{"id":"https://openalex.org/W7212184673","doi":"https://doi.org/10.21203/rs.3.rs-9950101/v1","title":"GWAS integrating maternal and child genetics reveals novel risk-modifying loci for fetal alcohol spectrum disorders (FASD)","display_name":"GWAS integrating maternal and child genetics reveals novel risk-modifying loci for fetal alcohol spectrum disorders (FASD)","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212184673","doi":"https://doi.org/10.21203/rs.3.rs-9950101/v1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622852"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-9950101/v1","doi":"https://doi.org/10.21203/rs.3.rs-9950101/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9950101/v1","pdf_url":"https://www.researchsquare.com/article/rs-9950101/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-9950101/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151126340","display_name":"Robert Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Carter","raw_affiliation_strings":["Institute of Human Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019155720","display_name":"Vivek Ruhela","orcid":"https://orcid.org/0000-0003-4652-2376","observed_orcids":["https://orcid.org/0000-0003-4652-2376"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Ruhela","raw_affiliation_strings":["Columbia Univeristy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Univeristy","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037549775","display_name":"Corina Lesseur","orcid":"https://orcid.org/0000-0001-6744-6750","observed_orcids":["https://orcid.org/0000-0001-6744-6750"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corina Lesseur","raw_affiliation_strings":["Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005219923","display_name":"Ariadna Cilleros\u2010Portet","orcid":"https://orcid.org/0000-0001-7564-6840","observed_orcids":["https://orcid.org/0000-0001-7564-6840"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariadna Cilleros-Portet","raw_affiliation_strings":["Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010069159","display_name":"Sandra W. Jacobson","orcid":"https://orcid.org/0000-0002-9768-2671","observed_orcids":["https://orcid.org/0000-0002-9768-2671"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra W. Jacobson","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026175668","display_name":"Joseph L. Jacobson","orcid":"https://orcid.org/0000-0001-8271-280X","observed_orcids":["https://orcid.org/0000-0001-8271-280X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph L. Jacobson","raw_affiliation_strings":["Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021539154","display_name":"Ernesta M. Meintjes","orcid":"https://orcid.org/0000-0002-0781-3632","observed_orcids":["https://orcid.org/0000-0002-0781-3632"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Ernesta Meintjes","raw_affiliation_strings":["University of Cape Town Faculty of Health Sciences"],"raw_orcid":"https://orcid.org/0000-0002-0781-3632","affiliations":[{"raw_affiliation_string":"University of Cape Town Faculty of Health Sciences","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009553111","display_name":"Neil C. Dodge","orcid":"https://orcid.org/0000-0002-5666-3060","observed_orcids":["https://orcid.org/0000-0002-5666-3060"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Dodge","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057456974","display_name":"Tugba Akkaya-Hocagil","orcid":"https://orcid.org/0000-0003-3603-4491","observed_orcids":["https://orcid.org/0000-0003-3603-4491"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tugba Akkaya-Hocagil","raw_affiliation_strings":["Department of Biostatistics, School of Medicine, Ankara University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Medicine, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078913456","display_name":"H. Eugene Hoyme","orcid":"https://orcid.org/0000-0002-1979-693X","observed_orcids":["https://orcid.org/0000-0002-1979-693X"]},"institutions":[{"id":"https://openalex.org/I1305840828","display_name":"Sanford Health","ror":"https://ror.org/003smky23","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305840828"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Eugene Hoyme","raw_affiliation_strings":["Sanford Children's Genomic Medicine Consortium, Sanford Health, Sioux Falls, South Dakota; Department of Pediatrics, USA","University of Arizona College of Medicine, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Children's Genomic Medicine Consortium, Sanford Health, Sioux Falls, South Dakota; Department of Pediatrics, USA","institution_ids":["https://openalex.org/I1305840828"]},{"raw_affiliation_string":"University of Arizona College of Medicine, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134802826","display_name":"Haoxiang Cheng","orcid":"https://orcid.org/0000-0002-1393-6006","observed_orcids":["https://orcid.org/0000-0002-1393-6006"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoxiang