{"id":"https://openalex.org/W7212019589","doi":"https://doi.org/10.1038/s41586-026-11002-8","title":"A serpin\u2013myeloid axis in pancreatic cancer heterogeneity and immune evasion","display_name":"A serpin\u2013myeloid axis in pancreatic cancer heterogeneity and immune evasion","publication_year":2026,"publication_date":"2026-09-09","ids":{"openalex":"https://openalex.org/W7212019589","doi":"https://doi.org/10.1038/s41586-026-11002-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/40667068","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12262235"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-026-11002-8","doi":"https://doi.org/10.1038/s41586-026-11002-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-026-11002-8","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/s41586-026-11002-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074432798","display_name":"Chiara Falcomat\u00e0","orcid":"https://orcid.org/0000-0001-9269-2582","observed_orcids":["https://orcid.org/0000-0001-9269-2582"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiara Falcomat\u00e0","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073035301","display_name":"Maximilian M. Schaefer","orcid":"https://orcid.org/0000-0002-6038-7847","observed_orcids":["https://orcid.org/0000-0002-6038-7847"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maximilian M. Schaefer","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-6038-7847","affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544870","display_name":"Bhavya Singh","orcid":"https://orcid.org/0000-0001-6641-6429","observed_orcids":["https://orcid.org/0000-0001-6641-6429"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavya Singh","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-6641-6429","affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118272928","display_name":"Divya Chhamalwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Chhamalwan","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043616851","display_name":"Alexander Tepper","orcid":"https://orcid.org/0000-0003-1384-9241","observed_orcids":["https://orcid.org/0000-0003-1384-9241"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Tepper","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043813099","display_name":"Sebastian Rune Nielsen","orcid":"https://orcid.org/0000-0002-8449-476X","observed_orcids":["https://orcid.org/0000-0002-8449-476X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian R. Nielsen","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093397958","display_name":"Hunter T. Potak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter T. Potak","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011248615","display_name":"Maxime Dhainaut","orcid":"https://orcid.org/0000-0003-3832-7095","observed_orcids":["https://orcid.org/0000-0003-3832-7095"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxime Dhainaut","raw_affiliation_strings":["Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060957335","display_name":"G\u00fcrkan Mollaoglu","orcid":"https://orcid.org/0000-0003-0679-7463","observed_orcids":["https://orcid.org/0000-0003-0679-7463"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gurkan Mollaoglu","raw_affiliation_strings":["Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035589989","display_name":"Matthew D. Park","orcid":"https://orcid.org/0000-0003-3488-3262","observed_orcids":["https://orcid.org/0000-0003-3488-3262"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Park","raw_affiliation_strings":["Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-3488-3262","affiliations":[{"raw_affiliation_string":"Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070354041","display_name":"Miriam M\u00e9rad","orcid":"https://orcid.org/0000-0002-4481-7827","observed_orcids":["https://orcid.org/0000-0002-4481-7827"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Merad","raw_affiliation_strings":["Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4481-7827","affiliations":[{"raw_affiliation_string":"Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039833294","display_name":"Alessia Baccarini","orcid":"https://orcid.org/0000-0003-4727-0668","observed_orcids":["https://orcid.org/0000-0003-4727-0668"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessia Baccarini","raw_affiliation_strings":["Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068360947","display_name":"Brian D. Brown","orcid":"https://orcid.org/0000-0002-3670-8778","observed_orcids":["https://orcid.org/0000-0002-3670-8778"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian D. Brown","raw_affiliation_strings":["Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu"],"raw_orcid":"https://orcid.org/0000-0002-3670-8778","affiliations":[{"raw_affiliation_string":"Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. brian.brown@mssm.edu","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068360947"],"corresponding_institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":{"value":12690,"currency":"USD","value_usd":12690},"fwci":5.1865,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.9648962,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"658","issue":"8138","first_page":"1330","last_page":"1340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.06710000336170197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-carcinoma","display_name":"pancreatic