{"id":"https://openalex.org/W7212021768","doi":"https://doi.org/10.1016/j.redox.2026.104388","title":"Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors","display_name":"Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors","publication_year":2026,"publication_date":"2026-09-09","ids":{"openalex":"https://openalex.org/W7212021768","doi":"https://doi.org/10.1016/j.redox.2026.104388","pmid":"https://pubmed.ncbi.nlm.nih.gov/42743757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13663902"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2026.104388","doi":"https://doi.org/10.1016/j.redox.2026.104388","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2026.104388","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231726003873/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213231726003873/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060202571","display_name":"Liu Fan","orcid":"https://orcid.org/0000-0001-9647-6705","observed_orcids":["https://orcid.org/0000-0001-9647-6705"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Liu","raw_affiliation_strings":["Department of Clinical Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151040310","display_name":"Yuxin Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Pang","raw_affiliation_strings":["Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087249304","display_name":"Luoyang Wang","orcid":"https://orcid.org/0000-0002-1396-0057","observed_orcids":["https://orcid.org/0000-0002-1396-0057"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luoyang Wang","raw_affiliation_strings":["Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127861512","display_name":"Dimkpa Christabel Kechiyerunda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Christabel Kechiyerunda Dimkpa","raw_affiliation_strings":["Department of Clinical Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150974460","display_name":"Bei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bei Zhang","raw_affiliation_strings":["Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China. Electronic address: zhangbei124@aliyun.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China. Electronic address: zhangbei124@aliyun.com","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043784736","display_name":"Jie Liang","orcid":"https://orcid.org/0000-0002-2487-6862","observed_orcids":["https://orcid.org/0000-0002-2487-6862"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Liang","raw_affiliation_strings":["Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China. Electronic address: J.liang0811@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-2487-6862","affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, China. Electronic address: J.liang0811@gmail.com","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043784736","https://openalex.org/A5150974460"],"corresponding_institution_ids":["https://openalex.org/I108688024"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":{"value":4310,"currency":"USD","value_usd":4310},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3467804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"97","issue":null,"first_page":"104388","last_page":"104388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.4733999967575073,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.4733999967575073,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.23970000445842743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8069999814033508},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.8899999856948853},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7730000019073486},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7820000052452087},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.7749999761581421},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.753000020980835},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":1.0},{"id":"https://openalex.org/keywords/nanomaterials","display_name":"nanomaterials","score":0.8370000123977661},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7049999833106995},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.7754999995231628},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7598000168800354},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5461000204086304},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5206999778747559},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47269999980926514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4564000070095062},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4417000114917755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39309999346733093},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.31619998812675476},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3156999945640564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.290800005197525},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27549999952316284},{"id":"https://openalex.org/C3020391436","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte