysis":[98],"identified":[99],"pathways":[103],"involved":[104],"xenobiotic":[106],"metabolism,":[107,110],"cytochrome":[108],"P450-mediated":[109],"docking":[113],"predicted":[114],"stronger":[115],"binding":[116],"to":[119,193],"Ahr2":[120,123,144,167,203],"than":[121],"agonist":[124],"TCDD.":[125],"Then":[126],"we":[127],"investigated":[128],"role":[130,243],"Ahr":[132,268],"ROS":[135,160,179,222,256],"TBBPA-induced":[137,174,207,249],"defects":[140],"using":[141,169],"microinjection":[142],"translation-blocking":[145,171],"morpholino":[146,172],"antioxidant":[149,218],"N-acetylcysteine":[150],"(NAC),":[151],"respectively.":[152],"Immunohistochemistry":[153],"confirmed":[154],"concentration-dependent":[155],"induction":[156],"Cyp1a":[158,177],"at":[161],"environmentally":[162],"relevant":[163],"concentrations":[164],"(\u22650.005":[165],"\u00b5M).":[166],"knockdown":[168,204],"a":[170,241],"rescued":[173,205,220,227],"alterations":[175,208],"expression,":[178],"levels,":[180],"DNA":[181,224],"damage,":[182],"expression":[184],"chondrogenesis-related":[186],"markers":[187,197],"(Sox10":[188],"Sox2),":[190],"epithelial":[192],"mesenchymal":[194],"transition":[195],"(EMT)":[196],"(E-cadherin,":[198],"N-cadherin,":[199],"Snail2).":[201],"Furthermore,":[202],"several":[206],"parameters.":[212],"Co-exposure":[213],"NAC":[219],"damage":[225],"only":[228],"ceratohyal":[229],"length,":[231],"whereas":[232],"other":[233],"parameters":[235],"remained":[236],"disrupted.":[237],"These":[238],"findings":[239],"establish":[240],"causal":[242],"for":[244],"Ahr-Cyp1a":[246],"axis":[247],"developmental":[252],"toxicity":[253],"identify":[255],"an":[258],"important":[259],"downstream":[260],"contributor,":[261],"indicating":[262],"both":[264],"ROS-dependent":[265],"ROS-independent":[267],"mechanisms":[269],"underlined":[270],"observed":[272],"induced":[274],"defects.":[276]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-12T00:00:00"}