ductal carcinoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/serpins","display_name":"serpins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/serpine1","display_name":"SERPINE1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-2","display_name":"plasminogen activator inhibitor-2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8759999871253967},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8029999732971191},{"id":"https://openalex.org/keywords/immunosuppressive-macrophages","display_name":"immunosuppressive macrophages","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cd18","display_name":"CD18","score":0.7110000252723694},{"id":"https://openalex.org/keywords/anti-pd-1-combination-therapy","display_name":"anti-PD-1 combination therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7953000068664551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7080000042915344},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6269000172615051},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5576000213623047},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5259000062942505},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5175999999046326},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4449999928474426},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4374000132083893},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.32170000672340393},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.3192000091075897},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C102715595","wikidata":"https://www.wikidata.org/wiki/Q172861","display_name":"Ecological niche","level":3,"score":0.3077000081539154},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.2623000144958496},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2621000111103058},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.2558000087738037},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s41586-026-11002-8","doi":"https://doi.org/10.1038/s41586-026-11002-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-026-11002-8","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"doi:10.1101/2025.06.11.659098","doi":"https://doi.org/10.1101/2025.06.11.659098","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.06.11.659098","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40667068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40667068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42717081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42717081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13716829","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13716829/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12262235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12262235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41586-026-11002-8","doi":"https://doi.org/10.1038/s41586-026-11002-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-026-11002-8","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7089446283","display_name":"Deconvoluting the contributions of the IFNy pathway components to lung TME and tumor immunity","funder_award_id":"1f30ca287690-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000872736","display_name":"Conduits: Mount Sinai Health System Translational Science Hub","funder_award_id":"UL1TR004419","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000875604","display_name":"Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity","funder_award_id":"U01CA282114","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000887383","display_name":"Deciphering the molecular control of intratumoral dendritic cells","funder_award_id":"R01CA257195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000921276","display_name":"Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity","funder_award_id":"R01CA254104","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1497915798","https://openalex.org/W1968416941","https://openalex.org/W1970170720","https://openalex.org/W1973401140","https://openalex.org/W1993782263","https://openalex.org/W2005281127","https://openalex.org/W2029677015","https://openalex.org/W2031211461","https://openalex.org/W2058689904","https://openalex.org/W2070050178","https://openalex.org/W2087749727","https://openalex.org/W2115746733","https://openalex.org/W2125281412","https://openalex.org/W2135449612","https://openalex.org/W2154790710","https://openalex.org/W2182290275","https://openalex.org/W2252568502","https://openalex.org/W2336715782","https://openalex.org/W2484573964","https://openalex.org/W2607211817","https://openalex.org/W2791482536","https://openalex.org/W2832881433","https://openalex.org/W2889433609","https://openalex.org/W2896105679","https://openalex.org/W2898075889","https://openalex.org/W2913268845","