{"id":"https://openalex.org/W7212220392","doi":"https://doi.org/10.1039/d6cb00249h","title":"Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry","display_name":"Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7212220392","doi":"https://doi.org/10.1039/d6cb00249h","pmid":"https://pubmed.ncbi.nlm.nih.gov/42781329","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13598754"},"language":"en","primary_location":{"id":"doi:10.1039/d6cb00249h","doi":"https://doi.org/10.1039/d6cb00249h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6cb00249h","pdf_url":null,"source":{"id":"https://openalex.org/S4210222191","display_name":"RSC Chemical Biology","issn_l":"2633-0679","issn":["2633-0679"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1039/d6cb00249h","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151405637","display_name":"Xu-Xue Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53592917","display_name":"Jiangxi Normal University","ror":"https://ror.org/05nkgk822","country_code":"CN","type":"education","lineage":["https://openalex.org/I53592917"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuxue Liu","raw_affiliation_strings":["National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China","institution_ids":["https://openalex.org/I53592917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023749086","display_name":"Xiangyang Gao","orcid":"https://orcid.org/0000-0003-1795-7127","observed_orcids":["https://orcid.org/0000-0003-1795-7127"]},"institutions":[{"id":"https://openalex.org/I53592917","display_name":"Jiangxi Normal University","ror":"https://ror.org/05nkgk822","country_code":"CN","type":"education","lineage":["https://openalex.org/I53592917"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyang Gao","raw_affiliation_strings":["National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China","institution_ids":["https://openalex.org/I53592917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093477450","display_name":"Sasipa Booranamonthol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sasipa Booranamonthol","raw_affiliation_strings":["School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151401130","display_name":"Peng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53592917","display_name":"Jiangxi Normal University","ror":"https://ror.org/05nkgk822","country_code":"CN","type":"education","lineage":["https://openalex.org/I53592917"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wu","raw_affiliation_strings":["National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China","institution_ids":["https://openalex.org/I53592917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026316461","display_name":"Rung\u2010Yi Lai","orcid":"https://orcid.org/0000-0002-2076-0969","observed_orcids":["https://orcid.org/0000-0002-2076-0969"]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Rung-Yi Lai","raw_affiliation_strings":["School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-2076-0969","affiliations":[{"raw_affiliation_string":"School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100360212","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0002-8135-2221","observed_orcids":["https://orcid.org/0000-0002-8135-2221","https://orcid.org/0000-0001-6915-7581"]},"institutions":[{"id":"https://openalex.org/I53592917","display_name":"Jiangxi Normal University","ror":"https://ror.org/05nkgk822","country_code":"CN","type":"education","lineage":["https://openalex.org/I53592917"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China"],"raw_orcid":"https://orcid.org/0000-0002-8135-2221","affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China","institution_ids":["https://openalex.org/I53592917"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026316461","https://openalex.org/A5100360212"],"corresponding_institution_ids":["https://openalex.org/I53592917","https://openalex.org/I82475049"],"apc_list":{"value":1600,"currency":"GBP","value_usd":1962},"apc_paid":{"value":1600,"currency":"GBP","value_usd":1962},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36607143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"11","first_page":"2109","last_page":"2123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radical-sam-enzymes","display_name":"radical SAM enzymes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/5-deoxyadenosyl-radical","display_name":"5'-deoxyadenosyl radical","score":0.9340000152587891},{"id":"https://openalex.org/keywords/iron-sulfur-clusters","display_name":"iron-sulfur