{"id":"https://openalex.org/W7212233185","doi":"https://doi.org/10.64898/2026.09.08.750036","title":"The Principal Component Life Trajectory (PCLT): Mapping Sex-Specific Physiological Change Across the Human Lifespan","display_name":"The Principal Component Life Trajectory (PCLT): Mapping Sex-Specific Physiological Change Across the Human Lifespan","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212233185","doi":"https://doi.org/10.64898/2026.09.08.750036"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.750036","doi":"https://doi.org/10.64898/2026.09.08.750036","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750036","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750036.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750036.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056098706","display_name":"Lars N. Royall","orcid":"https://orcid.org/0009-0004-5401-6726","observed_orcids":["https://orcid.org/0009-0004-5401-6726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars Royall","raw_affiliation_strings":["Alpine Institute for Longevity Research and Diagnostics, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alpine Institute for Longevity Research and Diagnostics, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047584448","display_name":"Jordan J. Baechle","orcid":"https://orcid.org/0000-0002-4498-6647","observed_orcids":["https://orcid.org/0000-0002-4498-6647"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan J. Baechle","raw_affiliation_strings":["Alpine Institute for Longevity Research and Diagnostics, Basel, Switzerland","Texas Tech University Health and Science Center, Lubbock, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alpine Institute for Longevity Research and Diagnostics, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Texas Tech University Health and Science Center, Lubbock, Texas, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020867859","display_name":"Ana STANKOV\u0130\u0106","orcid":"https://orcid.org/0000-0002-0580-816X","observed_orcids":["https://orcid.org/0000-0002-0580-816X","https://orcid.org/0009-0003-1536-7403"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ana Stankovic","raw_affiliation_strings":["Alpine Institute for Longevity Research and Diagnostics, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alpine Institute for Longevity Research and Diagnostics, Basel, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020867859"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.21140000224113464,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.21140000224113464,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.19020000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/physiological-biomarkers","display_name":"physiological biomarkers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.699999988079071},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5699999928474426},{"id":"https://openalex.org/keywords/adolescence","display_name":"adolescence","score":0.7329999804496765},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.7139999866485596},{"id":"https://openalex.org/keywords/trajectory-distance","display_name":"trajectory distance","score":0.6669999957084656},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.6370000243186951},{"id":"https://openalex.org/keywords/health-monitoring","display_name":"health monitoring","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5910000205039978},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.5842999815940857},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.5242999792098999},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4602000117301941},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3928000032901764},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3864000141620636},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.34700000286102295},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3255000114440918},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C1691868","wikidata":"https://www.wikidata.org/wiki/Q1811049","display_name":"Life course approach","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.2996000051498413},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.28859999775886536},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.28439998626708984},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2809000015258789},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.26969999074935913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26919999718666077},{"id":"https://openalex.org/C2992101111","wikidata":"https://www.wikidata.org/wiki/Q6545098","display_name":"Life history","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C120174047","wikidata":"https://www.wikidata.org/wiki/Q847073","display_name":"Euclidean distance","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.08.750036","doi":"https://doi.org/10.64898/2026.09.08.750036","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750036","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750036.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.750036","doi":"https://doi.org/10.64898/2026.09.08.750036","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750036","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.08.750036.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212233185.pdf","grobid_xml":"https://content.openalex.org/works/W7212233185.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1658682427","https://openalex.org/W2020525292","https://openalex.org/W2022904272","https://openalex.org/W2126104386","https://openalex.org/W2126525177","https://openalex.org/W2147945158","https://openalex.org/W2418872436","https://openalex.org/W2905818017","https://openalex.org/W2940893790","https://openalex.org/W2949100461","https://openalex.org/W2973799453","https://openalex.org/W3109735199","https://openalex.org/W3128732455","https://openalex.org/W3160304067","https://openalex.org/W3164240006","https://openalex.org/W4295885382","https://openalex.org/W4319662697","https://openalex.org/W4362674168","https://openalex.org/W4380184661","https://openalex.org/W4386334003","https://openalex.org/W4389391124","https://openalex.org/W4389440153","https://openalex.org/W4401585036","https://openalex.org/W4402897667","https://openalex.org/W4411036731"],"related_works":["https://openalex.org/W2147945158","https://openalex.org/W1600799865","https://openalex.org/W2346435849","https://openalex.org/W2784330444","https://openalex.org/W2288696091","https://openalex.org/W7105024845","https://openalex.org/W2511661550","https://openalex.org/W4401903552","https://openalex.org/W7204169113","https://openalex.org/W3000806458"],"abstract_inverted_index":{"Abstract":[0],"Age-":[1],"and":[2,52,82,105,112,136],"sex-related":[3],"variation":[4],"in":[5,48,70,92],"physiological":[6,36,131],"biomarkers":[7,44],"is":[8,100],"well":[9],"documented,":[10],"yet":[11],"how":[12],"coordinated":[13],"systemic":[14],"physiology":[15],"unfolds":[16],"across":[17,133],"life":[18],"stages":[19],"at":[20],"the":[21,29,49,134],"population":[22],"level":[23],"remains":[24],"unclear.":[25],"Here,":[26],"we":[27,65],"introduce":[28],"Principal":[30],"Component":[31],"Life":[32],"Trajectory":[33,62],"(PCLT),":[34],"reconstructing":[35],"trajectories":[37],"via":[38],"multivariate":[39],"analysis":[40],"of":[41],"54":[42],"blood-based":[43],"from":[45],"11,124":[46],"participants":[47],"National":[50],"Health":[51],"Nutrition":[53],"Examination":[54],"Survey":[55],"(NHANES).":[56],"Quantifying":[57],"year-on-year":[58],"progression":[59],"with":[60,102],"Euclidean":[61],"Distance":[63],"(ETD),":[64],"identify":[66],"five":[67],"distinct":[68],"phases":[69],"an":[71,93],"unbiased":[72],"manner:":[73],"Early":[74],"adolescence,":[75],"Sexual":[76,78],"Divergence,":[77],"Convergence,":[79],"Late":[80],"Adulthood,":[81],"Advanced":[83],"Aging.":[84],"Trajectories":[85],"show":[86],"early,":[87],"pronounced":[88],"sexual":[89],"divergence":[90],"validated":[91],"ethnically":[94],"distinct,":[95],"independent":[96],"cohort.":[97],"Chronic":[98],"disease":[99],"associated":[101],"PCLT":[103,123],"displacement":[104],"increased":[106],"ETD":[107],"progression,":[108],"whereas":[109],"metabolic,":[110],"behavioural,":[111],"psychosocial":[113],"factors":[114],"generate":[115],"graded,":[116],"phase-specific":[117],"perturbations.":[118],"Together,":[119],"these":[120],"findings":[121],"establish":[122],"as":[124],"a":[125],"reproducible":[126],"framework":[127],"for":[128,137],"characterizing":[129],"structured":[130],"change":[132],"lifespan":[135],"monitoring":[138],"population-level":[139],"health":[140],"dynamics.":[141]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-12T00:00:00"}
