{"id":"https://openalex.org/W7212290179","doi":"https://doi.org/10.17615/zfk7-0585","title":"Chronic kidney disease in adults with sickle cell trait: A systematic review and meta-analysis","display_name":"Chronic kidney disease in adults with sickle cell trait: A systematic review and meta-analysis","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212290179","doi":"https://doi.org/10.17615/zfk7-0585"},"language":"en","primary_location":{"id":"doi:10.17615/zfk7-0585","doi":"https://doi.org/10.17615/zfk7-0585","is_oa":true,"landing_page_url":"https://doi.org/10.17615/zfk7-0585","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/zfk7-0585","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038958984","display_name":"Diego J Aparcana-Granda","orcid":"https://orcid.org/0000-0001-9993-0029","observed_orcids":["https://orcid.org/0000-0001-9993-0029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aparcana-Granda, Diego J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151397609","display_name":"Andres R Aquino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aquino, Andres R","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062069151","display_name":"Yagahira E. Castro-Sesquen","orcid":"https://orcid.org/0000-0001-6824-9206","observed_orcids":["https://orcid.org/0000-0001-6824-9206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Castro Sesquen, Yagahira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075327487","display_name":"Vimal Kumar Derebail","orcid":"https://orcid.org/0000-0002-7662-7497","observed_orcids":["https://orcid.org/0000-0002-7662-7497"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derebail, Vimal K","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121072673","display_name":"Seyed Mehdi Nouraie","orcid":"https://orcid.org/0000-0001-7465-0581","observed_orcids":["https://orcid.org/0000-0001-7465-0581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nouraie, Seyed Mehdi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151382865","display_name":"Pierre Luckens Adelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adelson, Pierre Luckens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030174386","display_name":"Santosh L. Saraf","orcid":"https://orcid.org/0000-0002-8584-4194","observed_orcids":["https://orcid.org/0000-0002-8584-4194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saraf, Santosh L","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009041510","display_name":"Ronald Diego Mondrag\u00f3n Calixto","orcid":"https://orcid.org/0000-0002-2465-1065","observed_orcids":["https://orcid.org/0000-0002-2465-1065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mondrag\u00f3n Calixto, Ronald Diego","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083667935","display_name":"John Kwagyan","orcid":"https://orcid.org/0000-0003-2711-1969","observed_orcids":["https://orcid.org/0000-0003-2711-1969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwagyan, John","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094313727","display_name":"Carmela Gelida Barboza Justiniano","orcid":"https://orcid.org/0000-0002-5069-6873","observed_orcids":["https://orcid.org/0000-0002-5069-6873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barboza Justiniano, Carmela Gelida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020863136","display_name":"Marina Jerebtsova","orcid":"https://orcid.org/0000-0001-7723-4954","observed_orcids":["https://orcid.org/0000-0001-7723-4954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerebtsova, Marina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67285922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9150000214576721},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5419999957084656},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.703000009059906},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.8169999718666077},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.895799994468689},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7351999878883362},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.6542999744415283},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6488000154495239},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5971999764442444},{"id":"https://openalex.org/C2777566322","wikidata":"https://www.wikidata.org/wiki/Q3536635","display_name":"Sickle cell trait","level":3,"score":0.57669997215271},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5167999863624573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4562000036239624},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.4043000042438507},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.34700000286102295},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17615/zfk7-0585","doi":"https://doi.org/10.17615/zfk7-0585","is_oa":true,"landing_page_url":"https://doi.org/10.17615/zfk7-0585","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.17615/zfk7-0585","doi":"https://doi.org/10.17615/zfk7-0585","is_oa":true,"landing_page_url":"https://doi.org/10.17615/zfk7-0585","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409259344","https://openalex.org/W2141198361","https://openalex.org/W2604112617","https://openalex.org/W2910832821","https://openalex.org/W4405039283","https://openalex.org/W1888502878","https://openalex.org/W3025323215","https://openalex.org/W3206031330","https://openalex.org/W2924629015","https://openalex.org/W2016032242"],"abstract_inverted_index":{"Sickle":[0],"cell":[1],"trait":[2],"(SCT)":[3],"may":[4],"increase":[5],"the":[6,17,21,76,183,198,225,235],"risk":[7,70,217,236],"of":[8,20,41,56,71,100,118,153,218,227,237],"chronic":[9],"kidney":[10],"disease":[11,61],"(CKD).":[12],"We":[13,45],"aim":[14],"to":[15,30,105,197],"determine":[16],"pooled":[18,80,151],"statistics":[19],"association":[22,226],"between":[23],"SCT":[24,81,107,113,154,233],"and":[25,39,66,109,137,189,231,240],"CKD.":[26],"Studies":[27],"published":[28],"up":[29],"May":[31],"2024":[32],"on":[33],"PubMed,":[34],"Embase,":[35],"Global":[36],"Health":[37],"Library,":[38],"Web":[40],"Science":[42],"were":[43,102,222],"screened.":[44],"included":[46,186,201],"studies":[47,94,184],"reporting":[48],"odds":[49,117],"ratios":[50,54],"(OR)":[51],"or":[52,97],"hazard":[53],"(HR)":[55],"CKD":[57,228,239],"and/or":[58,143],"end-stage":[59],"renal":[60],"(ESRD)":[62],"comparing":[63],"adults":[64],"with":[65,87,95,158,229],"without":[67,111],"SCT.":[68,112],"The":[69,79,150],"bias":[72,101],"was":[73,83,91,160,167,173],"evaluated":[74],"using":[75],"ROBINS-E":[77],"tool.":[78],"prevalence":[82,152],"calculated":[84],"among":[85,155],"patients":[86],"CKD/ESRD.":[88],"Random-effects":[89],"analysis":[90],"performed.":[92],"Only":[93],"low":[96],"some":[98],"concerns":[99],"included,":[103],"corresponding":[104],"18,847":[106],"participants":[108,114],"1,060,818":[110],"had":[115],"higher":[116,175,216],"having":[119],"an":[120],"eGFR":[121,138],"\u2264":[122,139],"60":[123,140],"ml/min/1.73":[124,141],"m\u00b2":[125,142],"(OR:":[126,132,145],"1.62,":[127],"95%":[128,134,147,193,206],"CI:":[129,135,148,163,194,207],"1.39-1.89),":[130],"proteinuria":[131,144],"2.02,":[133],"1.61-2.54),":[136],"1.79,":[146],"1.44-2.22).":[149],"African":[156],"Americans":[157],"ESRD":[159,178],"10%":[161],"(95%":[162],"8-12%);":[164],"however,":[165],"heterogeneity":[166],"very":[168],"high":[169],"(I\u00b2:":[170],"85.6%).":[171],"There":[172],"a":[174,215],"HR":[176],"for":[177,224],"(p":[179],"=":[180],"0.04)":[181],"in":[182],"that":[185,200,212],"both":[187],"males":[188,213],"females":[190,203],"(HR:":[191,204],"1.72,":[192],"1.13-2.61)":[195],"compared":[196],"study":[199],"only":[202],"0.75,":[205],"0.39":[208],"-":[209],"1.44),":[210],"suggesting":[211],"have":[214],"ESRD.":[219,241],"Controversial":[220],"results":[221],"observed":[223],"hypertension":[230],"diabetes.":[232],"increases":[234],"developing":[238],"PROSPERO":[242],"registration:":[243],"CRD42021275274.":[244]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-12T00:00:00"}
