{"id":"https://openalex.org/W7212059296","doi":"https://doi.org/10.1038/s42255-020-00281-8","title":"Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report","display_name":"Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W7212059296","doi":"https://doi.org/10.1038/s42255-020-00281-8"},"language":"en","primary_location":{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/180519","doi":"https://doi.org/10.1038/s42255-020-00281-8","is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/180519","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hollstein, T., Schulte, D. M., Schulz, J., Gl\u00fcck, A., Ziegler, A. G., Bonifacio, E., Wendorff, M., Franke, A., Schreiber, S., Bornstein, S. R., & Laudes, M. (2020). Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report. Nature Metabolism, 2, 1021\u20131024. https://doi.org/10.1038/s42255-020-00281-8","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113226151","display_name":"Tim Hollstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hollstein, Tim; https://orcid.org/0000-0002-4048-2978","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070227503","display_name":"Dominik Maria Schulte","orcid":"https://orcid.org/0000-0002-4622-6051","observed_orcids":["https://orcid.org/0000-0002-4622-6051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schulte, Dominik M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103466889","display_name":"Juliane Schulz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schulz, Juliane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066456946","display_name":"Andreas Gl\u00fcck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gl\u00fcck, Andreas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112555413","display_name":"Anette G. Ziegler","orcid":"https://orcid.org/0000-0002-6290-5548","observed_orcids":["https://orcid.org/0000-0002-6290-5548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ziegler, Anette G","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150906634","display_name":"Ezio Bonifacio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonifacio, Ezio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012632196","display_name":"Mareike Wendorff","orcid":"https://orcid.org/0000-0001-8185-8516","observed_orcids":["https://orcid.org/0000-0001-8185-8516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendorff, Mareike; https://orcid.org/0000-0001-8185-8516","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150973598","display_name":"Andre Franke","orcid":"https://orcid.org/0000-0003-1530-5811","observed_orcids":["https://orcid.org/0000-0003-1530-5811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franke, Andre; https://orcid.org/0000-0003-1530-5811","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151088622","display_name":"Stefan Schreiber","orcid":"https://orcid.org/0000-0003-2254-7771","observed_orcids":["https://orcid.org/0000-0003-2254-7771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schreiber, Stefan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150901647","display_name":"Stefan R Bornstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bornstein, Stefan R","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103241078","display_name":"Matthias Laudes","orcid":"https://orcid.org/0000-0003-3763-4368","observed_orcids":["https://orcid.org/0000-0003-3763-4368","https://orcid.org/0000-0002-7846-955X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laudes, Matthias; https://orcid.org/0000-0002-7846-955X","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41362699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9570000171661377},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/diabetic-ketoacidosis","display_name":"diabetic ketoacidosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.6330000162124634},{"id":"https://openalex.org/keywords/ace2-receptor","display_name":"ACE2 receptor","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.804099977016449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7900999784469604},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7275999784469604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47920000553131104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4767000079154968},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4636000096797943},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.43779999017715454},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42149999737739563},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.42149999737739563},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3817000091075897},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.32820001244544983},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.3174999952316284},{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.2971000075340271},{"id":"https://openalex.org/C2779511750","wikidata":"https://www.wikidata.org/wiki/Q922215","display_name":"Insulitis","level":4,"score":0.2847000062465668},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.28130000829696655},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.2750999927520752},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C2908810637","wikidata":"https://www.wikidata.org/wiki/Q1797833","display_name":"Autoimmune diabetes","level":4,"score":0.2623000144958496}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/180519","doi":"https://doi.org/10.1038/s42255-020-00281-8","is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/180519","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hollstein, T., Schulte, D. M., Schulz, J., Gl\u00fcck, A., Ziegler, A. G., Bonifacio, E., Wendorff, M., Franke, A., Schreiber, S., Bornstein, S. R., & Laudes, M. (2020). Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report. Nature Metabolism, 2, 1021\u20131024. https://doi.org/10.1038/s42255-020-00281-8","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3116448287","https://openalex.org/W4212886856","https://openalex.org/W4301394377","https://openalex.org/W3159759777","https://openalex.org/W4366463049","https://openalex.org/W3159681971","https://openalex.org/W4367843777","https://openalex.org/W4281757309","https://openalex.org/W3155380089","https://openalex.org/W4292883117"],"abstract_inverted_index":{"Here":[0],"we":[1,176],"report":[2,140],"a":[3,16,31,78,96,107],"case":[4,66],"where":[5],"the":[6,20,93,148,171,194],"manifestations":[7],"of":[8,22,45,52,62,111,150,173,193],"insulin-dependent":[9],"diabetes":[10,28,116,151],"occurred":[11],"following":[12],"SARS-CoV-2":[13,84,157,179],"infection":[14,71],"in":[15,19,152],"young":[17],"individual":[18],"absence":[21],"autoantibodies":[23,123],"typical":[24],"for":[25,81],"type":[26,114],"1":[27,115],"mellitus.":[29,117],"Specifically,":[30],"19-year-old":[32],"white":[33],"male":[34],"presented":[35],"at":[36],"our":[37,139],"emergency":[38],"department":[39],"with":[40],"diabetic":[41],"ketoacidosis,":[42],"C-peptide":[43],"level":[44],"0.62":[46],"\u00b5g":[47],"l\u20131,":[48],"blood":[49],"glucose":[50],"concentration":[51],"30.6":[53],"mmol":[54],"l\u20131":[55],"(552":[56],"mg":[57],"dl\u20131)":[58],"and":[59,135,147],"haemoglobin":[60],"A1c":[61],"16.8%.":[63],"The":[64],"patient\u00b4s":[65],"history":[67],"revealed":[68],"probable":[69],"COVID-19":[70,146],"5\u20137":[72],"weeks":[73],"before":[74],"admission,":[75],"based":[76],"on":[77,166,196],"positive":[79],"test":[80],"antibodies":[82],"against":[83,126],"proteins":[85],"as":[86,119],"determined":[87],"by":[88],"enzyme-linked":[89],"immunosorbent":[90],"assay.":[91],"Interestingly,":[92],"patient":[94],"carried":[95],"human":[97],"leukocyte":[98],"antigen":[99],"genotype":[100],"(HLA":[101],"DR1-DR3-DQ2)":[102],"considered":[103],"to":[104],"provide":[105],"only":[106],"slightly":[108],"elevated":[109],"risk":[110],"developing":[112],"autoimmune":[113],"However,":[118],"noted,":[120],"no":[121],"serum":[122],"were":[124],"observed":[125],"islet":[127],"cells,":[128],"glutamic":[129],"acid":[130],"decarboxylase,":[131],"tyrosine":[132],"phosphatase,":[133],"insulin":[134],"zinc-transporter":[136],"8.":[137],"Although":[138],"cannot":[141],"fully":[142],"establish":[143],"causality":[144],"between":[145],"development":[149],"this":[153,174],"patient,":[154],"considering":[155],"that":[156,178],"entry":[158],"receptors,":[159],"including":[160],"angiotensin-converting":[161],"enzyme":[162],"2,":[163],"are":[164],"expressed":[165],"pancreatic":[167,186],"\u03b2-cells":[168],"and,":[169],"given":[170],"circumstances":[172],"case,":[175],"suggest":[177],"infection,":[180],"or":[181],"COVID-19,":[182],"might":[183],"negatively":[184],"affect":[185],"function,":[187],"perhaps":[188],"through":[189],"direct":[190],"cytolytic":[191],"effects":[192],"virus":[195],"\u03b2-cells.":[197]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-10T00:00:00"}