{"id":"https://openalex.org/W7212124289","doi":"https://doi.org/10.64898/2026.09.07.749796","title":"Associative memory formation reshapes the learning trajectory of a novel cognitive map","display_name":"Associative memory formation reshapes the learning trajectory of a novel cognitive map","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212124289","doi":"https://doi.org/10.64898/2026.09.07.749796"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.07.749796","doi":"https://doi.org/10.64898/2026.09.07.749796","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749796","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.07.749796","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030946617","display_name":"Nathalie Immerzeel","orcid":"https://orcid.org/0009-0004-3758-8239","observed_orcids":["https://orcid.org/0009-0004-3758-8239"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nathalie Immerzeel","raw_affiliation_strings":["Biozentrum, University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0004-3758-8239","affiliations":[{"raw_affiliation_string":"Biozentrum, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019642729","display_name":"Cecilia Gallego-Carracedo","orcid":"https://orcid.org/0000-0002-0478-2359","observed_orcids":["https://orcid.org/0000-0002-0478-2359"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cecilia Gallego-Carracedo","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0478-2359","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119808112","display_name":"Lorenzo Mauro","orcid":"https://orcid.org/0009-0007-5103-1797","observed_orcids":["https://orcid.org/0009-0007-5103-1797"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lorenzo Mauro","raw_affiliation_strings":["Biozentrum, University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0007-5103-1797","affiliations":[{"raw_affiliation_string":"Biozentrum, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072148140","display_name":"Catalin Mitelut","orcid":"https://orcid.org/0000-0003-0471-9816","observed_orcids":["https://orcid.org/0000-0003-0471-9816"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Catalin Mitelut","raw_affiliation_strings":["Biozentrum, University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0471-9816","affiliations":[{"raw_affiliation_string":"Biozentrum, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071843618","display_name":"Flavio Donato","orcid":"https://orcid.org/0000-0002-0732-1654","observed_orcids":["https://orcid.org/0000-0002-0732-1654"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Flavio Donato","raw_affiliation_strings":["Biozentrum, University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0732-1654","affiliations":[{"raw_affiliation_string":"Biozentrum, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071843618"],"corresponding_institution_ids":["https://openalex.org/I1850255"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11904","display_name":"Spatial Cognition and Navigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/associative-memory","display_name":"associative memory","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6620000004768372},{"id":"https://openalex.org/keywords/ca3","display_name":"CA3","score":0.7919999957084656},{"id":"https://openalex.org/keywords/place-cells","display_name":"place cells","score":0.875},{"id":"https://openalex.org/keywords/cognitive-maps","display_name":"cognitive maps","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fear-memory","display_name":"fear memory","score":0.9309999942779541},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.527999997138977},{"id":"https://openalex.org/keywords/population-activity","display_name":"population activity","score":0.5270000100135803},{"id":"https://openalex.org/keywords/remapping","display_name":"remapping","score":0.5080000162124634},{"id":"https://openalex.org/keywords/memory-encoding","display_name":"memory encoding","score":0.33399999141693115},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C170494330","wikidata":"https://www.wikidata.org/wiki/Q1778434","display_name":"Cognitive map","level":3,"score":0.6801999807357788},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.6290000081062317},{"id":"https://openalex.org/C53442348","wikidata":"https://www.wikidata.org/wiki/Q745101","display_name":"Content-addressable memory","level":3,"score":0.5971999764442444},{"id":"https://openalex.org/C197792726","wikidata":"https://www.wikidata.org/wiki/Q191062","display_name":"Mnemonic","level":2,"score":0.5961999893188477},{"id":"https://openalex.org/C159423971","wikidata":"https://www.wikidata.org/wiki/Q177251","display_name":"Associative