{"id":"https://openalex.org/W7212062104","doi":"https://doi.org/10.64898/2026.09.04.749244","title":"Specific basal ganglia, amygdala, and cortical neurons are associated with borderline personality disorder (BPD)","display_name":"Specific basal ganglia, amygdala, and cortical neurons are associated with borderline personality disorder (BPD)","publication_year":2026,"publication_date":"2026-09-09","ids":{"openalex":"https://openalex.org/W7212062104","doi":"https://doi.org/10.64898/2026.09.04.749244","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818653","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622577"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.04.749244","doi":"https://doi.org/10.64898/2026.09.04.749244","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.04.749244","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.04.749244.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.04.749244.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114354080","display_name":"Hazal Senturk","orcid":"https://orcid.org/0009-0003-1357-6260","observed_orcids":["https://orcid.org/0009-0003-1357-6260"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hazal Senturk","raw_affiliation_strings":["Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305"],"raw_orcid":"https://orcid.org/0009-0003-1357-6260","affiliations":[{"raw_affiliation_string":"Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020139198","display_name":"Hadar Segal\u2010Gavish","orcid":"https://orcid.org/0000-0002-2656-4037","observed_orcids":["https://orcid.org/0000-0002-2656-4037"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hadar Segal-Gavish","raw_affiliation_strings":["Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305"],"raw_orcid":"https://orcid.org/0000-0002-2656-4037","affiliations":[{"raw_affiliation_string":"Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074000150","display_name":"Jason Tucciarone","orcid":"https://orcid.org/0000-0002-6053-2952","observed_orcids":["https://orcid.org/0000-0002-6053-2952"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Tucciarone","raw_affiliation_strings":["Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305","Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305"],"raw_orcid":"https://orcid.org/0000-0002-6053-2952","affiliations":[{"raw_affiliation_string":"Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024497692","display_name":"Laramie E. Duncan","orcid":"https://orcid.org/0000-0003-1131-661X","observed_orcids":["https://orcid.org/0000-0003-1131-661X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laramie Duncan","raw_affiliation_strings":["Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305","Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305"],"raw_orcid":"https://orcid.org/0000-0003-1131-661X","affiliations":[{"raw_affiliation_string":"Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024497692"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11093","display_name":"Personality Disorders and Psychopathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11093","display_name":"Personality Disorders and Psychopathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borderline-personality-disorder","display_name":"borderline personality disorder","score":1.0},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.843999981880188},{"id":"https://openalex.org/keywords/d2-medium-spiny-neurons","display_name":"D2 medium spiny neurons","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-type-specific-gene-expression","display_name":"cell type-specific gene expression","score":0.6779999732971191},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2780600973","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Borderline personality disorder","level":2,"score":0.7682999968528748},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7232999801635742},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5257999897003174},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.521399974822998},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5091999769210815},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.43720000982284546},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.3937000036239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3630000054836273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3172000050544739},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.28690001368522644},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.04.749244","doi":"https://doi.org/10.64898/2026.09.04.749244","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.04.749244","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.04.749244.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622577","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622577/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.04.749244","doi":"https://doi.org/10.64898/2026.09.04.749244","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.04.749244","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/09/2026.09.04.749244.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1863699325","display_name":"Sex hormones and post-traumatic stress disorder (PTSD)","funder_award_id":"R01MH123486","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2428533740","display_name":"Sex Chromosome GWAS of Post-Traumatic Stress Disorder (PTSD)","funder_award_id":"R21MH125358","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337840","display_name":"Stanford Maternal and Child Health Research Institute","ror":"https://ror.org/00yt0ea73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212062104.pdf","grobid_xml":"https://content.openalex.org/works/W7212062104.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1995180357","https://openalex.org/W2051314902","https://openalex.org/W2061619540","https://openalex.org/W2948054808","https://openalex.org/W2952673268","https://openalex.org/W3159995594","https://openalex.org/W4286449197","https://openalex.org/W4322616886","https://openalex.org/W4366351853","https://openalex.org/W4387568450","https://openalex.org/W4389670555","https://openalex.org/W4399459044","https://openalex.org/W4406633332","https://openalex.org/W7169808269"],"related_works":["https://openalex.org/W170085179","https://openalex.org/W2889561980","https://openalex.org/W2901832058","https://openalex.org/W320968531","https://openalex.org/W2030980207","https://openalex.org/W1628571550","https://openalex.org/W2592490003","https://openalex.org/W2793686646","https://openalex.org/W3026082234","https://openalex.org/W2517900560"],"abstract_inverted_index":{"Borderline":[0],"personality":[1],"disorder":[2],"(BPD)":[3],"is":[4],"clinically":[5],"significant":[6],"and":[7,32],"poorly":[8],"understood":[9],"biologically.":[10],"We":[11],"tested":[12],"which":[13],"human":[14],"brain":[15],"cell":[16,39],"types":[17,27,40],"preferentially":[18],"use":[19],"genes":[20],"associated":[21],"with":[22],"BPD,":[23],"implicating":[24],"two":[25],"major":[26],"of":[28,48],"neurons:":[29],"LAMP5":[30],"interneurons":[31],"D2":[33],"medium":[34],"spiny":[35],"neurons.":[36],"These":[37],"interrogable":[38],"provide":[41],"new":[42],"avenues":[43],"for":[44],"investigating":[45],"the":[46],"neurobiology":[47],"BPD.":[49]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-09-10T00:00:00"}