{"id":"https://openalex.org/W7212137254","doi":"https://doi.org/10.64898/2026.09.05.749600","title":"The small molecule inhibitor SU056-mediated targeting of YB1 inhibits the Rb pathway in triple negative breast cancer tumors","display_name":"The small molecule inhibitor SU056-mediated targeting of YB1 inhibits the Rb pathway in triple negative breast cancer tumors","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212137254","doi":"https://doi.org/10.64898/2026.09.05.749600","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818332","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622606"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.05.749600","doi":"https://doi.org/10.64898/2026.09.05.749600","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.05.749600","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.05.749600.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.05.749600.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151148832","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Case Western Reserve University, Cleveland, Ohio, USA","MetroHealth System, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"MetroHealth System, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1299218025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051560747","display_name":"Yeaji Kim","orcid":"https://orcid.org/0000-0002-9349-1763","observed_orcids":["https://orcid.org/0000-0002-9349-1763"]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeaji Kim","raw_affiliation_strings":["Case Western Reserve University, Cleveland, Ohio, USA","MetroHealth System, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"MetroHealth System, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1299218025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151215149","display_name":"Xiaotong Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaotong Zhao","raw_affiliation_strings":["Cleveland State University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland State University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I102607778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010430262","display_name":"Kristen Weber Bonk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Weber Bonk","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020136425","display_name":"Ruth A. Keri","orcid":"https://orcid.org/0000-0002-1640-3088","observed_orcids":["https://orcid.org/0000-0002-1640-3088"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Keri","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-1640-3088","affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159976371","display_name":"Bin Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Su","raw_affiliation_strings":["Cleveland State University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland State University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I102607778"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022235271","display_name":"Khalid Sossey\u2010Alaoui","orcid":"https://orcid.org/0000-0002-2410-7633","observed_orcids":["https://orcid.org/0000-0002-2410-7633"]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khalid Sossey-Alaoui","raw_affiliation_strings":["Case Comprehensive Cancer Center, Cleveland, Ohio, USA","Case Western Reserve University, Cleveland, Ohio, USA","MetroHealth System, Cleveland, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-2410-7633","affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"MetroHealth System, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1299218025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022235271"],"corresponding_institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/yb-1","display_name":"YB-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7480000257492065},{"id":"https://openalex.org/keywords/rb-pathway","display_name":"Rb pathway","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.8040000200271606},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cyclin-d","display_name":"cyclin D","score":0.824999988079071},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.925000011920929},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8859999775886536},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.39100000262260437},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7727000117301941},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5594000220298767},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.510699987411499},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5077000260353088},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48829999566078186},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.4860000014305115},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.47870001196861267},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47600001096725464},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.47589999437332153},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44040000438690186},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4140999913215637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40369999408721924},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.3984000086784363},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.3626999855041504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35899999737739563},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.34380000829696655},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32339999079704285},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.30799999833106995},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.29820001125335693},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2874000072479248},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2815999984741211},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.275299996137619},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.274399995803833},{"id":"https://openalex.org/C2780278673","wikidata":"https://www.wikidata.org/wiki/Q476743","display_name":"Nude mouse","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.26930001378059387},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.258899986743927},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.25780001282691956}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.05.749600","doi":"https://doi.org/10.64898/2026.09.05.749600","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.05.749600","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.05.749600.