{"id":"https://openalex.org/W7212227699","doi":"https://doi.org/10.64898/2026.09.10.750593","title":"Hantavirus mutagenesis is impacted by mutagens and host antiviral proteins","display_name":"Hantavirus mutagenesis is impacted by mutagens and host antiviral proteins","publication_year":2026,"publication_date":"2026-09-11","ids":{"openalex":"https://openalex.org/W7212227699","doi":"https://doi.org/10.64898/2026.09.10.750593"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.10.750593","doi":"https://doi.org/10.64898/2026.09.10.750593","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750593","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750593.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750593.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047324606","display_name":"Christopher Ruis","orcid":"https://orcid.org/0000-0003-0977-5534","observed_orcids":["https://orcid.org/0000-0003-0977-5534"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4405265962","display_name":"Cambridge Centre for AI in Medicine","ror":"https://ror.org/02n7g3y50","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4405265962"]},{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["GB","PL"],"is_corresponding":true,"raw_author_name":"Christopher Ruis","raw_affiliation_strings":["Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland","Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, UK","Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]},{"raw_affiliation_string":"Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4405265962"]},{"raw_affiliation_string":"Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084268602","display_name":"Julian Parkhill","orcid":"https://orcid.org/0000-0002-7069-5958","observed_orcids":["https://orcid.org/0000-0002-7069-5958"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian Parkhill","raw_affiliation_strings":["Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-7069-5958","affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140650100","display_name":"Rodrigo Andres Floto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4405265962","display_name":"Cambridge Centre for AI in Medicine","ror":"https://ror.org/02n7g3y50","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4405265962"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Andres Floto","raw_affiliation_strings":["Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, UK","Department of Medicine, University of Cambridge, Cambridge, UK","Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4405265962"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047324606"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4405265962","https://openalex.org/I4654613"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.15039999783039093,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hantavirus","display_name":"hantavirus","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/zap","display_name":"ZAP","score":0.6990000009536743},{"id":"https://openalex.org/keywords/apobec","display_name":"APOBEC","score":0.8159999847412109},{"id":"https://openalex.org/keywords/virus-adaptation","display_name":"viral adaptation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6100000143051147},{"id":"https://openalex.org/keywords/zoonotic-viruses","display_name":"zoonotic viruses","score":0.7300000190734863},{"id":"https://openalex.org/keywords/viral-genetic-diversity","display_name":"viral genetic diversity","score":0.5139999985694885},{"id":"https://openalex.org/keywords/tissue-tropism","display_name":"tissue tropism","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8385000228881836},{"id":"https://openalex.org/C2775992772","wikidata":"https://www.wikidata.org/wiki/Q29001073","display_name":"Hantavirus","level":3,"score":0.8384000062942505},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.7476999759674072},{"id":"https://openalex.org/C2776162770","wikidata":"https://www.wikidata.org/wiki/Q4653351","display_name":"APOBEC","level":4,"score":0.6998999714851379},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6137999892234802},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5055000185966492},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.49470001459121704},{"id":"https://openalex.org/C2910208175","wikidata":"https://www.wikidata.org/wiki/Q29001073","display_name":"Hantavirus Infection","level":4,"score":0.4837999939918518},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47780001163482666},{"id":"https://openalex.org/C2777794978","wikidata":"https://www.wikidata.org/wiki/Q6137239","display_name":"Hantavirus pulmonary syndrome","level":4,"score":0.40119999647140503},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.34150001406669617},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.31700000166893005},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.3093999922275543},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.2662000060081482},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.10.750593","doi":"https://doi.org/10.64898/2026.09.10.750593","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750593","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750593.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.10.750593","doi":"https://doi.org/10.64898/2026.09.10.750593","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750593","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/11/2026.09.10.750593.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1827369112","display_name":null,"funder_award_id":"107032AIA","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2837399179","display_name":"Understanding the pathobiology of Mycobacterium abscessus infection","funder_award_id":"226602/Z/22/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5682672817","display_name":"Understanding the pathobiology of Mycobacterium abscessus infection","funder_award_id":"226602","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320009","display_name":"Cystic Fibrosis Trust","ror":"https://ror.org/03xeae684"},{"id":"https://openalex.org/F4320326958","display_name":"Fondation Botnar","ror":"https://ror.org/033ztm745"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212227699.pdf","grobid_xml":"https://content.openalex.org/works/W7212227699.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3047054214"],"related_works":["https://openalex.org/W7097125827","https://openalex.org/W3110075829","https://openalex.org/W992378567","https://openalex.org/W6893063890","https://openalex.org/W3135171567","https://openalex.org/W1968224295","https://openalex.org/W112600855","https://openalex.org/W7037862660","https://openalex.org/W3087021091","https://openalex.org/W1970235827"],"abstract_inverted_index":{"Abstract":[0],"Hantaviruses":[1],"are":[2,58,102,193],"emerging":[3],"zoonotic":[4],"viruses":[5,119],"that":[6,22,55,57,101,149,165,187],"infect":[7],"humans":[8,125],"with":[9,121,174],"high":[10],"fatality":[11],"rates.":[12],"We":[13,53,81,161],"currently":[14],"have":[15,63],"a":[16,64,137],"poor":[17],"understanding":[18],"of":[19,38,75,90,129,144,178],"the":[20,29,36,76,142,175,201],"processes":[21],"contribute":[23],"to":[24,71,95,104,140,196],"hantavirus":[25,51,197],"mutagenesis":[26,170],"and":[27,44,126,189],"therefore":[28,183],"potential":[30],"for":[31,114,205],"viral":[32,206],"adaptation.":[33,207],"To":[34],"understand":[35],"drivers":[37],"mutations":[39],"in":[40,84,97,124,155,171],"hantaviruses,":[41,88,173],"we":[42,109,147],"calculated":[43],"compared":[45],"mutational":[46,85,116,153],"spectra":[47],"across":[48,60,87,159],"14":[49],"divergent":[50],"species.":[52],"found":[54,82,148],"mutagens":[56,188],"conserved":[59],"host":[61,98,190],"species":[62],"major":[65,194],"impact":[66,143],"on":[67],"hantaviruses":[68],"mutagenesis,":[69,198],"contributing":[70],"at":[72],"least":[73],"six":[74],"12":[77],"possible":[78],"mutation":[79,157],"types.":[80],"differences":[83,132],"signatures":[86,117],"some":[89],"which":[91],"may":[92],"be":[93],"due":[94],"variation":[96],"mutagen":[99],"levels":[100],"known":[103],"influence":[105],"somatic":[106],"mutations.":[107],"However,":[108],"could":[110],"find":[111,163],"no":[112,127],"evidence":[113,128,164],"differential":[115],"between":[118,133],"associated":[120],"distinct":[122],"diseases":[123],"tissue":[130],"tropism":[131],"reservoir":[134],"hosts.":[135],"Using":[136],"novel":[138],"method":[139],"quantify":[141],"ZAP-mediated":[145],"selection,":[146],"ZAP":[150],"greatly":[151],"influences":[152],"patterns":[154],"transition":[156],"types":[158],"hantaviruses.":[160],"also":[162],"APOBEC":[166],"family":[167],"proteins":[168,192],"drive":[169],"all":[172],"likely":[176],"exception":[177],"Nova":[179],"virus.":[180],"Our":[181],"results":[182],"provide":[184],"strong":[185],"support":[186],"antiviral":[191],"contributors":[195],"thereby":[199],"generating":[200],"genetic":[202],"diversity":[203],"necessary":[204]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-12T00:00:00"}