subsets","level":4,"score":0.2662999927997589},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2621000111103058}],"mesh":[{"descriptor_ui":"D000097784","descriptor_name":"Metabolic Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.redox.2026.104388","doi":"https://doi.org/10.1016/j.redox.2026.104388","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2026.104388","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231726003873/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13663902","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663902/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663902/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biol","raw_type":"Text"},{"id":"pmid:42743757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42743757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8fb8cdde85b34379b656fe916a68a768","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8fb8cdde85b34379b656fe916a68a768","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 97, Iss , Pp 104388- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2026.104388","doi":"https://doi.org/10.1016/j.redox.2026.104388","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2026.104388","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231726003873/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000366069","display_name":null,"funder_award_id":"82502198","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326964","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212021768.pdf","grobid_xml":"https://content.openalex.org/works/W7212021768.grobid-xml"},"referenced_works_count":365,"referenced_works":["https://openalex.org/W785895034","https://openalex.org/W1137283600","https://openalex.org/W1487536884","https://openalex.org/W1504397512","https://openalex.org/W1508063629","https://openalex.org/W1553125696","https://openalex.org/W1561349380","https://openalex.org/W1563775926","https://openalex.org/W1580207422","https://openalex.org/W1597804198","https://openalex.org/W1606441102","https://openalex.org/W1690266756","https://openalex.org/W1799438310","https://openalex.org/W1829383857","https://openalex.org/W1908076156","https://openalex.org/W1912751031","https://openalex.org/W1963232095","https://openalex.org/W1966913704","https://openalex.org/W1967727543","https://openalex.org/W1969529585","https://openalex.org/W1973328612","https://openalex.org/W1975602384","https://openalex.org/W1976714959","https://openalex.org/W1977216892","https://openalex.org/W1978029697","https://openalex.org/W1978451085","https://openalex.org/W1982795546","https://openalex.org/W1982919756","https://openalex.org/W1983973679","https://openalex.org/W1984379998","https://openalex.org/W1985361047","https://openalex.org/W1986669241","https://openalex.org/W1988881559","https://openalex.org/W1988988639","https://openalex.org/W1991344058","https://openalex.org/W1992776568","https://openalex.org/W1993722218","https://openalex.org/W1995391551","https://openalex.org/W1996311090","https://openalex.org/W1998052953","https://openalex.org/W2001201690","https://openalex.org/W2001415306","https://openalex.org/W2002344508","https://openalex.org/W2005299533","https://openalex.org/W2014092584","https://openalex.org/W2017950381","https://openalex.org/W2018775174","https://openalex.org/W2022234371","https://openalex.org/W2031869158","https://openalex.org/W2037977240","https://openalex.org/W2044345732","https://openalex.org/W2045475405","https://openalex.org/W2050297562","https://openalex.org/W2051752701","https://openalex.org/W2051836526","https://openalex.org/W2052085642","https://openalex.org/W2057635215","https://openalex.org/W2057843591","https://openalex.org/W2064431906","https://openalex.org/W2070807787","https://openalex.org/W2073025161","https://openalex.org/W2074230664","https://openalex.org/W2074947114","https://openalex.org/W2075391300","https://openalex.org/W2075735730","https://openalex.org/W2077121920","https://openalex.org/W2079999658","https://openalex.org/W2086637568","https://openalex.org/W2087343327","https://openalex.org/W2093168274","https://openalex.org/W2097259163","https://openalex.org/W2102142500","https://openalex.org/W2103119361","https://openalex.org/W2104527627","https://openalex.org/W2107413005","https://openalex.org/W2109596491","