https://openalex.org/W2964286623","https://openalex.org/W2982017357","https://openalex.org/W2984946521","https://openalex.org/W2999401147","https://openalex.org/W3023998523","https://openalex.org/W3028304854","https://openalex.org/W3031767666","https://openalex.org/W3083058958","https://openalex.org/W3092782633","https://openalex.org/W3095442910","https://openalex.org/W3095726304","https://openalex.org/W3096075115","https://openalex.org/W3112993115","https://openalex.org/W3126839734","https://openalex.org/W3131453373","https://openalex.org/W3132259578","https://openalex.org/W3208778541","https://openalex.org/W3212143351","https://openalex.org/W4200497629","https://openalex.org/W4200550013","https://openalex.org/W4205183812","https://openalex.org/W4210583065","https://openalex.org/W4210708031","https://openalex.org/W4210804638","https://openalex.org/W4220765071","https://openalex.org/W4288447807","https://openalex.org/W4292641742","https://openalex.org/W4296713553","https://openalex.org/W4301370467","https://openalex.org/W4313857442","https://openalex.org/W4317434093","https://openalex.org/W4319984980","https://openalex.org/W4320491309","https://openalex.org/W4324046169","https://openalex.org/W4360610306","https://openalex.org/W4375955055","https://openalex.org/W4376129031","https://openalex.org/W4385520050","https://openalex.org/W4386788919","https://openalex.org/W4388126446","https://openalex.org/W4388735142","https://openalex.org/W4388793436","https://openalex.org/W4390946922","https://openalex.org/W4391168817","https://openalex.org/W4400923013","https://openalex.org/W4402171859","https://openalex.org/W4402261463","https://openalex.org/W4402634369","https://openalex.org/W4403959937","https://openalex.org/W4409729919","https://openalex.org/W4412522195","https://openalex.org/W4414090333","https://openalex.org/W4416794182","https://openalex.org/W7124435809","https://openalex.org/W7131666946","https://openalex.org/W7134270725","https://openalex.org/W7148668288","https://openalex.org/W7160524990"],"related_works":["https://openalex.org/W4411370730","https://openalex.org/W7213255480","https://openalex.org/W7148668288","https://openalex.org/W7130389531","https://openalex.org/W7167884277","https://openalex.org/W4406104419","https://openalex.org/W7122536032","https://openalex.org/W4220658951","https://openalex.org/W4409682522","https://openalex.org/W3039537938"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1,212],"carcinoma":[2],"(PDAC)":[3],"is":[4,26,32],"characterized":[5],"by":[6,163],"a":[7,27],"highly":[8],"immunosuppressive,":[9],"extracellular":[10,106],"matrix-rich":[11],"microenvironment,":[12],"yet":[13],"tumours":[14,149],"display":[15],"marked":[16],"heterogeneity1\u20134.":[17],"This":[18,62],"raises":[19],"the":[20,50],"question":[21],"of":[22,55,68,93,104,124,131,147,177],"whether":[23],"immune":[24,70,98,178,208],"resistance":[25,189],"global":[28],"tumour":[29,94,136],"property":[30],"or":[31,126,128,133],"organized":[33,207],"within":[34],"spatially":[35,110,206],"restricted":[36],"niches.":[37],"Here,":[38],"using":[39],"Perturb-map":[40],"spatial":[41,74,145,175],"functional":[42],"genomics,":[43],"we":[44],"determine":[45],"how":[46],"different":[47],"genes":[48],"shape":[49],"growth":[51],"and":[52,60,86,97,112,140,158,171,187,193,201],"cellular":[53],"environments":[54],"PDAC":[56,160],"clones":[57],"across":[58],"space":[59],"time.":[61],"analysis":[63,146],"revealed":[64,150],"early":[65],"gene-driven":[66],"remodelling":[67],"local":[69,174,184],"neighbourhoods":[71],"preceding":[72],"late-stage":[73],"clonal":[75],"dominance.":[76],"We":[77],"identify":[78,168],"SERPINE1":[79,170,192],"(encoding":[80,88],"plasminogen":[81],"activator":[82],"inhibitor":[83],"1":[84],"(PAI1))":[85],"SERPINB2":[87,172],"PAI2)":[89],"as":[90,173],"dominant":[91],"regulators":[92],"microenvironment":[95],"control":[96,137,186],"evasion.":[99],"These":[100,166],"serpins":[101],"promote":[102],"stabilization":[103],"fibrin-rich":[105,195],"matrix":[107],"niches":[108,153,196],"that":[109,151],"retain":[111],"programme":[113,198],"macrophages":[114,200],"towards":[115],"immunosuppressive":[116,152,199],"states":[117],"while":[118],"excluding":[119],"cytotoxic":[120],"T":[121,203],"cells.":[122],"Loss":[123],"Serpine1":[125],"Serpinb2,":[127],"pharmacological":[129],"inhibition":[130],"PAI1":[132],"CD18,":[134],"improves":[135],"in":[138,190,210],"mice":[139],"synergizes":[141],"with":[142],"anti-PD-1.":[143],"Multimodal":[144],"patient":[148],"form":[154],"around":[155],"rare":[156],"SERPINB2-":[157],"SERPINE1-expressing":[159],"subpopulations,":[161],"dominated":[162],"SPP1+/MARCO+":[164],"macrophages.":[165],"findings":[167],"cancer-derived":[169],"organizers":[176],"suppression,":[179],"linking":[180],"tumour-intrinsic":[181],"heterogeneity":[182],"to":[183],"microenvironmental":[185],"immunotherapy":[188],"PDAC.":[191],"SERPINB2-driven":[194],"locally":[197],"exclude":[202],"cells,":[204],"enabling":[205],"evasion":[209],"pancreatic":[211],"carcinoma.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-10T00:00:00"}