{"id":"https://openalex.org/W7212160685","doi":"https://doi.org/10.64898/2026.09.06.749651","title":"Deep Learning-based Modeling Enhances Efficacy of Natural Ligand CAR Binders Targeting CD70","display_name":"Deep Learning-based Modeling Enhances Efficacy of Natural Ligand CAR Binders Targeting CD70","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212160685","doi":"https://doi.org/10.64898/2026.09.06.749651","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818546","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622484"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.06.749651","doi":"https://doi.org/10.64898/2026.09.06.749651","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.06.749651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.06.749651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.06.749651.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038168390","display_name":"Amrik S. Kang","orcid":"https://orcid.org/0000-0003-0445-5654","observed_orcids":["https://orcid.org/0000-0003-0445-5654"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrik S Kang","raw_affiliation_strings":["Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA","Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA","UCSF/Gladstone Institute for Genomic Immunology, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0003-0445-5654","affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"UCSF/Gladstone Institute for Genomic Immunology, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058176725","display_name":"Radhika Dalal","orcid":"https://orcid.org/0000-0002-7128-5635","observed_orcids":["https://orcid.org/0000-0002-7128-5635"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radhika Dalal","raw_affiliation_strings":["Biophysics Graduate Program, University of California, San Francisco, San Francisco, CA","Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0002-7128-5635","affiliations":[{"raw_affiliation_string":"Biophysics Graduate Program, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151127812","display_name":"Mingcheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingcheng Li","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077404629","display_name":"Anupam Anand Ojha","orcid":"https://orcid.org/0000-0001-6588-3092","observed_orcids":["https://orcid.org/0000-0001-6588-3092"]},"institutions":[{"id":"https://openalex.org/I4387153999","display_name":"Flatiron Institute","ror":"https://ror.org/00sekdz59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupam Anand Ojha","raw_affiliation_strings":["Center for Computational Biology, Flatiron Institute, New York, NY","Center for Computational Mathematics, Flatiron Institute, New York, NY"],"raw_orcid":"https://orcid.org/0000-0001-6588-3092","affiliations":[{"raw_affiliation_string":"Center for Computational Biology, Flatiron Institute, New York, NY","institution_ids":["https://openalex.org/I4387153999"]},{"raw_affiliation_string":"Center for Computational Mathematics, Flatiron Institute, New York, NY","institution_ids":["https://openalex.org/I4387153999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042713878","display_name":"Sujata B. Walunj","orcid":"https://orcid.org/0000-0001-5896-2921","observed_orcids":["https://orcid.org/0000-0001-5896-2921"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujata Walunj","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0001-5896-2921","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021355660","display_name":"Caitlin E. Cornell","orcid":"https://orcid.org/0000-0001-7675-1415","observed_orcids":["https://orcid.org/0000-0001-7675-1415"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin E Cornell","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, Berkeley, CA"],"raw_orcid":"https://orcid.org/0000-0001-7675-1415","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, Berkeley, CA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030619729","display_name":"Ruyan Rahnama","orcid":"https://orcid.org/0000-0003-3025-3546","observed_orcids":["https://orcid.org/0000-0003-3025-3546"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruyan Rahnama","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","Department of Pediatrics, University of California San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0003-3025-3546","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Pediatrics, University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090370978","display_name":"Abhilash Barpanda","orcid":"https://orcid.org/0000-0001-8158-4949","observed_orcids":["https://orcid.org/0000-0001-8158-4949"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhilash Barpanda","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0001-8158-4949","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119436600","display_name":"Sanjana Prudhvi","orcid":"https://orcid.org/0009-0000-9963-8984","observed_orcids":["https://orcid.org/0009-0000-9963-8984"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjana Prudhvi","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0009-0000-9963-8984","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082247125","display_name":"Trishna S. Patel","orcid":"https://orcid.org/0000-0002-3017-5771","observed_orcids":["https://orcid.org/0000-0002-3017-5771"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trishna S Patel","raw_affiliation_strings":["Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA","Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0002-3017-5771","affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030184484","display_name":"Mark Aspinall-O\u2019Dea","orcid":"https://orcid.org/0000-0002-5526-974X","observed_orcids":["https://orcid.org/0000-0002-5526-974X"]},"institutions":[{"id":"https://openalex.org/I4210094381","display_name":"Charles River Laboratories (United Kingdom)","ror":"https://ror.org/00q2mch05","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210094381","https://openalex.org/I4210126295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Aspinall-O\u2019Dea","raw_affiliation_strings":["Charles River Laboratories England, High Peak, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles River Laboratories England, High Peak, United Kingdom","institution_ids":["https://openalex.org/I4210094381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109778427","display_name":"Beth Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094381","display_name":"Charles River Laboratories (United Kingdom)","ror":"https://ror.org/00q2mch05","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210094381","https://openalex.org/I4210126295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Beth