{"id":"https://openalex.org/W7211898692","doi":"https://doi.org/10.64898/2026.09.03.749091","title":"Hck signaling drives long-distance ECM degradation through endo-exocytosis coupling in macrophages","display_name":"Hck signaling drives long-distance ECM degradation through endo-exocytosis coupling in macrophages","publication_year":2026,"publication_date":"2026-09-07","ids":{"openalex":"https://openalex.org/W7211898692","doi":"https://doi.org/10.64898/2026.09.03.749091"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.03.749091","doi":"https://doi.org/10.64898/2026.09.03.749091","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/07/2026.09.03.749091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/07/2026.09.03.749091.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138875377","display_name":"Cristina Torres Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cristina Torres-Torres","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068648735","display_name":"Marco Ruscone","orcid":"https://orcid.org/0000-0002-7607-0203","observed_orcids":["https://orcid.org/0000-0002-7607-0203"]},"institutions":[{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Marco Ruscone","raw_affiliation_strings":["Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020319334","display_name":"Satish Babu Moparthi","orcid":"https://orcid.org/0000-0001-7493-3848","observed_orcids":["https://orcid.org/0000-0001-7493-3848","https://orcid.org/0000-0002-4309-8840"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210113666","display_name":"Institut de Myologie","ror":"https://ror.org/0270xt841","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210100892","https://openalex.org/I4210113666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Satish Babu Moparthi","raw_affiliation_strings":["Institute National de la Sant\u00e9 de la Recherche M\u00e9dicale, Institut de Myologie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute National de la Sant\u00e9 de la Recherche M\u00e9dicale, Institut de Myologie, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210113666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038880431","display_name":"Luc\u00eda Campos Perell\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucia Campos-Perello","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056040454","display_name":"Anne\u2010Pascale Bouin","orcid":"https://orcid.org/0000-0002-9616-6173","observed_orcids":["https://orcid.org/0000-0002-9616-6173"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Pascale Bouin","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067446196","display_name":"Fabrice Senger","orcid":"https://orcid.org/0000-0002-3391-2044","observed_orcids":["https://orcid.org/0000-0002-3391-2044"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Senger","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002634275","display_name":"Ingrid Bourrin\u2010Reynard","orcid":"https://orcid.org/0000-0002-0521-0715","observed_orcids":["https://orcid.org/0000-0002-0521-0715"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ingrid Bourrin-Reynard","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025484270","display_name":"Christiane I. Oddou","orcid":"https://orcid.org/0000-0002-0992-570X","observed_orcids":["https://orcid.org/0000-0002-0992-570X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christiane Oddou","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042828826","display_name":"Victoria Pakulska","orcid":"https://orcid.org/0000-0001-7502-1111","observed_orcids":["https://orcid.org/0000-0001-7502-1111"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]},{"id":"https://openalex.org/I4210155958","display_name":"Laboratoire Biologie \u00e0 Grande \u00c9chelle","ror":"https://ror.org/05exke706","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I177483745","https://openalex.org/I2738703131","https://openalex.org/I4210091409","https://openalex.org/I4210113668","https://openalex.org/I4210155509","https://openalex.org/I4210155958","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Victoria Pakulska","raw_affiliation_strings":["Laboratoire EDYP, BIG-BGE, CEA, 38054 Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire EDYP, BIG-BGE, CEA, 38054 Grenoble, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I3020098449","https://openalex.org/I4210155958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085954072","display_name":"Yohann Cout\u00e9","orcid":"https://orcid.org/0000-0003-3896-6196","observed_orcids":["https://orcid.org/0000-0003-3896-6196"]},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]},{"id":"https://openalex.org/I4210155958","display_name":"Laboratoire Biologie \u00e0 Grande \u00c9chelle","ror":"https://ror.org/05exke706","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I177483745","https://openalex.org/I2738703131","https://openalex.org/I4210091409","https://openalex.org/I4210113668","https://openalex.org/I4210155509","https://openalex.org/I4210155958","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yohann Coute","raw_affiliation_strings":["Laboratoire EDYP, BIG-BGE, CEA, 38054 Grenoble, France"],"raw_orcid":"https://orcid.org/0000-0003-3896-6196","affiliations":[{"raw_affiliation_string":"Laboratoire EDYP, BIG-BGE, CEA, 38054 Grenoble, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I3020098449","https://openalex.org/I4210155958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008983132","display_name":"Alexe\u00ef Grichine","orcid":"https://orcid.org/0000-0002-7335-9706","observed_orcids":["https://orcid.org/0000-0002-7335-9706"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexei Grichine","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061154457","display_name":"Laurence Calzone","orcid":"https://orcid.org/0000-0002-7835-1148","observed_orcids":["https://orcid.org/0000-0002-7835-1148"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Calzone","raw_affiliation_strings":["Institut Curie, INSERM, U1331, Mines ParisTech, Universit\u00e9 PSL, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, INSERM, U1331, Mines ParisTech, Universit\u00e9 PSL, 75005, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I70768539","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013071253","display_name":"St\u00e9phane Vassilopoulos","orcid":"https://orcid.org/0000-0003-0172-330X","observed_orcids":["https://orcid.org/0000-0003-0172-330X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210113666","display_name":"Institut de Myologie","ror":"https://ror.org/0270xt841","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210100892","https://openalex.org/I4210113666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Vassilopoulos","raw_affiliation_strings":["Institute National de la Sant\u00e9 de la Recherche M\u00e9dicale, Institut de Myologie, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-0172-330X","affiliations":[{"raw_affiliation_string":"Institute National de la Sant\u00e9 de la Recherche M\u00e9dicale, Institut de Myologie, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210113666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090539581","display_name":"Emmanuelle Planus","orcid":"https://orcid.org/0000-0002-3981-906X","observed_orcids":["https://orcid.org/0000-0002-3981-906X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuelle Planus","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061539239","display_name":"Olivier Destaing","orcid":"https://orcid.org/0000-0001-7622-3700","observed_orcids":["https://orcid.org/0000-0001-7622-3700"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Olivier Destaing","raw_affiliation_strings":["Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Biosciences, Centre de Recherche Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5061539239"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210160510","https://openalex.org/I899635006"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fibrinogen-degradation","display_name":"fibrinogen degradation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.878000020980835},{"id":"https://openalex.org/keywords/cathepsins","display_name":"cathepsins","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cd63","display_name":"CD63","score":0.7870000004768372},{"id":"https://openalex.org/keywords/acidic-vesicles","display_name":"acidic vesicles","score":0.6790000200271606},{"id":"https://openalex.org/keywords/optogenetic-manipulation","display_name":"optogenetic manipulation","score":0.5609999895095825},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7074999809265137},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.6765000224113464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6672999858856201},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6564000248908997},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6067000031471252},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5335000157356262},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4964999854564667},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.4697999954223633},{"id":"https://openalex.org/C151701858","wikidata":"https://www.wikidata.org/wiki/Q14902024","display_name":"Cathepsin S","level":4,"score":0.4659000039100647},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4390000104904175},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.3684000074863434},{"id":"https://openalex.org/C64863464","wikidata":"https://www.wikidata.org/wiki/Q3190616","display_name":"Juxtacrine