{"id":"https://openalex.org/W7212132880","doi":"https://doi.org/10.1016/j.sbsr.2026.101101","title":"In vitro evaluation of reactive oxygen species sensor for in vivo monitoring of periprosthetic infection and inflammation","display_name":"In vitro evaluation of reactive oxygen species sensor for in vivo monitoring of periprosthetic infection and inflammation","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7212132880","doi":"https://doi.org/10.1016/j.sbsr.2026.101101"},"language":"en","primary_location":{"id":"doi:10.1016/j.sbsr.2026.101101","doi":"https://doi.org/10.1016/j.sbsr.2026.101101","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sbsr.2026.101101","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214180426001522/pdf","source":{"id":"https://openalex.org/S2764350490","display_name":"Sensing and Bio-Sensing Research","issn_l":"2214-1804","issn":["2214-1804"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensing and Bio-Sensing Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2214180426001522/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132992159","display_name":"Helene Noordhuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P.H. (Helene) Noordhuis","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Human Movement Science, Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Human Movement Science, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021810396","display_name":"Claudine J. C. Lamoth","orcid":"https://orcid.org/0000-0002-6495-2823","observed_orcids":["https://orcid.org/0000-0002-6495-2823"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Claudine J.C. Lamoth","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Human Movement Science, Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Human Movement Science, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004811626","display_name":"Paul C. Jutte","orcid":"https://orcid.org/0000-0002-6022-2807","observed_orcids":["https://orcid.org/0000-0002-6022-2807"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul C. Jutte","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Orthopaedics, Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Orthopaedics, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003669219","display_name":"Pieter E. Oomen","orcid":"https://orcid.org/0000-0001-8395-7331","observed_orcids":["https://orcid.org/0000-0001-8395-7331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter E. Oomen","raw_affiliation_strings":["Paramedir B.V., Roden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paramedir B.V., Roden, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042432592","display_name":"Edwin Alserda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edwin Alserda","raw_affiliation_strings":["Paramedir B.V., Roden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paramedir B.V., Roden, the Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159767618","display_name":"Carlos Cordeiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos A. Cordeiro","raw_affiliation_strings":["Paramedir B.V., Roden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paramedir B.V., Roden, the Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091150017","display_name":"Charlotte Christina Roossien","orcid":"https://orcid.org/0000-0001-6489-6967","observed_orcids":["https://orcid.org/0000-0001-6489-6967"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"C.C. (Charissa) Roossien","raw_affiliation_strings":["University of Groningen, Faculty of Science and Engineering, Engineering and Technology Institute Groningen (ENTEG), Department of Bio-inspired MEMS and Biomedical Devices, Groningen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Groningen, Faculty of Science and Engineering, Engineering and Technology Institute Groningen (ENTEG), Department of Bio-inspired MEMS and Biomedical Devices, Groningen, the Netherlands","institution_ids":["https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091150017"],"corresponding_institution_ids":["https://openalex.org/I169381384"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55640727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"101101","last_page":"101101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-peroxide-detection","display_name":"hydrogen peroxide detection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/electrochemical-sensor","display_name":"electrochemical sensor","score":0.7490000128746033},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9520000219345093},{"id":"https://openalex.org/keywords/periprosthetic-inflammation","display_name":"periprosthetic inflammation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hip-and-knee-implants","display_name":"hip and knee implants","score":0.5759999752044678},{"id":"https://openalex.org/keywords/septic-loosening","display_name":"septic loosening","score":0.8040000200271606},{"id":"https://openalex.org/keywords/aseptic-loosening","display_name":"aseptic loosening","score":0.9909999966621399},{"id":"https://openalex.org/keywords/implant-failure","display_name":"implant failure","score":0.5230000019073486},{"id":"https://openalex.org/keywords/synovial-fluid-proteins","display_name":"synovial fluid proteins","score":0.7710000276565552},{"id":"https://openalex.org/keywords/protein-adsorption","display_name":"protein adsorption","score":0.871999979019165},{"id":"https://openalex.org/keywords/m-phenylenediamine","display_name":"m-phenylenediamine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nafion","display_name":"Nafion","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8797000050544739},{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.7465999722480774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5658000111579895},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5339000225067139},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.5062000155448914},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.45590001344680786},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.421099990606308},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39469999074935913},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35089999437332153},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3395000100135803},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30480000376701355},{"id":"https://openalex.org/C3019879152","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Infection risk","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C2775956843","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Septic