{"id":"https://openalex.org/W7212149482","doi":"https://doi.org/10.2196/80683","title":"Implementation of a national synthetic data infrastructure for privacy-compliant innovation of analytical workflows in the Czech National Health Information System (Preprint)","display_name":"Implementation of a national synthetic data infrastructure for privacy-compliant innovation of analytical workflows in the Czech National Health Information System (Preprint)","publication_year":2025,"publication_date":"2025-07-15","ids":{"openalex":"https://openalex.org/W7212149482","doi":"https://doi.org/10.2196/80683"},"language":"en","primary_location":{"id":"doi:10.2196/80683","doi":"https://doi.org/10.2196/80683","is_oa":true,"landing_page_url":"https://doi.org/10.2196/80683","pdf_url":null,"source":{"id":"https://openalex.org/S2764650051","display_name":"JMIR Medical Informatics","issn_l":"2291-9694","issn":["2291-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Medical Informatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2196/80683","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073396312","display_name":"Martin Komenda","orcid":"https://orcid.org/0000-0003-0572-5767","observed_orcids":["https://orcid.org/0000-0003-0572-5767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Komenda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0572-5767","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033587592","display_name":"Daniel Klime\u0161","orcid":"https://orcid.org/0009-0001-9679-7602","observed_orcids":["https://orcid.org/0009-0001-9679-7602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Klime\u0161","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-9679-7602","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055664444","display_name":"Ale\u0161 Tichop\u00e1d","orcid":"https://orcid.org/0000-0002-1308-0877","observed_orcids":["https://orcid.org/0000-0002-1308-0877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ales Tichopad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1308-0877","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047238963","display_name":"Ji\u0159\u00ed Jarkovsk\u00fd","orcid":"https://orcid.org/0000-0002-1400-0111","observed_orcids":["https://orcid.org/0000-0002-1400-0111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji\u0159\u00ed Jarkovsk\u00fd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1400-0111","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085994615","display_name":"Ond\u0159ej M\u00e1jek","orcid":"https://orcid.org/0000-0002-0034-3084","observed_orcids":["https://orcid.org/0000-0002-0034-3084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ond\u0159ej M\u00e1jek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0034-3084","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045455980","display_name":"Jan Mu\u017e\u00edk","orcid":"https://orcid.org/0000-0003-1750-4865","observed_orcids":["https://orcid.org/0000-0003-1750-4865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Mu\u017e\u00edk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1750-4865","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083791579","display_name":"Milo\u0161 T\u00e1borsk\u00fd","orcid":"https://orcid.org/0000-0002-5036-2347","observed_orcids":["https://orcid.org/0000-0002-5036-2347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milo\u0161 T\u00e1borsk\u00fd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5036-2347","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115905600","display_name":"Vladim\u00edra T\u011b\u0161itelov\u00e1","orcid":"https://orcid.org/0009-0007-5228-4462","observed_orcids":["https://orcid.org/0009-0007-5228-4462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladim\u00edra T\u011b\u0161itelov\u00e1","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5228-4462","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119004245","display_name":"J. Habetinek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Hab\u011bt\u00ednek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003934490","display_name":"Ladislav Du\u0161ek","orcid":"https://orcid.org/0000-0002-8589-4378","observed_orcids":["https://orcid.org/0000-0002-8589-4378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladislav Du\u0161ek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8589-4378","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14400","display_name":"Medical Coding and Health Information","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-data","display_name":"synthetic data","score":0.9739999771118164},{"id":"https://openalex.org/keywords/health-data-infrastructure","display_name":"health data infrastructure","score":0.6690000295639038},{"id":"https://openalex.org/keywords/privacy-preserving-data-sharing","display_name":"privacy-preserving data sharing","score":0.6480000019073486},{"id":"https://openalex.org/keywords/secondary-use-of-health-data","display_name":"secondary use of health data","score":0.8349999785423279},{"id":"https://openalex.org/keywords/national-health-information-system","display_name":"national health information systems","score":0.8230000138282776},{"id":"https://openalex.org/keywords/health-registries","display_name":"health registries","score":0.925000011920929},{"id":"https://openalex.org/keywords/european-health-data-space","display_name":"European Health Data Space","score":0.8349999785423279},{"id":"https://openalex.org/keywords/research-data-access","display_name":"research data access","score":0.5509999990463257},{"id":"https://openalex.org/keywords/individual-patient-data","display_name":"individual patient data","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.636900007724762},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5501999855041504},{"id":"https://openalex.org/C180198813","wikidata":"https://www.wikidata.org/wiki/Q121182","display_name":"Information system","level":2,"score":0.5087000131607056},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.43160000443458557},{"id":"https://openalex.org/C2777842544","wikidata":"https://www.wikidata.org/wiki/Q9056","display_name":"Czech","level":2,"score":0.4237000048160553},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.4189000129699707},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.3874000012874603},{"id":"https://openalex.org/C3017977704","wikidata":"https://www.wikidata.org/wiki/Q18745135","display_name":"Health