{"id":"https://openalex.org/W7212148641","doi":"https://doi.org/10.64898/2026.09.08.750270","title":"Comprehensive functional mapping of accessory chromosomes identifies a dominant virulence-regulator paralog in tomato wilt pathogen","display_name":"Comprehensive functional mapping of accessory chromosomes identifies a dominant virulence-regulator paralog in tomato wilt pathogen","publication_year":2026,"publication_date":"2026-09-09","ids":{"openalex":"https://openalex.org/W7212148641","doi":"https://doi.org/10.64898/2026.09.08.750270"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.08.750270","doi":"https://doi.org/10.64898/2026.09.08.750270","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750270","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.08.750270.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.08.750270.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032987140","display_name":"Masaya Yamazaki","orcid":"https://orcid.org/0000-0003-4151-4983","observed_orcids":["https://orcid.org/0000-0003-4151-4983","https://orcid.org/0009-0004-8262-9837"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaya Yamazaki","raw_affiliation_strings":["Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan","United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan"],"raw_orcid":"https://orcid.org/0009-0004-8262-9837","affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101901480","display_name":"Hiroki Saito","orcid":"https://orcid.org/0009-0002-7889-7818","observed_orcids":["https://orcid.org/0009-0002-7889-7818","https://orcid.org/0000-0001-7839-8053"]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Saito","raw_affiliation_strings":["College of Life Science, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan","institution_ids":["https://openalex.org/I135768898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006586977","display_name":"Shuta Asai","orcid":"https://orcid.org/0000-0003-1898-1786","observed_orcids":["https://orcid.org/0000-0003-1898-1786"]},"institutions":[{"id":"https://openalex.org/I4210100240","display_name":"RIKEN Center for Sustainable Resource Science","ror":"https://ror.org/010rf2m76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuta Asai","raw_affiliation_strings":["Center for Sustainable Resource Science, RIKEN, Yokohama, Kanagawa, 230-0045, Japan","Faculty of Agriculture, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Sustainable Resource Science, RIKEN, Yokohama, Kanagawa, 230-0045, Japan","institution_ids":["https://openalex.org/I4210100240","https://openalex.org/I4210110652"]},{"raw_affiliation_string":"Faculty of Agriculture, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059445588","display_name":"Takashi Kamakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kamakura","raw_affiliation_strings":["Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033287634","display_name":"Ken Komatsu","orcid":"https://orcid.org/0000-0003-3323-7314","observed_orcids":["https://orcid.org/0000-0003-3323-7314"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Komatsu","raw_affiliation_strings":["Faculty of Agriculture, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan","United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Agriculture, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085763416","display_name":"Takayuki Arazoe","orcid":"https://orcid.org/0000-0001-8804-315X","observed_orcids":["https://orcid.org/0000-0001-8804-315X"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Arazoe","raw_affiliation_strings":["Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047789755","display_name":"Tsutomu Arie","orcid":"https://orcid.org/0000-0002-4604-6608","observed_orcids":["https://orcid.org/0000-0002-4604-6608"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsutomu Arie","raw_affiliation_strings":["Faculty of Agriculture, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Agriculture, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo, 183-0054, Japan","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047789755"],"corresponding_institution_ids":["https://openalex.org/I92614990"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12858","display_name":"Plant Disease Resistance and Genetics","score":0.09870000183582306,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/accessory-chromosomes","display_name":"accessory chromosomes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/fusarium-oxysporum-f-sp-lycopersici","display_name":"Fusarium oxysporum f. sp. lycopersici","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tomato-wilt","display_name":"tomato wilt","score":0.9459999799728394},{"id":"https://openalex.org/keywords/virulence-regulation","display_name":"virulence regulation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.781000018119812},{"id":"https://openalex.org/keywords/neofunctionalization","display_name":"neofunctionalization","score":0.9350000023841858},{"id":"https://openalex.org/keywords/deletion-mutants","display_name":"deletion mutants","score":0.746999979019165},{"id":"https://openalex.org/keywords/host-specificity","display_name":"host specificity","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8988000154495239},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.791700005531311},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7724000215530396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6212999820709229},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.6171000003814697},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5820000171661377},{"id":"https://openalex.org/C107110972","wikidata":"https://www.wikidata.org/wiki/Q6992868","display_name":"Neofunctionalization","level":4,"score":0.553600013256073},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.4253999888896942},{"id":"https://openalex.org/C2910535243","wikidata":"https://www.wikidata.org/wiki/Q5113922","display_name":"Chromosomal region","level":4,"score":0.4059000015258789},{"id":"https://openalex.org/C2776914050","wikidata":"https://www.wikidata.org/wiki/Q19597524","display_name":"Host adaptation","level":4,"score":0.3727000057697296},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.37220001220703125},{"id":"https://openalex.org/C57808653","wikidata":"https://www.wikidata.org/wiki/Q7446270","display_name":"Segmental