{"id":"https://openalex.org/W7212043281","doi":"https://doi.org/10.1016/j.xjidi.2026.100532","title":"The expression of IL-1\u03b2 and NLRP3 inflammasome components in hidradenitis suppurativa lesional skin","display_name":"The expression of IL-1\u03b2 and NLRP3 inflammasome components in hidradenitis suppurativa lesional skin","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7212043281","doi":"https://doi.org/10.1016/j.xjidi.2026.100532"},"language":"en","primary_location":{"id":"doi:10.1016/j.xjidi.2026.100532","doi":"https://doi.org/10.1016/j.xjidi.2026.100532","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjidi.2026.100532","pdf_url":null,"source":{"id":"https://openalex.org/S4210189051","display_name":"JID Innovations","issn_l":"2667-0267","issn":["2667-0267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innovations","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.xjidi.2026.100532","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043057731","display_name":"Sneha Shrotri","orcid":"https://orcid.org/0000-0001-8528-5313","observed_orcids":["https://orcid.org/0000-0001-8528-5313"]},"institutions":[{"id":"https://openalex.org/I4210110460","display_name":"Ampel BioSolutions (United States)","ror":"https://ror.org/01z71je29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sneha Shrotri","raw_affiliation_strings":["AMPEL BioSolutions LLC, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AMPEL BioSolutions LLC, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I4210110460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013671021","display_name":"Andrea R. Daamen","orcid":"https://orcid.org/0000-0002-0301-2811","observed_orcids":["https://orcid.org/0000-0002-0301-2811"]},"institutions":[{"id":"https://openalex.org/I4210110460","display_name":"Ampel BioSolutions (United States)","ror":"https://ror.org/01z71je29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea R. Daamen","raw_affiliation_strings":["AMPEL BioSolutions LLC, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AMPEL BioSolutions LLC, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I4210110460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051248102","display_name":"Mittie K. Doyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mittie K. Doyle","raw_affiliation_strings":["Avalo Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Avalo Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083070808","display_name":"Inbal Zafir\u2010Lavie","orcid":"https://orcid.org/0000-0002-8316-5753","observed_orcids":["https://orcid.org/0000-0002-8316-5753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Inbal Zafir-Lavie","raw_affiliation_strings":["Avalo Therapeutics, Chesterbrook, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Avalo Therapeutics, Chesterbrook, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I4210110460","display_name":"Ampel BioSolutions (United States)","ror":"https://ror.org/01z71je29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter E. Lipsky","raw_affiliation_strings":["AMPEL BioSolutions LLC, Charlottesville, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AMPEL BioSolutions LLC, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I4210110460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043874873"],"corresponding_institution_ids":["https://openalex.org/I4210110460"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70594462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"100532","last_page":"100532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12731","display_name":"Hidradenitis Suppurativa and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12731","display_name":"Hidradenitis Suppurativa and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hidradenitis-suppurativa","display_name":"hidradenitis suppurativa","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lesional-skin","display_name":"lesional skin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/nummular-eczema","display_name":"nummular eczema","score":1.0},{"id":"https://openalex.org/keywords/il-1-cytokine-family","display_name":"IL-1 family cytokines","score":0.7620000243186951},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tissue-stem-cells","display_name":"tissue stem cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/myeloid-activation","display_name":"myeloid activation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hair-follicle","display_name":"hair follicle","score":0.6150000095367432},{"id":"https://openalex.org/keywords/apocrine-sweat-glands","display_name":"apocrine sweat glands","score":0.8420000076293945},{"id":"https://openalex.org/keywords/skin-barrier","display_name":"skin barrier","score":0.6060000061988831},{"id":"https://openalex.org/keywords/autoinflammatory-skin-disease","display_name":"autoinflammatory skin disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2776002364","wikidata":"https://www.wikidata.org/wiki/Q341999","display_name":"Hidradenitis suppurativa","level":3,"score":0.8443999886512756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7225000262260437},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6136000156402588},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.462799996137619},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.37770000100135803},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36880001425743103},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36629998683929443},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31029999256134033},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2937000095844269},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2558000087738037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.xjidi.2026.100532","doi":"https://doi.org/10.1016/j.xjidi.2026.100532","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjidi.2026.100532","pdf_url":null,"source":{"id":"https://openalex.org/S4210189051","display_name":"JID