https://openalex.org/W2110710660","https://openalex.org/W2114977287","https://openalex.org/W2119677763","https://openalex.org/W2121313100","https://openalex.org/W2123318646","https://openalex.org/W2127123481","https://openalex.org/W2128327754","https://openalex.org/W2128957395","https://openalex.org/W2131199230","https://openalex.org/W2133604289","https://openalex.org/W2137445290","https://openalex.org/W2141312960","https://openalex.org/W2141575322","https://openalex.org/W2143463421","https://openalex.org/W2144055188","https://openalex.org/W2144408701","https://openalex.org/W2144491171","https://openalex.org/W2146791037","https://openalex.org/W2148676724","https://openalex.org/W2150241267","https://openalex.org/W2154553542","https://openalex.org/W2154740756","https://openalex.org/W2154975058","https://openalex.org/W2156783526","https://openalex.org/W2157579772","https://openalex.org/W2157739158","https://openalex.org/W2158393416","https://openalex.org/W2160315372","https://openalex.org/W2160472691","https://openalex.org/W2163207984","https://openalex.org/W2163802608","https://openalex.org/W2164364292","https://openalex.org/W2166332777","https://openalex.org/W2167432954","https://openalex.org/W2170390714","https://openalex.org/W2190766406","https://openalex.org/W2208375447","https://openalex.org/W2226550825","https://openalex.org/W2226666706","https://openalex.org/W2263577129","https://openalex.org/W2340662778","https://openalex.org/W2344961767","https://openalex.org/W2345624579","https://openalex.org/W2398298261","https://openalex.org/W2415427537","https://openalex.org/W2464870374","https://openalex.org/W2501174056","https://openalex.org/W2513737916","https://openalex.org/W2515394036","https://openalex.org/W2520771124","https://openalex.org/W2523989131","https://openalex.org/W2525994542","https://openalex.org/W2530067632","https://openalex.org/W2530187865","https://openalex.org/W2552744670","https://openalex.org/W2583602950","https://openalex.org/W2587363764","https://openalex.org/W2589066097","https://openalex.org/W2590503019","https://openalex.org/W2605702841","https://openalex.org/W2606686724","https://openalex.org/W2607349616","https://openalex.org/W2613367831","https://openalex.org/W2732589699","https://openalex.org/W2740391009","https://openalex.org/W2765354611","https://openalex.org/W2768499679","https://openalex.org/W2776512049","https://openalex.org/W2787578932","https://openalex.org/W2792241901","https://openalex.org/W2792588868","https://openalex.org/W2792889166","https://openalex.org/W2793071845","https://openalex.org/W2793670085","https://openalex.org/W2799849968","https://openalex.org/W2799980410","https://openalex.org/W2800005274","https://openalex.org/W2800172676","https://openalex.org/W2801641802","https://openalex.org/W2803429008","https://openalex.org/W2803781307","https://openalex.org/W2804000651","https://openalex.org/W2805352134","https://openalex.org/W2805618319","https://openalex.org/W2807582146","https://openalex.org/W2808751821","https://openalex.org/W2809065047","https://openalex.org/W2884108060","https://openalex.org/W2885721164","https://openalex.org/W2886611160","https://openalex.org/W2890792187","https://openalex.org/W2890844960","https://openalex.org/W2899145148","https://openalex.org/W2899298350","https://openalex.org/W2900747079","https://openalex.org/W2904437342","https://openalex.org/W2905666395","https://openalex.org/W2909486828","https://openalex.org/W2910787601","https://openalex.org/W2911288043","https://openalex.org/W2912225074","https://openalex.org/W2912800028","https://openalex.org/W2913136103","https://openalex.org/W2913558101","https://openalex.org/W2914861898","https://openalex.org/W2939126720","https://openalex.org/W2940767284","https://openalex.org/W2946836511","https://openalex.org/W2948216378","https://openalex.org/W2949319488","https://openalex.org/W2953979824","https://openalex.org/W2955964880","https://openalex.org/W2966588036","https://openalex.org/W2972690193","https://openalex.org/W2972902789","https://openalex.org/W2979336802","https://openalex.org/W2979799294","https://openalex.org/W2993863269","https://openalex.org/W2994966294","https://openalex.org/W3002808620","https://openalex.org/W3009581439","https://openalex.org/W3011326164","https://openalex.org/W3011367360","https://openalex.org/W3013752652","https://openalex.org/W3014737021","https://openalex.org/W3018793810","https://openalex.org/W3033720690","https://openalex.org/W3034101653","https://openalex.org/W3037638109","https://openalex.org/W3040911066","https://openalex.org/W3041426930","https://openalex.org/W3043462158","https://openalex.org/W3045379462","https://openalex.org/W3046