{"id":"https://openalex.org/W7212167695","doi":"https://doi.org/10.1159/res/aepag007","title":"Multidimensional Clinical Deterioration in Interstitial Lung Disease: Longitudinal Concordance of Frailty, Patient-Reported Outcomes, and Lung Function in a Multinational European Registry Cohort Study","display_name":"Multidimensional Clinical Deterioration in Interstitial Lung Disease: Longitudinal Concordance of Frailty, Patient-Reported Outcomes, and Lung Function in a Multinational European Registry Cohort Study","publication_year":2026,"publication_date":"2026-09-04","ids":{"openalex":"https://openalex.org/W7212167695","doi":"https://doi.org/10.1159/res/aepag007","pmid":"https://pubmed.ncbi.nlm.nih.gov/42715138","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722467"},"language":"en","primary_location":{"id":"doi:10.1159/res/aepag007","doi":"https://doi.org/10.1159/res/aepag007","is_oa":true,"landing_page_url":"https://doi.org/10.1159/res/aepag007","pdf_url":"https://karger.com/res/article-pdf/doi/10.1159/res/aepag007/4583220/000554223.pdf","source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://karger.com/res/article-pdf/doi/10.1159/res/aepag007/4583220/000554223.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071628869","display_name":"Silke Tello","orcid":"https://orcid.org/0000-0002-1466-7282","observed_orcids":["https://orcid.org/0000-0002-1466-7282"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silke Tello","raw_affiliation_strings":["Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135860587","display_name":"Anita C. Windhorst","orcid":"https://orcid.org/0000-0002-7357-2080","observed_orcids":["https://orcid.org/0000-0002-7357-2080"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anita C. Windhorst","raw_affiliation_strings":["Institute of Medical Informatics, Justus-Liebig-University Giessen, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Justus-Liebig-University Giessen, Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135830988","display_name":"Heva Mustafa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heva Mustafa","raw_affiliation_strings":["Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066849323","display_name":"Poornima Mahavadi","orcid":"https://orcid.org/0000-0002-7580-4738","observed_orcids":["https://orcid.org/0000-0002-7580-4738"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Poornima Mahavadi","raw_affiliation_strings":["Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121285921","display_name":"Juergen Behr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juergen Behr","raw_affiliation_strings":["Department of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the DZL, Munich, Germany","European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine V, LMU University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the DZL, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075038951","display_name":"Bruno Crestani","orcid":"https://orcid.org/0000-0002-2961-3455","observed_orcids":["https://orcid.org/0000-0002-2961-3455","https://orcid.org/0009-0009-4987-0377"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Crestani","raw_affiliation_strings":["European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","Service de Pneumologie, Centre Constitutif Maladies Pulmonaires Rares, H\u00f4pital Bichat, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]},{"raw_affiliation_string":"Service de Pneumologie, Centre Constitutif Maladies Pulmonaires Rares, H\u00f4pital Bichat, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012539336","display_name":"Carlo Vancheri","orcid":"https://orcid.org/0000-0002-5120-9926","observed_orcids":["https://orcid.org/0000-0002-5120-9926"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Vancheri","raw_affiliation_strings":["European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","Regional Referral Centre for Rare Lung Diseases, A.O.U. Policlinico G. Rodolico-San Marco, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]},{"raw_affiliation_string":"Regional Referral Centre for Rare Lung Diseases, A.O.U. Policlinico G. Rodolico-San Marco, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055981872","display_name":"Mar\u00eda Molina\u2010Molina","orcid":"https://orcid.org/0000-0002-1852-1723","observed_orcids":["https://orcid.org/0000-0002-1852-1723"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Molina Molina","raw_affiliation_strings":["European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","ILD Unit, Pneumology Department, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]},{"raw_affiliation_string":"ILD Unit, Pneumology Department, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225","https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125214595","display_name":"Andreas