Cheng","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151193606","display_name":"Jia Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Chen","raw_affiliation_strings":["Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005885222","display_name":"Ke Hao","orcid":"https://orcid.org/0000-0002-1815-9197","observed_orcids":["https://orcid.org/0000-0002-1815-9197"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Hao","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":"https://orcid.org/0000-0002-1815-9197","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076434543","display_name":"Maya A. Deyssenroth","orcid":"https://orcid.org/0000-0003-2913-2392","observed_orcids":["https://orcid.org/0000-0003-2913-2392"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya A. Deyssenroth","raw_affiliation_strings":["Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004919781","display_name":"Giuseppe Tosto","orcid":"https://orcid.org/0000-0001-7075-8245","observed_orcids":["https://orcid.org/0000-0001-7075-8245"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Tosto","raw_affiliation_strings":["Columbia Univeristy"],"raw_orcid":"https://orcid.org/0000-0001-7075-8245","affiliations":[{"raw_affiliation_string":"Columbia Univeristy","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.996999979019165},{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.777999997138977},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.8399999737739563},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.9900000095367432},{"id":"https://openalex.org/keywords/height-for-age","display_name":"height-for-age","score":0.7799999713897705},{"id":"https://openalex.org/keywords/syntaxin-6","display_name":"syntaxin 6","score":0.8640000224113464},{"id":"https://openalex.org/keywords/foxd3","display_name":"FOXD3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/wwox","display_name":"WWOX","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cop1","display_name":"COP1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/placental-gene-expression","display_name":"placental gene expression","score":0.828000009059906},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.5199999809265137},{"id":"https://openalex.org/keywords/neurobehavioral-outcomes","display_name":"neurobehavioral outcomes","score":0.718999981880188},{"id":"https://openalex.org/keywords/fasd-diagnosis","display_name":"FASD diagnosis","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2776885448","wikidata":"https://www.wikidata.org/wiki/Q10860589","display_name":"Transmission disequilibrium test","level":5,"score":0.5250999927520752},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5199999809265137},{"id":"https://openalex.org/C3020575016","wikidata":"https://www.wikidata.org/wiki/Q400277","display_name":"Fetal alcohol","level":3,"score":0.5009999871253967},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.49970000982284546},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.45190000534057617},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.438400000333786},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.41519999504089355},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4081999957561493},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4027999937534332},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.3991999924182892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3871000111103058},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.36410000920295715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35600000619888306},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.3472000062465668},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34119999408721924},{"id":"https://openalex.org/C2908952752","wikidata":"https://www.wikidata.org/wiki/Q400277","display_name":"Fetal Alcohol Spectrum Disorder","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2976999878883362},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C169594400","wikidata":"https://www.wikidata.org/wiki/Q244775","display_name":"Twin study","level":3,"score":0.2513999938964844}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21203/rs.3.rs-9950101/v1","doi":"https://doi.org/10.21203/rs.3.rs-9950101/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9950101/v1","pdf_url":"https://www.researchsquare.com/article/rs-9950101/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622852","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622852/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622852/pdf/nihpp-rs9950101v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmid:42818975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-9950101/v1","doi":"https://doi.org/10.21203/rs.3.rs-9950101/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9950101/v1","pdf_url":"https://www.researchsquare.com/article/rs-9950101/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1340132978","display_name":"The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans","funder_award_id":"K23AA020516","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G3995207635","display_name":"Neural Bases of Eyeblink Conditioning in