885739","https://openalex.org/W3048917756","https://openalex.org/W3082064887","https://openalex.org/W3084585517","https://openalex.org/W3087253698","https://openalex.org/W3089058844","https://openalex.org/W3090862270","https://openalex.org/W3093444306","https://openalex.org/W3098244549","https://openalex.org/W3100435286","https://openalex.org/W3101066670","https://openalex.org/W3103691049","https://openalex.org/W3108058006","https://openalex.org/W3111227304","https://openalex.org/W3112883386","https://openalex.org/W3114668559","https://openalex.org/W3118819394","https://openalex.org/W3119279345","https://openalex.org/W3120004864","https://openalex.org/W3120330194","https://openalex.org/W3124687622","https://openalex.org/W3128687890","https://openalex.org/W3144602689","https://openalex.org/W3153022440","https://openalex.org/W3153096965","https://openalex.org/W3156444602","https://openalex.org/W3158959815","https://openalex.org/W3165724578","https://openalex.org/W3166144051","https://openalex.org/W3169102532","https://openalex.org/W3190048637","https://openalex.org/W3196185901","https://openalex.org/W3207300098","https://openalex.org/W3207718037","https://openalex.org/W3208805822","https://openalex.org/W3211198314","https://openalex.org/W3212154747","https://openalex.org/W3212198885","https://openalex.org/W3214694784","https://openalex.org/W3217162438","https://openalex.org/W4210395904","https://openalex.org/W4210498051","https://openalex.org/W4221047167","https://openalex.org/W4229376509","https://openalex.org/W4245957869","https://openalex.org/W4280645431","https://openalex.org/W4282966989","https://openalex.org/W4283013977","https://openalex.org/W4283319121","https://openalex.org/W4284889558","https://openalex.org/W4285008554","https://openalex.org/W4286499734","https://openalex.org/W4289334508","https://openalex.org/W4294740346","https://openalex.org/W4297973592","https://openalex.org/W4303859051","https://openalex.org/W4307338561","https://openalex.org/W4310782891","https://openalex.org/W4311330861","https://openalex.org/W4311863221","https://openalex.org/W4312018503","https://openalex.org/W4313361318","https://openalex.org/W4315753545","https://openalex.org/W4317934591","https://openalex.org/W4318591481","https://openalex.org/W4323046210","https://openalex.org/W4323066875","https://openalex.org/W4323533761","https://openalex.org/W4365479582","https://openalex.org/W4368347894","https://openalex.org/W4368618067","https://openalex.org/W4378675433","https://openalex.org/W4381334673","https://openalex.org/W4385324067","https://openalex.org/W4385812932","https://openalex.org/W4385996357","https://openalex.org/W4386304015","https://openalex.org/W4386347912","https://openalex.org/W4386951739","https://openalex.org/W4387452756","https://openalex.org/W4388290259","https://openalex.org/W4388880158","https://openalex.org/W4389117214","https://openalex.org/W4389163114","https://openalex.org/W4389640117","https://openalex.org/W4390491724","https://openalex.org/W4390494387","https://openalex.org/W4390673205","https://openalex.org/W4391333739","https://openalex.org/W4391898681","https://openalex.org/W4391899438","https://openalex.org/W4393231181","https://openalex.org/W4394850655","https://openalex.org/W4394978792","https://openalex.org/W4395051464","https://openalex.org/W4399300778","https://openalex.org/W4399301575","https://openalex.org/W4399381175","https://openalex.org/W4399661101","https://openalex.org/W4399920013","https://openalex.org/W4400266078","https://openalex.org/W4400624065","https://openalex.org/W4401414506","https://openalex.org/W4401425388","https://openalex.org/W4401433801","https://openalex.org/W4401747367","https://openalex.org/W4401794295","https://openalex.org/W4401951636","https://openalex.org/W4402433532","https://openalex.org/W4402504792","https://openalex.org/W4402515260","https://openalex.org/W4403383752","https://openalex.org/W4403509460","https://openalex.org/W4403940998","https://openalex.org/W4403997913","https://openalex.org/W4404557877","https://openalex.org/W4405137174","https://openalex.org/W4405171093","https://openalex.org/W4405256173","https://openalex.org/W4405653184","https://openalex.org/W4406187756","https://openalex.org/W4406188148","https://openalex.org/W4406534809","https://openalex.org/W4407393203","https://openalex.org/W4408192459","https://openalex.org/W4408244775","https://openalex.org/W4408943715","https://openalex.org/W4409240173","https://openalex.org/W4409412608","https://openalex.org/W4409519426","https://openalex.org/W4409632848","https://openalex.org/W4409741881","https://openalex.org/W4410220069","https://openalex.org/W4410240766","https://openalex