{"id":"https://openalex.org/W7212015256","doi":"https://doi.org/10.3389/fnagi.2026.1893842","title":"Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities","display_name":"Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities","publication_year":2026,"publication_date":"2026-09-09","ids":{"openalex":"https://openalex.org/W7212015256","doi":"https://doi.org/10.3389/fnagi.2026.1893842","pmid":"https://pubmed.ncbi.nlm.nih.gov/42780438","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13598075"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2026.1893842","doi":"https://doi.org/10.3389/fnagi.2026.1893842","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1893842","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1893842/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1893842/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5154526689","display_name":"Isabelle Gallagher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabelle Gallagher","raw_affiliation_strings":["Department of Psychology, The University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, The University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063097605","display_name":"Makenna B. McGill","orcid":"https://orcid.org/0000-0003-4316-7719","observed_orcids":["https://orcid.org/0000-0003-4316-7719"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makenna B. McGill","raw_affiliation_strings":["Department of Psychology, The University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, The University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010996988","display_name":"David M. Schnyer","orcid":"https://orcid.org/0000-0002-7472-2853","observed_orcids":["https://orcid.org/0000-0002-7472-2853"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Schnyer","raw_affiliation_strings":["Department of Psychology, University of Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Rhode Island","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075786587","display_name":"Andreana P. Haley","orcid":"https://orcid.org/0000-0003-1861-7861","observed_orcids":["https://orcid.org/0000-0003-1861-7861"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andreana P. Haley","raw_affiliation_strings":["Department of Psychology, The University of Texas at Austin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, The University of Texas at Austin","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075786587"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66664953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"1893842","last_page":"1893842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"default mode network","score":0.8889999985694885},{"id":"https://openalex.org/keywords/midlife","display_name":"midlife","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cognitive-vulnerability","display_name":"cognitive vulnerability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/verbal-fluency","display_name":"verbal fluency","score":0.8629999756813049},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/low-hdl-cholesterol","display_name":"low HDL cholesterol","score":0.8799999952316284},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.703000009059906},{"id":"https://openalex.org/keywords/network-segregation","display_name":"network segregation","score":0.5370000004768372},{"id":"https://openalex.org/keywords/modularity","display_name":"modularity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/global-efficiency","display_name":"global efficiency","score":0.8809999823570251},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.41200000047683716},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.6884999871253967},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6502000093460083},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.5799999833106995},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5738000273704529},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.47839999198913574},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4668999910354614},{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.4359999895095825},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C2777693730","wikidata":"https://www.wikidata.org/wiki/Q1140549","display_name":"Abdominal obesity","level":4,"score":0.36000001430511475},{"id":"https://openalex.org/C536788834","wikidata":"https://www.wikidata.org/wiki/Q7002588","display_name":"Neuropsychological assessment","level":4,"score":0.35499998927116394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35350000858306885},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3257000148296356},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.3255000114440918},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C64708745","wikidata":"https://www.wikidata.org/wiki/Q2998010","display_name":"Partial correlation","level":3,"score":0.30799999833106995},{"id":"https://openalex.org/C134290984","wikidata":"https://www.wikidata.org/wiki/Q5141241","display_name":"Cognitive skill","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.29580000042915344},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.2808000147342682},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.2766999900341034},{"id":"https://openalex.org/C8290200","wikidata":"https://www.wikidata.org/wiki/Q5021165","display_name":"California Verbal Learning Test","level":4,"score":0.27309998869895935},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2540999948978424}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnagi.2026.1893842","doi":"https://doi.org/10.3389/fnagi.2026.1893842","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1893842","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1893842/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmid:42780438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42780438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13598075","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42780438/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:066042ee6beb491e84854346e810d294","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/066042ee6beb491e84854346e810d294","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 18 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2026.1893842","doi":"https://doi.org/10.3389/fnagi.2026.1893842","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1893842","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1893842/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6659306287765503,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1547741318","display_name":"Neuroimaging Cognitive Vulnerability in Hypertension","funder_award_id":"R01NS075565","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4657372591","display_name":"Cognitive Enhancement Through Transcranial Laser Therapy","funder_award_id":"R21AG050898","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212015256.pdf","grobid_xml":"https://content.openalex.org/works/W7212015256.