arthritis","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C3017807761","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Joint disease","level":4,"score":0.2574000060558319},{"id":"https://openalex.org/C2983449737","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Clinical diagnosis","level":2,"score":0.25529998540878296}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.sbsr.2026.101101","doi":"https://doi.org/10.1016/j.sbsr.2026.101101","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sbsr.2026.101101","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214180426001522/pdf","source":{"id":"https://openalex.org/S2764350490","display_name":"Sensing and Bio-Sensing Research","issn_l":"2214-1804","issn":["2214-1804"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensing and Bio-Sensing Research","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.7442986","doi":"https://doi.org/10.2139/ssrn.7442986","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7442986","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1016/j.sbsr.2026.101101","doi":"https://doi.org/10.1016/j.sbsr.2026.101101","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sbsr.2026.101101","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214180426001522/pdf","source":{"id":"https://openalex.org/S2764350490","display_name":"Sensing and Bio-Sensing Research","issn_l":"2214-1804","issn":["2214-1804"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensing and Bio-Sensing Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212132880.pdf","grobid_xml":"https://content.openalex.org/works/W7212132880.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1162433881","https://openalex.org/W1418299297","https://openalex.org/W1989987141","https://openalex.org/W1990580287","https://openalex.org/W2007439548","https://openalex.org/W2017258609","https://openalex.org/W2040403236","https://openalex.org/W2057104805","https://openalex.org/W2075406896","https://openalex.org/W2085026278","https://openalex.org/W2105794640","https://openalex.org/W2114809075","https://openalex.org/W2118974470","https://openalex.org/W2127464507","https://openalex.org/W2128148040","https://openalex.org/W2128213565","https://openalex.org/W2128429789","https://openalex.org/W2158193380","https://openalex.org/W2160040847","https://openalex.org/W2193053539","https://openalex.org/W2195203295","https://openalex.org/W2414810296","https://openalex.org/W2624746905","https://openalex.org/W2740695644","https://openalex.org/W2747690336","https://openalex.org/W3003147045","https://openalex.org/W3022757405","https://openalex.org/W3092504203","https://openalex.org/W3135210496","https://openalex.org/W3154658958","https://openalex.org/W3157317511","https://openalex.org/W3176696270","https://openalex.org/W3200744154","https://openalex.org/W4212837065","https://openalex.org/W4224045169","https://openalex.org/W4295591987","https://openalex.org/W4321496946","https://openalex.org/W4385840822","https://openalex.org/W4392546504","https://openalex.org/W4399014226","https://openalex.org/W4400942500","https://openalex.org/W4403706288","https://openalex.org/W4405334246","https://openalex.org/W4409635838","https://openalex.org/W4414529107","https://openalex.org/W7131631149"],"related_works":["https://openalex.org/W7221245508","https://openalex.org/W7220601458","https://openalex.org/W4384407175","https://openalex.org/W2108535366","https://openalex.org/W4416120417","https://openalex.org/W4414867067","https://openalex.org/W7062518080","https://openalex.org/W2088793559","https://openalex.org/W3176696270","https://openalex.org/W3195731076"],"abstract_inverted_index":{"Introduction":[0],"Differentiating":[1],"wear-induced":[2],"hip":[3],"and":[4,11,16,64,80,103,131,140,240],"knee":[5],"implant":[6],"failure,":[7],"such":[8],"as":[9],"aseptic":[10],"septic":[12],"loosening,":[13],"is":[14],"challenging":[15],"can":[17],"result":[18],"in":[19,38,55,68,192,199,215,226,233,249],"unnecessary":[20],"operations":[21],"or":[22,118,128,133,202],"untreated":[23],"infections,":[24],"worsening":[25],"patient":[26],"outcomes.":[27],"These":[28],"failure":[29,92],"modes":[30,93],"arise":[31],"from":[32,196,230],"overlapping":[33],"biological":[34,242],"pathways,":[35],"but":[36,150],"differ":[37],"local":[39],"H\u2082O\u2082":[40,57,74],"levels,":[41],"reaching":[42],"up":[43,122],"to":[44,84,88,108,123,160,188,222],"100":[45],"\u03bcM":[46,51],"during":[47,52],"infection":[48,148,217],"versus":[49],"5":[50],"inflammation.":[53],"Continuous":[54],"vivo":[56,216,250],"monitoring":[58],"could":[59],"increase":[60],"true":[61],"positive":[62],"diagnoses":[63],"reduce":[65],"complications.":[66],"This":[67],"vitro":[69],"study":[70],"evaluated":[71],"an":[72,193,200,227],"electrochemical":[73],"sensor":[75],"under":[76],"simulated":[77],"healthy,":[78],"inflamed,":[79],"infected":[81,194],"joint":[82,195,204,229],"conditions,":[83,208],"assess":[85],"its":[86],"ability":[87],"distinguish":[89,189,223],"between":[90],"these":[91],"after":[94,158],"protein":[95,116],"adsorption.":[96],"Methods":[97],"Platinum":[98],"sensors":[99,185],"coated":[100],"with":[101],"Nafion-":[102],"m":[104],"-phenylenediamine":[105],"were":[106,151,174,186,220],"exposed":[107],"phosphate-buffered":[109],"saline,":[110],"protein-rich":[111,162],"fluid":[112,115],"containing":[113],"synovial":[114],"analogues,":[117],"blood":[119],"serum":[120],"for":[121,147,153,213],"16":[124],"h":[125],"at":[126],"35":[127],"40":[129],"\u00b0C":[130],"7.4":[132],"6.7":[134],"pH.":[135],"Results":[136],"Sensor":[137],"sensitivity,":[138],"noise,":[139],"limit":[141],"of":[142],"detection":[143,149],"met":[144],"the":[145,161,180],"requirements":[146],"insufficient":[152],"reliably":[154],"detecting":[155],"inflammation,":[156],"particularly":[157],"exposure":[159],"fluid.":[163],"The":[164,184],"linearity":[165],"remained":[166],"excellent":[167],"across":[168,205],"all":[169,206],"conditions":[170,190,224],"(>0.985).":[171],"Noise":[172],"levels":[173],"influenced":[175],"by":[176],"fabrication":[177],"variability,":[178],"decreasing":[179],"overall":[181],"reproducibility.":[182],"Conclusion":[183],"able":[187],"seen":[191,198,225,232],"those":[197,231],"inflamed":[201,228],"healthy":[203,235],"testing":[207],"suggesting":[209],"potential":[210],"clinical":[211],"utility":[212],"continuous":[214],"monitoring.":[218],"They":[219],"unable":[221],"a":[234],"joint.":[236],"Longer":[237],"test":[238],"durations":[239],"broader":[241],"interactions":[243],"should":[244],"be":[245],"researched":[246],"before":[247],"starting":[248],"studies.":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-11T00:00:00"}