G\u00fcnther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]},{"id":"https://openalex.org/I4210154233","display_name":"Cardio-Pulmonary Institute","ror":"https://ror.org/04ckbty56","country_code":"DE","type":"facility","lineage":["https://openalex.org/I114090438","https://openalex.org/I149899117","https://openalex.org/I200763008","https://openalex.org/I4210102801","https://openalex.org/I4210154233"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Guenther","raw_affiliation_strings":["Agaplesion Lung Clinic Waldhof Elgershausen, Greifenstein, Germany","Cardio-Pulmonary Institute (CPI), Giessen, Germany","Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","Institute for Lung Health, Justus-Liebig-University Giessen, Member of the DZL, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agaplesion Lung Clinic Waldhof Elgershausen, Greifenstein, Germany","institution_ids":[]},{"raw_affiliation_string":"Cardio-Pulmonary Institute (CPI), Giessen, Germany","institution_ids":["https://openalex.org/I4210154233"]},{"raw_affiliation_string":"Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute for Lung Health, Justus-Liebig-University Giessen, Member of the DZL, Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033766167","display_name":"Ekaterina Krauss","orcid":"https://orcid.org/0000-0001-8682-4294","observed_orcids":["https://orcid.org/0000-0001-8682-4294"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ekaterina Krauss","raw_affiliation_strings":["Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany, ekaterina.krauss@innere.med.uni-giessen.de","European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany, ekaterina.krauss@innere.med.uni-giessen.de"],"raw_orcid":"https://orcid.org/0000-0001-8682-4294","affiliations":[{"raw_affiliation_string":"Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, Justus-Liebig-University Giessen, UGMLC, Member of the DZL, Giessen, Germany, ekaterina.krauss@innere.med.uni-giessen.de","institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"]},{"raw_affiliation_string":"European IPF/ILD Registry and Biobank (eurILDreg), Giessen, Germany, ekaterina.krauss@innere.med.uni-giessen.de","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5033766167"],"corresponding_institution_ids":["https://openalex.org/I200763008","https://openalex.org/I4210131615"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65700156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.7269999980926514},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.9160000085830688},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.35100001096725464},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9210000038146973},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.5640000104904175},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.880299985408783},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.8287000060081482},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.7494000196456909},{"id":"https://openalex.org/C16020263","wikidata":"https://www.wikidata.org/wiki/Q1778553","display_name":"DLCO","level":5,"score":0.6316999793052673},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.620199978351593},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.5924999713897705},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C2908964109","wikidata":"https://www.wikidata.org/wiki/Q5282128","display_name":"Patient registry","level":2,"score":0.5055000185966492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48989999294281006},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42309999465942383},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.41190001368522644},{"id":"https://openalex.org/C55520419","wikidata":"https://www.wikidata.org/wiki/Q660995","display_name":"Vital capacity","level":5,"score":0.3555000126361847},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.27070000767707825},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2515999972820282},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.25110000371932983},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.2508000135421753}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1159/res/aepag007","doi":"https://doi.org/10.1159/res/aepag007","is_oa":true,"landing_page_url":"https://doi.org/10.1159/res/aepag007","pdf_url":"https://karger.com/res/article-pdf/doi/10.1159/res/aepag007/4583220/000554223.pdf","source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},{"id":"pmid:42715138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42715138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration; international review of thoracic diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722467","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1159/res/aepag007","doi":"https://doi.org/10.1159/res/aepag007","is_oa":true,"landing_page_url":"https://doi.org/10.1159/res/aepag007","pdf_url":"https://karger.com/res/article-pdf/doi/10.1159/res/aepag007/4583220/000554223.pdf","source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320326487","display_name":"Deutsches Zentrum f\u00fcr Lungenforschung","ror":"https://ror.org/03dx11k66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212167695.pdf","grobid_xml":"https://content.openalex.org/works/W7212167695.