data","level":3,"score":0.3691999912261963},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.35420000553131104},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.328900009393692},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C110354214","wikidata":"https://www.wikidata.org/wiki/Q6314146","display_name":"Engineering management","level":1,"score":0.31130000948905945},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.28139999508857727},{"id":"https://openalex.org/C2778759051","wikidata":"https://www.wikidata.org/wiki/Q5691085","display_name":"Health information exchange","level":4,"score":0.28110000491142273},{"id":"https://openalex.org/C121017731","wikidata":"https://www.wikidata.org/wiki/Q11661","display_name":"Information technology","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.2791000008583069},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C2988170871","wikidata":"https://www.wikidata.org/wiki/Q11000047","display_name":"Healthcare system","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C138827492","wikidata":"https://www.wikidata.org/wiki/Q6661985","display_name":"Data processing","level":2,"score":0.2558000087738037}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2196/80683","doi":"https://doi.org/10.2196/80683","is_oa":true,"landing_page_url":"https://doi.org/10.2196/80683","pdf_url":null,"source":{"id":"https://openalex.org/S2764650051","display_name":"JMIR Medical Informatics","issn_l":"2291-9694","issn":["2291-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Medical Informatics","raw_type":"journal-article"},{"id":"doi:10.2196/preprints.80683","doi":"https://doi.org/10.2196/preprints.80683","is_oa":false,"landing_page_url":"https://doi.org/10.2196/preprints.80683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2196/80683","doi":"https://doi.org/10.2196/80683","is_oa":true,"landing_page_url":"https://doi.org/10.2196/80683","pdf_url":null,"source":{"id":"https://openalex.org/S2764650051","display_name":"JMIR Medical Informatics","issn_l":"2291-9694","issn":["2291-9694"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Medical Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W77869065","https://openalex.org/W2058337746","https://openalex.org/W2083384763","https://openalex.org/W2109426455","https://openalex.org/W2117424616","https://openalex.org/W2120751691","https://openalex.org/W2128128412","https://openalex.org/W2159024459","https://openalex.org/W2190333735","https://openalex.org/W2462928578","https://openalex.org/W2565681887","https://openalex.org/W2794456447","https://openalex.org/W2806810105","https://openalex.org/W2883330559","https://openalex.org/W2891108302","https://openalex.org/W2963693643","https://openalex.org/W2973190536","https://openalex.org/W2996889063","https://openalex.org/W3012501605","https://openalex.org/W3015471667","https://openalex.org/W3022574011","https://openalex.org/W3163598698","https://openalex.org/W3169401499","https://openalex.org/W3173857640","https://openalex.org/W3175737276","https://openalex.org/W4229446766","https://openalex.org/W4313644512","https://openalex.org/W4385735191","https://openalex.org/W4387457231","https://openalex.org/W4391594239","https://openalex.org/W4402392401","https://openalex.org/W4403415329","https://openalex.org/W4403844673","https://openalex.org/W4407218667","https://openalex.org/W4413684012","https://openalex.org/W7213303528"],"related_works":["https://openalex.org/W4412470032","https://openalex.org/W6889872625","https://openalex.org/W7162620632","https://openalex.org/W4412569790","https://openalex.org/W7167815063","https://openalex.org/W7061185934","https://openalex.org/W7214748058","https://openalex.org/W7119763954","https://openalex.org/W4409630735","https://openalex.org/W7214097788"],"abstract_inverted_index":{"UNSTRUCTURED":[0],"Synthetic":[1],"data":[2,20,31,39,64,89],"represent":[3],"an":[4],"approach":[5],"that":[6,33,148],"may":[7],"potentially":[8],"address":[9],"the":[10,14,22,35,46,60,68,96,113,132,142,180,198,201],"longstanding":[11],"tension":[12],"between":[13],"growing":[15],"demand":[16],"for":[17,52,80],"primary":[18,84],"health":[19,85,102,109],"and":[21,56,82,110,128,137,145,168,185,192],"imperative":[23],"to":[24,115,118,141,152,197,211],"protect":[25],"individual":[26],"privacy.":[27],"By":[28,195],"creating":[29],"synthetic":[30,63,88,143],"sets":[32],"mirror":[34],"structure":[36],"of":[37,76,98,162,170,182,200],"real":[38,156],"but":[40],"do":[41],"not":[42],"disclose":[43],"personal":[44],"identifiers,":[45],"system":[47,173],"enables":[48],"meaningful":[49],"secondary":[50],"use":[51],"research,":[53],"policy":[54],"analysis":[55],"innovation.":[57],"We":[58,130,159],"present":[59],"Czech":[61],"Republic\u2019s":[62],"infrastructure,":[65],"developed":[66],"within":[67],"National":[69],"Health":[70,203],"Information":[71],"System":[72],"(NHIS),":[73],"as":[74],"one":[75],"Europe's":[77],"pioneering":[78],"models":[79],"sharing":[81],"analysing":[83],"data.":[86,158],"The":[87,123,172],"pool":[90],"is":[91,208],"currently":[92],"being":[93],"built":[94],"on":[95],"basis":[97],"four":[99],"large":[100],"national":[101,183],"registries":[103],"(health":[104],"services":[105],"reimbursements,":[106],"cancer,":[107],"reproductive":[108],"mortality),":[111],"with":[112],"potential":[114],"be":[116],"expanded":[117],"all":[119],"61":[120],"NHIS":[121],"agendas.":[122],"main":[124],"principles":[125,199],"are":[126,149],"transparency":[127],"fairness.":[129],"describe":[131],"process":[133],"by":[134,189],"which":[135],"researchers":[136],"institutions":[138],"gain":[139],"access":[140],"database":[144],"develop":[146],"scripts":[147],"later":[150],"used":[151],"obtain":[153],"outputs":[154,164],"from":[155],"patient-level":[157],"provide":[160],"examples":[161],"such":[163],"across":[165],"medical":[166],"disciplines":[167],"aspects":[169],"healthcare.":[171],"has":[174,186],"already":[175],"proven":[176],"its":[177],"value":[178],"in":[179],"development":[181],"strategies":[184],"been":[187],"validated":[188],"academic,":[190],"governmental":[191],"commercial":[193],"stakeholders.":[194],"adhering":[196],"European":[202],"Data":[204],"Space,":[205],"this":[206],"model":[207],"becoming":[209],"transferable":[210],"other":[212],"EU":[213],"countries.":[214]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-11T00:00:00"}