Walker","raw_affiliation_strings":["Charles River Laboratories England, High Peak, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles River Laboratories England, High Peak, United Kingdom","institution_ids":["https://openalex.org/I4210094381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151266152","display_name":"Clare Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094381","display_name":"Charles River Laboratories (United Kingdom)","ror":"https://ror.org/00q2mch05","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210094381","https://openalex.org/I4210126295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Adams","raw_affiliation_strings":["Charles River Laboratories England, High Peak, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles River Laboratories England, High Peak, United Kingdom","institution_ids":["https://openalex.org/I4210094381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030364434","display_name":"Veronica Steri","orcid":"https://orcid.org/0000-0003-2499-6618","observed_orcids":["https://orcid.org/0000-0003-2499-6618"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Steri","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0003-2499-6618","affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033141354","display_name":"Paul J. Phojanakong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Phojanakong","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126175626","display_name":"Juan Antonio Camara Serrano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Antonio Camara Serrano","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151160332","display_name":"Hua Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Li","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Zeng","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051411569","display_name":"Jos\u00e9 M. Rivera","orcid":"https://orcid.org/0000-0002-9126-4559","observed_orcids":["https://orcid.org/0000-0002-9126-4559"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Rivera","raw_affiliation_strings":["Department of Pediatrics, University of California San Francisco, San Francisco, CA","Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084102341","display_name":"Daniel A. Fletcher","orcid":"https://orcid.org/0000-0002-1890-5364","observed_orcids":["https://orcid.org/0000-0002-1890-5364"]},"institutions":[{"id":"https://openalex.org/I4210109986","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109986"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A Fletcher","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, Berkeley, CA","Parker Institute for Cancer Immunotherapy, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0002-1890-5364","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, Berkeley, CA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Parker Institute for Cancer Immunotherapy, San Francisco, CA","institution_ids":["https://openalex.org/I4210109986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053709403","display_name":"Benjamin J. Huang","orcid":"https://orcid.org/0000-0001-6996-0833","observed_orcids":["https://orcid.org/0000-0001-6996-0833"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J Huang","raw_affiliation_strings":["Department of Pediatrics, University of California San Francisco, San Francisco, CA","Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041965787","display_name":"Sonya M. Hanson","orcid":"https://orcid.org/0000-0001-8960-5353","observed_orcids":["https://orcid.org/0000-0001-8960-5353"]},"institutions":[{"id":"https://openalex.org/I4387153999","display_name":"Flatiron Institute","ror":"https://ror.org/00sekdz59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonya M Hanson","raw_affiliation_strings":["Center for Computational Biology, Flatiron Institute, New York, NY","Center for Computational Mathematics, Flatiron Institute, New York, NY"],"raw_orcid":"https://orcid.org/0000-0001-8960-5353","affiliations":[{"raw_affiliation_string":"Center for Computational Biology, Flatiron Institute, New York, NY","institution_ids":["https://openalex.org/I4387153999"]},{"raw_affiliation_string":"Center for Computational Mathematics, Flatiron Institute, New York, NY","institution_ids":["https://openalex.org/I4387153999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060434510","display_name":"Pilar Cossio","orcid":"https://orcid.org/0000-0002-5404-9948","observed_orcids":["https://orcid.org/0000-0002-5404-9948"]},"institutions":[{"id":"https://openalex.org/I4387153999","display_name":"Flatiron Institute","ror":"https://ror.org/00sekdz59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pilar Cossio","raw_affiliation_strings":["Center for Computational Biology, Flatiron Institute, New York, NY","Center for Computational Mathematics, Flatiron Institute, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-5404-9948","affiliations":[{"raw_affiliation_string":"Center for Computational Biology, Flatiron Institute, New York, NY","institution_ids":["https://openalex.org/I4387153999"]},{"raw_affiliation_string":"Center for Computational Mathematics, Flatiron Institute, New York, NY","institution_ids":["https://openalex.org/I4387153999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906927","display_name":"Tanja Kortemme","orcid":"https://orcid.org/0000-0002-8494-680X","observed_orcids":["https://orcid.org/0000-0002-8494-680X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanja Kortemme","raw_affiliation_strings":["Biohub, San Francisco, San Francisco, CA","Biophysics Graduate Program, University of California, San Francisco, San Francisco, CA","Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0002-8494-680X","affiliations":[{"raw_affiliation_string":"Biohub, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Biophysics Graduate Program, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040998041","display_name":"Justin Eyquem","orcid":"https://orcid.org/0000-0001-8262-1190","observed_orcids":["https://orcid.org/0000-0001-8262-1190"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210109986","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Eyquem","raw_affiliation_strings":["Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA","Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA","Parker Institute for Cancer Immunotherapy, San Francisco, CA","UCSF/Gladstone Institute for Genomic Immunology, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0001-8262-1190","affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Parker Institute for Cancer Immunotherapy, San Francisco, CA","institution_ids":["https://openalex.org/I4210109986"]},{"raw_affiliation_string":"UCSF/Gladstone Institute for