.org/W4410241138","https://openalex.org/W4410917194","https://openalex.org/W4411505807","https://openalex.org/W4411887076","https://openalex.org/W4412470655","https://openalex.org/W4412928952","https://openalex.org/W4412933114","https://openalex.org/W4412990796","https://openalex.org/W4413270680","https://openalex.org/W4413292544","https://openalex.org/W4413429402","https://openalex.org/W4413832811","https://openalex.org/W4414091128","https://openalex.org/W4414309706","https://openalex.org/W4415601464","https://openalex.org/W4415682556","https://openalex.org/W4415900212","https://openalex.org/W4416903236","https://openalex.org/W4416959716","https://openalex.org/W7128732398","https://openalex.org/W7131176049","https://openalex.org/W7160442563"],"related_works":["https://openalex.org/W2486467429","https://openalex.org/W4416845059","https://openalex.org/W7161171712","https://openalex.org/W7223142093","https://openalex.org/W3165724578","https://openalex.org/W7207665363","https://openalex.org/W4405137174","https://openalex.org/W7155642122","https://openalex.org/W4214775405","https://openalex.org/W2913894269"],"abstract_inverted_index":{"Adoptive":[0],"T":[1,57,64,164,245],"cell":[2,58,246],"therapy":[3,247],"faces":[4],"significant":[5],"hurdles":[6],"in":[7],"solid":[8,249],"tumors":[9],"due":[10],"to":[11,44,67,80,138,170,225],"the":[12,53,84,94,113,147,153,187,206],"immunosuppressive":[13,109],"tumor":[14],"microenvironment":[15],"(TME),":[16],"wherein":[17],"aberrant":[18],"accumulation":[19],"of":[20,30,131,146,208],"reactive":[21],"oxygen":[22],"species":[23],"(ROS)":[24],"serves":[25],"as":[26,97],"a":[27,124,218],"critical":[28],"driver":[29],"therapeutic":[31,203],"resistance.":[32],"Conventional":[33],"systemic":[34],"antioxidant":[35,73,133],"strategies":[36],"are":[37],"constrained":[38],"by":[39],"their":[40,77],"non-selectivity":[41],"and":[42,62,72,89,102,142,176,192,205,217,236],"potential":[43],"disrupt":[45],"physiological":[46],"ROS":[47,88],"signaling.":[48],"Here,":[49],"we":[50,122,151],"systematically":[51],"delineate":[52],"inherent":[54],"heterogeneity":[55],"among":[56],"subsets-including":[59],"effector,":[60],"memory,":[61],"regulatory":[63],"cells-with":[65],"respect":[66],"metabolic":[68,136,191],"preferences,":[69],"mitochondrial":[70],"dynamics,":[71],"gene":[74],"expression,":[75],"revealing":[76],"divergent":[78],"susceptibilities":[79],"oxidative":[81],"stress.":[82,210],"Furthermore,":[83],"intricate":[85],"interplay":[86],"between":[87,190],"diverse":[90],"immune":[91],"subsets":[92],"within":[93],"TME,":[95],"such":[96],"myeloid-derived":[98],"suppressor":[99],"cells":[100],"(MDSCs)":[101],"tumor-associated":[103],"macrophages":[104],"(TAMs),":[105],"collectively":[106],"orchestrates":[107],"an":[108,213],"network":[110],"that":[111],"underscores":[112],"imperative":[114],"for":[115,248],"selective":[116],"intervention.":[117],"Building":[118],"upon":[119],"this":[120,222],"foundation,":[121],"propose":[123],"multi-layered":[125],"intervention":[126],"framework":[127,156,185],"encompassing:":[128],"(i)":[129],"reinforcement":[130],"intrinsic":[132],"defenses;":[134],"(ii)":[135],"reprogramming":[137],"potentiate":[139],"redox":[140,182,193,234],"capacity;":[141],"(iii)":[143],"nanomaterial-based":[144],"remodeling":[145],"pro-oxidative":[148],"microenvironment.":[149],"Notably,":[150],"introduce":[152],"first":[154],"combinatorial":[155],"centered":[157],"on":[158],"nanomaterial-enabled":[159],"TME":[160],"modulation":[161],"integrated":[162,214],"with":[163,239],"cell-intrinsic":[165],"orchestration-a":[166],"strategy":[167],"rationally":[168],"designed":[169],"synergistically":[171],"preserve":[172],"stem-like":[173],"memory":[174],"phenotypes":[175],"augment":[177],"antitumor":[178],"persistence":[179],"through":[180],"multidimensional":[181],"regulation.":[183],"This":[184],"emphasizes":[186],"profound":[188],"coupling":[189],"homeostasis":[194],"while":[195],"critically":[196],"addressing":[197],"current":[198],"challenges,":[199],"including":[200],"cellular":[201],"selectivity,":[202],"windows,":[204],"risk":[207],"reductive":[209],"By":[211],"providing":[212],"mechanistic":[215],"roadmap":[216],"clear":[219],"translational":[220],"trajectory,":[221],"review":[223],"aims":[224],"guide":[226],"future":[227],"efforts":[228],"toward":[229],"subset-selective":[230],"interventions,":[231],"spatiotemporally":[232],"controlled":[233],"modulation,":[235],"synergistic":[237],"integration":[238],"existing":[240],"immunotherapies,":[241],"ultimately":[242],"advancing":[243],"adoptive":[244],"tumors.":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-10T00:00:00"}