{"id":"https://openalex.org/W7212061329","doi":"https://doi.org/10.64898/2026.09.04.749300","title":"Transcription-Coupled Chromatin Reinforcement Maintains the Mature Cardiomyocyte State","display_name":"Transcription-Coupled Chromatin Reinforcement Maintains the Mature Cardiomyocyte State","publication_year":2026,"publication_date":"2026-09-08","ids":{"openalex":"https://openalex.org/W7212061329","doi":"https://doi.org/10.64898/2026.09.04.749300"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.04.749300","doi":"https://doi.org/10.64898/2026.09.04.749300","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.04.749300","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/08/2026.09.04.749300.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/08/2026.09.04.749300.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046908490","display_name":"H F Tang","orcid":"https://orcid.org/0000-0002-9034-3597","observed_orcids":["https://orcid.org/0000-0002-9034-3597"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Han-Hsuan Tang","raw_affiliation_strings":["Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, 106, Roosevelt Road, Section 4, Daan, Taipei, Taiwan","Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-9034-3597","affiliations":[{"raw_affiliation_string":"Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, 106, Roosevelt Road, Section 4, Daan, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105714087","display_name":"Hsin-Yi Tseng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Yi Tseng","raw_affiliation_strings":["Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067448867","display_name":"Chia\u2010Yeh Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Yeh Lin","raw_affiliation_strings":["Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024150433","display_name":"Cheng-Fu Kao","orcid":"https://orcid.org/0000-0002-8875-8152","observed_orcids":["https://orcid.org/0000-0002-8875-8152"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210132902","display_name":"Institute of Cellular and Organismic Biology, Academia Sinica","ror":"https://ror.org/048evbw70","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Cheng-Fu Kao","raw_affiliation_strings":["Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, 106, Roosevelt Road, Section 4, Daan, Taipei, Taiwan","Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, 106, Roosevelt Road, Section 4, Daan, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Cellular and Organismic Biology, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210132902","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024150433"],"corresponding_institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210132902","https://openalex.org/I84653119"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.20170000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnf20","display_name":"RNF20","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.9133999943733215},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7336000204086304},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.49309998750686646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49050000309944153},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.47620001435279846},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4171000123023987},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.36320000886917114},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3612000048160553},{"id":"https://openalex.org/C3017707949","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Negative regulator","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.2879999876022339},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C3017643693","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Sex chromatin","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2662999927997589},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.04.749300","doi":"https://doi.org/10.64898/2026.09.04.749300","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.04.749300","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/08/2026.09.04.749300.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.04.749300","doi":"https://doi.org/10.64898/2026.09.04.749300","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.04.749300","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/08/2026.09.04.749300.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212061329.pdf","grobid_xml":"https://content.openalex.org/works/W7212061329.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2946374792","https://openalex.org/W4317213634","https://openalex.org/W2741060746","https://openalex.org/W4388736618","https://openalex.org/W2912901928","https://openalex.org/W3137575993","https://openalex.org/W4385799238","https://openalex.org/W2981024144","https://openalex.org/W7220987516","https://openalex.org/W4312303778"],"abstract_inverted_index":{"Abstract":[0],"Chromatin":[1],"homeostasis":[2],"is":[3,53],"fundamental":[4],"to":[5,139],"maintaining":[6,56],"transcriptional":[7,66],"programs":[8,67],"that":[9,22,47,62],"stabilize":[10],"cell":[11,26,129],"states":[12,27],"while":[13,124],"permitting":[14],"plasticity":[15],"for":[16,37,55],"timely":[17],"state":[18,123],"transitions.":[19],"However,":[20],"mechanisms":[21],"actively":[23],"sustain":[24],"mature":[25,64,120],"after":[28],"their":[29],"establishment":[30],"remain":[31],"poorly":[32],"defined":[33],"despite":[34],"being":[35],"essential":[36],"lifelong":[38],"maintenance":[39],"of":[40,73,83,102],"specialized":[41],"cellular":[42],"functions.":[43],"Here":[44],"we":[45],"demonstrate":[46],"the":[48,77,119],"transcription-coupled":[49,114],"chromatin":[50,57,115,137],"regulator":[51],"RNF20":[52,74],"crucial":[54],"accessibility":[58],"at":[59],"identity-associated":[60],"promoters":[61],"support":[63,109],"cardiomyocyte":[65,121,133],"in":[68,112],"adult":[69,84],"murine":[70],"cardiomyocytes.":[71],"Depletion":[72],"progressively":[75],"erodes":[76],"transcriptional,":[78],"structural,":[79],"and":[80,86],"functional":[81],"integrity":[82],"cardiomyocytes":[85],"activates":[87],"AP-1-associated":[88],"stress-responsive":[89,104],"enhancer":[90],"elements":[91],"without":[92],"cell-cycle":[93],"re-entry.":[94],"Spatial":[95],"transcriptomics":[96],"further":[97],"revealed":[98],"a":[99,110],"subendocardial":[100],"localization":[101],"this":[103],"state.":[105],"Together,":[106],"these":[107],"findings":[108],"model":[111],"which":[113],"reinforcement":[116,138],"continuously":[117],"stabilizes":[118],"attractor":[122],"constraining":[125],"transitions":[126,141],"toward":[127,142],"pathological":[128,143],"states.":[130,144],"Teaser":[131],"Mature":[132],"identity":[134],"requires":[135],"continuous":[136],"resist":[140]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-10T00:00:00"}
