{"id":"https://openalex.org/W7212229459","doi":"https://doi.org/10.1016/j.neuint.2026.106260","title":"Evidence for similar enzymatic but different cellular generation of pE79-modified \u03b1-synuclein in PD and AD mouse models","display_name":"Evidence for similar enzymatic but different cellular generation of pE79-modified \u03b1-synuclein in PD and AD mouse models","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212229459","doi":"https://doi.org/10.1016/j.neuint.2026.106260","pmid":"https://pubmed.ncbi.nlm.nih.gov/42727643"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuint.2026.106260","doi":"https://doi.org/10.1016/j.neuint.2026.106260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuint.2026.106260","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuint.2026.106260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066105549","display_name":"Alexandra Bluhm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Bluhm","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151342766","display_name":"Merle Gro\u00dfmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Merle Gro\u00dfmann","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127906141","display_name":"Charlotte Minister","orcid":"https://orcid.org/0009-0002-9510-9721","observed_orcids":["https://orcid.org/0009-0002-9510-9721"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Charlotte Minister","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany"],"raw_orcid":"https://orcid.org/0009-0002-9510-9721","affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032976541","display_name":"Sarah Schrempel","orcid":"https://orcid.org/0009-0003-2436-2866","observed_orcids":["https://orcid.org/0009-0003-2436-2866"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Schrempel","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany"],"raw_orcid":"https://orcid.org/0009-0003-2436-2866","affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151342436","display_name":"Maria Antonia Joseph","orcid":"https://orcid.org/0009-0009-6673-4510","observed_orcids":["https://orcid.org/0009-0009-6673-4510"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Antonia Joseph","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, 30559, Germany"],"raw_orcid":"https://orcid.org/0009-0009-6673-4510","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, 30559, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044034350","display_name":"Max Holzer","orcid":"https://orcid.org/0000-0003-1754-9932","observed_orcids":["https://orcid.org/0000-0003-1754-9932"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max Holzer","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1754-9932","affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062742783","display_name":"Claude Sauter","orcid":"https://orcid.org/0000-0002-8766-287X","observed_orcids":["https://orcid.org/0000-0002-8766-287X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210158086","display_name":"Institut de Biologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05qpmg879","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210158086","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Sauter","raw_affiliation_strings":["CNRS, Architecture et R\u00e9activit\u00e9 de l'ARN, UPR 9002, Institut de Biologie Mol\u00e9culaire et Cellulaire, Universit\u00e9 de Strasbourg, Strasbourg, 67084, France"],"raw_orcid":"https://orcid.org/0000-0002-8766-287X","affiliations":[{"raw_affiliation_string":"CNRS, Architecture et R\u00e9activit\u00e9 de l'ARN, UPR 9002, Institut de Biologie Mol\u00e9culaire et Cellulaire, Universit\u00e9 de Strasbourg, Strasbourg, 67084, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I4210158086","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036942545","display_name":"Wei Xiang","orcid":"https://orcid.org/0000-0002-1897-3738","observed_orcids":["https://orcid.org/0000-0002-1897-3738"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wei Xiang","raw_affiliation_strings":["University Hospital Erlangen, Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Erlangen, 91054, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Erlangen, Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Erlangen, 91054, Germany","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017237952","display_name":"Malte Feja","orcid":"https://orcid.org/0000-0002-8670-5495","observed_orcids":["https://orcid.org/0000-0002-8670-5495"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Malte Feja","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, 30559, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8670-5495","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, 30559, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108785384","display_name":"Stephan Schilling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089758","display_name":"Anhalt