Innovations","issn_l":"2667-0267","issn":["2667-0267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innovations","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.xjidi.2026.100532","doi":"https://doi.org/10.1016/j.xjidi.2026.100532","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjidi.2026.100532","pdf_url":null,"source":{"id":"https://openalex.org/S4210189051","display_name":"JID Innovations","issn_l":"2667-0267","issn":["2667-0267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JID Innovations","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.612076997756958,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315428","display_name":"Cerecor","ror":"https://ror.org/0077rhe26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1529674879","https://openalex.org/W1533217355","https://openalex.org/W1825622469","https://openalex.org/W2035315634","https://openalex.org/W2064038850","https://openalex.org/W2076029586","https://openalex.org/W2110755088","https://openalex.org/W2137070227","https://openalex.org/W2159707944","https://openalex.org/W2160965670","https://openalex.org/W2491204772","https://openalex.org/W2694182897","https://openalex.org/W2771968994","https://openalex.org/W2792194337","https://openalex.org/W2903052440","https://openalex.org/W3008268007","https://openalex.org/W3037431440","https://openalex.org/W3080707874","https://openalex.org/W3080991193","https://openalex.org/W3092754589","https://openalex.org/W3115291267","https://openalex.org/W3122547302","https://openalex.org/W4225120914","https://openalex.org/W4323653185","https://openalex.org/W4362657627","https://openalex.org/W4367172292","https://openalex.org/W4379376898","https://openalex.org/W4389030365","https://openalex.org/W4389226684","https://openalex.org/W4389570212","https://openalex.org/W4389976613","https://openalex.org/W4390651042","https://openalex.org/W4391450331","https://openalex.org/W4392908378","https://openalex.org/W4401076211","https://openalex.org/W4404387195","https://openalex.org/W4404864440","https://openalex.org/W4408464665","https://openalex.org/W4412672565","https://openalex.org/W4413971810","https://openalex.org/W4414569174","https://openalex.org/W7134128484"],"related_works":["https://openalex.org/W7169874600","https://openalex.org/W2903052440","https://openalex.org/W7221600345","https://openalex.org/W4378530747","https://openalex.org/W2160965670","https://openalex.org/W4399963617","https://openalex.org/W4379376898","https://openalex.org/W4400825351","https://openalex.org/W7215089536","https://openalex.org/W3042634019"],"abstract_inverted_index":{"Hidradenitis":[0],"suppurativa":[1],"(HS)":[2],"is":[3,18],"a":[4,12,34,181,189],"chronic,":[5],"relapsing":[6],"inflammatory":[7],"skin":[8,68,92],"disease":[9],"that":[10],"imposes":[11],"profound":[13],"burden":[14],"on":[15],"patients":[16],"and":[17,59,65,69,78,105,119,126,131,143,161,172,187],"increasingly":[19],"recognized":[20],"as":[21,33,82,84,107,109,180],"an":[22],"autoinflammatory":[23],"disorder.":[24],"Among":[25],"implicated":[26],"pathogenic":[27],"mechanisms,":[28],"interleukin-1\u03b2":[29],"(IL-1\u03b2)":[30],"has":[31,48],"emerged":[32],"candidate":[35],"driver":[36],"of":[37,96,111,184],"disease,":[38],"but":[39],"its":[40],"role":[41],"in":[42,141,156],"HS":[43,67,89,157,185],"relative":[44],"to":[45,159],"other":[46],"dermatoses":[47],"not":[49],"been":[50],"clearly":[51],"defined.":[52],"To":[53],"address":[54],"this,":[55],"we":[56],"analyzed":[57],"bulk":[58],"single-cell":[60],"transcriptomic":[61],"datasets":[62],"from":[63],"lesional":[64,91],"non-lesional":[66],"compared":[70],"them":[71],"with":[72,116,123,165],"psoriasis":[73],"(PSO),":[74],"atopic":[75],"dermatitis":[76],"(ATD)":[77],"nummular":[79],"eczema":[80],"(NME)":[81],"well":[83,108],"normal":[85],"skin.":[86],"Across":[87],"independent":[88],"cohorts,":[90],"demonstrated":[93],"consistent":[94,182],"enrichment":[95],"specific":[97],"IL-1":[98,139,149],"family":[99],"members,":[100],"including":[101],"IL-1\u03b2,":[102],"IL-18,":[103],"IL-33":[104],"IL-36,":[106],"components":[110,167],"the":[112],"NLRP3":[113,166],"inflammasome,":[114],"together":[115],"broad":[117],"myeloid":[118,171],"lymphoid":[120],"activation,":[121],"along":[122],"reduced":[124],"barrier":[125],"adhesion,":[127],"apocrine":[128],"sweat":[129],"gland":[130],"hair":[132],"follicle":[133],"gene":[134],"signatures.":[135],"Comparative":[136],"analyses":[137],"revealed":[138],"involvement":[140],"PSO":[142],"NME,":[144],"whereas":[145],"ATD":[146],"showed":[147],"minimal":[148],"activity.":[150],"Single-cell":[151],"profiling":[152],"localized":[153],"IL-1\u03b2":[154,179],"expression":[155],"primarily":[158],"macrophages":[160],"tissue":[162],"stem":[163],"cells,":[164],"broadly":[168],"expressed":[169],"across":[170],"stromal":[173],"compartments.":[174],"Collectively,":[175],"these":[176],"findings":[177],"position":[178],"mediator":[183],"immunopathology":[186],"provide":[188],"rationale":[190],"for":[191],"biomarker-driven":[192],"therapeutic":[193],"strategies":[194],"targeting":[195],"IL-1\u03b2-related":[196],"pathways.":[197]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-10T00:00:00"}