duplication","level":5,"score":0.35749998688697815},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.35370001196861267},{"id":"https://openalex.org/C62130838","wikidata":"https://www.wikidata.org/wiki/Q5196163","display_name":"Pathogenicity island","level":4,"score":0.34279999136924744},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3310000002384186},{"id":"https://openalex.org/C2779430813","wikidata":"https://www.wikidata.org/wiki/Q139958","display_name":"Fusarium oxysporum","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.2858999967575073},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C119401833","wikidata":"https://www.wikidata.org/wiki/Q7802158","display_name":"Tiling array","level":5,"score":0.27489998936653137},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C134486438","wikidata":"https://www.wikidata.org/wiki/Q3123214","display_name":"Forward genetics","level":4,"score":0.2603999972343445},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.08.750270","doi":"https://doi.org/10.64898/2026.09.08.750270","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750270","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.08.750270.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.08.750270","doi":"https://doi.org/10.64898/2026.09.08.750270","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.08.750270","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.08.750270.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G164215363","display_name":"\u75c5\u539f\u30b2\u30ce\u30df\u30af\u30b9\u306b\u3088\u308b\u571f\u58cc\u8a3a\u65ad\u6cd5\u306e\u958b\u767a","funder_award_id":"JPMJPR16O1","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G2130288986","display_name":"Construction of filamentous fungal artificial chromosome and analysis of horizontal transfer and pathogenicity evolution mechanisms in the tomato wilt fungus.","funder_award_id":"18K19218","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4160592173","display_name":"Elucidation of the evolution and function of the accessory chromosomes in ascomycete fungi and their application asnovel transformation vector","funder_award_id":"19H00939","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G851238543","display_name":"Analysis of cause of pandemic of fusarium diseases of plants and development for outbreak prediction based on future-epidemiology","funder_award_id":"23H00331","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8756155984","display_name":"\u690d\u7269\u75c5\u539f\u83cc\u5bc4\u751f\u6210\u7acb\u6a5f\u69cb\u306e\u89e3\u660e\u3068\u5703\u5834\u3067\u306e\u5fdc\u7528","funder_award_id":"JPMJFR2101","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"}],"funders":[{"id":"https://openalex.org/F4320322716","display_name":"Japan International Cooperation Agency","ror":"https://ror.org/022es3t03"},{"id":"https://openalex.org/F4320325836","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338111","display_name":"Precursory Research for Embryonic Science and Technology","ror":null},{"id":"https://openalex.org/F4320338125","display_name":"Science and Technology Research Partnership for Sustainable Development","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212148641.pdf","grobid_xml":"https://content.openalex.org/works/W7212148641.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310835598","https://openalex.org/W3044831147","https://openalex.org/W4402688287","https://openalex.org/W4416694376","https://openalex.org/W3032168668","https://openalex.org/W4392143255","https://openalex.org/W4389155570","https://openalex.org/W2796158301","https://openalex.org/W2554699402","https://openalex.org/W2747649474"],"abstract_inverted_index":{"Abstract":[0],"Accessory":[1],"chromosomes":[2],"(ACs)":[3],"serve":[4],"as":[5,165],"flexible":[6],"genomic":[7],"compartments":[8],"that":[9,111,134,150,172,208],"facilitate":[10],"rapid":[11],"adaptive":[12],"evolution":[13],"in":[14,223],"eukaryotic":[15],"microbes.":[16],"In":[17],"the":[18,85,141,153,161,173,182,200],"tomato":[19],"wilt":[20],"pathogen":[21],"Fusarium":[22,142],"oxysporum":[23,225],"f.":[24],"sp.":[25],"lycopersici":[26],",":[27,136],"ACs":[28],"are":[29,112],"essential":[30],"for":[31,114],"virulence":[32,116,157,180,211],"and":[33,40,129,181,219],"host":[34],"specificity;":[35],"however,":[36],"their":[37,49],"structural":[38],"complexity":[39],"functional":[41,64,95,197],"redundancy":[42],"have":[43],"hindered":[44],"a":[45,55,62,77,93,137,166,196],"systematic":[46,101],"characterization":[47,96],"of":[48,66,79,97,103,122,140,155,169,184,210],"distinct":[50],"roles.":[51],"Here,":[52],"we":[53,74],"established":[54],"CRISPR/Cas9-based":[56],"chromosomal":[57,120],"dissection":[58,121],"platform":[59],"to":[60,179],"generate":[61],"comprehensive":[63],"map":[65],"pathogenicity":[67],"determinants":[68],"within":[69,199,213],"ACs.":[70],"Using":[71],"this":[72,104],"platform,":[73],"successfully":[75],"generated":[76],"library":[78,105],"36":[80],"large":[81],"deletion":[82,183],"mutants":[83],"across":[84],"approximately":[86],"10":[87],"Mb":[88],"putative":[89],"AC":[90,109,162],"region,":[91,163],"enabling":[92],"chromosome-scale":[94],"these":[98],"compartments.":[99],"A":[100],"screen":[102],"identified":[106],"seven":[107],"discrete":[108],"segments":[110],"indispensable":[113],"full":[115],"toward":[117],"tomato.":[118],"High-resolution":[119],"one":[123],"virulence-associated":[124],"segment":[125],"through":[126],"iterative":[127],"subdivision":[128],"targeted":[130],"gene":[131,158,203],"disruption":[132],"revealed":[133],"FTF1a-1":[135],"single":[138],"member":[139],"transcription":[143],"factor":[144],"1":[145],"(":[146],"FTF1":[147,202],")":[148],"family":[149],"originated":[151],"from":[152],"duplication":[154],"core-chromosomal":[156],"FTF2":[159],"into":[160],"functions":[164],"dominant":[167],"regulator":[168],"virulence.":[170],"Given":[171],"FTF1a-3":[174],"paralog":[175],"contributes":[176],"only":[177],"marginally":[178],"other":[185],"paralogs":[186],"does":[187],"not":[188],"markedly":[189],"affect":[190],"disease":[191],"development,":[192],"our":[193],"findings":[194],"demonstrate":[195],"hierarchy":[198],"duplicated":[201],"family.":[204],"These":[205],"results":[206],"imply":[207],"neofunctionalization":[209],"genes":[212],"plastic":[214],"fungal":[215],"genomes":[216],"promotes":[217],"hyper-virulence":[218],"drives":[220],"host-specific":[221],"adaptation":[222],"F.":[224],".":[226]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-11T00:00:00"}
