{"id":"https://openalex.org/W7212106925","doi":"https://doi.org/10.5798/dicletip.2037192","title":"Protective Effects of Esculetin at two Different Doses on Oxidative Stress, Inflammation, and Fibrotic Changes in AlCl\u2083-Induced Cardiotoxicity in Rats","display_name":"Protective Effects of Esculetin at two Different Doses on Oxidative Stress, Inflammation, and Fibrotic Changes in AlCl\u2083-Induced Cardiotoxicity in Rats","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7212106925","doi":"https://doi.org/10.5798/dicletip.2037192"},"language":"en","primary_location":{"id":"doi:10.5798/dicletip.2037192","doi":"https://doi.org/10.5798/dicletip.2037192","is_oa":true,"landing_page_url":"https://doi.org/10.5798/dicletip.2037192","pdf_url":"https://dergipark.org.tr/en/download/article-file/6429910","source":{"id":"https://openalex.org/S2738126186","display_name":"Dicle Medical Journal / Dicle Tip Dergisi","issn_l":"1300-2945","issn":["1300-2945","1308-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318396","host_organization_name":"Dicle University Medical School","host_organization_lineage":["https://openalex.org/P4310318396"],"host_organization_lineage_names":["Dicle University Medical School"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dicle T\u0131p Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/6429910","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069742022","display_name":"Tansu Ku\u015fat","orcid":"https://orcid.org/0000-0001-7237-1562","observed_orcids":["https://orcid.org/0000-0001-7237-1562"]},"institutions":[{"id":"https://openalex.org/I173761726","display_name":"Karab\u00fck University","ror":"https://ror.org/04wy7gp54","country_code":"TR","type":"education","lineage":["https://openalex.org/I173761726"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tansu Ku\u015fat","raw_affiliation_strings":["KARAB\u00dcK \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KARAB\u00dcK \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I173761726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011925904","display_name":"Feyza Ba\u015fak","orcid":"https://orcid.org/0000-0002-9335-1103","observed_orcids":["https://orcid.org/0000-0002-9335-1103"]},"institutions":[{"id":"https://openalex.org/I173761726","display_name":"Karab\u00fck University","ror":"https://ror.org/04wy7gp54","country_code":"TR","type":"education","lineage":["https://openalex.org/I173761726"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Feyza Ba\u015fak","raw_affiliation_strings":["Karabuk University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karabuk University","institution_ids":["https://openalex.org/I173761726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021720325","display_name":"Orhan \u00d6nalan","orcid":"https://orcid.org/0000-0001-9780-7051","observed_orcids":["https://orcid.org/0000-0001-9780-7051"]},"institutions":[{"id":"https://openalex.org/I173761726","display_name":"Karab\u00fck University","ror":"https://ror.org/04wy7gp54","country_code":"TR","type":"education","lineage":["https://openalex.org/I173761726"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Orhan \u00d6nalan","raw_affiliation_strings":["Karabuk University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karabuk University","institution_ids":["https://openalex.org/I173761726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084568492","display_name":"Ali \u015eenol","orcid":"https://orcid.org/0000-0003-4080-7776","observed_orcids":["https://orcid.org/0000-0003-4080-7776"]},"institutions":[{"id":"https://openalex.org/I45642913","display_name":"K\u0131r\u0131kkale University","ror":"https://ror.org/01zhwwf82","country_code":"TR","type":"education","lineage":["https://openalex.org/I45642913"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali \u015eenol","raw_affiliation_strings":["K\u0131r\u0131kkale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K\u0131r\u0131kkale University","institution_ids":["https://openalex.org/I45642913"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"3","first_page":"701","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esculetin","display_name":"esculetin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.8220000267028809},{"id":"https://openalex.org/keywords/aluminum-chloride","display_name":"aluminum chloride","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5709999799728394},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8370000123977661},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8331999778747559},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7943000197410583},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7651000022888184},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7319999933242798},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6859999895095825},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6352999806404114},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6168000102043152},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5853999853134155},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5633000135421753},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5210999846458435},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.3409999907016754},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.3140000104904175},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26980000734329224},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.25870001316070557}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5798/dicletip.2037192","doi":"https://doi.org/10.5798/dicletip.2037192","is_oa":true,"landing_page_url":"https://doi.org/10.5798/dicletip.2037192","pdf_url":"https://dergipark.org.tr/en/download/article-file/6429910","source":{"id":"https://openalex.org/S2738126186","display_name":"Dicle