University of Applied Sciences","ror":"https://ror.org/0076zct58","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210089758"]},{"id":"https://openalex.org/I4210145647","display_name":"Fraunhofer Institute for Cell Therapy and Immunology","ror":"https://ror.org/04x45f476","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210145647","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Schilling","raw_affiliation_strings":["Fraunhofer Institute for Cell Therapy and Immunology, Department of Molecular Drug Design and Target Validation, Halle (Saale), 06120, Germany; Faculty of Applied Biosciences and Process Engineering, Anhalt University of Applied Sciences, K\u00f6then, 06366, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Cell Therapy and Immunology, Department of Molecular Drug Design and Target Validation, Halle (Saale), 06120, Germany; Faculty of Applied Biosciences and Process Engineering, Anhalt University of Applied Sciences, K\u00f6then, 06366, Germany","institution_ids":["https://openalex.org/I4210089758","https://openalex.org/I4210145647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088088039","display_name":"Anja Schulze","orcid":"https://orcid.org/0000-0002-3358-8299","observed_orcids":["https://orcid.org/0000-0002-3358-8299"]},"institutions":[{"id":"https://openalex.org/I4210089758","display_name":"Anhalt University of Applied Sciences","ror":"https://ror.org/0076zct58","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210089758"]},{"id":"https://openalex.org/I4210145647","display_name":"Fraunhofer Institute for Cell Therapy and Immunology","ror":"https://ror.org/04x45f476","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210145647","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Schulze","raw_affiliation_strings":["Fraunhofer Institute for Cell Therapy and Immunology, Department of Molecular Drug Design and Target Validation, Halle (Saale), 06120, Germany; Faculty of Applied Biosciences and Process Engineering, Anhalt University of Applied Sciences, K\u00f6then, 06366, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3358-8299","affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Cell Therapy and Immunology, Department of Molecular Drug Design and Target Validation, Halle (Saale), 06120, Germany; Faculty of Applied Biosciences and Process Engineering, Anhalt University of Applied Sciences, K\u00f6then, 06366, Germany","institution_ids":["https://openalex.org/I4210089758","https://openalex.org/I4210145647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058647332","display_name":"Franziska Richter","orcid":"https://orcid.org/0000-0003-0803-4398","observed_orcids":["https://orcid.org/0000-0003-0803-4398"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franziska Richter","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, 30559, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0803-4398","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, 30559, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040572132","display_name":"Maike Hartlage\u2010R\u00fcbsamen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maike Hartlage-R\u00fcbsamen","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005145881","display_name":"Steffen Ro\u00dfner","orcid":"https://orcid.org/0000-0002-9959-283X","observed_orcids":["https://orcid.org/0000-0002-9959-283X"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Steffen Ro\u00dfner","raw_affiliation_strings":["Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany. Electronic address: steffen.rossner@medizin.uni-leipzig.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute - Centre of Neuropathology and Brain Research, University of Leipzig, Leipzig, 04103, Germany. Electronic address: steffen.rossner@medizin.uni-leipzig.de","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5005145881"],"corresponding_institution_ids":["https://openalex.org/I926574661"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":{"value":4170,"currency":"USD","value_usd":4170},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64990797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":null,"first_page":"106260","last_page":"106260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9369999766349792},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8669999837875366},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8130000233650208},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glutaminyl-cyclase","display_name":"glutaminyl cyclase","score":0.8539999723434448},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.7950000166893005},{"id":"https://openalex.org/keywords/substantia-nigra-neurons","display_name":"substantia nigra