FASD","funder_award_id":"R01AA016781","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5433379174","display_name":"Identification of fetal alcohol-affected children: Alterations in imprinted gene expression and methylation as biomarkers of neurobehavioral and growth impairment.","funder_award_id":"R01AA027916","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5780193468","display_name":"Polygenic Risk Scores for Alzheimer's Disease in Hispanic/Latinx Populations","funder_award_id":"RF1AG082009","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8067249829","display_name":"Identification of FASD in South African Children","funder_award_id":"U01AA014790","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8360716821","display_name":"Behavioral Characteristics and Neural Correlates of Reading Impairment in FASD","funder_award_id":"R01AA023503","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000889395","display_name":"GLASS-AD: Global Latinos Sequencing Study for Alzheimer's Disease","funder_award_id":"U01AG081817","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000895417","display_name":"Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)","funder_award_id":"U19AG074865","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309272","display_name":"Wayne State University","ror":"https://ror.org/01070mq45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212184673.pdf","grobid_xml":"https://content.openalex.org/works/W7212184673.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7105766592","https://openalex.org/W2342889714","https://openalex.org/W4415085470","https://openalex.org/W4403449488","https://openalex.org/W4315795961","https://openalex.org/W2036749649","https://openalex.org/W4297692271","https://openalex.org/W2246246810","https://openalex.org/W3102444740","https://openalex.org/W2227236637"],"abstract_inverted_index":{"Abstract":[0],"Fetal":[1,61],"alcohol":[2,14],"spectrum":[3],"disorders":[4],"(FASD)":[5],"exhibit":[6],"wide":[7],"phenotypic":[8],"variability":[9],"not":[10],"explained":[11],"by":[12],"prenatal":[13],"exposure":[15],"(PAE)":[16],"alone.":[17],"While":[18],"genetic":[19,73],"factors":[20],"may":[21],"modify":[22],"vulnerability,":[23],"there":[24],"are":[25],"no":[26],"prior":[27],"FASD":[28,85,199,244,248],"genome-wide":[29,35,227],"association":[30],"studies":[31],"(GWAS).":[32],"We":[33,70],"performed":[34],"single-marker":[36,88],"and":[37,55,74,84,89,92,130,144,211,231,247],"gene-based":[38,90,135],"analyses":[39,91,136],"of":[40,229],"two":[41],"South":[42],"African":[43],"prospective":[44],"birth":[45],"cohorts":[46],"(Cape":[47],"Town":[48],"Longitudinal":[49],"Cohorts":[50],"(CTLC);":[51],"n=328":[52],"mother-child":[53],"dyads)":[54],"the":[56,93],"US":[57],"Collaborative":[58],"Initiative":[59],"on":[60,78,126,222],"Alcohol":[62],"Spectrum":[63],"Disorders":[64],"cohort":[65],"(CIFASD":[66],"n=429":[67],"children":[68,173],"only).":[69],"examined":[71],"main":[72],"gene-by-PAE":[75],"interaction":[76,134,165,182],"effects":[77],"working":[79,167,184],"memory,":[80,82],"recognition":[81,147],"height,":[83],"diagnosis":[86,200,249],"using":[87],"Haplotype-based":[94],"Transmission":[95],"Disequilibrium":[96],"Test":[97],"(HTDT),":[98],"which":[99],"integrates":[100],"maternal-child":[101],"genetics.":[102],"Genome-wide":[103],"genotype":[104],"array":[105],"data":[106,110,193],"were":[107,111,118,213],"used;":[108],"TOPMed-imputed":[109],"used":[112],"to":[113],"refine":[114],"results.":[115],"Risk-modifying":[116],"genes":[117],"then":[119],"tested":[120],"for":[121,166,183,243],"differential":[122],"mRNA":[123],"expression":[124],"based":[125,221],"PAE":[127],"in":[128,151,172,190,216,234],"placenta":[129,217],"child":[131,157,219,232],"blood.":[132],"Gene*PAE":[133,164,181],"identified":[137,174,194,237],"STX6":[138],"associated":[139,197],"with":[140,146,163,180,198],"height-for-age":[141],"Z-scores":[142],"(p=2.2\u00d710\u207b\u2076)":[143],"FOXD3":[145],"memory":[148,168,185],"performance":[149],"(p=4.7\u00d710\u207b\u2076)":[150],"children.":[152],"Single-marker":[153],"analysis":[154],"detected":[155],"one":[156,175],"SNP":[158],"approaching":[159],"significance":[160],"(rs2833924,":[161],"p=8.8x10-8)":[162],"performance.":[169,186],"CTLC+CIFASD":[170],"meta-analysis":[171],"significant":[176],"locus":[177],"(HTR1E;":[178],"pmeta=2.75\u00d710\u207b\u2076)":[179],"The":[187],"HTDT":[188],"test":[189],"CTLC":[191],"imputed":[192],"three":[195],"haplotypes":[196],"risk:":[201],"COP1":[202],"(padj=0.029),":[203],"WWOX":[204],"(padj=2\u00d710\u207b4),":[205],"TMEM38B":[206,212],"(padj=":[207],"0.019).":[208],"WWOX,":[209],"STX6,":[210],"differentially":[214],"expressed":[215],"and/or":[218],"blood":[220],"PAE.":[223],"In":[224],"this":[225],"first-ever":[226],"investigation":[228],"maternal":[230],"genetics":[233],"FASD,":[235],"we":[236],"multiple":[238],"biologically":[239],"plausible":[240],"risk-modifying":[241],"loci":[242],"neurobehavioral,":[245],"growth,":[246],"outcomes.":[250]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-11T00:00:00"}