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387980284","https://openalex.org/W7165743895","https://openalex.org/W4392203507","https://openalex.org/W6929280361","https://openalex.org/W3156683484","https://openalex.org/W4391432483","https://openalex.org/W7124706763","https://openalex.org/W7151073047","https://openalex.org/W2554494091","https://openalex.org/W4387982073"],"abstract_inverted_index":{"INTRODUCTION:":[0],"In":[1,47,215],"interstitial":[2],"lung":[3,10,117,134,223],"disease":[4],"(ILD),":[5],"progression":[6,186,311],"is":[7],"tracked":[8],"along":[9],"physiology,":[11],"patient-reported":[12,220,242,249,283],"outcome":[13],"measures":[14,287],"(PROMs),":[15],"and":[16,18,133,151,222,265,285,291,307],"frailty,":[17,131,219],"prior":[19],"registries":[20],"report":[21],"that":[22,293],"these":[23],"dimensions":[24],"correlate":[25],"at":[26,68,229],"the":[27,36,51,58,69,128,144,152,172,209,230,233,241,245,255,279,308],"group":[28],"level.":[29],"Whether":[30],"deterioration":[31,217],"on":[32,199,261,266],"one":[33],"axis":[34],"identifies":[35],"same":[37],"individual":[38,234],"patients":[39,123],"as":[40,66],"another":[41],"has":[42],"not":[43,155,271],"been":[44],"examined.":[45],"METHODS:":[46],"371":[48],"adults":[49],"from":[50],"multinational":[52],"European":[53],"ILD":[54,60,174,305],"Registry":[55],"(eurILDreg),":[56],"spanning":[57],"full":[59],"spectrum,":[61],"baseline-to-last-visit":[62],"change":[63],"was":[64,91,102,154,187],"classified":[65],"decline":[67,192,298],"minimal":[70],"clinically":[71],"important":[72],"difference":[73],"across":[74],"eight":[75,145],"instruments":[76,146],"(CFS,":[77],"MRC":[78],"dyspnoea,":[79],"K-BILD,":[80],"LCQ,":[81],"EQ-5D-5L,":[82],"cough":[83],"VAS,":[84],"FVC":[85,202,267],"%pred,":[86],"DLCO":[87],"%pred).":[88],"Patient-level":[89],"agreement":[90,238],"quantified":[92],"by":[93,157],"Cohen's":[94],"\u03ba,":[95],"interpreted":[96],"direction-sensitively;":[97],"a":[98,168],"pre-specified":[99],"window-matched":[100],"analysis":[101],"primary,":[103],"to":[104],"account":[105],"for":[106],"differinginstrument":[107],"follow-up":[108],"windows":[109],"differed":[110],"(analysis-specific":[111],"n":[112],"105-178).":[113],"Outcomes":[114],"(death":[115],"or":[116,167],"transplantation)":[118],"were":[119],"ascertained":[120],"in":[121,137,218,268],"312":[122],"(24":[124],"events).":[125],"RESULTS:":[126],"At":[127],"individual-patient":[129],"level,":[130],"PROMs,":[132],"function":[135],"deteriorated":[136],"largely":[138,226],"different":[139],"patients:":[140],"No":[141],"pair":[142],"of":[143,206,232,281,296,310],"exceeded":[147],"\u03ba":[148,165,181],"=":[149,182],"0.33,":[150],"discordance":[153],"explained":[156],"measurement":[158],"timing,":[159],"diagnostic":[160],"heterogeneity":[161],"(persisting":[162],"within":[163,240],"IPF,":[164],"0.07-0.26),":[166],"single":[169,263],"domain":[170],"-":[171],"two":[173],"PROMs":[175],"themselves":[176],"disagreed":[177],"(K-BILD":[178],"\u00d7":[179],"LCQ":[180],"-0.19).":[183],"Physiological":[184],"(FVC-defined)":[185],"independently":[188],"associated":[189],"with":[190,236,247],"K-BILD":[191,200],"(OR":[193],"5.03).":[194],"A":[195],"spirometry-invisible":[196],"subgroup":[197,246],"declining":[198,248],"while":[201],"remained":[203],"stable":[204],"(22%":[205],"134)":[207],"carried":[208],"highest":[210,256],"event":[211,257],"rate":[212],"(13.3%).":[213],"CONCLUSION:":[214],"ILD,":[216],"outcomes,":[221],"physiology":[224],"identified":[225],"non-overlapping":[227],"populations":[228],"level":[231],"patient,":[235],"low":[237],"even":[239],"domain.":[243],"Because":[244],"outcomes":[250,284,301],"but":[251],"preserved":[252],"spirometry":[253],"showed":[254],"rate,":[258],"assessment":[259,290],"based":[260],"any":[262],"measure,":[264],"particular,":[269],"may":[270],"capture":[272],"all":[273],"deteriorating":[274],"patients.":[275],"These":[276],"findings":[277],"support":[278],"integration":[280],"validated":[282],"frailty":[286],"into":[288],"multidimensional":[289],"indicate":[292],"prospective":[294],"validation":[295],"multi-axis":[297],"against":[299],"clinical":[300],"should":[302],"inform":[303],"future":[304],"research":[306],"design":[309],"criteria.":[312]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-11T00:00:00"}