Medical Journal / Dicle Tip Dergisi","issn_l":"1300-2945","issn":["1300-2945","1308-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318396","host_organization_name":"Dicle University Medical School","host_organization_lineage":["https://openalex.org/P4310318396"],"host_organization_lineage_names":["Dicle University Medical School"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dicle T\u0131p Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/2037192","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/dicletip/article/2037192","pdf_url":null,"source":{"id":"https://openalex.org/S2738126186","display_name":"Dicle Medical Journal / Dicle Tip Dergisi","issn_l":"1300-2945","issn":["1300-2945","1308-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318396","host_organization_name":"Dicle University Medical School","host_organization_lineage":["https://openalex.org/P4310318396"],"host_organization_lineage_names":["Dicle University Medical School"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dicle T\u0131p Dergisi, Vol. 53 No. 3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.5798/dicletip.2037192","doi":"https://doi.org/10.5798/dicletip.2037192","is_oa":true,"landing_page_url":"https://doi.org/10.5798/dicletip.2037192","pdf_url":"https://dergipark.org.tr/en/download/article-file/6429910","source":{"id":"https://openalex.org/S2738126186","display_name":"Dicle Medical Journal / Dicle Tip Dergisi","issn_l":"1300-2945","issn":["1300-2945","1308-9889"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318396","host_organization_name":"Dicle University Medical School","host_organization_lineage":["https://openalex.org/P4310318396"],"host_organization_lineage_names":["Dicle University Medical School"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dicle T\u0131p Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326538","display_name":"Karab\u00fck \u00dcniversitesi","ror":"https://ror.org/04wy7gp54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212106925.pdf","grobid_xml":"https://content.openalex.org/works/W7212106925.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1848715460","https://openalex.org/W2294080015","https://openalex.org/W2801888228","https://openalex.org/W2898480640","https://openalex.org/W2947342074","https://openalex.org/W2952567274","https://openalex.org/W3114921619","https://openalex.org/W3136311408","https://openalex.org/W3173171792","https://openalex.org/W4307720916","https://openalex.org/W4382918954","https://openalex.org/W4388979715","https://openalex.org/W4391281069","https://openalex.org/W4402415217","https://openalex.org/W4402710334","https://openalex.org/W4403660676","https://openalex.org/W4406325797","https://openalex.org/W4406786297","https://openalex.org/W4409430834","https://openalex.org/W4412161335","https://openalex.org/W4412357307","https://openalex.org/W4413641084","https://openalex.org/W4414584687","https://openalex.org/W4415984381","https://openalex.org/W4416337175","https://openalex.org/W7151016268"],"related_works":["https://openalex.org/W7212464770","https://openalex.org/W3136311408","https://openalex.org/W4290028321","https://openalex.org/W7216301866","https://openalex.org/W6892574333","https://openalex.org/W4417532892","https://openalex.org/W3004954184","https://openalex.org/W2996501529","https://openalex.org/W4413641084","https://openalex.org/W4309552117"],"abstract_inverted_index":{"Objective:":[0],"Aluminum":[1],"chloride":[2],"(AlCl\u2083)":[3],"is":[4,22],"an":[5],"environmental":[6],"toxicant":[7],"that":[8],"promotes":[9],"cardiotoxicity":[10],"primarily":[11],"by":[12],"inducing":[13],"oxidative":[14,114],"stress":[15],"and":[16,31,76,107,120,133,142,157,164],"inflammatory":[17,129],"responses.":[18],"Esculetin":[19],"(ESC),":[20],"which":[21],"a":[23,46],"naturally":[24],"occurring":[25],"coumarin":[26],"derivative,":[27],"possesses":[28],"antioxidant,":[29],"anti-inflammatory,":[30],"antifibrotic":[32],"activities.":[33],"This":[34],"study":[35,93],"evaluated":[36],"the":[37,91,128,134],"protective":[38],"effects":[39],"of":[40,98,136],"ESC":[41],"against":[42],"AlCl\u2083-induced":[43],"cardiotoxicity,":[44],"with":[45,161],"focus":[47],"on":[48],"dose-related":[49],"responses.Methods:":[50],"35":[51],"male":[52],"Wistar":[53],"albino":[54],"rats":[55],"were":[56,85,110,124,147],"randomly":[57],"assigned":[58],"to":[59,112,126,153],"five":[60],"experimental":[61,83],"groups":[62],"(n=7":[63],"per":[64],"group):":[65],"Control,":[66],"Vehicle,":[67],"AlCl\u2083":[68,71,77,150],"(10":[69],"mg/kg),":[70,75],"+":[72,78],"ESC50":[73],"(50":[74],"ESC100":[79],"(100":[80],"mg/kg).":[81],"All":[82],"treatments":[84],"administered":[86],"orally":[87],"once":[88],"daily":[89],"throughout":[90],"14-day":[92],"period.":[94],"Cardiac":[95],"tissue":[96,169],"levels":[97,156],"malondialdehyde":[99],"(MDA),":[100],"reduced":[101,162],"glutathione":[102],"(GSH),":[103],"superoxide":[104],"dismutase":[105],"(SOD),":[106],"catalase":[108],"(CAT)":[109],"determined":[111],"assess":[113],"stress.":[115],"Tumor":[116],"necrosis":[117],"factor-alpha":[118],"(TNF-\u03b1)":[119],"interleukin-1":[121],"beta":[122],"(IL-1\u03b2)":[123],"measured":[125],"evaluate":[127],"response.":[130],"Histopathological":[131],"changes":[132],"immunoreactivity":[135],"inducible":[137],"nitric":[138],"oxide":[139],"synthase":[140],"(iNOS)":[141],"alpha-smooth":[143],"muscle":[144],"actin":[145],"(\u03b1-SMA)":[146],"also":[148],"evaluated.Results:":[149],"exposure":[151],"led":[152],"increased":[154],"MDA":[155],"decreased":[158],"GSH":[159],"levels,":[160],"SOD":[163],"CAT":[165],"activities":[166],"in":[167],"heart":[168],"(P":[170]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-11T00:00:00"}