Genomic Immunology, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055852791","display_name":"Arun P. Wiita","orcid":"https://orcid.org/0000-0002-7465-6964","observed_orcids":["https://orcid.org/0000-0002-7465-6964"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210109986","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun P Wiita","raw_affiliation_strings":["Biohub, San Francisco, San Francisco, CA","Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","Parker Institute for Cancer Immunotherapy, San Francisco, CA"],"raw_orcid":"https://orcid.org/0000-0002-7465-6964","affiliations":[{"raw_affiliation_string":"Biohub, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Parker Institute for Cancer Immunotherapy, San Francisco, CA","institution_ids":["https://openalex.org/I4210109986"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5055852791"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210109986"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd70","display_name":"CD70","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cd27","display_name":"CD27","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/conformational-flexibility","display_name":"conformational flexibility","score":0.6830000281333923},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.582099974155426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5231999754905701},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5181000232696533},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.436599999666214},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4065999984741211},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38269999623298645},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.3571999967098236},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3127000033855438},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.2992999851703644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2937000095844269},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.26649999618530273},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2648000121116638},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.25029999017715454}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.06.749651","doi":"https://doi.org/10.64898/2026.09.06.749651","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.06.749651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.06.749651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622484","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622484/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.06.749651","doi":"https://doi.org/10.64898/2026.09.06.749651","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.06.749651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.06.749651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1348001003","display_name":null,"funder_award_id":"T32GM141323","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G2342450115","display_name":null,"funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G839201715","display_name":null,"funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320337824","funder_display_name":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320306192","display_name":"Silicon Valley Community Foundation","ror":"https://ror.org/001ader08"},{"id":"https://openalex.org/F4320306439","display_name":"Multiple Myeloma Research Foundation","ror":"https://ror.org/03ww1bx13"},{"id":"https://openalex.org/F4320306523","display_name":"Alexander and Margaret Stewart Trust","ror":"https://ror.org/03nsgj842"},{"id":"https://openalex.org/F4320315119","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02"},{"id":"https://openalex.org/F4320319356","display_name":"Flatiron Health","ror":"https://ror.org/0508h6p74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337586","display_name":"Hyundai Hope On Wheels","ror":"https://ror.org/01f6q3121"},{"id":"https://openalex.org/F4320337824","display_name":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco","ror":"https://ror.org/05yndxy10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212160685.pdf","grobid_xml":"https://content.openalex.org/works/W7212160685.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405041650","https://openalex.org/W4417018558","https://openalex.org/W3212170036","https://openalex.org/W4413466252","https://openalex.org/W4310102710","https://openalex.org/W4403734679","https://openalex.org/W7208063410","https://openalex.org/W7116598692","https://openalex.org/W4224244393","https://openalex.org/W4404064676"],"abstract_inverted_index":{"Abstract":[0],"CD70":[1],"is":[2],"well-recognized":[3],"as":[4,134],"a":[5,19,86,117,135],"promising":[6,136],"\u201cpan-cancer\u201d":[7],"chimeric":[8],"antigen":[9],"receptor":[10],"(CAR)":[11],"T-cell":[12],"target.":[13],"Prior":[14],"work":[15,128],"has":[16],"shown":[17],"that":[18,142],"\u201cnatural":[20],"ligand\u201d":[21],"(NL)-based":[22],"CAR":[23,60,96,132],"targeting":[24],"CD70,":[25],"employing":[26],"its":[27,66],"physiological":[28],"interaction":[29],"partner":[30],"CD27,":[31],"may":[32],"have":[33],"therapeutic":[34,138],"advantages":[35],"over":[36],"antibody-":[37],"based":[38],"CARs.":[39],"Yet":[40],"while":[41],"antibody-based":[42],"CARs":[43],"are":[44],"routinely":[45],"optimized":[46],"by":[47],"affinity":[48],"maturation":[49],"of":[50,57,94,100,119,151],"their":[51],"scFv,":[52],"whether":[53],"the":[54,82,92],"binding":[55],"sequence":[56],"an":[58],"NL":[59],"can":[61],"be":[62,146],"engineered":[63],"to":[64,78,148],"improve":[65],"function":[67],"remains":[68],"unexplored.":[69],"Here,":[70],"we":[71],"combined":[72],"deep":[73],"learning":[74],"with":[75],"physics-based":[76],"modeling":[77,144],"redesign":[79],"residues":[80],"at":[81],"CD27:CD70":[83],"interface,":[84],"identifying":[85],"CD27":[87,130],"variant,":[88],"\u201cN88A\u201d,":[89],"which":[90],"enhances":[91],"efficacy":[93,150],"CD70-targeting":[95],"T-cells":[97,133],"across":[98],"models":[99],"acute":[101],"myeloid":[102],"leukemia,":[103],"multiple":[104],"myeloma,":[105],"and":[106,140],"renal":[107],"cell":[108],"carcinoma.":[109],"Biophysical":[110],"approaches,":[111],"including":[112],"molecular":[113],"dynamics":[114],"simulations,":[115],"support":[116],"mechanism":[118],"increased":[120],"binder":[121],"conformational":[122],"freedom":[123],"underlying":[124],"potency":[125],"enhancement.":[126],"Our":[127],"presents":[129],"N88A":[131],"new":[137],"option":[139],"proposes":[141],"computational":[143],"could":[145],"applied":[147],"enhance":[149],"other":[152],"NL-based":[153],"immunotherapies.":[154]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-11T00:00:00"}