neurons","score":0.9150000214576721},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.875},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.6743999719619751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5979999899864197},{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.5534999966621399},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5529000163078308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4722000062465668},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4311000108718872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39250001311302185},{"id":"https://openalex.org/C78885561","wikidata":"https://www.wikidata.org/wiki/Q189055","display_name":"Cellular compartment","level":3,"score":0.3571000099182129},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.351500004529953},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.3483000099658966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3467000126838684},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.3368000090122223},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27399998903274536},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.2732999920845032},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019881","descriptor_name":"Aminoacyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.neuint.2026.106260","doi":"https://doi.org/10.1016/j.neuint.2026.106260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuint.2026.106260","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},{"id":"pmid:42727643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42727643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry international","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05823640v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05823640","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurochemistry International, 2026, 200, pp.106260. ⟨10.1016/j.neuint.2026.106260⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open.fau.de:openfau/41971","doi":null,"is_oa":true,"landing_page_url":"https://open.fau.de/handle/openfau/41971","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/524767","doi":null,"is_oa":true,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/524767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"doi:10.24406/publica-10517","doi":"https://doi.org/10.24406/publica-10517","is_oa":true,"landing_page_url":"https://doi.org/10.24406/publica-10517","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1016/j.neuint.2026.106260","doi":"https://doi.org/10.1016/j.neuint.2026.106260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuint.2026.106260","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7680925718","display_name":null,"funder_award_id":"2022_EKSE.163","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"}],"funders":[{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W40479657","https://openalex.org/W1502167342","https://openalex.org/W1505905194","https://openalex.org/W1518422193","https://openalex.org/W1527671059","https://openalex.org/W1601052838","https://openalex.org/W1647861543","https://openalex.org/W1652524709","https://openalex.org/W1860081569","https://openalex.org/W1955736456","https://openalex.org/W1961885071","https://openalex.org/W1964747897","https://openalex.org/W1965533650","https://openalex.org/W1979591162","https://openalex.org/W1988893910","https://openalex.org/W1989880163","https://openalex.org/W1990632702","https://openalex.org/W1997895427","https://openalex.org/W1999014597","https://openalex.org/W2000348798","https://openalex.org/W2001210466","https://openalex.org/W2006959956","https://openalex.org/W2008014055","https://openalex.org/W2011574003","https://openalex.org/W2013313629","https://openalex.org/W2016124510","https://openalex.org/W2016859011","https://openalex.org/W2019831056","https://openalex.org/W2022036302","https://openalex.org/W2024053743","https://openalex.org/W2029000167","https://openalex.org/W2029578532","https://openalex.org/W2032574021","https://openalex.org/W2033369082","https://openalex.org/W2035570763","https://openalex.org/W2035829209","https://openalex.org/W2039733567","https://openalex.org/W2045318395","https://openalex.org/W2047842684","https://openalex.org/W2048383114","https://openalex.org/W2049737588","https://openalex.org/W2050786534","https://openalex.org/W2051804431","https://openalex.org/W2052322755","https://openalex.org/W2058848526","https://openalex.org/W2058884892","https://openalex.org/W2059261643","https://openalex.org/W2060358364","https://openalex.org/W2061250188","https://openalex.org/W2062224058","https://openalex.org/W2071087722","https://openalex.org/W2072720067","https://openalex.org/W2072840073","https://openalex.org/W2075591819","https://openalex.org/W2080949995","https://openalex.org/W2082907050","https://openalex.org/W2083440158","https://openalex.org/W2088753260","https://openalex.org/W2089791279","https://openalex.org/W2090638862","https://openalex.org/W2093171209","https://openalex.org/W2095253097","https://openalex.org/W2096846979","https://openalex.org/W2097292535","https://openalex.org/W2105028929","https://openalex.org/W2108244474","https://openalex.org/W2108865709","https://openalex.org/W2119591418","https://openalex.org/W2121937669","https://openalex.org/W2123869107","https://openalex.org/W2125820195","https://openalex.org/W2129034908","https://openalex.org/W2140225001","https://openalex.org/W2141226820","https://openalex.org/W2146034371","https://openalex.org/W2146180881","https://openalex.org/W2161323536","https://openalex.org/W2164149983","https://openalex.org/W2171288469","https://openalex.org/W2188721487","https://openalex.org/W2324575072","https://openalex.org/W2432301206","https://openalex.org/W2587082207","https://openalex.org/W2801998557","https://openalex.org/W2889904213","https://openalex.org/W2899806378","https://openalex.org/W2935986978","https://openalex.org/W3004000546","https://openalex.org/W3005903690","https://openalex.org/W3035800697","https://openalex.org/W3039696582","https://openalex.org/W3118586567","https://openalex.org/W3165115994","https://openalex.org/W3185892560","https://openalex.org/W3186436929","https://openalex.org/W3189977438","https://openalex.org/W3193924564","https://openalex.org/W4286007990","https://openalex.org/W4286267517","https://openalex.org/W4290612181","https://openalex.org/W4312194536","https://openalex.org/W4322754763","https://openalex.org/W4378189256","https://openalex.org/W4406951550","https://openalex.org/W4410008817"],"related_works":["https://openalex.org/W4286007990","https://openalex.org/W4286267517","https://openalex.org/W4210245563","https://openalex.org/W3185892560","https://openalex.org/W3155571996","https://openalex.org/W4386285018","https://openalex.org/W2013025427","https://openalex.org/W4225410860","https://openalex.org/W4417306477","https://openalex.org/W6989151374"],"abstract_inverted_index":{"The":[0,48,215],"\u03b1-synuclein":[1],"(aSyn)":[2],"pathology":[3],"is":[4,32,42,51],"a":[5,62,74,97,166],"predominant":[6],"feature":[7],"of":[8,78,100,124,129,140,174,227],"synucleinopathies":[9],"such":[10,30],"as":[11,84,91],"Parkinson's":[12],"disease":[13,161],"(PD).":[14],"Triggers":[15],"that":[16,41,128,193],"may":[17],"induce":[18],"aSyn":[19,33,71,79,107,181,228],"aggregation":[20],"are":[21],"not":[22],"completely":[23],"understood,":[24],"but":[25],"include":[26],"post-translational":[27],"modifications.":[28],"One":[29],"modification":[31],"truncation":[34],"exposing":[35],"the":[36,111,158,194,205,221,234,242],"N-terminal":[37],"glutamine":[38],"79":[39],"residue":[40],"subsequently":[43],"converted":[44],"into":[45],"pyroglutamate":[46],"(pE).":[47],"pE79-aSyn":[49,101,141,175,207],"variant":[50],"prone":[52],"to":[53,72,135],"oligomerisation":[54],"and":[55,86,104,117,147,152,180,199,211,229,238],"thus":[56],"highly":[57],"neurotoxic.":[58],"Here,":[59,165],"we":[60],"used":[61],"Thy1-aSyn":[63,125],"PD":[64,210,235],"mouse":[65,163,213,222,236,244],"model":[66,237],"overexpressing":[67,108],"human":[68],"wild":[69],"type":[70],"reveal":[73,136],"possible":[75],"spatial":[76],"association":[77],"with":[80,87,102,150,171,176,224],"matrix":[81],"metalloproteinase-9":[82],"(MMP-9)":[83],"aSyn-truncating":[85],"isoglutaminyl":[88],"cyclase":[89],"(isoQC)":[90],"pE-forming":[92],"enzymes,":[93],"respectively.":[94],"We":[95],"observed":[96],"cellular":[98,168,216],"co-localisation":[99,149,173],"MMP-9":[103,116,151,198],"isoQC":[105,130,153],"in":[106,110,157,183,204,209,233,241],"neurons":[109],"substantia":[112],"nigra.":[113],"In":[114,133],"addition,":[115],"GFAP":[118],"protein":[119],"expression":[120,169,226,240],"increased":[121],"during":[122],"aging":[123],"mice,":[126],"whereas":[127],"was":[131,154,187],"reduced.":[132],"order":[134],"potential":[137],"cross-disease":[138],"mechanisms":[139],"pathology,":[142],"its":[143,230],"cell":[144],"type-specific":[145],"appearance":[146],"immunohistochemical":[148],"also":[155],"evaluated":[156],"tg2576":[159],"Alzheimer's":[160],"(AD)":[162],"model.":[164,245],"different":[167],"pattern":[170],"substantial":[172],"MMP-9,":[177],"isoQC,":[178,200],"QC":[179],"predominantly":[182],"amyloid":[184],"plaque-surrounding":[185],"astrocytes":[186],"detected.":[188],"Together,":[189],"these":[190],"data":[191],"indicate":[192],"same":[195],"enzymatic":[196],"activities,":[197],"might":[201],"be":[202],"involved":[203],"subsequent":[206],"generation":[208],"AD":[212,243],"models.":[214],"origins,":[217],"however,":[218],"differ":[219],"between":[220],"models":[223],"neuronal":[225],"modifying":[231],"enzymes":[232],"astrocytic":[239]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-12T00:00:00"}