property","level":2,"score":0.565500020980835},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.5637999773025513},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5339999794960022},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5324000120162964},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.491100013256073},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4893999993801117},{"id":"https://openalex.org/C43729271","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial memory","level":4,"score":0.45989999175071716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42590001225471497},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.42010000348091125},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3937000036239624},{"id":"https://openalex.org/C7149132","wikidata":"https://www.wikidata.org/wiki/Q1377840","display_name":"Forgetting","level":2,"score":0.3928999900817871},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39250001311302185},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C93424556","wikidata":"https://www.wikidata.org/wiki/Q1080996","display_name":"Sensory memory","level":4,"score":0.36820000410079956},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.36169999837875366},{"id":"https://openalex.org/C2993691153","wikidata":"https://www.wikidata.org/wiki/Q492","display_name":"Memory formation","level":3,"score":0.3538999855518341},{"id":"https://openalex.org/C2983526489","wikidata":"https://www.wikidata.org/wiki/Q133500","display_name":"Associative learning","level":2,"score":0.35089999437332153},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.3262999951839447},{"id":"https://openalex.org/C100660578","wikidata":"https://www.wikidata.org/wiki/Q18733","display_name":"Recall","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C27511587","wikidata":"https://www.wikidata.org/wiki/Q2178623","display_name":"Spatial relation","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2777742833","wikidata":"https://www.wikidata.org/wiki/Q1964083","display_name":"Reciprocal","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C40506919","wikidata":"https://www.wikidata.org/wiki/Q7452469","display_name":"Sequence learning","level":2,"score":0.2897999882698059},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.287200003862381},{"id":"https://openalex.org/C27853696","wikidata":"https://www.wikidata.org/wiki/Q3480151","display_name":"Interference theory","level":4,"score":0.26269999146461487},{"id":"https://openalex.org/C111437709","wikidata":"https://www.wikidata.org/wiki/Q1277874","display_name":"Hebbian theory","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C120620853","wikidata":"https://www.wikidata.org/wiki/Q506355","display_name":"Bidirectional associative memory","level":4,"score":0.258899986743927},{"id":"https://openalex.org/C64754055","wikidata":"https://www.wikidata.org/wiki/Q7574053","display_name":"Spatial contextual awareness","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C12186640","wikidata":"https://www.wikidata.org/wiki/Q6815743","display_name":"Memory model","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C30390489","wikidata":"https://www.wikidata.org/wiki/Q4680748","display_name":"Adaptive memory","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.07.749796","doi":"https://doi.org/10.64898/2026.09.07.749796","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749796","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.07.749796","doi":"https://doi.org/10.64898/2026.09.07.749796","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749796","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1591199750","https://openalex.org/W1607671357","https://openalex.org/W1920095995","https://openalex.org/W1965070330","https://openalex.org/W1965189326","https://openalex.org/W1980747802","https://openalex.org/W1983600855","https://openalex.org/W1994363342","https://openalex.org/W1999251867","https://openalex.org/W2014806995","https://openalex.org/W2016454630","https://openalex.org/W2017766656","https://openalex.org/W2025806474","https://openalex.org/W2029210342","https://openalex.org/W2031822869","https://openalex.org/W2033797595","https://openalex.org/W2036773579","https://openalex.org/W2041656098","https://openalex.org/W2047148152","https://openalex.org/W2052515926","https://openalex.org/W2061960110","https://openalex.org/W2063303712","https://openalex.org/W2076953551","https://openalex.org/W2078075786","https://openalex.org/W2082235945","https://openalex.org/W2086967399","https://openalex.org/W2089485366","https://openalex.org/W2093069982","https://openalex.org/W2131141854","https://openalex.org/W2132611303","https://openalex.org/W2141674392","https://openalex.org/W2155505956","https://openalex.org/W2155547196","https://openalex.org/W2159887581","https://openalex.org/W2168136532","https://openalex.org/W2171332611","https://openalex.org/W2261030667","https://openalex.org/W2275929617","https://openalex.org/W2471048879","https://openalex.org/W2604616981","https://openalex.org/W2621961142","https://openalex.org/W2883712683","https://openalex.org/W2887114371","https://openalex.org/W2896846197","https://openalex.org/W2903169737","https://openalex.org/W2949065250","https://openalex.org/W2968451269","https://openalex.org/W2972591097","https://openalex.org/W2997421847","https://openalex.org/W2998470023","https://openalex.org/W3081613549","https://openalex.org/W3082162714","https://openalex.org/W3161871721","https://openalex.org/W3207218175","https://openalex.org/W3212173726","https://openalex.org/W4220696485","https://openalex.org/W4220706288","https://openalex.org/W4224232972","https://openalex.org/W4224319396","https://openalex.org/W4226238242","https://openalex.org/W4293004892","https://openalex.org/W4309679711","https://openalex.org/W4321188323","https://openalex.org/W4388488592","https://openalex.org/W4392471559","https://openalex.org/W4401606961","https://openalex.org/W4403729763","https://openalex.org/W4404819321","https://openalex.org/W4407958160","https://openalex.org/W4409310097","https://openalex.org/W4409644552","https://openalex.org/W4411035859","https://openalex.org/W4412466180","https://openalex.org/W4412692346","https://openalex.org/W4414033397","https://openalex.org/W4415708155","https://openalex.org/W7096570344","https://openalex.org/W7134967402"],"related_works":["https://openalex.org/W4379880629","https://openalex.org/W2955208574","https://openalex.org/W3161871721","https://openalex.org/W3087467736","https://openalex.org/W2134946041","https://openalex.org/W2094457768","https://openalex.org/W6920875527","https://openalex.org/W2051316207","https://openalex.org/W2883712683","https://openalex.org/W2795632951"],"abstract_inverted_index":{"Abstract":[0],"Learning":[1],"never":[2],"occurs":[3],"on":[4,58],"a":[5,85,109,113,119,183,201,253,262],"blank":[6],"slate,":[7],"as":[8,96],"each":[9],"experience":[10,73],"an":[11,68,72,104],"animal":[12],"encounters":[13],"in":[14,75,112],"its":[15,197,271],"daily":[16],"life":[17],"is":[18,88],"encoded":[19,102],"by":[20,24],"circuits":[21],"already":[22,181],"shaped":[23],"previous":[25],"ones.":[26],"During":[27],"such":[28],"experiences,":[29,124],"the":[30,37,62,80,161,164,172,178,207,220,258,267],"hippocampus":[31],"builds":[32],"place-cell-based":[33],"cognitive":[34,128,264],"maps":[35,84,129],"of":[36,71,163,171,186,223,261,270],"environments":[38],"explored,":[39],"and":[40,54,116,130,144,150,189,196,226,243],"encodes":[41],"ensemble-based":[42],"memories":[43],"for":[44],"associations":[45],"among":[46],"events":[47],"that":[48,139,204,230],"occur":[49],"within":[50,61],"them.":[51],"These":[52],"spatial":[53,191,241],"mnemonic":[55],"representations":[56],"draw":[57],"neurons":[59,95],"embedded":[60],"same":[63,81],"network.":[64],"However,":[65],"whether":[66],"forming":[67],"associative":[69,105],"memory":[70,107,111,131,158,247],"unfolding":[74],"one":[76,87,100],"context":[77],"changes":[78],"how":[79],"hippocampal":[82],"network":[83],"different":[86,114],"unknown.":[89],"Here,":[90],"we":[91],"longitudinally":[92],"imaged":[93],"CA3":[94,251],"mice":[97],"familiarized":[98],"with":[99,147,193,206],"environment,":[101,115],"either":[103],"fear":[106,143],"or":[108],"context-only":[110],"then":[117],"explored":[118],"novel":[120,173,179,215],"one.":[121,174],"Across":[122],"separate":[123],"neuronal":[125],"recruitment":[126],"into":[127,252],"ensembles":[132],"followed":[133],"structured,":[134],"partially":[135],"orthogonal":[136],"allocation":[137],"rules":[138],"were":[140],"consistent":[141],"across":[142],"neutral":[145],"memories,":[146],"ensemble":[148],"membership":[149],"place-cell":[151],"identity":[152],"showing":[153],"no":[154],"reciprocal":[155],"enrichment.":[156],"Fear":[157],"encoding":[159,248],"left":[160],"properties":[162],"familiar":[165,208],"map":[166,180,209,216,265],"unchanged,":[167],"while":[168,210],"altering":[169],"those":[170],"From":[175],"first":[176],"exposure,":[177],"recruited":[182],"familiar-like":[184],"fraction":[185],"place":[187,236],"cells":[188,237],"supported":[190],"decoding":[192,224],"near-familiar":[194],"precision,":[195],"population":[198,273],"activity":[199],"occupied":[200],"latent":[202,228],"subspace":[203],"aligned":[205],"remaining":[211],"context-specific.":[212],"Yet":[213],"this":[214],"failed":[217],"to":[218,239,244],"undergo":[219],"experience-dependent":[221,268],"refinement":[222,269],"precision":[225,260],"across-day":[227],"alignment":[229],"normally":[231],"accompanies":[232],"familiarization,":[233],"even":[234],"though":[235],"continued":[238],"gain":[240],"information":[242],"remap.":[245],"Associative":[246],"therefore":[249],"shifts":[250],"distinct":[254],"representational":[255],"regime,":[256],"decoupling":[257],"immediate":[259],"new":[263],"from":[266],"context-specific":[272],"embedding.":[274]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-11T00:00:00"}