clusters","score":0.7720000147819519},{"id":"https://openalex.org/keywords/photoactivation","display_name":"photoactivation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/formylglycine","display_name":"formylglycine","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7584999799728394},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.6818000078201294},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6503999829292297},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5781000256538391},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4925999939441681},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.3278000056743622},{"id":"https://openalex.org/C84211826","wikidata":"https://www.wikidata.org/wiki/Q5260078","display_name":"Deoxyribozyme","level":3,"score":0.32659998536109924},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.24969999492168427}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/d6cb00249h","doi":"https://doi.org/10.1039/d6cb00249h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6cb00249h","pdf_url":null,"source":{"id":"https://openalex.org/S4210222191","display_name":"RSC Chemical Biology","issn_l":"2633-0679","issn":["2633-0679"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Chemical Biology","raw_type":"journal-article"},{"id":"pmid:42781329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42781329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13598754","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42781329/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Chem Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3ea1f2dab6dc4ad6a71aa6676bc7139d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3ea1f2dab6dc4ad6a71aa6676bc7139d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RSC Chemical Biology, Vol 7, Iss 11, Pp 2109-2109 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1039/d6cb00249h","doi":"https://doi.org/10.1039/d6cb00249h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6cb00249h","pdf_url":null,"source":{"id":"https://openalex.org/S4210222191","display_name":"RSC Chemical Biology","issn_l":"2633-0679","issn":["2633-0679"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4837218186","display_name":null,"funder_award_id":"U22A20451","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5205579436","display_name":null,"funder_award_id":"22477049","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7895488281","display_name":null,"funder_award_id":"22567020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000371895","display_name":null,"funder_award_id":"Project code 215520","funder_id":"https://openalex.org/F4320322574","funder_display_name":"Suranaree University of Technology"},{"id":"https://openalex.org/G9000373062","display_name":null,"funder_award_id":"22607086","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000376087","display_name":null,"funder_award_id":"Project code: 215520","funder_id":"https://openalex.org/F4320329659","funder_display_name":"Thailand Science Research and Innovation"},{"id":"https://openalex.org/G9000384122","display_name":null,"funder_award_id":"22625701","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322574","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78"},{"id":"https://openalex.org/F4320329659","display_name":"Thailand Science Research and Innovation","ror":"https://ror.org/000025p04"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W41220400","https://openalex.org/W1599030128","https://openalex.org/W1976866213","https://openalex.org/W1983639577","https://openalex.org/W1989362657","https://openalex.org/W1996941025","https://openalex.org/W1997894773","https://openalex.org/W2004939146","https://openalex.org/W2009008810","https://openalex.org/W2013347964","https://openalex.org/W2021802134","https://openalex.org/W2022897757","https://openalex.org/W2028286294","https://openalex.org/W2029120628","https://openalex.org/W2034270556","https://openalex.org/W2039020750","https://openalex.org/W2041399238","https://openalex.org/W2042137812","https://openalex.org/W2048064762","https://openalex.org/W2050117377","https://openalex.org/W2051067390","https://openalex.org/W2060936398","https://openalex.org/W2065373434","https://openalex.org/W2076558529","https://openalex.org/W2088264214","https://openalex.org/W2089410224","https://openalex.org/W2090611477","https://openalex.org/W2092788715","https://openalex.org/W2111113725","https://openalex.org/W2111854009","https://openalex.org/W2113428287","https://openalex.org/W2114596717","https://openalex.org/W2132446594","https://openalex.org/W2139973477","https://openalex.org/W2150710339","https://openalex.org/W2155212912","https://openalex.org/W2164545938","https://openalex.org/W2165385826","https://openalex.org/W2166554692","https://openalex.org/W2172791605","https://openalex.org/W2212455551","https://openalex.org/W2264473432","https://openalex.org/W2279725871","https://openalex.org/W2282470139","https://openalex.org/W2309149573","https://openalex.org/W2320446052","https://openalex.org/W2324850324","https://openalex.org/W2330007989","https://openalex.org/W2333303357","https://openalex.org/W2344199752","https://openalex.org/W2361660721","https://openalex.org/W2396643508","https://openalex.org/W2405824217","https://openalex.org/W2509346019","https://openalex.org/W2564928567","https://openalex.org/W2598798124","https://openalex.org/W2614051244","https://openalex.org/W2675350756","https://openalex.org/W2755025259","https://openalex.org/W2765975792","https://openalex.org/W2766395974","https://openalex.org/W2768059482","https://openalex.org/W2769324218","https://openalex.org/W2781651750","https://openalex.org/W2792353965","https://openalex.org/W2802187948","https://openalex.org/W2892934299","https://openalex.org/W2898306622","https://openalex.org/W2920095441","https://openalex.org/W2921147565","https://openalex.org/W2940128429","https://openalex.org/W2944940486","https://openalex.org/W2949759563","https://openalex.org/W2972844371","https://openalex.org/W2995478740","https://openalex.org/W3109221695","https://openalex.org/W3115924303","https://openalex.org/W3119738283","https://openalex.org/W3161916976","https://openalex.org/W3174953714","https://openalex.org/W3184390680","https://openalex.org/W3195314931","https://openalex.org/W3204567320","https://openalex.org/W3206425985","https://openalex.org/W3215360475","https://openalex.org/W4200562442","https://openalex.org/W4210532014","https://openalex.org/W4210741132","https://openalex.org/W4212986842","https://openalex.org/W4220893507","https://openalex.org/W4220969851","https://openalex.org/W4224947625","https://openalex.org/W4236650579","https://openalex.org/W4281777980","https://openalex.org/W4285390938","https://openalex.org/W4312095257","https://openalex.org/W4313214653","https://openalex.org/W4313554934","https://openalex.org/W4328049526","https://openalex.org/W4362632611","https://openalex.org/W4367319112","https://openalex.org/W4378745734","https://openalex.org/W4380730862","https://openalex.org/W4385834196","https://openalex.org/W4387527415","https://openalex.org/W4388333989","https://openalex.org/W4388839879","https://openalex.org/W4390816536","https://openalex.org/W4391775211","https://openalex.org/W4394710711","https://openalex.org/W4396852130","https://openalex.org/W4400972757","https://openalex.org/W4401398687","https://openalex.org/W4405595613","https://openalex.org/W4405949015","https://openalex.org/W4410117165","https://openalex.org/W4412793554","https://openalex.org/W4412822501","https://openalex.org/W4413397682","https://openalex.org/W4415823570","https://openalex.org/W4416910616","https://openalex.org/W4417261028","https://openalex.org/W7131218983","https://openalex.org/W7134112576"],"related_works":["https://openalex.org/W4412793554","https://openalex.org/W4306664328","https://openalex.org/W3208385768","https://openalex.org/W4200569640","https://openalex.org/W4225383320","https://openalex.org/W2765819225","https://openalex.org/W2061269899","https://openalex.org/W2110506044","https://openalex.org/W1979280203","https://openalex.org/W2169221210"],"abstract_inverted_index":{"-adenosylmethionine":[0],"(SAM)":[1],"by":[2,107],"an":[3],"iron-sulfur":[4],"cluster,":[5],"generating":[6],"the":[7,25,52,84,117,127],"highly":[8],"reactive":[9],"5'-deoxyadenosyl":[10],"radical":[11,61,66,104,161],"(5'-dAdo\u02d9),":[12],"which":[13],"initiates":[14],"a":[15,87],"broad":[16],"range":[17],"of":[18,27,48,54,86,119,129],"challenging":[19],"transformations.":[20,125],"Recent":[21],"advances":[22,153],"have":[23,69],"expanded":[24],"reactivity":[26],"rSAM":[28,120,130,155],"enzymes":[29,121,131,156],"beyond":[30],"their":[31,146],"natural":[32],"roles,":[33],"revealing":[34],"unprecedented":[35],"mechanistic":[36],"flexibility":[37],"and":[38,75,112,165],"synthetic":[39],"potential.":[40],"Photochemical":[41],"activation":[42],"strategies":[43],"now":[44],"enable":[45],"light-driven":[46],"reduction":[47],"[4Fe-4S]":[49],"clusters":[50],"in":[51,148],"presence":[53],"biological":[55],"or":[56],"chemical":[57,149,163],"photosensitizers,":[58],"thereby":[59],"initiating":[60],"formation.":[62],"In":[63],"parallel,":[64],"cobalamin-dependent":[65],"SAM":[67,81],"methyltransferases":[68],"opened":[70],"new":[71],"avenues":[72],"for":[73,132,140,160],"ethyl":[74],"fluoromethyl":[76],"transfer":[77],"chemistry":[78],"using":[79],"corresponding":[80],"analogues.":[82],"Notably,":[83],"use":[85],"strategically":[88],"engineered,":[89],"stable":[90],"analogue,":[91],"such":[92],"as":[93,157],"7-deazaadenine-tetrazole-substituted":[94],"F-SAM":[95],"(F-7dz-tSAM),":[96],"has":[97,135],"successfully":[98],"overcome":[99],"inherent":[100],"cofactor":[101],"degradation.":[102],"Noncanonical":[103],"reactivity,":[105],"exemplified":[106],"ArsL-catalyzed":[108],"C-As":[109],"bond":[110],"formation":[111,139],"NosL-mediated":[113],"photoinduced":[114],"trifluoromethylation,":[115],"demonstrates":[116],"capacity":[118],"to":[122],"perform":[123],"new-to-nature":[124,166],"Lastly,":[126],"repurposing":[128],"formylglycine":[133],"generation":[134],"enabled":[136],"orthogonal":[137],"aldehyde-tag":[138],"bioorthogonal":[141],"protein":[142],"labeling,":[143],"further":[144],"expanding":[145],"utility":[147],"biology.":[150],"Collectively,":[151],"these":[152],"establish":[154],"versatile":[158],"platforms":[159],"biocatalysis,":[162],"biology,":[164],"chemistry.":[167]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-12T00:00:00"}