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622606","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622606/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.05.749600","doi":"https://doi.org/10.64898/2026.09.05.749600","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.05.749600","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/10/2026.09.05.749600.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313694","display_name":"METAvivor","ror":"https://ror.org/01me1hv80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212137254.pdf","grobid_xml":"https://content.openalex.org/works/W7212137254.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393071373","https://openalex.org/W4396769361","https://openalex.org/W2018297869","https://openalex.org/W2337394860","https://openalex.org/W2298831087","https://openalex.org/W7141593282","https://openalex.org/W7219862214","https://openalex.org/W4392379341","https://openalex.org/W3127123310","https://openalex.org/W2925242943"],"abstract_inverted_index":{"Background:":[0],"Triple-negative":[1],"breast":[2],"cancer":[3,94,112],"(TNBC)":[4],"tumors":[5],"lack":[6],"expression":[7,156],"of":[8,20,75,111,215,246,254,300,311,320,326],"estrogen":[9],"receptor":[10,13],"(ER),":[11],"progesterone":[12],"(PR),":[14],"and":[15,38,53,70,89,118,124,146,154,162,180,188,209,221,250,265,273,286,297,306,324],"HER2,":[16],"limiting":[17,178],"the":[18,46,134,231,243,274,279,312],"availability":[19],"targeted":[21],"therapeutic":[22,202],"options.":[23],"As":[24],"a":[25,31,62,102],"result,":[26],"TNBC":[27,51,115,128,159,216,247,257,283,303],"is":[28,61],"characterized":[29],"by":[30],"high":[32],"propensity":[33],"for":[34,105,141,239],"metastasis,":[35,88],"rapid":[36],"recurrence,":[37],"poor":[39],"overall":[40],"prognosis.":[41],"Despite":[42],"significant":[43],"research":[44],"efforts,":[45],"molecular":[47],"mechanisms":[48],"that":[49,66,113,230],"drive":[50,114],"progression":[52,117,193,223,288,323],"metastasis":[54],"remain":[55],"incompletely":[56],"understood.Y-box":[57],"binding":[58],"protein-1":[59],"(YB1)":[60],"multifunctional":[63],"DNA/RNA-binding":[64],"protein":[65,153],"regulates":[67],"transcription,":[68],"translation,":[69],"mRNA":[71,155],"stability.":[72],"Aberrant":[73],"activation":[74],"YB1":[76,106,238,255,301],"has":[77],"been":[78],"implicated":[79],"in":[80,92,107,127,158],"multiple":[81],"oncogenic":[82,244],"processes,":[83],"including":[84,96],"proliferation,":[85,259],"survival,":[86],"invasion,":[87],"therapy":[90],"resistance":[91],"several":[93],"types,":[95],"TNBC.":[97],"Our":[98,227],"investigations":[99],"have":[100],"revealed":[101],"central":[103],"role":[104],"regulating":[108],"key":[109],"hallmarks":[110],"tumor":[116,163,219,287,304],"metastatic":[119,222,307],"dissemination.":[120],"Methods:":[121],"Cell":[122,191],"viability":[123],"drug":[125],"sensitivity":[126],"cell":[129,160,248,258,284,321],"lines":[130,161,249],"were":[131,149,167],"assessed":[132],"using":[133,169,196,206],"MTT":[135],"assay":[136],"to":[137,151,184,217,318],"determine":[138],"IC\u2085\u2080":[139],"values":[140],"pharmacologic":[142,298],"inhibitors.":[143],"Western":[144],"blotting":[145],"quantitative":[147],"RT-PCR":[148],"used":[150],"quantify":[152],"levels":[157],"samples.":[164],"Oncogenic":[165],"phenotypes":[166],"evaluated":[168,205],"2D":[170],"colony":[171],"formation":[172],"assays,":[173,177],"3D":[174],"tumorsphere":[175,262],"growth":[176,220,285,305],"dilution,":[179],"transwell":[181],"migration":[182],"assays":[183],"assess":[185,218],"proliferative,":[186],"stem-like,":[187],"migratory":[189,266],"capacities.":[190],"cycle":[192,322],"was":[194,204],"analyzed":[195],"flow":[197],"cytometry-based":[198],"assays.":[199],"In":[200],"vivo":[201],"efficacy":[203],"preclinical":[207],"xenograft":[208,211],"patient-derived":[210],"(PDX)":[212],"mouse":[213],"models":[214],"following":[224],"treatment.":[225],"Results:":[226],"studies":[228],"demonstrate":[229],"small-molecule":[232],"inhibitor":[233,276],"SU056,":[234],"which":[235],"specifically":[236],"targets":[237],"degradation,":[240],"significantly":[241],"suppresses":[242],"behavior":[245],"tumors.":[251],"Pharmacologic":[252],"inhibition":[253,319],"reduced":[256],"clonogenic":[260],"growth,":[261],"formation,":[263],"stemness":[264],"capacity.":[267],"Importantly,":[268],"combined":[269],"treatment":[270],"with":[271,290],"SU056":[272],"CDK4/6":[275],"palbociclib":[277],"enhanced":[278],"inhibitory":[280],"effect":[281],"on":[282],"compared":[289],"either":[291],"agent":[292],"alone.":[293],"Mechanistically,":[294],"both":[295],"genetic":[296],"targeting":[299],"suppressed":[302],"potential":[308],"through":[309],"modulation":[310],"Cyclin":[313],"D/CDK4/6/Rb":[314],"signaling":[315],"axis,":[316],"leading":[317],"induction":[325],"G1":[327],"arrest.":[328],"Conclusion:":[329],"-TNBC.":[330]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-11T00:00:00"}