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1834081378","https://openalex.org/W1973776237","https://openalex.org/W1974594322","https://openalex.org/W1975246421","https://openalex.org/W1990134753","https://openalex.org/W1999664376","https://openalex.org/W2003497549","https://openalex.org/W2020044743","https://openalex.org/W2025009638","https://openalex.org/W2044832776","https://openalex.org/W2052644075","https://openalex.org/W2060523616","https://openalex.org/W2063435176","https://openalex.org/W2068252829","https://openalex.org/W2069444194","https://openalex.org/W2084892943","https://openalex.org/W2088515634","https://openalex.org/W2095226068","https://openalex.org/W2117140276","https://openalex.org/W2117340355","https://openalex.org/W2121483283","https://openalex.org/W2130010412","https://openalex.org/W2136145485","https://openalex.org/W2136573752","https://openalex.org/W2143104968","https://openalex.org/W2147546041","https://openalex.org/W2151721316","https://openalex.org/W2154121929","https://openalex.org/W2167822639","https://openalex.org/W2557111525","https://openalex.org/W2591418495","https://openalex.org/W2597348720","https://openalex.org/W2598596494","https://openalex.org/W2606872799","https://openalex.org/W2623854426","https://openalex.org/W2793214327","https://openalex.org/W2903766786","https://openalex.org/W2940855794","https://openalex.org/W2943618953","https://openalex.org/W2949455193","https://openalex.org/W2950120067","https://openalex.org/W2951583631","https://openalex.org/W2951617899","https://openalex.org/W2977901079","https://openalex.org/W3001558060","https://openalex.org/W3042626934","https://openalex.org/W3099687598","https://openalex.org/W3109735199","https://openalex.org/W3113337118","https://openalex.org/W3117237609","https://openalex.org/W3145650693","https://openalex.org/W3180685144","https://openalex.org/W4224987307","https://openalex.org/W4284975306","https://openalex.org/W4295898305","https://openalex.org/W4313519298","https://openalex.org/W4323971778","https://openalex.org/W4360597941","https://openalex.org/W4367047728","https://openalex.org/W4368617825","https://openalex.org/W4376117628","https://openalex.org/W4378574627","https://openalex.org/W4386506162","https://openalex.org/W4392089930","https://openalex.org/W4399388126","https://openalex.org/W4401164724","https://openalex.org/W4404698599","https://openalex.org/W4406549958","https://openalex.org/W4413865205","https://openalex.org/W4416598360","https://openalex.org/W4416673741"],"related_works":["https://openalex.org/W3099687598","https://openalex.org/W3145650693","https://openalex.org/W2977901079","https://openalex.org/W4210540340","https://openalex.org/W3113337118","https://openalex.org/W2468827089","https://openalex.org/W4285726683","https://openalex.org/W7212905344","https://openalex.org/W4205796866","https://openalex.org/W4406210982"],"abstract_inverted_index":{"Objective":[0],"Metabolic":[1],"syndrome":[2,285],"(MetS)":[3],"may":[4],"amplify":[5],"neural":[6],"vulnerability":[7],"via":[8,95],"vascular":[9],"and":[10,32,69,82,88,100,121,126,157,211,250,291,302,313],"inflammatory":[11],"pathways.":[12],"Existing":[13],"literature":[14],"suggests":[15],"there":[16],"are":[17,292],"alterations":[18],"to":[19,35,114,220,294,309],"functional":[20,278],"brain":[21,279],"network":[22,140,280,311],"organization":[23,281],"in":[24,42,118,136,166,243,276,307],"adults":[25,50],"with":[26,67,163,194,217,240,247,265,283],"MetS,":[27],"though":[28],"the":[29,72,137,255,298],"specific":[30],"patterns":[31],"their":[33],"relation":[34],"cognitive":[36,127,295,314],"vulnerabilities":[37],"warrant":[38],"further":[39],"investigation,":[40],"particularly":[41],"a":[43],"midlife":[44,290,308],"sample.":[45],"Method":[46],"Cognitively":[47],"unimpaired,":[48],"community-dwelling":[49],"(":[51,224],"N":[52],"=":[53,58,144,149,172,177,182,187,200,205,233],"223;":[54],"ages":[55],"40\u201365;":[56],"MetS":[57,130,218,237,258],"73)":[59],"were":[60,65,112,161],"included.":[61],"Resting-state":[62],"fMRI":[63],"data":[64],"preprocessed":[66],"fMRIPrep":[68],"analyzed":[70],"using":[71],"Schaefer":[73],"400-parcel":[74],"atlas.":[75],"Functional":[76],"connectivity":[77,135,165,191,262],"(FC)":[78],"metrics":[79,120,125,223],"included":[80],"within-":[81],"between-network":[83],"connectivity,":[84,246],"system":[85],"segregation,":[86],"modularity,":[87],"global":[89],"efficiency.":[90],"Cognitive":[91],"performance":[92],"was":[93,192,238,263],"measured":[94],"neuropsychological":[96],"tests":[97],"for":[98,107],"memory":[99],"executive":[101],"functioning.":[102],"Generalized":[103],"linear":[104],"models":[105],"(adjusted":[106,198],"age,":[108],"sex,":[109],"framewise":[110],"displacement)":[111],"used":[113],"examine":[115],"group":[116,219],"differences":[117,275],"FC":[119,124,222],"associations":[122],"between":[123],"performance.":[128,269],"Results":[129],"participants":[131],"showed":[132],"reduced":[133,164],"within-network":[134,244],"default":[138],"mode":[139],"(DMN;":[141],"adjusted":[142,170,180],"p":[143,171,181,199,225],"0.038,":[145],"partial":[146,174,184,202,229],"\u03b7":[147,175,185,230],"2":[148,176,186,204,231],"0.035).":[150],"Follow-up":[151],"component-level":[152],"analyses":[153,208],"indicated":[154],"abdominal":[155,248],"obesity":[156,249],"low":[158,251],"HDL":[159,252],"cholesterol":[160,253],"associated":[162,193,239,264,282],"DMN":[167,190,245,261],"(abdominal":[168],"obesity:":[169],"0.027,":[173],"0.029;":[178],"cholesterol:":[179],"0.002,":[183],"0.058).":[188],"Reduced":[189,260],"poorer":[195,266],"verbal":[196,267],"fluency":[197,268],"0.026,":[201],"R":[203],"0.037).":[206],"Exploratory":[207],"identified":[209],"age":[210],"sex":[212],"as":[213,254],"factors":[214],"that":[215,273],"interacted":[216],"influence":[221],"\u2019s":[226,232],"<":[227],"0.050,":[228],"0.020\u20130.030).":[234],"Conclusion":[235],"Midlife":[236],"modest":[241],"reductions":[242],"primary":[256],"contributing":[257],"components.":[259],"These":[270],"findings":[271],"suggest":[272],"subtle":[274],"higher-order":[277],"metabolic":[284],"can":[286],"be":[287],"detected":[288],"during":[289],"related":[293],"functioning,":[296],"highlighting":[297],"importance":[299],"of":[300,304],"prevention":[301],"intervention":[303],"cardiometabolic":[305],"risk":[306],"preserve":[310],"integrity":[312],"health.":[315]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-10T00:00:00"}