signalling","level":4,"score":0.364300012588501},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.3562000095844269},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.33660000562667847},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.33379998803138733},{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.329800009727478},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.31220000982284546},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.2874000072479248},{"id":"https://openalex.org/C200786668","wikidata":"https://www.wikidata.org/wiki/Q3498029","display_name":"Invadopodia","level":4,"score":0.2831999957561493},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25850000977516174}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.03.749091","doi":"https://doi.org/10.64898/2026.09.03.749091","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/07/2026.09.03.749091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.03.749091","doi":"https://doi.org/10.64898/2026.09.03.749091","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.03.749091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/07/2026.09.03.749091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8053393850","display_name":"France-BioImaging (Biological Imaging Next-Generation Instrument)","funder_award_id":"ANR-24-INBS-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7211898692.pdf","grobid_xml":"https://content.openalex.org/works/W7211898692.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W71612995","https://openalex.org/W1996360865","https://openalex.org/W1999251467","https://openalex.org/W2054076584","https://openalex.org/W2088641898","https://openalex.org/W2157293287","https://openalex.org/W2166791066","https://openalex.org/W2809151631","https://openalex.org/W3116459870","https://openalex.org/W7117412002"],"related_works":["https://openalex.org/W2149587786","https://openalex.org/W2118810030","https://openalex.org/W2102768625","https://openalex.org/W2021977327","https://openalex.org/W7099720729","https://openalex.org/W2085442465","https://openalex.org/W2006797103","https://openalex.org/W2024217848","https://openalex.org/W3147675151","https://openalex.org/W2923532320"],"abstract_inverted_index":{"Summary":[0],"The":[1],"diversity":[2],"of":[3,35,38,40,52,92,103,110,116,133,145,154,165,189],"strategies":[4],"implicated":[5],"in":[6,68,127,170],"extracellular":[7],"matrix":[8,74],"(ECM)":[9],"degradation":[10,39,54,66,94,156],"supporting":[11],"cell":[12,215],"invasion":[13,177,182],"has":[14],"been":[15],"poorly":[16],"achieved.":[17],"Unlike":[18],"invasive":[19,172],"breast":[20],"cancer":[21],"cells,":[22],"which":[23,199],"predominantly":[24],"degrade":[25],"the":[26,108,114,131,134,163,167,213],"ECM":[27,42,53,57,155,190],"locally":[28,59],"via":[29],"an":[30],"invadosome-associated":[31],"degradation,":[32,191],"dynamic":[33],"quantification":[34],"live":[36],"imaging":[37],"physiological":[41],"such":[43],"as":[44,119],"fibrinogen":[45,93],"showed":[46,82],"that":[47,83],"macrophages":[48],"employ":[49],"different":[50,175],"modes":[51,188],"since":[55],"digesting":[56],"both":[58,73,192],"and":[60,77,99,126,140,143,160],"at":[61,107,113,208,212],"long":[62],"distance.":[63],"Long":[64],"distance":[65],"occurring":[67],"macrophage":[69,214],"is":[70,183],"dependent":[71],"on":[72],"metalloproteases":[75],"(MMPs)":[76],"cathepsins":[78,97,201],"release.":[79,151],"Optogenetic":[80],"manipulation":[81],"HCK":[84,197],"signaling":[85],"specifically":[86],"regulates":[87,200],"positively":[88],"this":[89,161],"new":[90,121],"mode":[91,153],"by":[95,148,185,196,203],"increasing":[96],"release":[98],"activating":[100],"localized":[101],"fusion":[102,207],"acidic":[104,205],"CD63-endolysosome":[105],"vesicles":[106,206],"vicinity":[109],"clathrin":[111,209],"hotspots":[112,210],"rear":[115],"macrophages,":[117],"appearing":[118],"a":[120],"exo-endocytosis":[122],"coupling.":[123],"Computational":[124],"biology":[125],"silico":[128],"simulations":[129],"support":[130],"importance":[132,164],"fine":[135],"spatiotemporal":[136],"coordination":[137],"between":[138],"MMPs":[139],"cathepsin":[141,146],"activities,":[142],"regulation":[144],"activity":[147,202],"local":[149],"acid":[150],"Different":[152],"can":[157],"thus":[158],"coexist":[159],"highlight":[162],"understanding":[166],"cathepsins-MMPs":[168],"synergy":[169],"shaping":[171],"behavior":[173],"across":[174],"physio-pathological":[176],"processes.":[178],"\u201cOne-sentence":[179],"summary\u201d":[180],"Macrophage":[181],"supported":[184],"two":[186],"distinct":[187],"are":[193],"partially":[194],"regulated":[195],"signaling,":[198],"stabilizing":[204],"located":[211],"rear.":[216]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-08T00:00:00"}